期刊
MICROORGANISMS
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms10122481
关键词
lactic acid bacteria; ultraviolet B; matrix metalloproteinases; activator protein-1; collagen
类别
In this study, the photoprotective effects of different strains of lactic acid bacteria on UVB-exposed skin fibroblasts were evaluated. Four specific strains were found to have potential photoprotective properties by inhibiting MMPs, MAPK, and AP-1 protein expression, and enhancing collagen production while reducing inflammation.
Ultraviolet B (UVB) exposure causes a breakdown of collagen, oxidative stress, and inflammation. UVB activates mitogen-activated protein kinase (MAPK), activator protein-1 (AP-1), and matrix metalloproteinases (MMPs). In this study, we evaluated 2,2 '-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(+)) radical scavenging activity and the photoprotective effect of lactic acid bacteria LAB strains, including Lactobacillus, Bifidobacterium, and Streptococcus genera in UVB-exposed skin fibroblasts. Nine LAB strains displayed antioxidant activity by regulating superoxide dismutase in UVB-exposed skin fibroblasts. Four LAB strains (MG4684, MG5368, MG4511, and MG5140) recovered type I procollagen level by inhibiting MMPs, MAPK, and AP-1 protein expression. Additionally, these four strains reduced the expression of proinflammatory cytokines by inhibiting oxidative stress. Therefore, L. fermentum MG4684, MG5368, L. rhamnosus MG4511, and S. thermophilus MG5140 are potentially photoprotective.
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