期刊
ANTIOXIDANTS
卷 11, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/antiox11122397
关键词
protein tyrosine phosphatase; reversible oxidation; bacterial phosphatase; virulence factor; antimicrobial therapy
资金
- IDUB Program's Research Project for Young Scientists MTN (Medical University of Gdansk, Gdansk, Poland)
- [71-1215]
This review focuses on the role of bacterial protein tyrosine phosphatases (PTPs) as virulence factors and explores the potential of inhibiting these enzymes to combat bacterial infections. This has important implications for the design of antimicrobial adjuvant therapy.
The review is focused on the bacterial protein tyrosine phosphatases (PTPs) utilized by bacteria as virulence factors necessary for pathogenicity. The inhibition of bacterial PTPs could contribute to the arrest of the bacterial infection process. This mechanism could be utilized in the design of antimicrobial therapy as adjuvants to antibiotics. The review summaries knowledge on pathogenic bacterial protein tyrosine phosphatases (PTPs) involved in infection process, such as: PTPA and PTPB from Staphylococcus aureus and Mycobacterium tuberculosis; SptP from Salmonella typhimurium; YopH from Yersinia sp. and TbpA from Pseudomonas aeruginosa. The review focuses also on the potential inhibitory compounds of bacterial virulence factors and inhibitory mechanisms such as the reversible oxidation of tyrosine phosphatases.
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