Glymphatic Dysfunction Induced Oxidative Stress and Neuro-Inflammation in Major Depression Disorders

Article Neurosciences

Metabolomics changes in brain-gut axis after unpredictable chronic mild stress

Qiuyue Xu et al.

Summary: This study reveals the presence of metabolic changes in both the brain and gut during depressive behavior, suggesting a potential role of the brain-gut axis in depression.

PSYCHOPHARMACOLOGY (2022)

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Review Cell Biology

Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function

Bhupesh Singla et al.

Summary: The lymphatic system plays a crucial role in immune surveillance and tissue homeostasis, and lymphangiogenesis, the formation of new lymphatic vessels, is involved in various physiological and pathological processes. Recent research progress in the molecular mechanisms of lymphangiogenesis has opened up new possibilities for therapeutic approaches in diseases such as neurological disorders, cardiac repair, autoimmune disease, obesity, and atherosclerosis.

CELLS (2022)

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Article Biochemistry & Molecular Biology

Antioxidant Biomolecules and Their Potential for the Treatment of Difficult-to-Treat Depression and Conventional Treatment-Resistant Depression

Maria Eugenia Riveros et al.

Summary: Major depression is a devastating disease that requires urgent new treatment approaches, as existing treatments are not effective for all patients. Studies suggest that depression is linked to mitochondrial dysfunction and neuroinflammation, leading to oxidative damage, while antioxidants and anti-inflammatory biomolecules show promise as potential treatments for depression.

ANTIOXIDANTS (2022)

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Article Clinical Neurology

Glymphatic system dysfunction in patients with early chronic kidney disease

Chang Min Heo et al.

Summary: This study evaluated the function of the glymphatic system in patients with early CKD using the DTI-ALPS index, finding a lower index in CKD patients compared to healthy controls. However, there was no significant correlation between the DTI-ALPS index and other clinical factors.

FRONTIERS IN NEUROLOGY (2022)

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Editorial Material Psychology, Multidisciplinary

Editorial: Uncertainty Induced Emotional Disorders During the COVID-19

Fushun Wang et al.

FRONTIERS IN PSYCHOLOGY (2022)

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Review Chemistry, Medicinal

Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders

Yao Jiang et al.

Summary: This study reviews the advancements in monoamine neurotransmitters in the field of Major Depressive Disorder (MDD) and their impact on new pathways such as inflammation, oxidative stress, neurotrophins, and neurogenesis. The monoamine hypothesis is extended to basic emotions, with dopamine, norepinephrine, and serotonin playing different roles. The paper also briefly discusses the potential of monoamine neurotransmitters as a therapeutic approach for MDD, along with their limited clinical efficacy, side effects, and delayed onset of action.

PHARMACEUTICALS (2022)

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Review Psychiatry

The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression

Simeng Gu et al.

Summary: Post-stroke depression is a common and serious consequence of stroke, but many aspects related to it are still unclear. The monoamine hypothesis suggests that three monoamines play a key role in depression, and current antidepressants target these monoamines for the treatment of post-stroke depression. Recent studies have also shown potential effects of monoamine-related emotional intervention in the treatment and prevention of post-stroke depression.

FRONTIERS IN PSYCHIATRY (2022)

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Review Biochemical Research Methods

G-Lymphatic, Vascular and Immune Pathways for Aβ Clearance Cascade and Therapeutic Targets For Alzheimer's Disease

Saurav Chakraborty et al.

Summary: Alzheimer's disease is an age-related neurodegenerative disease with various factors causing its progression. Clearance of amyloid beta-peptide is crucial, with neuroinflammation, oxidative stress, and apoptosis playing significant roles. Various physiological pathways are involved in the clearance of amyloid beta-peptide, and the formation of insoluble amyloid-beta leads to neurodegeneration and neuronal cell death.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2021)

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Review Neurosciences

Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties

Jennaya Christensen et al.

Summary: The glymphatic system is a recently discovered waste clearance system for the central nervous system, with important implications for neurological disorders. There is currently controversy regarding key aspects of this novel system, including its structure and function, which require further research to elucidate.

PROGRESS IN NEUROBIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Requirement of brain interleukin33 for aquaporin4 expression in astrocytes and glymphatic drainage of abnormal tau

Jean Wu et al.

Summary: IL33 is essential for regulating the expression of AQP4 in astrocytes, with its deficiency leading to abnormal tau accumulation in neurons and impaired drainage. This study suggests that different forms of AQP4 play distinct roles in glymphatic drainage, with p-AQP4 driving flow toward perivenous space while n-AQP4 may help remove neuronal wastes. Defects in IL33-related mechanisms may contribute to chronic neurodegeneration and tauopathy in aging mice.

MOLECULAR PSYCHIATRY (2021)

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Article Multidisciplinary Sciences

Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes

Liliana M. Sanmarco et al.

Summary: This study identifies a subset of astrocytes that limit inflammation in the central nervous system by inducing T cell apoptosis through TRAIL-DR5 signaling. The expression of TRAIL in these astrocytes is regulated by interferon-gamma produced by meningeal NK cells, which is modulated by the gut microbiome.

NATURE (2021)

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Review Biochemistry & Molecular Biology

Potential of Multiscale Astrocyte Imaging for Revealing Mechanisms Underlying Neurodevelopmental Disorders

Takuma Kumamoto et al.

Summary: Astrocytes provide support to neurons, modulate circuit formation, and maintain neuronal homeostasis. Dysfunction in astrocytes may contribute to various neurological disorders such as Rett syndrome, Alexander's disease, epilepsy, and autism. A multidisciplinary approach and advanced neuroimaging techniques are essential for understanding the mechanisms behind these diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

Leakage of astrocyte-derived extracellular vesicles in stress-induced exhaustion disorder: a cross-sectional study

Johanna Wallensten et al.

Summary: The study indicates that patients with SED have significantly elevated levels of astrocyte-derived EVs in their plasma compared to patients with MDD and healthy controls. Additionally, patients with MDD exhibit higher concentrations of GFAP-positive EVs and EVs co-expressing AQP4/GFAP compared to healthy controls.

SCIENTIFIC REPORTS (2021)

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Article Gastroenterology & Hepatology

Enhanced Meningeal Lymphatic Drainage Ameliorates Neuroinflammation and Hepatic Encephalopathy in Cirrhotic Rats

Shao-Jung Hsu et al.

Summary: This study demonstrated that enhancing meningeal lymphatic drainage can reduce neuroinflammation and ameliorate hepatic encephalopathy, suggesting a new therapeutic strategy for the treatment of HE.

GASTROENTEROLOGY (2021)

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Article Immunology

Acute systemic LPS-exposure impairs perivascular CSF distribution in mice

Oscar Manouchehrian et al.

Summary: The study aimed to measure the effect of acute inflammation on the glymphatic system by analyzing the distribution of CSF tracers after LPS injections. The results showed a significant decrease in perivascular CSF tracer flow and penetration into the parenchyma following LPS injections, without impacting AQP4 polarization, cytokines, astroglial and BBB markers, cerebral blood flow, or respiration.

JOURNAL OF NEUROINFLAMMATION (2021)

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Article Biochemistry & Molecular Biology

Noradrenaline as a key neurotransmitter in modulating microglial activation in stress response

Shuei Sugama et al.

Summary: The state of mind can influence susceptibility and progression of diseases in the central nervous system, with noradrenaline playing crucial roles in modulating microglial cells. Microglial cells under different conditions may have constructive or detrimental roles in surveillance activities, affecting brain waste clearance. This review discusses the underlying mechanism and roles of stress-induced microglial activation.

NEUROCHEMISTRY INTERNATIONAL (2021)

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Article Neurosciences

Glymphatic Drainage Blocking Aggravates Brain Edema, Neuroinflammation via Modulating TNF-α, IL-10, and AQP4 After Intracerebral Hemorrhage in Rats

Xichang Liu et al.

Summary: In experimental rats with intracerebral hemorrhage, modulation of the glymphatic system can alleviate neurological scores and suppress neuronal apoptosis. Cerebral lymphatic blockage exacerbates brain edema, neuroinflammation, and neuronal apoptosis by down-regulating AQP-4, up-regulating TNF-alpha, and inhibiting IL-10 expression.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Review Immunology

Metabolic Regulation of Thymic Epithelial Cell Function

Manpreet K. Semwal et al.

Summary: The thymus is crucial for T lymphocyte development, with thymic stromal cells playing an important role. Metabolic regulation of thymic stromal cell function is an emerging area of study.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression

Shanshan Li et al.

Summary: The study revealed the presence of astrocytic pyroptosis in depressive mice, which could be mitigated with treatment. Genetic knockout and overexpression experiments on mice also provided insights into the involvement of specific proteins in depression-related astrocyte loss.

JCI INSIGHT (2021)

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Article Neurosciences

Norepinephrine-Induced Calcium Signaling and Store-Operated Calcium Entry in Olfactory Bulb Astrocytes

Timo Fischer et al.

Summary: The study shows that norepinephrine induces a cytosolic calcium rise in olfactory bulb astrocytes, which is independent of neuronal activity and primarily mediated by PLC/IP3-dependent internal calcium release. Additionally, store-operated calcium entry (SOCE) plays a role in the late phase of the response.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Editorial Material Neurosciences

The Glymphatic-Lymphatic System Pathology and a New Categorization of Neurodegenerative Disorders

Pasquale Gallina et al.

FRONTIERS IN NEUROSCIENCE (2021)

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Review Neurosciences

Sex-related patterns of the gut-microbiota-brain axis in the neuropsychiatric conditions

Luana M. Manosso et al.

Summary: Sex differences play an essential role in neuropsychiatric disorders, potentially involving neuroanatomical, neurochemical, and physiological sex differences. The microbiota composition is sensitive to factors such as sex, age, and diet, influencing the bidirectional communication between the brain and the gut and impacting overall homeostasis.

BRAIN RESEARCH BULLETIN (2021)

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Review Biochemistry & Molecular Biology

The Glymphatic System (En)during Inflammation

Frida Lind-Holm Mogensen et al.

Summary: The glymphatic system is a fluid-transport system in the brain that plays a role in neurological diseases and neuroinflammation. It facilitates waste clearance in the brain, requires fluid exchange between perivascular spaces and the neuropil, and transports fluid back to the vasculature through lymphatic vessels.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Neurosciences

The Glymphatic System: A Novel Component of Fundamental Neurobiology

Lauren M. Hablitz et al.

Summary: The glymphatic system in the brain plays a key role in regulating interstitial fluid movement, waste clearance, and potentially brain immunity. Through the glymphatic system, there is potential to alter the local and global transport of signaling molecules and metabolites. Additionally, evidence suggests there is cross talk among the glymphatic system, cardiovascular system, gastrointestinal tract, and lymphatic system.

JOURNAL OF NEUROSCIENCE (2021)

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Review Neurosciences

Astrocyte-neuron signaling in the mesolimbic dopamine system: the hidden stars of dopamine signaling

Michelle Corkrum et al.

Summary: Astrocytes respond to dopamine signaling and modulate information processing in key brain regions. They exhibit circuit-specific modulation of neuronal networks, potentially serving as a therapeutic target for dopamine pathologies.

NEUROPSYCHOPHARMACOLOGY (2021)

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Review Geriatrics & Gerontology

Glymphatic System in the Central Nervous System, a Novel Therapeutic Direction Against Brain Edema After Stroke

Xiangyue Zhou et al.

Summary: This article discusses the impact of stroke-induced cerebral edema on neurological function recovery, the role and mechanisms of the glymphatic system in the formation and regression of brain edema after stroke, and points out a new direction for research on brain edema after stroke.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Article Neurosciences

Serotonin receptor 4 regulates hippocampal astrocyte morphology and function

Franziska E. Mueller et al.

Summary: Recent research has shown that the serotonin receptor 4 (5-HT4R) is expressed in hippocampal astrocytes, where its activation triggers RhoA activity via G alpha(13)-mediated signaling, leading to morphological changes. This signaling pathway can alter glutamatergic synaptic transmission, affecting the functional regulation of neuronal networks.

GLIA (2021)

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Article Neurosciences

Attenuation of Ischemic Stroke-Caused Brain Injury by a Monoamine Oxidase Inhibitor Involves Improved Proteostasis and Reduced Neuroinflammation

Yanying Liu et al.

MOLECULAR NEUROBIOLOGY (2020)

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Article Cell Biology

Ouabain, endogenous ouabain and ouabain-like factors: The Na+ pump/ouabain receptor, its linkage to NCX, and its myriad functions

Mordecai P. Blaustein et al.

CELL CALCIUM (2020)

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Review Biochemistry & Molecular Biology

Regulation of AQP4 in the Central Nervous System

Arno Vandebroek et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Pharmacology & Pharmacy

Role of oxidative stress in depression

Shvetank Bhatt et al.

DRUG DISCOVERY TODAY (2020)

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Article Physiology

Pharmacological Preconditioning Using Diazoxide Regulates Store-Operated Ca2+ Channels in Adult Rat Cardiomyocytes

Raul Sampieri et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Review Clinical Neurology

Gut microbiota and major depressive disorder: A systematic review and meta-analysis

Kenji Sanada et al.

JOURNAL OF AFFECTIVE DISORDERS (2020)

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Review Neurosciences

Astrocyte control of glutamatergic activity: Downstream effects on serotonergic function and emotional behavior

Neus Fullana et al.

NEUROPHARMACOLOGY (2020)

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Article Clinical Neurology

Impaired glymphatic function and clearance of tau in an Alzheimer's disease model

Ian F. Harrison et al.

BRAIN (2020)

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Article Clinical Neurology

Piperine Attenuates TBI-Induced Seizures via Inhibiting Cytokine-Activated Reactive Astrogliosis

Yabei Song et al.

FRONTIERS IN NEUROLOGY (2020)

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Review Biochemistry & Molecular Biology

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

Dominic S. A. Simpson et al.

ANTIOXIDANTS (2020)

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Review Neurosciences

The Bidirectional Relationship of Depression and Inflammation: Double Trouble

Eleonore Beurel et al.

NEURON (2020)

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Review Multidisciplinary Sciences

Glymphatic failure as a final common pathway to dementia

Maiken Nedergaard et al.

SCIENCE (2020)

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Review Neurosciences

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Hyuk Sung Kwon et al.

TRANSLATIONAL NEURODEGENERATION (2020)

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Article Integrative & Complementary Medicine

The Glymphatic System and Pain

Nanna Goldman et al.

MEDICAL ACUPUNCTURE (2020)

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Review Psychiatry

Gutted! Unraveling the Role of the Microbiome in Major Depressive Disorder

Thomaz F. S. Bastiaanssen et al.

HARVARD REVIEW OF PSYCHIATRY (2020)

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Article Neurosciences

Inhibition of hormonal and behavioral effects of stress by tryptophan in rats

Sumera Gul et al.

NUTRITIONAL NEUROSCIENCE (2019)

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Review Neurosciences

Inflaming sex differences in mood disorders

Jennifer R. Rainville et al.

NEUROPSYCHOPHARMACOLOGY (2019)

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Article Cell Biology

PDGF-B Is Required for Development of the Glymphatic System

Anne Sofie Munk et al.

CELL REPORTS (2019)

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Article Microbiology

The neuroactive potential of the human gut microbiota in quality of life and depression

Mireia Valles-Colomer et al.

NATURE MICROBIOLOGY (2019)

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Article Immunology

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

Burak Arioz et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Psychology, Multidisciplinary

A Model for Basic Emotions Using Observations of Behavior in Drosophila

Simeng Gu et al.

FRONTIERS IN PSYCHOLOGY (2019)

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Article Endocrinology & Metabolism

Corticosterone and serotonin similarly influence GABAergic and purinergic pathways to affect cortical inhibitory networks

C. A. Wotton et al.

JOURNAL OF NEUROENDOCRINOLOGY (2018)

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Article Neurosciences

Inflow of oxygen and glucose in brain tissue induced by intravenous norepinephrine: relationships with central metabolic and peripheral vascular responses

R. Aaron Bola et al.

JOURNAL OF NEUROPHYSIOLOGY (2018)

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Article Neurosciences

Evidence for astrocyte purinergic signaling in cortical sensory adaptation and serotonin-mediated neuromodulation

Elizabeth F. Quon et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2018)

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Review Clinical Neurology

A neuro-immune, neuro-oxidative and neuro-nitrosative model of prenatal and postpartum depression

Chutima Roomruangwong et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2018)

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Article Multidisciplinary Sciences

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

Yan Yang et al.

NATURE (2018)

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Review Clinical Neurology

The glymphatic pathway in neurological disorders

Martin Kaag Rasmussen et al.

LANCET NEUROLOGY (2018)

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Review Neurosciences

Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder

Lijuan Zhang et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Article Biology

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

Humberto Mestre et al.

ELIFE (2018)

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Article Clinical Neurology

Activated neuro-oxidative and neuro-nitrosative pathways at the end of term are associated with inflammation and physio-somatic and depression symptoms, while predicting outcome characteristics in mother and baby

Chutima Roomruangwong et al.

JOURNAL OF AFFECTIVE DISORDERS (2017)

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Article Neurosciences

Sleep deprivation induces changes in 5-HT actions and 5-HT1A receptor expression in the rat hippocampus

H. Azizi et al.

NEUROSCIENCE LETTERS (2017)

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Article Multidisciplinary Sciences

Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia

Neha Gupta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Review Clinical Neurology

Shared metabolic and immune-inflammatory, oxidative and nitrosative stress pathways in the metabolic syndrome and mood disorders

Luiz Gustavo Piccoli de Melo et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2017)

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Article Endocrinology & Metabolism

Oxidative stress, inflammation and treatment response in major depression

Daniel Lindqvist et al.

PSYCHONEUROENDOCRINOLOGY (2017)

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Review Psychiatry

The neurobiology of depression: An integrated view

Jason Dean et al.

ASIAN JOURNAL OF PSYCHIATRY (2017)

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Review Neurosciences

Reward and Aversion

Hailan Hu

ANNUAL REVIEW OF NEUROSCIENCE, VOL 39 (2016)

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Article Neurosciences

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

Masaaki Iwata et al.

BIOLOGICAL PSYCHIATRY (2016)

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Review Medicine, Research & Experimental

HIF1α and metabolic reprogramming in inflammation

Sarah E. Corcoran et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Multidisciplinary Sciences

Changes in the composition of brain interstitial ions control the sleep-wake cycle

Fengfei Ding et al.

SCIENCE (2016)

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Review Multidisciplinary Sciences

Maternal immune activation: Implications for neuropsychiatric disorders

Myka L. Estes et al.

SCIENCE (2016)

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Review Neurosciences

Neuromodulator and Emotion Biomarker for Stress Induced Mental Disorders

Simeng Gu et al.

NEURAL PLASTICITY (2016)

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Review Cell Biology

Redox Homeostasis and Mitochondrial Dynamics

Peter H. G. M. Willems et al.

CELL METABOLISM (2015)

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Article Pharmacology & Pharmacy

Serotonin and inhibitory response control: Focusing on the role of 5-HT1A receptors

Tommy Pattij et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2015)

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Article Biochemistry & Molecular Biology

Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger

Petros Andrikopoulos et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Editorial Material Clinical Neurology

Implications of the discovery of brain lymphatic pathways

Jeffrey J. Iliff et al.

LANCET NEUROLOGY (2015)

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Article Multidisciplinary Sciences

Structural and functional features of central nervous system lymphatic vessels

Antoine Louveau et al.

NATURE (2015)

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Article Biochemistry & Molecular Biology

Volume Transmission in Central Dopamine and Noradrenaline Neurons and Its Astroglial Targets

Kjell Fuxe et al.

NEUROCHEMICAL RESEARCH (2015)

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Article Cell & Tissue Engineering

Oxidative Stress and Adult Neurogenesis

Ti-Fei Yuan et al.

STEM CELL REVIEWS AND REPORTS (2015)

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Review Neurosciences

Depression as a Microglial Disease

Raz Yirmiya et al.

TRENDS IN NEUROSCIENCES (2015)

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Article Cell & Tissue Engineering

Oxidative Stress and Adult Neurogenesis

Ti-Fei Yuan et al.

STEM CELL REVIEWS AND REPORTS (2015)

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Article Clinical Neurology

Impairment of Paravascular Clearance Pathways in the Aging Brain

Benjamin T. Kress et al.

ANNALS OF NEUROLOGY (2014)

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Article Neurosciences

Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+ clearance and volume responses

Brian Roland Larsen et al.

GLIA (2014)

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Review Cell Biology

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Antonio Ayala et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)

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Review Biochemistry & Molecular Biology

Redox Regulation of Sodium and Calcium Handling

Stefan Wagner et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

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Article Neurosciences

Coverage of Blood Vessels by Astrocytic Endfeet Is Reduced in Major Depressive Disorder

Grazyna Rajkowska et al.

BIOLOGICAL PSYCHIATRY (2013)

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Article Immunology

Dysregulated relationship of inflammation and oxidative stress in major depression

B. J. Rawdin et al.

BRAIN BEHAVIOR AND IMMUNITY (2013)

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Article Cell Biology

α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice

Fengfei Ding et al.

CELL CALCIUM (2013)

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Article Pharmacology & Pharmacy

Inflammation, Serotonin and Major Depression

Mario Catena-Dell'Osso et al.

CURRENT DRUG TARGETS (2013)

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Article Immunology

Diverse age-related effects of Bacopa monnieri and donepezil in vitro on cytokine production, antioxidant enzyme activities, and intracellular targets in splenocytes of F344 male rats

Hannah P. Priyanka et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2013)

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Article Neurosciences

Photolysis of Caged Ca2+ But Not Receptor-Mediated Ca2+ Signaling Triggers Astrocytic Glutamate Release

Fushun Wang et al.

JOURNAL OF NEUROSCIENCE (2013)

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Review Cell Biology

Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants

Borut Poljsak et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)

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Article Neurosciences

Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex

M. Hinwood et al.

CEREBRAL CORTEX (2012)

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Article Endocrinology & Metabolism

Norepinephrine, Active Norepinephrine Transporter, and Norepinephrine-Metabolism Are Involved in the Generation of Reactive Oxygen Species in Human Ovarian Granulosa Cells

S. Saller et al.

ENDOCRINOLOGY (2012)

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Review Immunology

Sensing and reacting to microbes through the inflammasomes

Luigi Franchi et al.

NATURE IMMUNOLOGY (2012)

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Article Biochemistry & Molecular Biology

Astrocytes Modulate Neural Network Activity by Ca2+-Dependent Uptake of Extracellular K+

Fushun Wang et al.

SCIENCE SIGNALING (2012)

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Article Psychiatry

Antidepressants act on glial cells: SSRIs and serotonin elicit astrocyte calcium signaling in the mouse prefrontal cortex

Carola G. Schipke et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2011)

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Article Multidisciplinary Sciences

Serotonin and Dopamine Protect from Hypothermia/Rewarming Damage through the CBS/H2S Pathway

Fatemeh Talaei et al.

PLOS ONE (2011)

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Article Multidisciplinary Sciences

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema

Alexander S. Thrane et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Review Clinical Neurology

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

Michael Maes et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2011)

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Article Immunology

Pyroptosis - a cell death modality of its kind?

Oliver Kepp et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2010)

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Article Immunology

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

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