4.6 Review

Hot topics on fecal microbiota transplantation for the treatment of inflammatory bowel disease

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Review Gastroenterology & Hepatology

Efficacy of Fecal Microbiota Transplantation in the Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials

Nabil El Hage Chehade et al.

Summary: This study systematically reviewed the efficacy of fecal microbiota transplantation in patients with ulcerative colitis through double-blind randomized controlled trials. The results indicated that FMT can induce short-term clinical and endoscopic remission in patients with ulcerative colitis, with a comparable safety profile to placebo.

INFLAMMATORY BOWEL DISEASES (2023)

Article Medicine, General & Internal

Donor Screening Revisions of Fecal Microbiota Transplantation in Patients with Ulcerative Colitis

Xiaochen Zhang et al.

Summary: Fecal microbiota transplantation is considered a promising treatment for dysbiosis-related diseases. The authors report their experience with donor screening and provide references to improve future donor screening criteria.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Medicine, General & Internal

A Randomized Placebo-Controlled Trial of Combination Therapy With Post-triple-antibiotic-therapy Fecal Microbiota Transplantation and Alginate for Ulcerative Colitis: Protocol

Dai Ishikawa et al.

Summary: This study aims to investigate the role of alginate in FMT treatment for colitis. By drinking alginate after A-FMT, the intestinal environment can be improved, and the goal is to enhance the therapeutic effect and long-term remission rate. The study uses a double-blinded, randomized, placebo-controlled approach, and will assess clinical features, microbiota, and metabolomic analysis.

FRONTIERS IN MEDICINE (2022)

Review Gastroenterology & Hepatology

Adverse events of intestinal microbiota transplantation in randomized controlled trials: a systematic review and meta-analysis

Chong Chen et al.

Summary: This systematic review and meta-analysis evaluated the safety of intestinal microbiota transplantation (IMT). The results showed no significant increase in the incidence of serious adverse events and common adverse events with IMT. However, the delivery methods may affect the occurrence of common adverse events. To improve the safety of IMT, a thorough evaluation of patients' conditions and appropriate transplantation methods should be considered.

GUT PATHOGENS (2022)

Article Multidisciplinary Sciences

Strain-resolved analysis in a randomized trial of antibiotic pretreatment and maintenance dose delivery mode with fecal microbiota transplant for ulcerative colitis

Byron J. Smith et al.

Summary: Fecal microbiota transplant is a promising therapy for ulcerative colitis. This study found that antibiotic pretreatment contributes to microbiome engraftment and possibly clinical effectiveness, and identified associations between microbiome turnover and changes in bile acid composition.

SCIENTIFIC REPORTS (2022)

Article Biotechnology & Applied Microbiology

Long-term efficacy and safety of monotherapy with a single fresh fecal microbiota transplant for recurrent active ulcerative colitis: a prospective randomized pilot study

Haiming Fang et al.

Summary: The study demonstrates that monotherapy with a single fresh FMT is an effective and safe strategy for inducing long-term remission in patients with active UC, providing a potential alternative to drug therapy for recurrent or primary UC.

MICROBIAL CELL FACTORIES (2021)

Article Multidisciplinary Sciences

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Erez N. Baruch et al.

Summary: This study conducted a phase 1 clinical trial and found that FMT treatment in patients with anti-PD-1-refractory metastatic melanoma, along with reinduction of anti-PD-1 immunotherapy, resulted in clinical responses in some patients. This suggests that modulating the gut microbiota could be a promising approach in cancer treatment.

SCIENCE (2021)

Article Gastroenterology & Hepatology

Fecal Microbiota Transplantation in Chronic Pouchitis: A Randomized, Parallel, Double-Blinded Clinical Trial

Essi K. Karjalainen et al.

Summary: The fecal microbiota transplantation treatment did not show efficacy in treating chronic pouchitis, however the safety profile was good. Among patients who were using continuous antibiotics before the study, the relapse-free survival was shorter in the intervention group.

INFLAMMATORY BOWEL DISEASES (2021)

Article Multidisciplinary Sciences

Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients

Diwakar Davar et al.

Summary: The study demonstrated that fecal microbiota transplantation combined with anti-PD-1 therapy can overcome resistance to anti-PD-1 in a subset of PD-1 refractory melanoma patients, leading to clinical benefits. This approach induced changes in the gut microbiome and reprogrammed the tumor microenvironment, ultimately enhancing the efficacy of anti-PD-1 treatment.

SCIENCE (2021)

Review Medicine, General & Internal

Repeated Fecal Microbial Transplantations and Antibiotic Pre-Treatment Are Linked to Improved Clinical Response and Remission in Inflammatory Bowel Disease: A Systematic Review and Pooled Proportion Meta-Analysis

Valentin Mocanu et al.

Summary: Both repeated FMT and antibiotic pre-treatment strategies have shown improvements in clinical response and remission rates for IBD patients, associated with increased fecal microbiota richness and alpha-diversity, as well as the enrichment of several short-chain fatty acid (SCFA)-producing anaerobes.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Gastroenterology & Hepatology

Fecal microbiota transplantation for Crohn's disease: a systematic review and meta-analysis

F. Cheng et al.

Summary: Fecal microbiota transplantation (FMT) is shown to be an effective and safe therapy for Crohn's disease (CD), possibly due to its ability to increase the overall diversity of enteric microbiome. Studies indicate that fresh stool FMT may have a higher rate of clinical remission compared to frozen stool FMT. Further randomized controlled studies are necessary for more conclusive evidence.

TECHNIQUES IN COLOPROCTOLOGY (2021)

Article Medicine, General & Internal

Bacteroidetes Species Are Correlated with Disease Activity in Ulcerative Colitis

Kei Nomura et al.

Summary: Fecal microbiota transplantation following antibiotic therapy can improve dysbiosis in ulcerative colitis (UC) patients. The reduced abundance of Bacteroidetes species is correlated with UC activity, and certain key species may serve as potential biomarkers for disease activity.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Gastroenterology & Hepatology

Daily, oral FMT for long-term maintenance therapy in ulcerative colitis: results of a single-center, prospective, randomized pilot study

Jessica W. Crothers et al.

Summary: The study shows that long-term oral administration of frozen encapsulated FMT is safe and effective in treating UC, with sustained improvements in gut microbial composition. Some patients achieved clinical remission, and changes in MAIT cell cytokine production may be associated with treatment response.

BMC GASTROENTEROLOGY (2021)

Review Gastroenterology & Hepatology

Can control of gut microbiota be a future therapeutic option for inflammatory bowel disease?

Atsushi Nishida et al.

Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, involving Crohn's disease and ulcerative colitis, with aberrant immune activation possibly caused by genetic susceptibility and environmental factors. Studies have shown dysbiosis and altered metabolites from the gut microbiota to play a role in IBD pathogenesis. Interventions like fecal microbiota transplantation (FMT) are being explored as novel therapies for IBD, but their efficacy is still debated, requiring further research validation.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Article Microbiology

Dynamic Colonization of Microbes and Their Functions after Fecal Microbiota Transplantation for Inflammatory Bowel Disease

Nathaniel D. Chu et al.

Summary: The study on fecal microbiota transplantation (FMT) in patients with ulcerative colitis revealed dynamic colonization and persistence of transferred microbes, along with evaluation of microbial functions, including interactions with the host immune system. This research sheds light on the potential role of transferred microbial interactions in gut microbiome therapeutics for immune related diseases.
Review Medicine, General & Internal

Probiotics, Prebiotics and Synbiotics in Inflammatory Bowel Diseases

Katarzyna Akutko et al.

Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Medicine, General & Internal

The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease

Magdalena Stojek et al.

Summary: The exact pathogenesis of inflammatory bowel disease is not fully understood, but it is believed to involve genetic predisposition, environmental triggers, and exaggerated immune responses. Current management strategies focus on correcting immune responses, with potential new treatments like FMT showing promising results.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Pharmacology & Pharmacy

Long-term outcomes of antibiotic combination therapy for ulcerative colitis

Yuriko Nishikawa et al.

Summary: The study indicates that the revised antibiotic combination of amoxicillin, fosfomycin, and metronidazole (AFM) is effective in inducing remission and suitable for long-term maintenance of ulcerative colitis (UC) patients with fewer and milder adverse events compared to the previous therapy with amoxicillin, tetracycline, and metronidazole (ATM).

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2021)

Article Gastroenterology & Hepatology

Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study

Daniel Selvig et al.

DIGESTIVE DISEASES AND SCIENCES (2020)

Article Gastroenterology & Hepatology

Fecal Microbiota Transplant via Endoscopic Delivering Through Small Intestine and Colon: No Difference for Crohn's Disease

Zhenyu Yang et al.

DIGESTIVE DISEASES AND SCIENCES (2020)

Article Medicine, Research & Experimental

Fecal microbiota transplantation ameliorates active ulcerative colitis

Hui-Ting Chen et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

Article Biotechnology & Applied Microbiology

Efficacy of faecal microbiota transplantation in Crohn's disease: a new target treatment?

Liyuan Xiang et al.

MICROBIAL BIOTECHNOLOGY (2020)

Article Gastroenterology & Hepatology

Enhancing patient adherence to fecal microbiota transplantation maintains the long-term clinical effects in ulcerative colitis

Qianqian Li et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

Clinical results and microbiota changes after faecal microbiota transplantation for chronic pouchitis: a pilot study

Sabrina Just Kousgaard et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2020)

Article Gastroenterology & Hepatology

Capsule-Delivered Fecal Microbiota Transplant Is Safe and Well Tolerated in Patients with Ulcerative Colitis

Elizabeth Adler et al.

DIGESTIVE DISEASES AND SCIENCES (2019)

Article Medicine, General & Internal

Bacterial viability in faecal transplants: Which bacteria survive?

Lito E. Papanicolas et al.

EBIOMEDICINE (2019)

Review Medicine, General & Internal

Role of intestinal microbiota and metabolites in inflammatory bowel disease

Li-Na Dong et al.

CHINESE MEDICAL JOURNAL (2019)

Article Gastroenterology & Hepatology

Fecal microbiota transplant for Crohn disease: A study evaluating safety, efficacy, and microbiome profile

Liat Gutin et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2019)

Article Multidisciplinary Sciences

Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota

Dae-Wook Kang et al.

SCIENTIFIC REPORTS (2019)

Article Medicine, General & Internal

Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant

Zachariah DeFilipp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Biotechnology & Applied Microbiology

Timing for the second fecal microbiota transplantation to maintain the long-term benefit from the first treatment for Crohn's disease

Pan Li et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2019)

Article Medicine, General & Internal

Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis A Randomized Clinical Trial

Samuel P. Costello et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Article Biotechnology & Applied Microbiology

Faecal freezing preservation period influences colonization ability for faecal microbiota transplantation

M. Takahashi et al.

JOURNAL OF APPLIED MICROBIOLOGY (2019)

Article Medicine, General & Internal

The efficacy of fecal microbiota transplantation for patients with chronic pouchitis: A case series

Atsushi Nishida et al.

CLINICAL CASE REPORTS (2019)

Review Biochemistry & Molecular Biology

Human Gut Microbiome: Function Matters

Anna Heintz-Buschart et al.

TRENDS IN MICROBIOLOGY (2018)

Review Biotechnology & Applied Microbiology

Protocol for Fecal Microbiota Transplantation in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Haiming Fang et al.

BIOMED RESEARCH INTERNATIONAL (2018)

Article Medicine, Research & Experimental

The Safety of Fecal Microbiota Transplantation for Crohn's Disease: Findings from A Long-Term Study

Honggang Wang et al.

ADVANCES IN THERAPY (2018)

Review Gastroenterology & Hepatology

Systematic review: ileoanal pouch microbiota in health and disease

J. P. Segal et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2018)

Article Gastroenterology & Hepatology

Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection

Stephan J. Ott et al.

GASTROENTEROLOGY (2017)

Article Gastroenterology & Hepatology

European consensus conference on faecal microbiota transplantation in clinical practice

Giovanni Cammarota et al.

Review Gastroenterology & Hepatology

Systematic Review and Meta-analysis: Fecal Microbiota Transplantation for Treatment of Active Ulcerative Colitis

Neeraj Narula et al.

INFLAMMATORY BOWEL DISEASES (2017)

Article Gastroenterology & Hepatology

Results at Up to 30 Years After Ileal Pouch-Anal Anastomosis for Chronic Ulcerative Colitis

Amy L. Lightner et al.

INFLAMMATORY BOWEL DISEASES (2017)

Letter Gastroenterology & Hepatology

Successful treatment of pouchitis with Vedolizumab, but not fecal microbiota transfer (FMT), after proctocolectomy in ulcerative colitis

Mona Schmid et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2017)

Review Gastroenterology & Hepatology

Faecal Microbiota Transplantation for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Sudarshan Paramsothy et al.

JOURNAL OF CROHNS & COLITIS (2017)

Article Immunology

Establishing a Fecal Microbiota Transplant Service for the Treatment of Clostridium difficile Infection

Samuel P. Costello et al.

CLINICAL INFECTIOUS DISEASES (2016)

Letter Gastroenterology & Hepatology

Successful treatment of chronic Pouchitis utilizing fecal microbiota transplantation (FMT): a case report

Shuyang Fang et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2016)

Article Gastroenterology & Hepatology

Diagnosis of Helicobacter Pylori Infection is Associated with Lower Prevalence and Subsequent Incidence of Crohn's Disease

Lars E. Bartels et al.

JOURNAL OF CROHNS & COLITIS (2016)

Article Gastroenterology & Hepatology

Donor Species Richness Determines Faecal Microbiota Transplantation Success in Inflammatory Bowel Disease

Severine Vermeire et al.

JOURNAL OF CROHNS & COLITIS (2016)

Meeting Abstract Gastroenterology & Hepatology

Role of Fecal Microbiota Transplantation in Patients with Steroid Dependant Ulcerative Colitis

Charanpreet S. Grewal et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2016)

Letter Gastroenterology & Hepatology

Fecal Microbiota Transfer in Patients With Chronic Antibiotic-Refractory Pouchitis

Andreas Stallmach et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2016)

Article Gastroenterology & Hepatology

Increased Intestinal Microbial Diversity Following Fecal Microbiota Transplant for Active Crohn's Disease

Byron P. Vaughn et al.

INFLAMMATORY BOWEL DISEASES (2016)

Review Public, Environmental & Occupational Health

Adverse events in faecal microbiota transplant: a review of the literature

M. Baxter et al.

JOURNAL OF HOSPITAL INFECTION (2016)

Review Multidisciplinary Sciences

Systematic Review: Adverse Events of Fecal Microbiota Transplantation

Sinan Wang et al.

PLOS ONE (2016)

Article Pediatrics

Failure of Fecal Microbiota Transplantation in a Three-Year-Old Child with Severe Refractory Ulcerative Colitis

Hideki Kumagai et al.

PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION (2016)

Article Gastroenterology & Hepatology

Findings From a Randomized Controlled Trial of Fecal Transplantation for Patients With Ulcerative Colitis

Noortje G. Rossen et al.

GASTROENTEROLOGY (2015)

Article Gastroenterology & Hepatology

Fecal Microbial Transplant Effect on Clinical Outcomes and Fecal Microbiome in Active Crohn's Disease

David L. Suskind et al.

INFLAMMATORY BOWEL DISEASES (2015)

Article Gastroenterology & Hepatology

Fecal Microbial Transplantation in Early-Onset Colitis: Caution Advised

Y. Vandenplas et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2015)

Article Gastroenterology & Hepatology

Fecal Microbial Transplant Via Nasogastric Tube for Active Pediatric Ulcerative Colitis

David L. Suskind et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2015)

Article Medicine, Research & Experimental

Step-up fecal microbiota transplantation strategy: a pilot study for steroid-dependent ulcerative colitis

Bota Cui et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2015)

Article Gastroenterology & Hepatology

Fecal Microbiota Transplantation Improves the Quality of Life in Patients with Inflammatory Bowel Disease

Yao Wei et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2015)

Article Gastroenterology & Hepatology

Fecal microbiota transplantation through mid-gut for refractory Crohn's disease: Safety, feasibility, and efficacy trial results

Bota Cui et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015)

Meeting Abstract Gastroenterology & Hepatology

Long side-to-side isoperistaltic strictureplasty over the ileocecal valve: a prospective analysis of feasibility and medium term outcome

A. de Buck van Overstraeten et al.

JOURNAL OF CROHNS & COLITIS (2015)

Article Gastroenterology & Hepatology

Fecal Microbiota Transplantation Inducing Remission in Crohn's Colitis and the Associated Changes in Fecal Microbial Profile

Dina Kao et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2014)

Article Medicine, General & Internal

Case 25-2014: A 37-Year-Old Man with Ulcerative Colitis and Bloody Diarrhea

Elizabeth L. Hohmann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Gastroenterology & Hepatology

Fecal Microbiota Transplantation for Clostridium difficile Infection: Systematic Review and Meta-Analysis

Zain Kassam et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2013)

Article Gastroenterology & Hepatology

Temporal Bacterial Community Dynamics Vary Among Ulcerative Colitis Patients After Fecal Microbiota Transplantation

Sieglinde Angelberger et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2013)

Article Gastroenterology & Hepatology

Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn's disease

Takehide Fujimoto et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013)

Article Gastroenterology & Hepatology

Safety, Tolerability, and Clinical Response After Fecal Transplantation in Children and Young Adults With Ulcerative Colitis

Sachin Kunde et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2013)

Review Chemistry, Medicinal

Current and emerging drugs for the treatment of inflammatory bowel disease

John K. Triantafillidis et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2011)

Article Gastroenterology & Hepatology

Newly Developed Antibiotic Combination Therapy for Ulcerative Colitis: A Double-Blind Placebo-Controlled Multicenter Trial

Toshifumi Ohkusa et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2010)