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Review
Immunology
Dynamic changes in metabolites of the kynurenine pathway in Alzheimer's disease, Parkinson's disease, and Huntington's disease: A systematic Review and meta-analysis
Mobina Fathi et al.
Summary: This systematic review and meta-analysis aimed to assess the changes in kynurenine pathway metabolites in patients with neurodegenerative diseases. The results showed a significant decrease in tryptophan levels in Alzheimer's disease, Parkinson's disease, and Huntington's disease patients, along with lower levels of 3-hydroxykynurenine in AD patients and kynurenine in HD patients. These findings support the hypothesis that alterations in the kynurenine pathway may be involved in the pathogenesis of these diseases.
FRONTIERS IN IMMUNOLOGY (2022)
Article
Medicine, General & Internal
Phenylketonuria
Francjan J. van Spronsen et al.
Summary: Phenylketonuria is an inherited disorder of phenylalanine metabolism that can lead to severe neurological dysfunction if left untreated. Early diagnosis and treatment have a significant impact on patients' intelligence, with dietary restriction being the mainstay of current treatment.
NATURE REVIEWS DISEASE PRIMERS (2021)
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