期刊
ANTIOXIDANTS
卷 12, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/antiox12020284
关键词
Chaenomeles sinensis; oxylipins; anti-inflammation; neurotrophic effect; cytotoxicity
This study identified four new oxylipins obtained from Chaenomeles sinensis twigs, which have diverse biological activities including anti-inflammatory, antimicrobial, and regulatory effects. Among them, oxylipin D showed potent inhibitory effect on nitric oxide production, neurotrophic activity, and cytotoxicity in human cancer cell lines.
Oxylipins are important biological molecules with diverse roles in human and plants such as pro-/anti-inflammatory, antimicrobial, and regulatory activity. Although there is an increasing number of plant-derived oxylipins, most of their physiological roles in humans remain unclear. Here, we describe the isolation, identification, and biological activities of four new oxylipins, chaenomesters A-D (1-4), along with a known compound (5), obtained from Chaenomeles sinensis twigs. Their chemical structures were determined by spectroscopic (i.e., NMR) and spectrometric (i.e., HRMS) data analysis including H-1 NMR-based empirical rules and homonuclear-decoupled H-1 NMR experiments. Chaenomester D (4), an omega-3 oxylipin, showed a potent inhibitory effect on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells (NO production, 8.46 +/- 0.68 mu M), neurotrophic activity in C6 cells through the induction of the secretion of nerve growth factor (NGF, 157.7 +/- 2.4%), and cytotoxicity in A549 human cancer cell lines (IC50 = 27.4 mu M).
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