4.5 Article

Cefiderocol against Multi-Drug and Extensively Drug-Resistant Escherichia coli: An In Vitro Study in Poland

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Progressive Development of Cefiderocol Resistance in Escherichia coli During Therapy is Associated With an Increase in blaNDM-5 Copy Number and Gene Expression

Patricia J. Simner et al.

Summary: This study revealed the mechanisms by which New Delhi metallo-β-lactamase-producing Escherichia coli isolate developed relatively rapid resistance to cefiderocol through increased copy numbers of bla(NDM) genes. The findings highlight the importance of investigating increased bla(NDM-5) expression frequency in contributing to cefiderocol resistance.

CLINICAL INFECTIOUS DISEASES (2022)

Article Microbiology

Cefiderocol

María Cruz Soriano et al.

Revista Espanola de Quimioterapia (2022)

Article Microbiology

Occurrence of High Levels of Cefiderocol Resistance in Carbapenem-Resistant Escherichia coli before Its Approval in China: a Report from China CRE-Network

Qi Wang et al.

Summary: Cefiderocol, a new siderophore cephalosporin, has been approved in the United States and Europe but not in China. There is limited data on the antimicrobial susceptibility of cefiderocol in China. This study evaluated the susceptibility of carbapenem-resistant Enterobacterales (CRE) to cefiderocol in China and investigated the resistance mechanism. Cefiderocol showed activity against most CRE strains, but a high proportion of Escherichia coli showed high-level resistance. The resistance mechanism was found to involve the premature stop codon of cirA, the existence of bla(NDM-5), and the mutation of pbp3.

MICROBIOLOGY SPECTRUM (2022)

Article Infectious Diseases

Evolution of β-lactamase-mediated cefiderocol resistance

Christopher Frohlich et al.

Summary: This study investigated the impact of cefiderocol on resistance development and the evolution of beta-lactamases from different Ambler classes. The expression of bla(KPC-2), bla(CMY-2), bla(CTX-M-15), and bla(NDM-1) significantly reduced cefiderocol susceptibility, while mutations in these enzymes further increased cefiderocol resistance. Resistance development also led to collateral changes in sensitivity to other beta-lactam drugs and functional trade-offs.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2022)

Article Microbiology

Cefiderocol Antimicrobial Susceptibility Testing against Multidrug-Resistant Gram-Negative Bacilli: a Comparison to Disk Diffusion to Broth Microdilution

C. Paul Morris et al.

Summary: Interpretation of cefiderocol ASTs varies significantly depending on the breakpoints used by CLSI, FDA, and EUCAST. DD offers a convenient alternative approach to BMD methods for cefiderocol AST, except for isolates of Acinetobacter baumannii complex.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

Article Microbiology

Emergence of the New KPC-49 Variant Conferring an ESBL Phenotype with Resistance to Ceftazidime-Avibactam in the ST131-H30R1 Escherichia coli High-Risk Clone

Marta Hernandez-Garcia et al.

Summary: A ceftazidime-avibactam resistant ST131-Escherichia coli high-risk clone isolate was recovered from a patient with bacteremia in 2019, carrying a novel KPC-49 variant. Genomic analysis revealed high content of resistance and virulence genes in both isolates, with the bla(KPC-49) gene increasing ceftazidime-avibactam MIC and decreasing carbapenem MICs. The bla(KPC-3) and bla(KPC-49) genes were located on the transposon Tn4401a as part of an IncF [F1:A2:B20] plasmid.

PATHOGENS (2021)

Article Microbiology

Plasmid Mediated mcr-1.1 Colistin-Resistance in Clinical Extraintestinal Escherichia coli Strains Isolated in Poland

Piotr Majewski et al.

Summary: The study identified six extraintestinal Escherichia coli isolates that produce the mcr-1.1 gene, leading to colistin resistance. These strains also possess multiple virulence factors. The IncX4 plasmids carrying mcr genes were found to be disseminated among E. coli isolates and may facilitate the spread of colistin resistance genes between different clones.

FRONTIERS IN MICROBIOLOGY (2021)

Review Pharmacology & Pharmacy

Cefiderocol: A Review in Serious Gram-Negative Bacterial Infections

Yahiya Y. Syed

Summary: Cefiderocol is a cephalosporin with activity against carbapenem-resistant bacteria and nonfermenters, using the bacteria's iron uptake system to disrupt the cell wall and kill the bacteria. It has shown good effectiveness and safety in clinical trials for various serious bacterial infections, providing a useful addition to treatment options for adults with limited choices.
Article Microbiology

Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland - a Pilot Study

Elzbieta M. Stefaniuk et al.

Summary: A total of 65 colistin-resistant Enterobacterales isolates were analyzed in this study, with 45 identified as ESBL producers. CTX-M-1-like enzymes were the most common ESBLs. Additionally, one E. coli and seven Klebsiella pneumoniae strains produced carbapenemases.

POLISH JOURNAL OF MICROBIOLOGY (2021)

Review Microbiology

Antimicrobial Resistance in ESKAPE Pathogens

David M. P. De Oliveira et al.

CLINICAL MICROBIOLOGY REVIEWS (2020)

Article Infectious Diseases

ESBLs and resistance to ceftazidime/avibactam and ceftolozane/tazobactam combinations in Escherichia coli and Pseudomonas aeruginosa

Jose-Manuel Ortiz de la Rosa et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2019)

Article Immunology

Cefiderocol: Discovery, Chemistry, and In Vivo Profiles of a Novel Siderophore Cephalosporin

Takafumi Sato et al.

CLINICAL INFECTIOUS DISEASES (2019)

Article Immunology

Treatment Options for Carbapenem-resistant Gram-negative Bacterial Infections

Yohei Doi

CLINICAL INFECTIOUS DISEASES (2019)

Article Microbiology

Stability of Novel Siderophore Cephalosporin S-649266 against Clinically Relevant Carbapenemases

Tsukasa Ito-Horiyama et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

Article Microbiology

Increased frequency of integrons and β-lactamase-coding genes among extraintestinal Escherichia coli isolated with a 7-year interval

Joanna Mokracka et al.

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2013)

Article Infectious Diseases

Rapid emergence and spread of OXA-48-producing carbapenem-resistant Enterobacteriaceae isolates in Belgian hospitals

Youri Glupczynski et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2012)

Article Immunology

Rapid Detection of Carbapenemase-producing Enterobacteriaceae

Patrice Nordmann et al.

EMERGING INFECTIOUS DISEASES (2012)

Review Infectious Diseases

Extended-spectrum beta-lactamase-producing enterobacteriaceae: an emerging public-health concern

Johann D. D. Pitout et al.

LANCET INFECTIOUS DISEASES (2008)