4.6 Article

Infection Characteristics and Transcriptomics of African Swine Fever Virus in Bama Minipigs

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Virology

Effects of the NF-κB Signaling Pathway Inhibitor BAY11-7082 in the Replication of ASFV

Qi Gao et al.

Summary: This study found that ASFV infection activates the NF-kappa B signaling pathway and up-regulates the expression of IL-1 beta and IL-8. Inhibiting the NF-kappa B signaling pathway and interleukin-1 beta and interleukin-8 production can inhibit the replication of ASFV. These findings provide new insights into the molecular mechanism of ASFV infection and suggest the NF-kappa B signaling pathway as a potential target for controlling ASF.

VIRUSES-BASEL (2022)

Review Biochemistry & Molecular Biology

ISG20: an enigmatic antiviral RNase targeting multiple viruses

Severine Deymier et al.

Summary: ISG20 is an antiviral protein capable of inhibiting a broad spectrum of viruses through mechanisms such as degradation of viral nucleic acids and translational inhibition. Recent research has shed light on the molecular mechanisms and specificity or resistance to ISG20's antiviral action.

FEBS OPEN BIO (2022)

Article Virology

The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1

Maowen Sun et al.

Summary: African swine fever (ASF) is a lethal viral disease of pigs caused by African swine fever virus (ASFV). A recent study found that deleting the A137R gene in ASFV attenuates its virulence and promotes the expression of type I interferon (IFN) in primary porcine alveolar macrophages. The A137R protein negatively regulates the cGAS-STING-mediated IFN-beta signaling pathway through the autophagy-mediated lysosomal degradation of TBK1. This study enhances the understanding of ASFV immunoevasion strategies and provides new insights for the development of live attenuated ASF vaccines.

JOURNAL OF VIROLOGY (2022)

Article Infectious Diseases

Synergistic effect of the responses of different tissues against African swine fever virus

Wenhui Fan et al.

Summary: Research shows that different tissues cooperate in responding to African swine fever virus infection, coordinating defense against ASFV through an inflammatory cytokine storm and interferon activation. The lung and spleen are mainly involved in the innate immune response pathway; the liver and kidney are involved in the metabolic regulatory pathway and inflammatory response; the lymph nodes cooperate with the liver to complete energy metabolism regulation.

TRANSBOUNDARY AND EMERGING DISEASES (2022)

Article Multidisciplinary Sciences

Transcriptome profiling in swine macrophages infected with African swine fever virus at single-cell resolution

Yuxuan Zheng et al.

Summary: African swine fever virus (ASFV) infection leads to increased expression of viral transmembrane genes, activation of antiviral signaling pathways and inflammatory response. Cells infected with different viral loads show distinct transcriptomic changes during infection. Furthermore, ASFV infection activates the cell apoptosis pathway.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Immunology

African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1

Li Huang et al.

Summary: African swine fever virus infection inhibits porcine alveolar macrophages' production of type I interferon and an ASFV gene, pI215L, acts as a strong inhibitor of type I interferon production independent of its E2 enzyme activity. The mechanism involves pI215L interacting with RNF138 to degrade RNF128, ultimately reducing K63-linked polyubiquitination of TANK-binding kinase 1 and type I interferon production.

JOURNAL OF IMMUNOLOGY (2021)

Article Veterinary Sciences

Cytokine Storm in Domestic Pigs Induced by Infection of Virulent African Swine Fever Virus

Shuchao Wang et al.

Summary: African swine fever, caused by ASFV, is a highly contagious hemorrhagic disease in domestic pigs. The lack of effective vaccine development is largely due to gaps in knowledge regarding pathogenesis and immunology, specifically the role of cytokines in the host's immune response. Increased understanding of cytokine dynamics during ASFV infection could provide insights into developing potential therapeutic interventions.

FRONTIERS IN VETERINARY SCIENCE (2021)

Review Virology

African Swine Fever Virus Circulation between Tanzania and Neighboring Countries: A Systematic Review and Meta-Analysis

Jean N. Hakizimana et al.

Summary: The study systematically reviewed the molecular epidemiology of African swine fever (ASF) in Tanzania and its eight neighboring countries, revealing ongoing circulation of ASFV and multiple transboundary spread events between these countries. The findings emphasize the need for further research to enhance understanding of virus transmission dynamics and highlight the importance of a regional approach to control ASFV spread.

VIRUSES-BASEL (2021)

Article Microbiology

Genome-wide transcriptomic analysis of highly virulent African swine fever virus infection reveals complex and unique virus host interaction

Xiaohui Ju et al.

Summary: The study suggests that ASFV infection causes a strong suppression of host immune responses, leading to dysregulation of host chemokine axis and metabolic pathways in porcine alveolar macrophages.

VETERINARY MICROBIOLOGY (2021)

Article Biology

Development of a Dual ELISA for the Detection of CD2v-Unexpressed Lower-Virulence Mutational ASFV

Changjie Lv et al.

Summary: By expressing and purifying CD2v and p30 proteins via CHO cells, a dual enzyme-linked immunosorbent assay (ELISA) has been successfully established to differentiate between pigs infected with wild-type ASFV or CD2v-unexpressed lower-virulence mutants. This dual ELISA shows excellent specificity without cross-reactions with other viruses and can detect ASFV-infected positive serum samples up to dilutions of 5120 times, demonstrating high sensitivity. This dual ELISA approach can play an important role in ASFV epidemiology study and provide a solution for differential diagnosis.

LIFE-BASEL (2021)

Article Infectious Diseases

African swine fever virus genotype II in Mongolia, 2019

Ulaankhuu Ankhanbaatar et al.

Summary: African swine fever (ASF) is a severe haemorrhagic disease of pigs caused by the ASFV virus, which has spread to Europe and Asia. Mongolia reported its first outbreak on January 15th, 2019, becoming the second country in the region affected by the disease after China. The Mongolian ASFV belong to genotype II and serogroup 8, indicating a possible cross-border spread of the virus.

TRANSBOUNDARY AND EMERGING DISEASES (2021)

Article Virology

African Swine Fever Virus E120R Protein Inhibits Interferon Beta Production by Interacting with IRF3 To Block Its Activation

Huisheng Liu et al.

Summary: African swine fever is a devastating disease caused by ASFV, and the E120R protein of ASFV was identified as a key virulence factor that suppresses the host antiviral response by inhibiting interferon production. Targeting E120R could guide the development of ASFV live-attenuated vaccines.

JOURNAL OF VIROLOGY (2021)

Article Virology

Proteome Analysis in PAM Cells Reveals That African Swine Fever Virus Can Regulate the Level of Intracellular Polyamines to Facilitate Its Own Replication through ARG1

Qiangyun Ai et al.

Summary: In 2018, African swine fever broke out in China with a nearly 100% death rate after infection, and there is currently no effective vaccine available. Quantitative proteomics analysis identified 4218 proteins, including 306 up-regulated and 238 down-regulated differentially expressed proteins in porcine alveolar macrophages infected with ASFV. Pathway analysis revealed the regulation of protein and interaction pathways post ASFV infection, indicating the virus may facilitate its own replication by regulating small molecules in the host cell.

VIRUSES-BASEL (2021)

Article Immunology

Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection

Encheng Sun et al.

Summary: Recently, genotype I ASFVs have emerged in China, with SD/DY-I/21 showing low virulence, high transmissibility, mild infection onset, and chronic disease in pigs, along with causing necrotic skin lesions and joint swelling. The emergence of genotype I ASFVs presents more challenges for the control and prevention of African swine fever in China.

EMERGING MICROBES & INFECTIONS (2021)

Article Infectious Diseases

The African swine fever virus isolate Belgium 2018/1 shows high virulence in European wild boar

Jutta Pikalo et al.

TRANSBOUNDARY AND EMERGING DISEASES (2020)

Article Immunology

Replication and virulence in pigs of the first African swine fever virus isolated in China

Dongming Zhao et al.

EMERGING MICROBES & INFECTIONS (2019)

Article Cell Biology

Efficient generation of GHR knockout Bama minipig fibroblast cells using CRISPR/Cas9-mediated gene editing

Rui Wang et al.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2019)

Article Multidisciplinary Sciences

Architecture of African swine fever virus and implications for viral assembly

Nan Wang et al.

SCIENCE (2019)

Article Infectious Diseases

Infection of African swine fever in wild boar, China, 2018

Lin Li et al.

TRANSBOUNDARY AND EMERGING DISEASES (2019)

Article Peripheral Vascular Disease

Low-dose sustained-release deoxycorticosterone acetate-induced hypertension in Bama miniature pigs for renal sympathetic nerve denervation

Wenzheng Han et al.

JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION (2017)

Article Biochemistry & Molecular Biology

An experimental model for Staphylococcus aureus hepatic abscess in Bama minipig

R. G. Zhang et al.

GENETICS AND MOLECULAR RESEARCH (2014)

Article Immunology

African Swine Fever Virus Isolate, Georgia, 2007

Rebecca J. Rowlands et al.

EMERGING INFECTIOUS DISEASES (2008)

Article Biotechnology & Applied Microbiology

Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1

L Espert et al.

JOURNAL OF GENERAL VIROLOGY (2005)

Article Microbiology

Highly sensitive PCR assay for routine diagnosis of African swine fever virus in clinical samples

M Agüero et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2003)