4.6 Review

Early intervention in psoriasis: Where do we go from here?

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Review Dermatology

PASI 100 response rates in moderate to severe psoriasis: a systematic literature review and analysis of clinical practice guidelines

Isabel Belinchon Romero et al.

Summary: PASI 100 response rate is primarily used in research, and the achievement rate varies for different pharmacological treatments. Clinical practice guidelines provide limited comments on PASI 100.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

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Biological disease-modifying antirheumatic drugs may mitigate the risk of psoriatic arthritis in patients with chronic plaque psoriasis

Paolo Gisondi et al.

Summary: In patients with moderate-to-severe chronic plaque psoriasis, treatment with bDMARDs may delay or reduce the risk of incident PsA. The annual incidence rate of PsA was significantly lower in the bDMARDs group compared to the phototherapy group. Factors associated with a higher risk of PsA included older age, nail psoriasis, and psoriasis duration over 10 years.

ANNALS OF THE RHEUMATIC DISEASES (2022)

Article Dermatology

Risk of hospitalization and death due to infection in people with psoriasis: a population-based cohort study using the Clinical Practice Research Datalink

Z. Z. N. Yiu et al.

Summary: The study found that patients with psoriasis have a higher incidence rate of serious infection, as well as other infection-related risks. Further research is needed to understand how psoriasis predisposes to a higher risk of infection.

BRITISH JOURNAL OF DERMATOLOGY (2021)

Article Dermatology

The global, regional, and national burden of psoriasis in 195 countries and territories, 1990 to 2017: A systematic analysis from the Global Burden of Disease Study 2017

Sino Mehrmal et al.

Summary: There is a rising global prevalence, burden, and associated comorbidities of psoriasis, with a left-skewed age-specific prevalence distribution and roughly equal male-to-female ratio across all ages. Psoriasis burden is highest in high-income countries with a high sociodemographic index. A positive linear relationship between psoriasis prevalence and comorbidities such as cardiovascular disease, mental health, type 2 diabetes mellitus, stroke, non-Hodgkin lymphoma, Hodgkin lymphoma, nonmelanoma skin cancer, and inflammatory bowel disease is observed across all countries in 2017.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

Review Dermatology

Role of regulatory T cells in psoriasis pathogenesis and treatment

L. Nussbaum et al.

Summary: Psoriasis is a chronic inflammatory disease with a strong genetic component that can be triggered by environmental factors. Tregs play a fundamental role in immune homeostasis and contribute to the prevention of autoimmune disease by suppressing immune responses, but their functional regulation remains unclear in the context of psoriasis.

BRITISH JOURNAL OF DERMATOLOGY (2021)

Review Pharmacology & Pharmacy

Dose Tapering of Biologics in Patients with Psoriasis: A Scoping Review

C. A. J. Michielsens et al.

Summary: Biologic tapering appears to be effective and safe in psoriasis patients with stable low disease activity or clinical remission. More research is needed to address the current gaps in knowledge, particularly in terms of tapering criteria and strategies, long-term safety, predictors for successful tapering, cost-effectiveness, and evaluation of newer generation biologics.
Article Rheumatology

Tissue-Resident Memory CD8+T Cells From Skin Differentiate Psoriatic Arthritis From Psoriasis

Emmerik F. Leijten et al.

Summary: Compared to psoriasis, patients with PsA have increased regulatory CD4+ T cells in peripheral blood and a specific population of CD8+CCR10+ T cells that are enriched in PsA. These CD8+CCR10+ T cells express a tissue-resident memory T cell transcriptional signature and a Tc2/22-like cytokine profile, suggesting a potential role in the development of PsA.

ARTHRITIS & RHEUMATOLOGY (2021)

Letter Dermatology

Brazilian Consensus on Psoriasis 2020 and Treatment Algorithm of the Brazilian Society of Dermatology

Ricardo Romiti et al.

ANAIS BRASILEIROS DE DERMATOLOGIA (2021)

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IL-23 blockade with guselkumab potentially modifies psoriasis pathogenesis: rationale and study protocol of a phase 3b, randomised, double-blind, multicentre study in participants with moderate-to-severe plaque-type psoriasis (GUIDE)

Kilian Eyerich et al.

Summary: This study aims to compare the efficacy of Guselkumab treatment in patients with short-term and long-term plaque psoriasis, in order to investigate how it can modify the disease course by altering molecular and cellular drivers.

BMJ OPEN (2021)

Article Dermatology

Modifiable risk factors and the development of psoriatic arthritis in people with psoriasis

A. Green et al.

BRITISH JOURNAL OF DERMATOLOGY (2020)

Review Dermatology

Management of psoriasis as a systemic disease: what is the evidence?

N. J. Korman

BRITISH JOURNAL OF DERMATOLOGY (2020)

Article Dermatology

A Belgian consensus on the definition of a treat-to-target outcome set in psoriasis management

L. Grine et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Article Dermatology

Japanese guidance for use of biologics for psoriasis (the 2019 version)

Hidehisa Saeki et al.

JOURNAL OF DERMATOLOGY (2020)

Article Medicine, General & Internal

National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study

Rosa Parisi et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

Review Medicine, General & Internal

Early Intervention in Ulcerative Colitis: Ready for Prime Time?

Virginia Solitano et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Dermatology

Psoriasis and Treatment: Past, Present and Future Aspects

Claire Reid et al.

ACTA DERMATO-VENEREOLOGICA (2020)

Review Medicine, General & Internal

Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis

Emilie Sbidian et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2020)

Article Dermatology

French guidelines on the use of systemic treatments for moderate-to-severe psoriasis in adults

F. Amatore et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

Article Dermatology

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities

Craig A. Elmets et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

Article Dermatology

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics

Alan Menter et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

Review Immunology

Resolution of plaque-type psoriasis: what is left behind (and reinitiates the disease)

Theresa Benezeder et al.

SEMINARS IN IMMUNOPATHOLOGY (2019)

Article Dermatology

Duration of Psoriatic Skin Disease as Risk Factor for Subsequent Onset of Psoriatic Arthritis

Alexander Egeberg et al.

ACTA DERMATO-VENEREOLOGICA (2018)

Article Dermatology

Consensus on the management of patients with psoriatic arthritis in a dermatology setting

P. Gisondi et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2018)

Article Gastroenterology & Hepatology

Early intervention in Crohn's disease: towards disease modification trials

Silvio Danese et al.

Article Dermatology

From the Medical Board of the National Psoriasis Foundation: Treatment targets for plaque psoriasis

April W. Armstrong et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2017)

Review Medicine, General & Internal

Psoriatic Arthritis

Christopher T. Ritchlin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Rheumatology

Mitigation of disease- and treatment-related risks in patients with psoriatic arthritis

Martin Bergman et al.

ARTHRITIS RESEARCH & THERAPY (2017)

Article Rheumatology

Incidence and predictors for cardiovascular events in patients with psoriatic arthritis

Lihi Eder et al.

ANNALS OF THE RHEUMATIC DISEASES (2016)

Article Dermatology

Do Biologics Protect Patients With Psoriasis From Myocardial Infarction? A Retrospective Cohort

Wayne P. Gulliver et al.

JOURNAL OF CUTANEOUS MEDICINE AND SURGERY (2016)

Article Dermatology

Genetic prediction of the effectiveness of biologics for psoriasis treatment

Rika Nishikawa et al.

JOURNAL OF DERMATOLOGY (2016)

Review Immunology

T Helper Cell Subsets in Clinical Manifestations of Psoriasis

Marco Diani et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2016)

Article Dermatology

Psoriasis - The Life Course Approach

M. Dennis Linder et al.

ACTA DERMATO-VENEREOLOGICA (2016)

Article Dermatology

Think beyond the Skin: 2014 Canadian Expert Opinion Paper on Treating to Target in Plaque Psoriasis

Wayne Gulliver et al.

JOURNAL OF CUTANEOUS MEDICINE AND SURGERY (2015)

Article Rheumatology

Prevalence of Psoriatic Arthritis in a Large Cohort of Brazilian Patients with Psoriasis

Roberto Ranza et al.

JOURNAL OF RHEUMATOLOGY (2015)

Review Dermatology

Early intervention in psoriasis and immune-mediated inflammatory diseases: A hypothesis paper

G. Girolomoni et al.

JOURNAL OF DERMATOLOGICAL TREATMENT (2015)

Review Dermatology

PASI90 response: the new standard in therapeutic efficacy for psoriasis

L. Puig

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2015)

Article Rheumatology

Concept of Remission in Chronic Plaque Psoriasis

Paolo Gisondi et al.

JOURNAL OF RHEUMATOLOGY (2015)

Article Dermatology

Psoriasis Is Not Associated with Atherosclerosis and Incident Cardiovascular Events: The Rotterdam Study

Emmilia A. Dowlatshahi et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

Review Cardiac & Cardiovascular Systems

Psoriasis and Major Adverse Cardiovascular Events: A Systematic Review and Meta-Analysis of Observational Studies

Ehrin J. Armstrong et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2013)

Article Rheumatology

Early Psoriatic Arthritis

Dafna D. Gladman

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2012)

Article Dermatology

Definition of treatment goals for moderate to severe psoriasis: a European consensus

U. Mrowietz et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2011)

Review Dermatology

Skin-Resident T Cells: The Ups and Downs of On Site Immunity

Rachael A. Clark

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)

Article Dermatology

Psoriasis: is the impairment to a patient's life cumulative?

A. B. Kimball et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2010)

Article Dermatology

The Risk of Stroke in Patients with Psoriasis

Joel M. Gelfand et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)

Review Medicine, General & Internal

Mechanisms of Disease: Psoriasis.

Frank O. Nestle et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Review Biochemistry & Molecular Biology

Regulatory T cells and immune tolerance

Shimon Sakaguchi et al.

Article Medicine, General & Internal

Risk of myocardial infarction in patients with psoriasis

Joel M. Gelfand et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)

Review Medicine, General & Internal

Medical progress - Psoriasis

MP Schon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)