Natural Steroidal Lactone Induces G1/S Phase Cell Cycle Arrest and Intrinsic Apoptotic Pathway by Up-Regulating Tumor Suppressive miRNA in Triple-Negative Breast Cancer Cells

Article Biochemistry & Molecular Biology

Hesperidin potentially interacts with the catalytic site of gamma-secretase and modifies notch sensitive genes and cancer stemness marker expression in colon cancer cells and colonosphere

Atul Kumar Singh et al.

Summary: This study demonstrates the potential of hesperidin to bind to the catalytic site of GS and inhibit the Notch signaling pathway, leading to a decrease in cancer stemness and colonosphere formation.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2023)

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Article Pathology

MiR-181c suppresses triple-negative breast cancer tumorigenesis by targeting MAP4K4

Dan Xie et al.

Summary: Breast cancer is the most common cancer in women worldwide, and triple negative breast cancer is a highly aggressive subtype of breast cancer. This study demonstrates that miR-181c inhibits the proliferation and migration of triple negative breast cancer cells, promotes apoptosis, and regulates the cell cycle. Importantly, miR-181c suppresses the tumor-promoting effect of MAP4K4 by targeting its expression.

PATHOLOGY RESEARCH AND PRACTICE (2022)

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Review Pharmacology & Pharmacy

Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review

Lie Yuan et al.

Summary: Breast cancer is a major global health concern for women due to its high rates of morbidity and mortality. Chemotherapy is commonly used for breast cancer treatment, but resistance and toxic side effects are common. In recent years, natural products have gained attention for their low side effects, low toxicity, and effectiveness through multitarget therapy. Inducing apoptosis, a form of programmed cell death, is an important strategy for controlling excessive breast cancer cell proliferation. This review examines the current research on natural product-induced breast cancer cell apoptosis and summarizes the mechanisms involved. The hope is that this review will contribute to the search for candidate drugs derived from natural products to promote cell apoptosis and treat breast cancer.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biotechnology & Applied Microbiology

MiR-181c sensitizes ovarian cancer cells to paclitaxel by targeting GRP78 through the PI3K/Akt pathway

Li-ying Zhang et al.

Summary: The study identified miR-181c as downregulated in PTX-resistant ovarian cancer cells and tissues, which induced apoptosis and inhibited the PI3K/Akt pathway by directly targeting GRP78. Overexpression of miR-181c sensitized resistant ovarian cancer to PTX, suggesting a potential therapeutic strategy.

CANCER GENE THERAPY (2022)

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Article Oncology

Targeting HIF1-alpha/miR-326/ITGA5 axis potentiates chemotherapy response in triple-negative breast cancer

Ridho Assidicky et al.

Summary: In this study, we identified fibronectin (FN1) as a central driver gene in chemoresistance. Overexpression of miR-326 reversed FN1-driven chemoresistance by targeting the FN1 receptor, ITGA5. miR-326 expression was downregulated by increased hypoxia/HIF1A and ECM stiffness in chemoresistant tumors, leading to upregulation of ITGA5 and activation of the downstream FAK/Src signaling pathways. Overexpression of miR-326 or inhibition of ITGA5 overcame FN1-driven chemotherapy resistance in vitro by inhibiting the FAK/Src pathway and potentiated the efficacy of chemotherapy in vivo. Importantly, lower expression of miR-326 or higher levels of predicted miR-326 target genes were significantly associated with worse overall survival in chemotherapy-treated TNBC patients.

BREAST CANCER RESEARCH AND TREATMENT (2022)

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Article Biochemistry & Molecular Biology

Withaferin A mediated changes of miRNA expression in breast cancer-derived mammospheres

Kumari Sunita Prajapati et al.

Summary: Breast cancer is a heterogeneous disease, and WA inhibits the proliferation and stemness of breast cancer cells by modulating miRNA expression, thereby inhibiting mammosphere formation.

MOLECULAR CARCINOGENESIS (2022)

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Article Biochemistry & Molecular Biology

Rutin Potentially Binds the Gamma Secretase Catalytic Site, Down Regulates the Notch Signaling Pathway and Reduces Sphere Formation in Colonospheres

Atul Kumar Singh et al.

Summary: The study reveals that rutin can inhibit the notch signaling pathway and reduce the stemness/self-renewal property in colon cancer cells and colonospheres by targeting gamma secretase.

METABOLITES (2022)

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Review Medicine, Research & Experimental

Implications of Withaferin-A for triple-negative breast cancer chemoprevention

Harshini Mallipeddi et al.

Summary: The natural compound Withaferin-A has shown promising anti-tumoral activities against TNBC in both in-vitro and in-vivo experimental models, with studies indicating its potential to enhance chemotherapy efficacy. Derived from the ayurvedic medicinal plant Withania somnifera, Withaferin-A demonstrates anti-inflammatory and anti-cancer properties, highlighting its significance in the treatment of TNBC.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Pharmacology & Pharmacy

Five-Decade Update on Chemopreventive and Other Pharmacological Potential of Kurarinone: a Natural Flavanone

Shashank Kumar et al.

Summary: Kurarinone exhibits anticancer potential against various types of cancer cells by inducing apoptosis, inhibiting cell cycle progression, preventing metastasis, and modulating protein expression.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Pulveraven A from the fruiting bodies of Pulveroboletus ravenelii induces apoptosis in breast cancer cell via extrinsic apoptotic signaling pathway

Dahae Lee et al.

Summary: The study analyzed the anticancer activity of pulveraven A from Pulveroboletus ravenelii, demonstrating its induction of apoptotic cell death in breast cancer cells via the extrinsic apoptotic signaling pathway.

JOURNAL OF ANTIBIOTICS (2021)

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Article Multidisciplinary Sciences

Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling

Radhakrishnan Vishnubalaji et al.

Summary: TGF beta signaling in TNBC is complex and involves regulation of protein coding genes and long non-coding RNA. The study provides a comprehensive analysis of the transcriptional landscape in response to TGF beta activation and inhibition, revealing potential targets for TGF beta regulation in TNBC.

SCIENTIFIC REPORTS (2021)

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Article Biotechnology & Applied Microbiology

Identification of cancer stemness related miRNA(s) using integrated bioinformatics analysis and in vitro validation

Kumari Sunita Prajapati et al.

Summary: This study identified 22 common miRNAs involved in regulating major stem cell signaling pathways, including miRNAs associated with breast cancer stemness. The clinical relevance of these miRNAs was confirmed by survival analysis in breast cancer patients, showing poor overall survival and high expression levels in invasive breast cancer subgroups. Further validation in in vitro models demonstrated the downregulation of lead miRNA with phytochemical treatment.

3 BIOTECH (2021)

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Article Oncology

RNA-seq reveals novel mechanistic targets of withaferin A in prostate cancer cells

Su-Hyeong Kim et al.

CARCINOGENESIS (2020)

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Review Biochemistry & Molecular Biology

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

Alessia Indrieri et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biotechnology & Applied Microbiology

MiR-181c-5p Mitigates Tumorigenesis in Cervical Squamous Cell Carcinoma via Targeting Glycogen Synthase Kinase 3β Interaction Protein (GSKIP)

Niuniu Li et al.

ONCOTARGETS AND THERAPY (2020)

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Review Oncology

A Comprehensive Review and Perspective on Anticancer Mechanisms of Withaferin A in Breast Cancer

Eun-Ryeong Hahm et al.

CANCER PREVENTION RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Natural Agents Targeting Mitochondria in Cancer

Shalini Mani et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

RPN2 is targeted by miR-181c and mediates glioma progression and temozolomide sensitivity via the wnt/β-catenin signaling pathway

Jikui Sun et al.

CELL DEATH & DISEASE (2020)

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Article Pharmacology & Pharmacy

Induction of apoptosis in breast cancer cells by naphthylisoquinoline alkaloids

Prem Prakash Kushwaha et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2020)

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Review Oncology

Triple-negative breast cancer molecular subtyping and treatment progress

Li Yin et al.

BREAST CANCER RESEARCH (2020)

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Article Plant Sciences

Different effects of 4β-hydroxywithanolide E and withaferin A, two withanolides from Solanaceae plants, on the Akt signaling pathway in human breast cancer cells

Hui-Chun Wang et al.

PHYTOMEDICINE (2019)

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Article Cell Biology

The long noncoding RNA sONE represses triple-negative breast cancer aggressiveness through inducing the expression of miR-34a, miR-15a, miR-16, and let-7a

Rana A. Youness et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Oncology

MicroRNA-181c suppresses growth and metastasis of hepatocellular carcinoma by modulating NCAPG

Jiyuan Ai et al.

CANCER MANAGEMENT AND RESEARCH (2019)

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Article Medicine, Research & Experimental

Bulbine frutescens phytochemical inhibits notch signaling pathway and induces apoptosis in triple negative and luminal breast cancer cells

Prem Prakash Kushwaha et al.

LIFE SCIENCES (2019)

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Article Endocrinology & Metabolism

MiR-181c affects estrogen-dependent endometria carcinoma cell growth by targeting PTEN

Lili Zhuang et al.

ENDOCRINE JOURNAL (2019)

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Article Cell Biology

MCL-1 is a prognostic indicator and drug target in breast cancer

Kirsteen J. Campbell et al.

CELL DEATH & DISEASE (2018)

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Article Biotechnology & Applied Microbiology

Apoptosis regulator Bcl-2 is an independent prognostic marker for worse overall survival in triple-negative breast cancer patients

Petar Ozretic et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2018)

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Article Oncology

Epigenetic silencing of triple negative breast cancer hallmarks by Withaferin A

Katarzyna Szarc Vel Szic et al.

ONCOTARGET (2017)

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Article Biochemistry & Molecular Biology

miRBase: annotating high confidence microRNAs using deep sequencing data

Ana Kozomara et al.

NUCLEIC ACIDS RESEARCH (2014)

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Article Multidisciplinary Sciences

Pharmacological Levels of Withaferin A (Withania somnifera) Trigger Clinically Relevant Anticancer Effects Specific to Triple Negative Breast Cancer Cells

Katarzyna Szarc vel Szic et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

miR-181c Regulates the Mitochondrial Genome, Bioenergetics, and Propensity for Heart Failure In Vivo

Samarjit Das et al.

PLOS ONE (2014)

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Article Biotechnology & Applied Microbiology

In Vitro Antioxidant, Antibacterial, and Cytotoxic Activity and In Vivo Effect of Syngonium podophyllum and Eichhornia crassipes Leaf Extracts on Isoniazid Induced Oxidative Stress and Hepatic Markers

Shashank Kumar et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Article Oncology

Gambogenic Acid Induction of Apoptosis in a Breast Cancer Cell Line

Jing Zhou et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2013)

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Review Multidisciplinary Sciences

Chemistry and Biological Activities of Flavonoids: An Overview

Shashank Kumar et al.

SCIENTIFIC WORLD JOURNAL (2013)

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Article Multidisciplinary Sciences

Withaferin A-Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species

Eun-Ryeong Hahm et al.

PLOS ONE (2011)

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Article Plant Sciences

Antiproliferative Activity of Withanolides against Human Breast Cancer Cell Lines

Ruben P. Machin et al.

JOURNAL OF NATURAL PRODUCTS (2010)

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Review Biochemistry & Molecular Biology

Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine

Mohammad Hossein Mirjalili et al.

MOLECULES (2009)

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Article Multidisciplinary Sciences

Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis

SA Lakhani et al.

SCIENCE (2006)

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Article Oncology

Bcl-2/bcl-xL bispecific antisense treatment sensitizes breast carcinoma cells to doxorubicin, paclitaxel and cyclophosphamide

AP Simoes-Wüst et al.

BREAST CANCER RESEARCH AND TREATMENT (2002)

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Natural Steroidal Lactone Induces G1/S Phase Cell Cycle Arrest and Intrinsic Apoptotic Pathway by Up-Regulating Tumor Suppressive miRNA in Triple-Negative Breast Cancer Cells

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