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HPV-Associated Breast Cancer: Myth or Fact?

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Article Virology

Incidence of HPVs, EBV, and MMTV-Like Virus in Breast Cancer in Qatar

Ishita Gupta et al.

Summary: In this study, the presence of high-risk HPVs, EBV, and MMTV-like virus in 74 breast cancer samples from Qatar was explored using PCR. The results showed that HPV and EBV were present in 65% and 49% of the samples, respectively, with 47% of the samples positive for both oncoviruses. The MMTV-like virus alone was detected in 15% of the samples, but no significant association with clinicopathological features was observed. Co-presence of the three oncoviruses was found in 14% of the cases, but no significant association with clinicopathological features was noted.

INTERVIROLOGY (2022)

Review Biochemistry & Molecular Biology

Interrelated Oncogenic Viruses and Breast Cancer

Samia Afzal et al.

Summary: Breast cancer is a multifactorial disease, and recent evidence suggests that viruses may play a significant role in its pathogenesis and development. Although some viruses have been found to be associated with breast cancer, conclusive evidence on whether viruses actually cause breast cancer is still lacking.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

Article Biochemistry & Molecular Biology

Presence of Human Papillomavirus DNA in Malignant Neoplasia and Non-Malignant Breast Disease

Erika Maldonado-Rodriguez et al.

Summary: Breast cancer is a leading cause of cancer death among women worldwide. The presence of HPV DNA in malignant breast tumors has been reported by various research groups, although its role in mammary carcinogenesis is not fully understood. This study aimed to detect HPV DNA in breast tissue biopsies and classify them according to histology. The results showed that HPV DNA was present in both malignant and non-malignant breast disease, with a higher frequency in the non-malignant group.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2022)

Review Biology

Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent?

Rances Blanco et al.

Summary: Breast cancer is the most commonly diagnosed malignancy in women globally and HPV is considered a potential risk factor for its development. However, further epidemiological and experimental evidence is required to determine the role of HR-HPV infection in the progression of BC.

BIOLOGY-BASEL (2021)

Article Biotechnology & Applied Microbiology

The co-presence of high-risk human papillomaviruses and Epstein-Barr virus is linked with tumor grade and stage in Qatari women with breast cancer

Ishita Gupta et al.

Summary: The co-prevalence of high-risk HPV and EBV in breast cancer tissues from Qatari women suggests their association with tumor aggressiveness. This highlights the importance of further investigations to understand the underlying mechanisms of HPV and EBV cooperation in breast carcinogenesis.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

Article Virology

Detection of human papillomavirus genotypes, herpes simplex, varicella zoster and cytomegalovirus in breast cancer patients

Morvarid Golrokh Mofrad et al.

Summary: Viral infections, particularly high-risk HPV, may play a carcinogenic role in breast tumors. The presence of HSV-1 and low-risk HPV in BC samples suggests potential cancer-causing roles for these viruses that warrant further investigation.

VIROLOGY JOURNAL (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Biotechnology & Applied Microbiology

Presence of high-risk HPVs, EBV, and MMTV in human triple-negative breast cancer

Ishita Gupta et al.

Summary: Breast cancer is the most frequent disease among women worldwide, with the triple-negative subtype accounting for a significant percentage. Recent studies suggest the potential role of oncoviruses in breast cancer pathogenesis. This study found high detection rates of high-risk HPVs and EBV in patients with triple-negative breast cancer, as well as a presence of MMTV.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

Article Oncology

Low frequency of HPV positivity in breast tumors among patients from south-central Poland

Beata Biesaga et al.

Summary: This study analyzed HPV prevalence in breast cancers of 383 patients from south-central Poland, finding a 4.4% HPV positivity rate with HPV type 16 detected in two tumors. P16 overexpression was reported in these two cases.

INFECTIOUS AGENTS AND CANCER (2021)

Article Oncology

Human Papillomavirus (HPV) Detection by Chromogenic In Situ Hybridization (CISH) and p16 Immunohistochemistry (IHC) in Breast Intraductal Papilloma and Breast Carcinoma

Hua Guo et al.

Summary: HPV infection was detected in breast lesions and may play a role in the pathogenesis of breast cancer. Immunohistochemical stain for p16 is not a good surrogate marker for HPV infection in breast lesions.

CLINICAL BREAST CANCER (2021)

Article Oncology

Detection of High- and Low-Risk HPV DNA in Archived Breast Carcinoma Tissues from Ethiopian Women

Endale Gebregzabher et al.

Summary: This study revealed a low prevalence of HPV in Ethiopian breast cancer patients, but the association of high-risk HPV types with the disease was still observed.

INTERNATIONAL JOURNAL OF BREAST CANCER (2021)

Article Oncology

High-risk human papillomaviruses and Epstein-Barr virus in breast cancer in Lebanese women and their association with tumor grade: a molecular and tissue microarray study

Karim Nagi et al.

Summary: The study revealed the presence of high-risk HPVs and EBV in Lebanese women's breast cancer, with HPV detected in 65% of the samples and EBV in 40%. Furthermore, high-risk HPV types 52, 35, 58, 45, 16, and 51 were found to be most frequent in breast cancer in this population. Co-presence of high-risk HPVs and EBV was associated with tumor grade in 29% of the samples.

CANCER CELL INTERNATIONAL (2021)

Article Oncology

Planning for tomorrow: global cancer incidence and the role of prevention 2020-2070

Isabelle Soerjomataram et al.

Summary: The incidence of all cancers combined is predicted to double by 2070 relative to 2020, with the greatest increases expected in lower-resource settings. The global number of cancer patients is expected to rise due to demographic changes such as population aging and growth.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Public, Environmental & Occupational Health

Human papillomavirus, gene mutation and estrogen and progesterone receptors in breast cancer: a cross-sectional study

Abdallah Mohammed Elagali et al.

Summary: The study revealed an association between HPV genotypes and BC, with different HPV genotypes showing correlation with mutations in P53 and RB genes. Additionally, estrogen and progesterone receptors were expressed in a significant number of HPV-positive BC cases. However, there was no statistically significant association between HPV genotyping and BC grading, histological types, gene mutations, and receptor expression.

PAN AFRICAN MEDICAL JOURNAL (2021)

Review Oncology

Human papilloma virus (HPV) profiles in breast cancer: future management

Md Saimul Islam et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

Review Oncology

Key steps for effective breast cancer prevention

Kara L. Britt et al.

NATURE REVIEWS CANCER (2020)

Article Public, Environmental & Occupational Health

Trends in cervical cancer incidence rates by age, race/ethnicity, histological subtype, and stage at diagnosis in the United States

Farhad Islami et al.

PREVENTIVE MEDICINE (2019)

Review Virology

The endocytic trafficking pathway of oncogenic papillomaviruses

Snjezana Mikulicic et al.

PAPILLOMAVIRUS RESEARCH (2019)

Article Microbiology

Liquid biopsy in the diagnosis of HPV DNA in breast lesions

Sabrina De Carolis et al.

FUTURE MICROBIOLOGY (2018)

Article Oncology

Evidence of No Association Between Human Papillomavirus and Breast Cancer

Sara Bonlokke et al.

FRONTIERS IN ONCOLOGY (2018)

Review Medicine, Research & Experimental

The human papillomavirus (HPV)-related cancer biology: An overview

Rodrigo Pinheiro Araldi et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Dentistry, Oral Surgery & Medicine

Oral manifestations of human papillomavirus infections

Stina Syrjanen

EUROPEAN JOURNAL OF ORAL SCIENCES (2018)

Article Multidisciplinary Sciences

HPV infection and bacterial microbiota in breast milk and infant oral mucosa

Heidi Tuominen et al.

PLOS ONE (2018)

Article Virology

Prevalence of mucosal and cutaneous human papillomavirus in Moroccan breast cancer

Amal ElAmrani et al.

PAPILLOMAVIRUS RESEARCH (2018)

Review Biotechnology & Applied Microbiology

HPV entry into cells

Pinar Aksoy et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2017)

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HPV Status and Its Correlation with BCL2, p21, p53, Rb, and Survivin Expression in Breast Cancer in a Chinese Population

Ya-Wen Wang et al.

BIOMED RESEARCH INTERNATIONAL (2017)

Article Multidisciplinary Sciences

Association of High Risk Human Papillomavirus and Breast cancer: A UK based Study

Nadia Aziz Salman et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway

Martin Fischer et al.

SCIENTIFIC REPORTS (2017)

Article Computer Science, Interdisciplinary Applications

Viral warts (Human Papilloma Virus) as a potential risk for breast cancer among younger females

Suleman Atique et al.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2017)

Article Infectious Diseases

Human papillomavirus (HPV) contamination of gynaecological equipment

Caroline Gallay et al.

SEXUALLY TRANSMITTED INFECTIONS (2016)

Article Oncology

Detection of human papillomavirus-16 DNA in archived clinical samples of breast and lung cancer patients from North Pakistan

Naureen Ehsan Ilahi et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2016)

Article Biochemistry & Molecular Biology

The Influence of Ionizing Radiation on Exosome Composition, Secretion and Intercellular Communication

Karol Jelonek et al.

PROTEIN AND PEPTIDE LETTERS (2016)

Article Oncology

Human Papilloma viruses and Breast Cancer - Assessment of Causality

James Sutherland Lawson et al.

FRONTIERS IN ONCOLOGY (2016)

Review Biochemistry & Molecular Biology

The Role of Cytokines in Breast Cancer Development and Progression

Marcela Esquivel-Velazquez et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2015)

Article Multidisciplinary Sciences

No association between HPV positive breast cancer and expression of human papilloma viral transcripts

Orla M. Gannon et al.

SCIENTIFIC REPORTS (2015)

Article Oncology

Inconclusive role of human papillomavirus infection in breast cancer

Yi Zhou et al.

INFECTIOUS AGENTS AND CANCER (2015)

Article Oncology

Human Papilloma Viruses and Breast Cancer

James S. Lawson et al.

FRONTIERS IN ONCOLOGY (2015)

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Viral infections and colorectal cancer: A systematic review of epidemiological studies

Hongda Chen et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

Article Multidisciplinary Sciences

Detection of Human Papillomavirus DNA in Patients with Breast Tumor in China

Jie Li et al.

PLOS ONE (2015)

Review Cell Biology

Biological properties of extracellular vesicles and their physiological functions

Maria Yanez-Mo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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HPV infection and triple-negative breast cancers: an Italian case-control study

Andrea Fausto Piana et al.

VIROLOGY JOURNAL (2014)

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APOBEC3B mutagenesis in cancer

Kawai J. Kuong et al.

NATURE GENETICS (2013)

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Presence of Human Papilloma Virus in a Series of Breast Carcinoma from Argentina

Ana Laura Pereira Suarez et al.

PLOS ONE (2013)

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Unraveling the physiological functions of exosome secretion by tumors

Angelique Bobrie et al.

ONCOIMMUNOLOGY (2013)

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Are viruses associated with human breast cancer? Scrutinizing the molecular evidence

Deepti Joshi et al.

BREAST CANCER RESEARCH AND TREATMENT (2012)

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Prevalence of Human Papillomavirus in Breast Cancer A Systematic Review

Priscyla Waleska Simoes et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2012)

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The role of human papillomavirus infection in breast cancer

Ting Wang et al.

MEDICAL ONCOLOGY (2012)

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Integrins in mammary development

Karine Raymond et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)

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Human Papillomavirus Is Associated with Breast Cancer in the North Part of Iran

Afsaneh Sigaroodi et al.

SCIENTIFIC WORLD JOURNAL (2012)

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The Biology and Life-Cycle of Human Papillomaviruses

John Doorbar et al.

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Laminin 332 Expression in Breast Carcinoma

Soon-Young Kwon et al.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2012)

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Human papillomavirus infection and sporadic breast carcinoma risk: a meta-analysis

Ni Li et al.

BREAST CANCER RESEARCH AND TREATMENT (2011)

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No evidence for an association of human papillomavirus and breast carcinoma

Raimundo Geronimo Silva et al.

BREAST CANCER RESEARCH AND TREATMENT (2011)

Article Medicine, Research & Experimental

Low Prevalence of Human Papillomavirus (HPV) in Chinese Patients with Breast Cancer

X. Mou et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2011)

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High Prevalence of Human Papillomaviruses in Fresh Frozen Breast Cancer Samples

Annika Antonsson et al.

JOURNAL OF MEDICAL VIROLOGY (2011)

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Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile

Francisco Aguayo et al.

INFECTIOUS AGENTS AND CANCER (2011)

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Possible DNA Viral Factors of Human Breast Cancer

Chun-Ru Hsu et al.

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Human papillomavirus oncoproteins: pathways to transformation

Cary A. Moody et al.

NATURE REVIEWS CANCER (2010)

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HPV E6 protein interacts physically and functionally with the cellular telomerase complex

Xuefeng Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Human papillomavirus DNA detected in breast milk

Marja Sarkola et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2008)

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No evidence of Human papillomavirus DNA sequences in invasive breast carcinoma

Patricia de Cremoux et al.

BREAST CANCER RESEARCH AND TREATMENT (2008)

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BRCA1 interaction with human papillomavirus oncoproteins

XY Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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BRCA1 in hormonal carcinogenesis: basic and clinical research

EM Rosen et al.

ENDOCRINE-RELATED CANCER (2005)

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Cervical human papillomavirus screening by PCR: advantages of targeting the E6/E7 region

BJ Morris

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2005)

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Evidence for an association of human papillomavirus and breast carcinomas

APS Damin et al.

BREAST CANCER RESEARCH AND TREATMENT (2004)

Article Virology

Detection of human papillomavirus DNA in breast cancer of patients with cervical cancer history

A Widschwendter et al.

JOURNAL OF CLINICAL VIROLOGY (2004)

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Contamination of environmental surfaces by genital human papillomaviruses

S Strauss et al.

SEXUALLY TRANSMITTED INFECTIONS (2002)