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Neuroprotective Potentials of Flavonoids: Experimental Studies and Mechanisms of Action

ANTIOXIDANTS (2023)

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Hesperidin inhibits NOX4 mediated oxidative stress and inflammation by upregulating SIRT1 in experimental diabetic neuropathy

Anees Ahmed Syed et al.

Summary: Hesperidin, a flavonoid, exerts its pharmacological benefits by enhancing SIRT1 and inhibiting NOX4, leading to the improvement of diabetic neuropathy. This study confirmed the effects of hesperidin on oxidative stress, inflammation, NOX4, and SIRT1 through various experimental analyses in HFD-fed rats and rat glial C6 cells stimulated with Palmitate.

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Hepatoprotective and cognitive-enhancing effects of hesperidin against thioacetamide-induced hepatic encephalopathy in rats

Nada F. Abo El-Magd et al.

Summary: Hesperidin exhibits hepatoprotective effects and ameliorates hepatic encephalopathy through modulation of NLRP3/Sirt1/FOXO signaling pathway. It reduces liver enzymes, bile and ammonia levels, restores oxidant/antioxidant balance, improves motor and cognitive abilities, and enhances tissue architecture. Hesperidin also decreases IL-113 and caspase-1 expression.

LIFE SCIENCES (2023)

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Article Clinical Neurology

Association of Dietary Intake of Flavonols With Changes in Global Cognition and Several Cognitive Abilities

Thomas Monroe Holland et al.

Summary: This study investigates the association between dietary intakes of total flavonols and their constituents and the change in cognitive performance. The results suggest that higher intakes of total flavonols and certain flavonol constituents are associated with a slower decline in global cognition and multiple cognitive abilities.

NEUROLOGY (2023)

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Article Biochemistry & Molecular Biology

Senolytic Drug Quercetin Rescues Survival from Blue Light Toxicity in Drosophila Model

Dake Zhang et al.

Summary: This study investigated the protective effect of the senolytic drug quercetin on blue light toxicity using Drosophila melanogaster as a model organism. The results showed that quercetin can effectively prolong the survival of flies under blue light irradiation, increase the egg production of female flies, and affect their spontaneous activity and nutrient metabolism in a sex-specific manner.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2023)

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Article Geriatrics & Gerontology

Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age

Md Torikul Islam et al.

AGING CELL (2023)

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Article Cardiac & Cardiovascular Systems

Associations of dietary flavonoids and subclasses with total and cardiovascular mortality among 369,827 older people: The NIH-AARP Diet and Health Study

Yimin Zhao et al.

Summary: This study aimed to investigate the associations between flavonoid intake and total and cardiovascular mortality in older participants. The results showed that high flavonoid intake was associated with lower mortality rates in older adults.

ATHEROSCLEROSIS (2023)

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Article Biochemistry & Molecular Biology

Quercetin Attenuates Copper-Induced Apoptotic Cell Death and Endoplasmic Reticulum Stress in SH-SY5Y Cells by Autophagic Modulation

Joyeeta Chakraborty et al.

Summary: This study explores the potential of quercetin in combating copper-induced neurotoxicity. The research found that copper increased intracellular reactive oxygen species levels, leading to morphological deformities, nuclear condensation, mitochondrial membrane potential imbalance, and ultimately apoptotic cell death. However, quercetin reversed these changes through its antioxidant and anti-apoptotic properties, inducing autophagy. The study also revealed the role of quercetin in modulating ER stress and restoring ER homeostasis in mitochondria and ER.

BIOLOGICAL TRACE ELEMENT RESEARCH (2022)

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Review Environmental Sciences

Potential innovation against Alzheimer's disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery

Chenmala Karthika et al.

Summary: Alzheimer's disorder is difficult to manage and treat due to the complexity of the brain and the blood-brain barrier. A combined strategy using a nano-based formulation containing vitamin E, quercetin, and basil oil, administered nasally, shows promise in treating and alleviating Alzheimer's disease. Intranasal drug administration is a non-invasive approach that enhances bioavailability and bypasses the blood-brain barrier, reducing systemic side effects.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

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Flavonoids-Natural Gifts to Promote Health and Longevity

Xiaolan Fan et al.

Summary: This review highlights the association between aging and macromolecular damage, and discusses the potential of flavonoid molecules in delaying aging and prolonging healthy lifespan. The study suggests the need for further exploration of the clinical application of flavonoids in anti-aging treatment, which could provide valuable information for drug design and development.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Neurosciences

Research progress of natural products for the treatment of ischemic stroke

Jiaxin Li et al.

Summary: Stroke is a major cause of death and disability globally, and its incidence rate is increasing. Natural products have been used in traditional medicine and show potential in the treatment of stroke. This article reviews the neuroprotective effects of 33 natural compounds, some of which have potential as clinical treatments for ischemic stroke.

JOURNAL OF INTEGRATIVE NEUROSCIENCE (2022)

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Article Biochemistry & Molecular Biology

Quercetin ameliorates lipopolysaccharide-induced neuroinflammation and oxidative stress in adult zebrafish

Sukhdev Singh et al.

Summary: This study demonstrates that treatment with quercetin can improve neuroinflammation and oxidative stress caused by lipopolysaccharide, reducing inflammatory factor levels and increasing antioxidant levels.

MOLECULAR BIOLOGY REPORTS (2022)

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Article Nutrition & Dietetics

The Citrus Flavonoid Hesperetin Encounters Diabetes-Mediated Alzheimer-Type Neuropathologic Changes through Relieving Advanced Glycation End-Products Inducing Endoplasmic Reticulum Stress

Mei-Chou Lai et al.

Summary: The study found that hesperetin, a citrus flavonoid, can counteract the pathophysiological changes of Alzheimer's disease induced by advanced glycation end-products (AGEs). The underlying mechanisms include reducing oxidative stress and apoptosis, regulating protein expression, and decreasing endoplasmic reticulum stress.

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Bamboo Leaf Flavonoids Suppress Oxidative Stress-Induced Senescence of HaCaT Cells and UVB-Induced Photoaging of Mice through p38 MAPK and Autophagy Signaling

Yanpei Gu et al.

Summary: In this study, bamboo leaf flavonoids (BLF) were found to have an inhibitory effect on the senescence of HaCaT cells, possibly through their antioxidant and anti-inflammatory abilities, along with involvement of MAPK and autophagy mechanisms. Furthermore, the results were validated in UVB-induced photoaging mice, suggesting that BLF could be a potential therapeutic agent for intervening skin aging both in vitro and in vivo.

NUTRIENTS (2022)

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Article Neurosciences

Comparison Between Hesperidin, Coumarin, and Deferoxamine Iron Chelation and Antioxidant Activity Against Excessive Iron in the Iron Overloaded Mice

Mahdi Aalikhani et al.

Summary: In this study, it was found that hesperidin and coumarin could strongly chelate excessive iron and decrease iron deposition in the brain tissue. Additionally, hesperidin and coumarin also significantly increased the activity of antioxidant enzymes.

FRONTIERS IN NEUROSCIENCE (2022)

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Article Pediatrics

Quercetin Administration Following Hypoxia-Induced Neonatal Brain Damage Attenuates Later-Life Seizure Susceptibility and Anxiety-Related Behavior: Modulating Inflammatory Response

Yan Wu et al.

Summary: This study demonstrated that quercetin can attenuate anxiety, memory impairment, and cognitive deficits following hypoxia-induced neonatal seizure by modulating the inflammatory response through the TLR4/NF-kappa B pathway.

FRONTIERS IN PEDIATRICS (2022)

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Article Oncology

Senolysis-Based Elimination of Chemotherapy-Induced Senescent Breast Cancer Cells by Quercetin Derivative with Blocked Hydroxy Groups

Anna Lewinska et al.

Summary: Cellular senescence is associated with aging and age-related diseases, and the elimination of senescent cells is considered a promising anti-aging strategy. In this study, a quercetin derivative, QD3, was found to sensitize breast cancer cells to apoptotic cell death induced by an anti-cancer drug, and also reduce proinflammatory and HSP70-based responses. This suggests that a combination of pro-senescence and senolytic activities may be a novel anti-cancer strategy.

CANCERS (2022)

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Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products

Chun Ge et al.

Summary: Ferroptosis is a newly discovered form of regulatory cell death that is distinct from other types of cell death. It is characterized by iron-dependent lipid peroxidation and oxidative perturbation, and can be inhibited by iron chelators and lipophilic antioxidants. This process is implicated in various biological contexts, including iron homeostasis, lipid metabolism, and glutathione metabolism. Ferroptosis is closely related to physiological and pathological processes such as tumor progression, (neuro)degenerative diseases, and hepatic and renal failure. There is a need for the discovery of novel compounds that can modulate ferroptosis, despite the existence of some experimental reagents and approved clinical drugs with anti- or pro-ferroptotic properties. This review discusses the molecular mechanisms of ferroptotic death and its roles in different pathophysiological contexts, as well as chemical compounds and natural products that can induce or inhibit ferroptosis for the prevention and treatment of various diseases. It emphasizes the promising prospects of natural products in ferroptosis-associated therapy due to their multiple components, multiple biotargets, and slight side effects.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Novel Nutraceutical Compounds in Alzheimer Prevention

Ricardo Benjamin Maccioni et al.

Summary: The incidence of Alzheimer's disease is increasing worldwide. Prevention efforts, such as adopting a healthy lifestyle, using disease-modifying agents, and focusing on nutrition, can help mitigate symptoms or even prevent AD.

BIOMOLECULES (2022)

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Targeting neuroinflammation by polyphenols: A promising therapeutic approach against inflammation-associated depression

Mohammed Abu Tayab et al.

Summary: Depression is a prevalent and debilitating mental disorder that affects many people, leading to high suicide rates. Antidepressant medications do not alleviate symptoms in many patients, and some non-responsive patients exhibit increased inflammation. Polyphenols have anti-inflammatory effects and could be a promising adjunctive therapy for inflammation-associated depressive symptoms.

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Activity-differential search for amyloid-β aggregation inhibitors using LC-MS combined with principal component analysis

Mizuho Hanaki et al.

Summary: This study used LC-MS combined with PCA to analyze 46 crude drug extracts from 18 plants and identified 5 extracts with inhibitory activities against A beta 42 aggregation. From the analysis, several compounds were found to be associated with anti-aggregative properties and could be potential candidates for future AD therapies.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2022)

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Article Neurosciences

Preventive putative mechanisms involved in the psychopathologies of mice passively coping with psychosocial defeat stress by quercetin

Princewill Ikechukwu Ugwu et al.

Summary: The study found that quercetin can improve anxiety, depression, and cognitive defects induced by psychosocial stress through multiple mechanisms, including regulation of neurochemical release, increasing BDNF, etc. Additionally, quercetin can also reduce neuronal inflammation, oxidative stress, and apoptotic pathway, and improve stress-induced impairments by normalizing the HPA-axis.

BRAIN RESEARCH BULLETIN (2022)

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Article Biology

A multi-targeted approach to identify potential flavonoids against three targets in the SARS-CoV-2 life cycle

Sanjay Kumar et al.

Summary: Flavonoids, with their antiviral, anti-inflammatory, and antioxidative properties, show potential therapeutic effects against SARS-CoV-2. Naringin and hesperidin exhibit good binding relationships and stability with SARS-CoV-2 target proteins.

COMPUTERS IN BIOLOGY AND MEDICINE (2022)

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Article Plant Sciences

Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats

Ran Yang et al.

Summary: The study demonstrated that quercetin has neuroprotective effects by protecting the BBB in MCAO rats through the Sirt1 signaling pathway, reducing neurological deficits and cerebral infarct volume.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2022)

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Article Geriatrics & Gerontology

Senolytics Cocktail Dasatinib and Quercetin Alleviate Human Umbilical Vein Endothelial Cell Senescence via the TRAF6-MAPK-NF-κB Axis in a YTHDF2-Dependent Manner

Ting Fan et al.

Summary: This study demonstrates that D+Q can suppress LPS-induced HUVECs senescence by regulating RNA m6A, providing a new approach for the clinical treatment of age-related cardiovascular diseases.

GERONTOLOGY (2022)

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Article Neurosciences

Quercetin Alleviates Demyelination Through Regulating Microglial Phenotype Transformation to Mitigate Neuropsychiatric Symptoms in Mice with Vascular Dementia

Zihu Tan et al.

Summary: This research demonstrates that cerebral hypoperfusion worsens demyelination and reduces myelin sheath thickness in vascular dementia patients. However, the compound Quercetin shows potential in mitigating these effects and alleviating anxiety and depression-like behaviors. This is achieved through its regulation of microglial phenotype transformation, leading to increased secretion of anti-inflammatory cytokines and decreased production of pro-inflammatory factors.

MOLECULAR NEUROBIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Neuroinflammation in HIV-associated depression: evidence and future perspectives

Arish Mudra Rakshasa-Loots et al.

Summary: People living with HIV are at a high risk of mental illness, particularly depression. The neurobiological mechanisms underlying HIV-associated depression are not yet understood, but neuroinflammation may play a role. Current research has some debates, and replication studies in diverse populations are crucial.

MOLECULAR PSYCHIATRY (2022)

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Quercitrin improved cognitive impairment through inhibiting inflammation induced by microglia in Alzheimer's disease mice

Lixin Wang et al.

Summary: Quercitrin improves cognitive impairment in Alzheimer's disease model mice by alleviating the intensity of inflammatory response and reducing the accumulation of amyloid-beta plaques.

NEUROREPORT (2022)

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Article Neurosciences

Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy

Mustafa Onur Yildiz et al.

Summary: Hesperidin has protective effects against NaF-induced neurotoxicity by reducing lipid peroxidation, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress.

NEUROTOXICOLOGY (2022)

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Article Pharmacology & Pharmacy

Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1β, TNF-α, NF-κB, IκKB, and p53 genes in male Wistar rats

Sunday Solomon Josiah et al.

NEUROTOXICOLOGY (2022)

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Review Cell Biology

Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis

Chao Guo et al.

Summary: Quercetin, extracted from tea, onions, and apples, has a neuroprotective effect on experimental ischemic stroke. This systematic review and meta-analysis found that quercetin significantly improved neurological function score and reduced infarct volume. It also alleviated blood-brain barrier permeability and brain water content. The mechanisms of quercetin against focal cerebral ischemia involve antioxidation, antiapoptotic, anti-inflammation, and calcium overload reduction. Although the effect size may be overestimated due to study quality and publication bias, quercetin shows potential as a neuroprotective agent for human ischemic stroke.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Neurosciences

Quercetin Mitigates Methamphetamine-Induced Anxiety-Like Behavior Through Ameliorating Mitochondrial Dysfunction and Neuroinflammation

Fengrong Chen et al.

Summary: This study found that methamphetamine abuse can result in neurotoxic outcomes such as anxiety and depression. The researchers developed a mouse model of anxiety-like behavior induced by methamphetamine and identified mitochondria as a potential mechanism involved. They used quercetin, a mitochondrial protector, and found that it alleviated anxiety-like behavior and improved mitochondrial impairment. In vitro experiments also showed that quercetin could alleviate mitochondrial dysfunction induced by methamphetamine.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

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Review Pharmacology & Pharmacy

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

Shen Chen et al.

Summary: Depression is a global health problem that has serious impacts on the daily life of patients. The side effects of currently used antidepressants reduce patient compliance. Quercetin, a flavonol with various pharmacological effects, has been proven to have antidepressant properties. This review summarizes the evidence and mechanisms of using quercetin to treat depression and provides references for further research and clinical application of quercetin glycoside derivatives.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Integrative & Complementary Medicine

Fourteen-Day Evolution of COVID-19 Symptoms during the Third Wave in Nonvaccinated Subjects and Effects of Hesperidin Therapy: A Randomized, Double-Blinded, Placebo-Controlled Study

Jocelyn Dupuis et al.

Summary: Hesperidin 1000 mg daily may help reduce certain COVID-19 symptoms, but most nonvaccinated patients remain symptomatic after 14 days, with anosmia being the most frequently persisting symptom.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Quercetin Abrogates Oxidative Neurotoxicity Induced by Silver Nanoparticles in Wistar Rats

Samar S. Elblehi et al.

Summary: This study investigated the neurotoxicity induced by silver nanoparticles (AgNPs) and the neuroprotective effects of quercetin. The results showed that AgNP exposure increased oxidative stress and inflammation in the brain tissue, while quercetin effectively counteracted the negative effects of AgNPs by modulating tight junction proteins, antioxidant systems, and inflammatory responses.

LIFE-BASEL (2022)

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Therapeutic Potential and Clinical Evidence of Hesperidin as Neuroprotective Agent

Shivangi Joshi et al.

Central Nervous System Agents in Medicinal Chemistry (2022)

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Article Medicine, Research & Experimental

Quercetin alleviated multi-walled carbon nanotubes-induced neurotoxicity in mice through inhibition of oxidation, inflammation, and pyroptosis

Amira A. Sallam et al.

Summary: The study found that quercetin can alleviate neurotoxicity induced by multi-walled carbon nanotubes. This effect is achieved through antioxidant, anti-inflammatory, and antipyroptotic mechanisms.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Food Science & Technology

Polyphenols in edible herbal medicine: targeting gut-brain interactions in depression-associated neuroinflammation

Wenzhi Hao et al.

Summary: Supplementing with edible herbal medicine is an important strategy for nutrition, as polyphenols found in these medicines can modulate gut microbiota and potentially suppress neuroinflammation associated with depression.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

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The AMPK-SIRT1-FoxO1-NF-κB signaling pathway participates in hesperetin-mediated neuroprotective effects against traumatic brain injury via the NLRP3 inflammasome

Hai Song et al.

Summary: Hesperetin shows neuroprotective effects in acute cerebral damage following traumatic brain injury (TBI) by alleviating neurological deficits, cerebral edema, and neuronal apoptosis. It inhibits microglial activation and pro-inflammatory cytokine production, while promoting AMPK and SIRT1 expression. Hesperetin acts through the AMPK-SIRT1-FoxO1-NF-kappa B axis to curb inflammation and improve neurobehavioral function after TBI.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2022)

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Review Developmental Biology

The impact of obesity-related neuroinflammation on postpartum depression: A narrative review

Kenia Lourdes de Oliveira da Cruz et al.

Summary: Obesity is a serious health problem associated with chronic inflammation, metabolic diseases, and central nervous system disorders. It may also increase the risk of postpartum depression.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2022)

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Review Cell Biology

Iron Brain Menace: The Involvement of Ferroptosis in Parkinson Disease

Kai-Jung Lin et al.

Summary: Parkinson's disease is the second most common neurodegenerative disease and is associated with iron accumulation and iron-dependent phospholipid peroxidation, which leads to a novel cell death pathway called ferroptosis. Recent research has focused on targeting ferroptosis as a potential intervention for PD.

CELLS (2022)

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Article Biochemistry & Molecular Biology

Flavonoids from Lycium barbarum Leaves Exhibit Anti-Aging Effects through the Redox-Modulation

Yinhong Niu et al.

Summary: Lycium barbarum leaf flavonoid extracts have anti-aging and redox-modulating effects, which can alleviate oxidative stress-induced damage in cells and upregulate antioxidant enzyme activity and gene expression through the MAPK signaling pathway.

MOLECULES (2022)

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Potential therapeutic use of plant flavonoids in AD and PD

Sun Meng-Zhen et al.

Summary: Flavonoids have potential in attenuating Alzheimer's and Parkinson's disease through their anti-oxidative and neuroprotective effects. However, more rigorous studies are needed to develop effective drugs for treating these diseases.

HELIYON (2022)

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Molecular Pathophysiological Mechanisms in Huntington's Disease

Anamaria Jurcau

Summary: Huntington's disease is an inherited neurodegenerative disease that primarily affects medium spiny neurons in the striatum. The mutant huntingtin protein leads to neuronal loss through a series of molecular cascades, involving excitotoxicity, transcriptional dysregulation, and other key factors. In addition to neurons, astrocytes are also dysfunctional due to the presence of mutant huntingtin, and neuroinflammation may further contribute to the pathogenesis of Huntington's disease.

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Anxiolytic-like Effect of Quercetin Possibly through GABA Receptor Interaction Pathway: In Vivo and In Silico Studies

Md Shahazul Islam et al.

Summary: Scientific evidence suggests that quercetin has anxiolytic-like effects in experimental animals. This study aimed to evaluate its anxiolytic effects in mouse models and elucidate the possible mechanism of action. Quercetin was found to interact with the GABA receptor, showing a competitive ligand effect and enhancing the effects of standard anxiolytic drugs.

MOLECULES (2022)

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Review Cell Biology

Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer's Disease

Tarun Minocha et al.

Summary: Alzheimer's disease is a serious progressive neurodegenerative disorder in the elderly, and flavonoids have shown neuroprotective effects and potential as a source for AD treatment.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Plant Sciences

Flavonoids from Rhododendron nivale Hook. f delay aging via modulation of gut microbiota and glutathione metabolism

Xiao Guo et al.

Summary: This study explored the major active ingredients and anti-aging mechanisms of Rhododendron nivale Hook. f (R.n). The results showed that R.n possessed anti-aging activity by reshaping intestinal flora homeostasis and reinforcing the glutathione antioxidant system.

PHYTOMEDICINE (2022)

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Review Neurosciences

Insight into the potential role of ferroptosis in neurodegenerative diseases

Yingying Ji et al.

Summary: Ferroptosis, as a newly discovered form of cell death, plays a key role in the occurrence and development of neurodegenerative diseases. However, the underlying mechanism of ferroptosis in these diseases remains unclear, and further research is needed to explore its therapeutic potential.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

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Article Pharmacology & Pharmacy

Model yeast as a versatile tool to examine the antioxidant and anti-ageing potential of flavonoids, extracted from medicinal plants

Hira Zahoor et al.

Summary: There is a global demand for herbal extracts used in cosmetics, food, and health supplements. This study focuses on examining the antioxidant and anti-aging potential of flavonoids extracted from medicinal plants using Saccharomyces cerevisiae as a model organism. The results show that certain quercetin analogs can protect yeast cells against oxidative stress and extend the lifespan of wild-type S. cerevisiae.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Neurosciences

Pathogenesis of Huntington's Disease: An Emphasis on Molecular Pathways and Prevention by Natural Remedies

Zainab Irfan et al.

Summary: Huntington's disease is a neuro-degenerative disorder characterized by abnormal movements, cognitive and psychiatric disorders. The expansion of CAG trinucleotide in the htt gene leads to neuronal death and network degeneration in the brain, causing loss of motor coordination and muscle function.

BRAIN SCIENCES (2022)

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Article Immunology

Neuroinflammation and neuroprogression in depression: Effects of alternative drug treatments

Brandon Richardson et al.

Summary: The article discusses the pathophysiological mechanisms of depression, emphasizing the crucial role of inflammation in the development of MDD, highlighting the importance of anti-inflammatory treatment and potential effects of novel drugs.

BRAIN, BEHAVIOR, & IMMUNITY - HEALTH (2022)

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Article Integrative & Complementary Medicine

Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic Stress Disorder

Bombi Lee et al.

Summary: This study demonstrated that hesperidin has antidepressant effects in rats exposed to PTSD, indicating that this natural flavonoid may be an effective treatment for post-traumatic stress disorder.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2021)

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Review Neurosciences

Neuroinflammation and depression: A review

Romain Troubat et al.

Summary: Neuroinflammation interacts with key neurobiological factors of depression, potentially presenting a crucial therapeutic target for future treatments. This interaction may impact serotonin levels, HPA axis regulation, and hippocampal neurogenesis, leading to the pathophysiological cascade of increased glutamate levels and altered neurotransmission. It can be triggered by chronic inflammatory conditions or primary brain neuroinflammation, highlighting the importance of addressing neuroinflammation in the treatment of major depressive disorder.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

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Metabolomics analysis of the effects of quercetin on renal toxicity induced by cadmium exposure in rats

Tong Guan et al.

Summary: The study reveals that quercetin attenuated cadmium-induced nephrotoxicity by regulating the metabolism of lipids, amino acids, and purine, inhibiting oxidative stress, and protecting kidney functions.

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Article Environmental Sciences

Attenuation of sodium arsenite-induced cardiotoxicity and neurotoxicity with the antioxidant, anti-inflammatory, and antiapoptotic effects of hesperidin

Muslum Kuzu et al.

Summary: The study investigated the protective effect of hesperidin against sodium arsenite-induced heart and brain toxicity in rats. Results showed that hesperidin co-treatment had antioxidant, anti-inflammatory, and antiapoptotic effects, protecting tissue architecture and regulating all values.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

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Quercetin and/or Ascorbic Acid Modulatory Effect on Phenobarbital-Induced Sleeping Mice Possibly through GABAA and GABAB Receptor Interaction Pathway

Rajib Hossain et al.

Summary: Depressive disorder is a common illness that poses a challenge in the treatment of treatment-resistant depression. Research suggests that pre-treatment with quercetin and ascorbic acid can modify the sleep patterns of mice, potentially acting through the GABA receptor pathways.

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Hesperidin protects against behavioral alterations and loss of dopaminergic neurons in 6-OHDA-lesioned mice: the role of mitochondrial dysfunction and apoptosis

Michelle S. Antunes et al.

Summary: Hesperidin mitigates the degeneration of dopaminergic neurons in the substantia nigra pars compacta by preventing mitochondrial dysfunction and modulating apoptotic pathways, thus improving behavioral alterations in a relevant preclinical model of Parkinson's disease.

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Hesperidin downregulates kinases lrrk2 and gsk3β in a 6-OHDA induced Parkinson's disease model

Swathi Kesh et al.

Summary: Parkinson's disease is characterized by the depletion of dopamine and the formation of Lewy bodies, with hesperidin showing neuroprotective effects by downregulating kinases and oxidative stress markers in both in vitro and in vivo models. This suggests that hesperidin could be a promising drug in targeting kinases in a PD model induced by 6-OHDA.

NEUROSCIENCE LETTERS (2021)

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Article Cell Biology

Influence of early life stress on depression: from the perspective of neuroendocrine to the participation of gut microbiota

Xi Tan et al.

Aging-US (2021)

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Article Biochemistry & Molecular Biology

Biological evaluation of 7-O-amide hesperetin derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease

Mingfei Wu et al.

Summary: The study found that compounds 4d, 4e, and 7c exhibit strong antioxidant, anti-A β self-aggregation, and anti-neuroinflammatory activities. Additionally, compound 7c was able to inhibit the expression of iNOS and COX-2 proteins in BV2 cells.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

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Article Pharmacology & Pharmacy

Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin-converting enzyme II receptor (ACE2)

Chaima Mouffouk et al.

Summary: This study reviews the efficacy of many dietary flavonols as potential antiviral drugs, discussing the relationship between their structures and antiviral effects on SARS-CoV-2, and reports on the immunomodulatory, anti-inflammatory, and antiviral effects of secondary metabolites from this class of flavonoids.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Nutrition & Dietetics

Dietary patterns and depression risk in older adults: systematic review and meta-analysis

Pei-Yu Wu et al.

Summary: The study found an inverse association between healthy dietary patterns and depression risk in older adults, although there was high heterogeneity among the studies.

NUTRITION REVIEWS (2021)

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Article Biochemistry & Molecular Biology

The adjuvant aluminum fate - Metabolic tale based on the basics of chemistry and biochemistry

Aleksandar Cirovic et al.

Summary: This review highlights the mechanisms of aluminum toxicity, suggesting that interference with iron metabolism may lead to iron-mediated cell damage. Feasible solutions to avoid aluminum toxicity are provided, including postponement of vaccination with aluminum-containing adjuvants until the availability of suitable alternatives.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2021)

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Article Medicine, Research & Experimental

The protective effects of hesperidin against paclitaxel-induced peripheral neuropathy in rats

Halil Sezgin Semis et al.

Summary: The study showed that hesperidin has potential protective effects against paclitaxel-induced sciatic nerve damage by reducing apoptosis, alleviating endoplasmic reticulum stress, and relieving neuropathic pain associated with paclitaxel-induced peripheral neuropathy.

LIFE SCIENCES (2021)

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Article Medicine, Research & Experimental

Quercetin stimulates the non-amyloidogenic pathway via activation of ADAM10 and ADAM17 gene expression in aluminum chloride-induced Alzheimer's disease rat model

Asmaa M. Elfiky et al.

Summary: The present study demonstrated that quercetin has neuroprotective effects on Alzheimer's disease, attenuating cognitive impairment, neurotransmitter dysfunction and amyloid beta aggregation in the hippocampus through modulation of gene expression. Activation of ADAM10 and ADAM17 by quercetin may serve as potential therapeutic targets for counteracting Alzheimer's disease progression.

LIFE SCIENCES (2021)

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Article Plant Sciences

A mixture of quercetin 4′-O-rhamnoside and isoquercitrin from Tilia americana var. mexicana and its biotransformation products with antidepressant activity in mice

Gabriela Belen Martinez-Hernandez et al.

Summary: The study focuses on the evaluation of the antidepressant effect of the mixture of two flavonoids from Tilia americana, finding that FMix has antidepressant activity, possibly due to the interaction with metabolites of quercetin. Combining FMix with various serotonergic drugs enhances the antidepressant effect.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Quercetin exhibits potent antioxidant activity, restores motor and non-motor deficits induced by rotenone toxicity

Syeda Madiha et al.

Summary: The study demonstrated that quercetin supplementation significantly restored motor and nonmotor deficits induced by rotenone, enhanced antioxidant enzyme activities, and mitigated neurotransmitter alterations. Quercetin supplementation improves neurotransmitter levels by mitigating oxidative stress, leading to enhanced motor activity, cognitive functions, and reduced depressive behavior. Pre-supplementation of quercetin showed more significant results compared to post-supplementation, indicating the potential therapeutic effect of quercetin in reducing the risk and progression of Parkinson's disease.

PLOS ONE (2021)

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Article Clinical Neurology

Peripheral synucleinopathy in Parkinson disease with LRRK2 G2385R variants

Jing Yang et al.

Summary: The study found that p-syn deposition in the skin nerve fibers of G2385R carrier PD patients, as well as decreased small fiber density, were correlated with autonomic symptoms. PD patients with the G2385R variant showed a more peculiar clinical profile compared to noncarriers.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

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Article Multidisciplinary Sciences

Mechanism of quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus

Guoxiu Zu et al.

Summary: In this study, potential molecular targets of quercetin were identified using bioinformatics methods, and the therapeutic potential of quercetin in type 2 diabetes mellitus and Alzheimer's disease was explored. The study provides insights into potential therapeutic targets and pathways for further clinical research.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence

Elena Zoico et al.

Summary: This study demonstrated the senolytic effect of quercetin on pre-adipocytes and adipocytes in vitro, highlighting its ability to reduce cellular senescence by decreasing beta-galactosidase activity, suppressing ROS, and inhibiting inflammatory cytokines. Additionally, quercetin treatment led to a downregulation of miR-155-5p expression, modulating NF-kappa B activity and showing a trend towards upregulation of SIRT-1, suggesting a potential key mechanism of action for quercetin in reducing adipose tissue aging.

SCIENTIFIC REPORTS (2021)

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Article Chemistry, Multidisciplinary

Elucidating the Interaction of Human Ferritin with Quercetin and Naringenin: Implication of Natural Products in Neurodegenerative Diseases: Molecular Docking and Dynamics Simulation Insight

Anas Shamsi et al.

Summary: Recent research emphasizes the significant role of metal dyshomeostasis in Alzheimer's disease, where iron homeostasis is crucial for normal brain function. Flavonoids like quercetin and naringenin are explored for their therapeutic potential in treating neurodegenerative disorders. Studying the binding of these polyphenols with ferritin is vital for understanding their therapeutic mechanisms in AD.

ACS OMEGA (2021)

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Article Cell Biology

Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models

Wen-Wen Wang et al.

Summary: Studies show that quercetin can improve mitochondrial quality control, reduce oxidative stress, increase levels of mitophagy markers PINK1 and Parkin, and decrease alpha-synuclein expression in 6-OHDA-treated cells. In vivo, quercetin also helps alleviate PD-like motor behaviors, decrease neuronal death, reduce mitochondrial damage, and control alpha-synuclein accumulation in PD rats. The neuroprotective effect of quercetin is compromised when either Pink1 or Parkin is knocked down.

AGING-US (2021)

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Article Health Care Sciences & Services

Neuroprotective Effects of Hesperetin in Regulating Microglia Polarization after Ischemic Stroke by Inhibiting TLR4/NF-κB Pathway

Jiawen Zhang et al.

Summary: This study demonstrates that hesperidin can regulate the polarization of MCAO-induced microglia by inhibiting the TLR4-NF-kappa B pathway, providing new strategies for neuroprotection and nerve repair after ischemic stroke.

JOURNAL OF HEALTHCARE ENGINEERING (2021)

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Article Microbiology

Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study

Halil Ibrahim Guler et al.

Summary: This study calculated the potential of various flavonoids in propolis to bind to ACE-II receptors using in silico methods, with rutin showing the highest inhibition potential. These findings suggest that flavonoids in ethanolic propolis extracts may have high potential for COVID-19 treatment, pending further experimental validation.

ARCHIVES OF MICROBIOLOGY (2021)

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Article

Network Pharmacology-Based and Molecular Docking-Based Analysis of Suanzaoren Decoction for the Treatment of Parkinson’s Disease with Sleep Disorder

Yan-yun Liu et al.

Biomed Research International (2021)

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Article Biochemistry & Molecular Biology

Effects of quercetin on the alterations of serum elements in chronic unpredictable mild stress-induced depressed rats

Tong Guan et al.

Summary: This study suggests that quercetin has a regulatory effect on serum elements in CUMS rats, which may be mediated by reducing oxidative stress, inhibiting inflammation, and regulating a variety of neurotransmitter systems.

BIOMETALS (2021)

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Review Biotechnology & Applied Microbiology

Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles

Akram Bardestani et al.

Summary: Iron oxide nanoparticles (IONPs) have been proposed as targeted carriers to deliver therapeutic molecules in the central nervous system (CNS), but they may damage neural tissue. Quercetin (QC) has neuroprotective effects, but poor solubility and low bioavailability have led to the development of QC-involved nanoparticles. Combining quercetin with superparamagnetic iron oxide nanoparticles (QCSPIONs) can improve cognitive dysfunction and promote neurogenesis without toxicity by inhibiting protein aggregation and acting against iron overload.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Mechanistic insight into the capacity of natural polar phenolic compounds to abolish Alzheimer's disease-associated pathogenic effects of apoE4 forms

Christina Mountaki et al.

Summary: The study found that polar phenols can affect the AD-related pathogenic functions of apoE4 forms, with certain compounds preventing cellular changes by modulating redox status and improving the structure of apoE4 forms. This research provides evidence that natural compounds could modify the structure of apoE4 forms and ameliorate AD-related pathogenic effects.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: Implication in Alzheimer's disease therapeutics

Sandipan Chakraborty et al.

Summary: Through multiple approaches, neohesperidin is found to inhibit both BACE1 and Aβ aggregation, presenting as a potential non-toxic multi-potent scaffold for the development of Alzheimer's disease therapeutics.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Quercetin Attenuates Brain Oxidative Alterations Induced by Iron Oxide Nanoparticles in Rats

Mohamed F. Dora et al.

Summary: The study revealed that IONPs induced oxidative damage in the brains of rats, while quercetin supplementation could effectively protect the brain from oxidative injuries in a dose-dependent manner. It is recommended to supplement quercetin during IONP therapy to reduce potential health hazards.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer's Disease, Aging, Cancer, Inflammation, and Diabetes

Raushanara Akter et al.

Summary: Natural products have been traditionally used as drugs to treat a wide range of human diseases and have been important in the discovery of active compounds, biological activity patterns, and candidate drugs. SIRT6, a key gene involved in multiple diseases, can be modulated by natural compounds, offering potential for treatment and research of related diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Exploring the Impact of Flavonoids on Symptoms of Depression: A Systematic Review and Meta-Analysis

Sawan Ali et al.

Summary: The latest evidence suggests that dietary flavonoids have a significant effect on improving symptoms of depression, with higher intake of flavonoids potentially beneficial for alleviating depressive symptoms. Further research is needed to clarify the causal and mechanistic links, as well as confirm the functional brain changes associated with flavonoid consumption.

ANTIOXIDANTS (2021)

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Article Food Science & Technology

Quercetin Attenuates Atherosclerotic Inflammation by Inhibiting Galectin-3-NLRP3 Signaling Pathway

Hongxia Li et al.

Summary: This study investigates the anti-atherosclerotic properties of quercetin by modulating the Gal-3-NLRP3 pathway, showing promising effects in reducing atherosclerotic lesions. The findings suggest a potential strategy for the prevention and treatment of atherosclerosis using naturally-occurring quercetin.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Dietary Plant Polyphenols: Effects of Food Processing on Their Content and Bioavailability

Leila Arfaoui

Summary: Dietary plant polyphenols are natural bioactive compounds that have protective effects against chronic diseases, but these benefits are influenced by factors such as content, bioavailability, and processing methods.

MOLECULES (2021)

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Review Endocrinology & Metabolism

Stress-Related Brain Neuroinflammation Impact in Depression: Role of the Corticotropin-Releasing Hormone System and P2X7 Receptor

Susana Silberstein et al.

Summary: Depression and other psychiatric stress-related disorders are major causes of disability worldwide. Inflammatory processes have been identified as key pathophysiological mechanisms in psychiatric conditions, with the CRH system and P2X7 receptor playing essential roles in controlling these pathways.

NEUROIMMUNOMODULATION (2021)

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Article Biochemistry & Molecular Biology

Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms of Dendropanax morbifera Leaves

Hye-Jin Park et al.

Summary: The study found that isoquercitrin and quercetin from DML's ethyl acetate-soluble extracts (DMLE) significantly inhibit glutamate-induced oxidative cell death by regulating intracellular reactive oxygen species levels and mitochondrial superoxide generation, calcium ion imbalance, mitochondrial dysfunction, and nuclear translocation of apoptosis-inducing factor.

ANTIOXIDANTS (2021)

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Article Nutrition & Dietetics

Quercetin Ameliorates Gut Microbiota Dysbiosis That Drives Hypothalamic Damage and Hepatic Lipogenesis in Monosodium Glutamate-Induced Abdominal Obesity

Lijun Zhao et al.

Summary: The study found that dysbiosis of gut microbiota induced by MSG contributes to hypothalamic damage and liver retinol metabolism disorder. Dietary quercetin can modulate gut microbiota dysbiosis, alleviate damage, and improve abdominal obesity.

FRONTIERS IN NUTRITION (2021)

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Article Biochemistry & Molecular Biology

Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus

Yan Sun et al.

Summary: The study demonstrated that Quercitrin (Qc) has antidepressant-like effects in mice with LPS-induced depression by upregulating neuroplasticity signaling pathways and reducing neuroinflammation, ultimately alleviating depression-like behaviors.

ACS CHEMICAL NEUROSCIENCE (2021)

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Review Medicine, Research & Experimental

The impact of the phytotherapeutic agent quercetin on expression of genes and activity of signaling pathways

Soudeh Ghafouri-Fard et al.

Summary: Quercetin, a flavonoid found in various plants, exerts beneficial effects on human health by mediating antioxidant activities, immune-modulatory impacts, and regulating metabolic pathways. These effects are likely induced through modulation of signaling pathways and gene expression.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Medicine, Research & Experimental

Mechanistic insights and perspectives involved in neuroprotective action of quercetin

Amarjot Kaur Grewal et al.

Summary: Quercetin, a flavonoid widely distributed among plants, has significant pharmacological effects and therapeutic potential, showing neuroprotection by modulating and inhibiting a wide range of pathways. Its exact mechanisms of action remain a mystery, but studies have explored its role in enhancing neuronal longevity and neurogenesis in the context of neurodegenerative diseases.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Medicine, Research & Experimental

Evaluation of hesperetin-loaded on multiple wall carbon nanotubes on cerebral ischemia/reperfusion injury in rats

Akbar Hajizadeh Moghaddam et al.

Summary: The study developed Hst-MWCNTs as a carrier to enhance the bioavailability of Hst and treat cerebral I/R injury by reducing learning and memory deficits, infarct size, and oxidative stress levels. Additionally, the Hst-MWCNTs group showed increased antioxidant enzyme activities, reduced the expression of apoptotic protein Caspase-3, and increased the expression of anti-apoptotic protein Bcl-2.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Neurosciences

Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2

Yuechen Guan et al.

Summary: The study demonstrated that quercetin can alleviate CUMS-induced depression in vivo, potentially through upregulation of hippocampal Nrf2 and inhibition of iNOS to correct the central inflammatory response and oxidative-antioxidant imbalance.

BRAIN RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic Review

Juan Antonio Gimenez-Bastida et al.

Summary: Dietary (poly)phenols demonstrate anti-inflammatory effects by targeting the 5-LOX pathway, although research in this area is limited and requires further exploration.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid hesperidin

Dalia A. Mandour et al.

Summary: This study investigated the potential neuroprotective role of Hesperidin in an AD-like rat model induced experimentally by Scopolamine. The results showed that Hesp could improve spatial memory deficits, reduce oxidative imbalance, decrease amyloid beta-42 and acetylcholinesterase over activity, as well as protect histological architecture in the hippocampus and prefrontal cortex of AD rats.

JOURNAL OF MOLECULAR HISTOLOGY (2021)

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Article Endocrinology & Metabolism

Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway

Xia Zhu et al.

Summary: This study demonstrates that hesperetin has anxiolytic and antidepressant effects in diabetic rats, potentially through activation of the Nrf2/ARE pathway. Furthermore, activation of Nrf2/ARE pathway by hesperetin is facilitated by increased nuclear Nrf2 phosphorylation through PKC activation and GSK-3 beta inhibition.

METABOLIC BRAIN DISEASE (2021)

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Article Biochemistry & Molecular Biology

Evaluation of Enzyme Inhibitory Activity of Flavonoids by Polydopamine-Modified Hollow Fiber-Immobilized Xanthine Oxidase

Cong-Peng Zhao et al.

Summary: The study optimized the preparation parameters of PDA-modified hollow fiber-immobilized XOD and found the best conditions for immobilized XOD activity. In addition, the enzymatic reaction conditions, enzyme kinetics, and inhibition parameters were investigated, confirming the stability of the PDA-modified hollow fiber-immobilized XOD.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Multitarget neuroprotection by quercetin: Changes in gene expression in two perinatal asphyxia models

V. Cardozo et al.

Summary: Hypoxic-ischemic encephalopathy (HIE) leads to mortality and long-term neurologic morbidities in newborns, involving energy failure, excitotoxicity, and oxidative stress. Quercetin has been shown to have neuroprotective effects in perinatal asphyxia models, reducing mortality and affecting protein expression. The glycolytic pathway is strongly regulated by quercetin in both rat and piglet models, indicating potential neuroprotective mechanisms.

NEUROCHEMISTRY INTERNATIONAL (2021)

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Article Endocrinology & Metabolism

Metabolic functions of flavonoids: From human epidemiology to molecular mechanism

Wataru Aoi et al.

Summary: Dietary flavonoid intake is associated with the regulation of nutrient metabolism and has been shown to lower the risk of metabolic and cardiovascular diseases. Studies have also demonstrated that flavonoids can improve energy expenditure and glucose tolerance. Furthermore, some flavonoids may regulate thermogenesis and feeding behavior through modulating the autonomic and central nervous systems.

NEUROPEPTIDES (2021)

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Article Neurosciences

Neuroprotective effect of hesperidin against emamectin benzoate-induced neurobehavioral toxicity in rats

Peter A. Noshy et al.

Summary: The study revealed that Emamectin Benzoate (EMB) has adverse effects on the neurobehavioral functions of rats, while Hesperidin (HSP) can ameliorate these toxic effects by improving neural functions and reducing oxidative stress and inflammation.

NEUROTOXICOLOGY AND TERATOLOGY (2021)

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Article Biochemistry & Molecular Biology

Repeated endosulfan exposure induces changes in neurochemicals, decreases ATPase transmembrane ionic-pumps, and increased oxidative/nitrosative stress in the brains of rats: Reversal by quercetin

Mega O. Oyovwi et al.

Summary: This study demonstrated the potential of quercetin in ameliorating neurotoxicity induced by endosulfan through regulation of neurochemicals, ATPase activities, ammonia levels, and oxidative/nitrosative stress in rat brains. Quercetin was able to restore levels of neurotransmitters, inhibit acetylcholinesterase activity, and reduce oxidative/nitrosative stress caused by endosulfan exposure.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2021)

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Review Neurosciences

Update on the Relationship Between Depression and Neuroendocrine Metabolism

Wenxin Qiu et al.

Summary: This decade-long research has found a strong correlation between depression and metabolic diseases, showing that chronic inflammatory state, endocrine and immune systems are involved in the underlying mechanisms of both conditions. Exploring the comorbid mechanisms may lead to new clinical intervention strategies.

FRONTIERS IN NEUROSCIENCE (2021)

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Review Pharmacology & Pharmacy

Neuropharmacological Effects of Quercetin: A Literature-Based Review

Md. Shahazul Islam et al.

Summary: Quercetin, as a natural bioactive flavonoid, has demonstrated neuroprotective effects in neurodegenerative brain disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, making it a potential candidate for complementary medicine in preventing and treating various neurodegenerative diseases.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Immunology

Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer's disease: flavonoids and phenols

Meng Zhang et al.

Summary: Alzheimer's disease is characterized by amyloid plaques and tangles, with TXNIP playing a role in inflammation and apoptosis. Rutin, puerarin, baicalin, luteolin, and quercetin are potent TXNIP inhibitors for designing new agents, with rutin being the most effective flavonoid. Rosmarinic acid is the most potent TXNIP inhibitor among phenols.

INFLAMMOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy

Xiaojuan Han et al.

Summary: This study demonstrated that Quercetin inhibits NLRP3 inflammasome activation in microglia by promoting mitophagy, thus preventing neuronal injury and providing a potential novel therapeutic strategy for neuroinflammation-related diseases.

REDOX BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling

Margherita Grasso et al.

Summary: Nutraceuticals may enhance cognitive function through various molecular mechanisms, targeting the TGF-beta 1 signaling pathway to improve cognitive deficits in neurodegenerative diseases.

ANTIOXIDANTS (2021)

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Article Materials Science, Biomaterials

Potential molecular and graphene oxide chelators to dissolve amyloid-β plaques in Alzheimer's disease: a density functional theory study

Christina Liu et al.

Summary: The research showed that the molecules HQFUH and GO have the potential to be used in future Alzheimer's disease drug development and therapy, targeting toxic metal-Aβ interactions and reducing Aβ aggregation.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Biochemistry & Molecular Biology

Quercetin improves cognitive disorder in aging mice by inhibiting NLRP3 inflammasome activation

Han Li et al.

Summary: The study showed that quercetin could improve spatial learning and memory impairment in aging mice, as well as reduce neuroinflammation by regulating the Sirtuin1/NLRP3 pathway. This suggests that quercetin may help prevent age-related neurodegenerative diseases.

FOOD & FUNCTION (2021)

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Article Clinical Neurology

Hesperidin reduces adverse symptomatic intracerebral hemorrhage by promoting TGF-beta 1 for treating ischemic stroke using tissue plasminogen activator

Zhanzhong Qin et al.

NEUROLOGICAL SCIENCES (2020)

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Article Neurosciences

Neuroprotective Effect of Quercetin in Combination with Piperine Against Rotenone- and Iron Supplement-Induced Parkinson's Disease in Experimental Rats

Shakshi Sharma et al.

NEUROTOXICITY RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Quercetin in Animal Models of Alzheimer's Disease: A Systematic Review of Preclinical Studies

Xiao-Wen Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

The interaction of aluminium-based adjuvants with THP-1 macrophages in vitro: Implications for cellular survival and systemic translocation

Emma Shardlow et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2020)

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Review Biotechnology & Applied Microbiology

A Review on Structure, Modifications and Structure-Activity Relation of Quercetin and Its Derivatives

Rubin Thapa Magar et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2020)

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Letter Biochemistry & Molecular Biology

An aluminium adjuvant in a vaccine is an acute exposure to aluminium

Christopher Exley

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2020)

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Article Neurosciences

Hesperidin improves motor disability in rat spinal cord injury through anti-inflammatory and antioxidant mechanism via Nrf-2/HO-1 pathway

Seung-Dam Heo et al.

NEUROSCIENCE LETTERS (2020)

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Review Biochemistry & Molecular Biology

Neuroprotective Effects of Quercetin in Alzheimer's Disease

Haroon Khan et al.

BIOMOLECULES (2020)

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Article Immunology

Hesperidin methyl chalcone interacts with NFκB Ser276 and inhibits zymosan-induced joint pain and inflammation, and RAW 264.7 macrophage activation

Fernanda S. Rasquel-Oliveira et al.

INFLAMMOPHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Ameliorating effect of quercetin on epilepsy by inhibition of inflammation in glial cells

Dongmei Wu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

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Review Nutrition & Dietetics

Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability

Anna Mas-Capdevila et al.

NUTRIENTS (2020)

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Review Pharmacology & Pharmacy

Traditional Chinese Medicine in Depression Treatment: From Molecules to Systems

Chan Li et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Cell Biology

Neuroinflammation in pathogenesis of Alzheimer's disease: Phytochemicals as potential therapeutics

Alexander Vaiserman et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2020)

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Article Neurosciences

Hesperidin Ameliorates Anxiety-Depressive-Like Behavior in 6-OHDA Model of Parkinson's Disease by Regulating Striatal Cytokine and Neurotrophic Factors Levels and Dopaminergic Innervation Loss in the Striatum of Mice

Michelle S. Antunes et al.

MOLECULAR NEUROBIOLOGY (2020)

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Review Engineering, Chemical

Review of Evidence Available on Hesperidin-Rich Products as Potential Tools against COVID-19 and Hydrodynamic Cavitation-Based Extraction as a Method of Increasing Their Production

Francesco Meneguzzo et al.

PROCESSES (2020)

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Article Biochemistry & Molecular Biology

Flavones' and Flavonols' Antiradical Structure-Activity Relationship-A Quantum Chemical Study

Maciej Spiegel et al.

ANTIOXIDANTS (2020)

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Review Food Science & Technology

The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin

Gaber El-Saber Batiha et al.

FOODS (2020)

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Article Pharmacology & Pharmacy

Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress in the adult rat

Jariya Umka Welbat et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Review Pharmacology & Pharmacy

Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration

Md Sahab Uddin et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Review Neurosciences

Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System

Md Abdul Hannan et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

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Article Pharmacology & Pharmacy

The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway

Lulu Xie et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Multidisciplinary Sciences

Simultaneous determination of phenolic metabolites in Chinese citrus and grape cultivars

Yuan Chen et al.

PEERJ (2020)

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Review Immunology

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

Ruben Manuel Luciano Colunga Biancatelli et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Effect of hesperidin on fluoride-induced neurobehavioral and biochemical changes in rats

Pawan Jaiswal et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020)

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Article Biochemistry & Molecular Biology

Medicinal Plant Polyphenols Attenuate Oxidative Stress and Improve Inflammatory and Vasoactive Markers in Cerebral Endothelial Cells during Hyperglycemic Condition

Janice Taile et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

Antioxidant and Anti-Inflammatory Effects ofCitrusFlavonoid Hesperetin: Special Focus on Neurological Disorders

Amjad Khan et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

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ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration

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Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies

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Dietary quercetin attenuates depressive-like behaviors by inhibiting astrocyte reactivation in response to stress

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Polyphenols selectively reverse early-life stress-induced behavioural, neurochemical and microbiota changes in the rat

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Quercetin affects shoaling and anxiety behaviors in zebrafish: Involvement of neuroinflammation and neuron apoptosis

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Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations

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FOOD CHEMISTRY (2020)

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Article Nutrition & Dietetics

Flavonoid-Rich Orange Juice Intake and Altered Gut Microbiome in Young Adults with Depressive Symptom: A Randomized Controlled Study

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Article Multidisciplinary Sciences

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New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

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Identification of Six Flavonoids as Novel Cellular Antioxidants and Their Structure-Activity Relationship

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Targeting the Nrf2/ARE Signalling Pathway to Mitigate Isoproterenol-Induced Cardiac Hypertrophy: Plausible Role of Hesperetin in Redox Homeostasis

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Network Pharmacology-Based and Experimental Identification of the Effects of Quercetin on Alzheimer's Disease

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The Antidepressant-Like Effects of Hesperidin in Streptozotocin-Induced Diabetic Rats by Activating Nrf2/ARE/Glyoxalase 1 Pathway

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Integrating Pharmacology and Gut Microbiota Analysis to Explore the Mechanism of Citri Reticulatae Pericarpium Against Reserpine-Induced Spleen Deficiency in Rats

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Association Between Dietary Flavonoids Intake and Cognitive Function in an Italian Cohort

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Yuzu and Hesperidin Ameliorate Blood-Brain Barrier Disruption during Hypoxia via Antioxidant Activity

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Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-κB, ATF-6 pathways and activating Nrf2, Akt pathways

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Exploiting Citrus aurantium seeds and their secondary metabolites in the management of Alzheimer disease

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Nano-hesperetin enhances the functional recovery and endogenous remyelination of the optic pathway in focal demyelination model

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Hesperidin alleviates chronic restraint stress and lipopolysaccharide-induced Hippocampus and Frontal cortex damage in mice: Role of TLR4/NF-κB, p38 MAPK/JNK, Nrf2/ARE signaling

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Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection?

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The antidepressant effects of hesperidin on chronic unpredictable mild stress-induced mice

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EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model

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Review Biochemistry & Molecular Biology

Quercetin and Related Chromenone Derivatives as Monoamine Oxidase Inhibitors: Targeting Neurological and Mental Disorders

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Review Biochemistry & Molecular Biology

Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence

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Neuroactive Steroids and GABAergic Involvement in the Neuroendocrine Dysfunction Associated With Major Depressive Disorder and Postpartum Depression

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FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Article Nutrition & Dietetics

Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling

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Review Medicine, Research & Experimental

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

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Article Endocrinology & Metabolism

Cortico-hippocampal memory enhancing activity of hesperetin on scopolamine-induced amnesia in mice: role of antioxidant defense system, cholinergic neurotransmission and expression of BDNF

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METABOLIC BRAIN DISEASE (2019)

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Monoaminergic System Modulation in Depression and Alzheimer's Disease: A New Standpoint?

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Hesperetin inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways

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Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats

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REGULATORY TOXICOLOGY AND PHARMACOLOGY (2019)

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The Intestinal Fate of Citrus Flavanones and Their Effects on Gastrointestinal Health

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Effect of Hyperhomocysteinemia on Clinical Outcome and Hemorrhagic Transformation After Thrombolysis in Ischemic Stroke Patients

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The endotoxin hypothesis of neurodegeneration

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The Nrf2/HO-1 Axis as Targets for Flavanones: Neuroprotection by Pinocembrin, Naringenin, and Eriodictyol

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Oxidative Medicine and Cellular Longevity (2019)

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Article Gastroenterology & Hepatology

Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study

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WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Review Nutrition & Dietetics

Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans

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Review Medicine, Research & Experimental

Phytochemicals and cognitive health: Are flavonoids doing the trick?

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BIOMEDICINE & PHARMACOTHERAPY (2019)

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Monoaminergic system and depression

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The microbiome in systemic autoimmune disease: mechanistic insights from recent studies

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CURRENT OPINION IN RHEUMATOLOGY (2019)

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The gut microbiome and pharmacology: a prescription for therapeutic targeting of the gut-brain axis

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CURRENT OPINION IN PHARMACOLOGY (2019)

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Article Medicine, Research & Experimental

Antidepressive Effects of Taraxacum Officinale in a Mouse Model of Depression Are Due to Inhibition of Corticosterone Levels and Modulation of Mitogen-Activated Protein Kinase Phosphatase-1 (Mkp-1) and Brain-Derived Neurotrophic Factor (Bdnf) Expression

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MEDICAL SCIENCE MONITOR (2019)

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Article Chemistry, Medicinal

A Natural Phenolic Compound Quercetin Showed the Usefulness by Targeting Inflammatory, Oxidative Stress Markers and Augment 5-HT Levels in One of the Animal Models of Depression in Mice

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Article Chemistry, Medicinal

Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-kappa B signaling

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Review Food Science & Technology

Safety Aspects of the Use of Quercetin as a Dietary Supplement

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MOLECULAR NUTRITION & FOOD RESEARCH (2018)

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Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's disease

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Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats

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BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Immunology

Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction

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CELLULAR & MOLECULAR IMMUNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Hesperidin attenuates iron-induced oxidative damage and dopamine depletion in Drosophila melanogaster model of Parkinson's disease

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Article Biochemistry & Molecular Biology

Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway

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CHEMICO-BIOLOGICAL INTERACTIONS (2018)

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The Role of LRRK2 in Neurodegeneration of Parkinson Disease

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Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-kappa B Activation

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Beneficial Effects of Flavonoids Against Parkinson's Disease

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JOURNAL OF MEDICINAL FOOD (2018)

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Article Medicine, Research & Experimental

Hesperetin reduces myelin damage and ameliorates glial activation in lysolecithin-induced focal demyelination model of rat optic chiasm

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Article Neurosciences

Attenuation of Aluminum Chloride-Induced Neuroinflammation and Caspase Activation Through the AKT/GSK-3 beta Pathway by Hesperidin in Wistar Rats

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NEUROTOXICITY RESEARCH (2018)

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Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants

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PHYTOMEDICINE (2018)

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Adverse Reactions to Vaccination From Anaphylaxis to Autoimmunity

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VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE (2018)

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Quercetin attenuates AZT-induced neuroinflammation in the CNS

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SCIENTIFIC REPORTS (2018)

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Epidemiology of Adult DSM-5 Major Depressive Disorder and Its Specifiers in the United States

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JAMA PSYCHIATRY (2018)

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Quercetin in Food: Possible Mechanisms of Its Effect on Memory

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JOURNAL OF FOOD SCIENCE (2018)

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Inflammasome signalling in brain function and neurodegenerative disease

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NATURE REVIEWS NEUROSCIENCE (2018)

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Editorial Material Gastroenterology & Hepatology

Focus on the gut-brain axis: multiple sclerosis, the intestinal barrier and the microbiome

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WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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Article Medicine, Research & Experimental

Bioactive phenolic fraction of Citrus maxima abate lipopolysaccharide-induced sickness behaviour and anorexia in mice: In-silico molecular docking and dynamic studies of biomarkers against NF-κB

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BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Medicine, Research & Experimental

Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury

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LIFE SCIENCES (2018)

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Article Pharmacology & Pharmacy

Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain

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FRONTIERS IN PHARMACOLOGY (2018)

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Article Neurosciences

Neuroprotective Effect of Quercetin Nanocrystal in a 6-Hydroxydopamine Model of Parkinson Disease: Biochemical and Behavioral Evidence

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Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice

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NEUROLOGY RESEARCH INTERNATIONAL (2018)

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Article Physiology

Quercetin Protects Against Stress-Induced Anxiety- and Depression-Like Behavior and Improves Memory in Male Mice

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PHYSIOLOGICAL RESEARCH (2018)

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Review Food Science & Technology

Health-promoting effects of the citrus flavanone hesperidin

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CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2017)

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Protective Role of Quercetin in Cadmium-Induced Cholinergic Dysfunctions in Rat Brain by Modulating Mitochondrial Integrity and MAP Kinase Signaling

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MOLECULAR NEUROBIOLOGY (2017)

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Editorial Material Clinical Neurology

BACE1 inhibition could block CSF tau increase

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NATURE REVIEWS NEUROLOGY (2017)

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Hesperidin ameliorates cognitive dysfunction, oxidative stress and apoptosis against aluminium chloride induced rat model of Alzheimer's disease

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Article Plant Sciences

Hesperidin, a citrus flavonoid, protects against L-methionine-induced hyperhomocysteinemia by abrogation of oxidative stress, endothelial dysfunction and neurotoxicity in Wistar rats

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PHARMACEUTICAL BIOLOGY (2017)

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Article Public, Environmental & Occupational Health

Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats

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TOXICOLOGY AND INDUSTRIAL HEALTH (2017)

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Article Biochemistry & Molecular Biology

Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-κB and HO-1/Nrf2 Pathways

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Glutamate, T cells and multiple sclerosis

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Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease

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JOURNAL OF NEUROCHEMISTRY (2017)

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Article Biochemistry & Molecular Biology

Aluminium in brain tissue in familial Alzheimer's disease

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JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2017)

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Review Endocrinology & Metabolism

The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?

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METABOLIC BRAIN DISEASE (2017)

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Review Psychiatry

Dietary patterns and depression risk: A meta-analysis

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Article Biochemistry & Molecular Biology

Quercetin ameliorates learning and memory via the Nrf2-ARE signaling pathway in D-galactose-induced neurotoxicity in mice

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Review Virology

Flavonoids: promising natural compounds against viral infections

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ARCHIVES OF VIROLOGY (2017)

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Article Nutrition & Dietetics

Citrus consumption and incident dementia in elderly Japanese: the Ohsaki Cohort 2006 Study

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BRITISH JOURNAL OF NUTRITION (2017)

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Review Biochemistry & Molecular Biology

Gut Microbiota, Nitric Oxide, and Microglia as Prerequisites for Neurodegenerative Disorders

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ACS CHEMICAL NEUROSCIENCE (2017)

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Article Cell Biology

Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation

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AGEING RESEARCH REVIEWS (2017)

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Article Neurosciences

Antidepressant-like effects of quercetin in diabetic rats are independent of hypothalamic-pituitary-adrenal axis

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ACTA NEUROPSYCHIATRICA (2016)

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Review Cell Biology

Role of RAGE in Alzheimer's Disease

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CELLULAR AND MOLECULAR NEUROBIOLOGY (2016)

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Brain Protection and Cognitive Function: Cocoa Flavonoids as Nutraceuticals

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CURRENT PHARMACEUTICAL DESIGN (2016)

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Article Nutrition & Dietetics

Flavonoid-rich orange juice is associated with acute improvements in cognitive function in healthy middle-aged males

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EUROPEAN JOURNAL OF NUTRITION (2016)

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Article Neurosciences

Antidepressant-like effects of quercetin in diabetic rats are independent of hypothalamic-pituitary-adrenal axis

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ACTA NEUROPSYCHIATRICA (2016)

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Review Medicine, Research & Experimental

Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions

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BIOMEDICINE & PHARMACOTHERAPY (2016)

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Review Medicine, Research & Experimental

Multifaceted effects of aluminium in neurodegenerative diseases: A review

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ERK-dependent brain-derived neurotrophic factor regulation by hesperidin in mice exposed to chronic mild stress

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BRAIN RESEARCH BULLETIN (2016)

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Article Nutrition & Dietetics

The effects of flavanone-rich citrus juice on cognitive function and cerebral blood flow: an acute, randomised, placebo-controlled cross-over trial in healthy, young adults

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BRITISH JOURNAL OF NUTRITION (2016)

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Article Pharmacology & Pharmacy

Pleiotropic Effects of Tocotrienols and Quercetin on Cellular Senescence: Introducing the Perspective of Senolytic Effects of Phytochemicals

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CURRENT DRUG TARGETS (2016)

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PASS assisted prediction and pharmacological evaluation of hesperidin against scopolamine induced amnesia in mice

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EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

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Article Cell Biology

Hesperidin Alleviates Lipopolysaccharide-Induced Neuroinflammation in Mice by Promoting the miRNA-132 Pathway

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INFLAMMATION (2016)

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Article Agriculture, Multidisciplinary

Inhibition of Human Monoamine Oxidase: Biological and Molecular Modeling Studies on Selected Natural Flavonoids

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2016)

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Article Plant Sciences

Neuroprotective effects of ginseng protein on PI3K/Akt signaling pathway in the hippocampus of D-galactose/AlCl3 inducing rats model of Alzheimer's disease

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JOURNAL OF ETHNOPHARMACOLOGY (2016)

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Review Chemistry, Medicinal

Recent Knowledge on Medicinal Plants as Source of Cholinesterase Inhibitors for the Treatment of Dementia

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MINI-REVIEWS IN MEDICINAL CHEMISTRY (2016)

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QUERCETIN ATTENUATES NEURONAL DEATH AGAINST ALUMINUM-INDUCED NEURODEGENERATION IN THE RAT HIPPOCAMPUS

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NEUROSCIENCE (2016)

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Review Cell Biology

Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Article Clinical Neurology

Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury

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SPINAL CORD (2016)

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Article Geriatrics & Gerontology

SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson

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FRONTIERS IN AGING NEUROSCIENCE (2016)

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Article Public, Environmental & Occupational Health

Neuroprotective effect of quercetin against oxidative damage and neuronal apoptosis caused by cadmium in hippocampus

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TOXICOLOGY AND INDUSTRIAL HEALTH (2016)

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Article Integrative & Complementary Medicine

Antioxidative Properties and Effect of Quercetin and Its Glycosylated Form (Rutin) on Acetylcholinesterase and Butyrylcholinesterase Activities

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JOURNAL OF EVIDENCE-BASED INTEGRATIVE MEDICINE (2016)

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Article Nutrition & Dietetics

Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults

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AMERICAN JOURNAL OF CLINICAL NUTRITION (2015)

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Review Immunology

On vaccine's adjuvants and autoimmunity: Current evidence and future perspectives

Paolo Pellegrino et al.

AUTOIMMUNITY REVIEWS (2015)

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Article Behavioral Sciences

Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice

Chaoyun Li et al.

BEHAVIOURAL BRAIN RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and Inflammatory Cytokines Level in Mice Hippocampus

Ashok Jangra et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2015)

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Article Clinical Neurology

Role of Environmental Contaminants in the Etiology of Alzheimer's Disease: A Review

Manivannan Yegambaram et al.

CURRENT ALZHEIMER RESEARCH (2015)

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Article Chemistry, Medicinal

Evidence for the Involvement of Potassium Channel Inhibition in the Antidepressant-Like Effects of Hesperidin in the Tail Suspension Test in Mice

Franciele Donato et al.

JOURNAL OF MEDICINAL FOOD (2015)

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Article Clinical Neurology

Effect of hesperidin on neurobehavioral, neuroinflammation, oxidative stress and lipid alteration in intracerebroventricular streptozotocin induced cognitive impairment in mice

Hayate Javed et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2015)

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Article Biochemistry & Molecular Biology

Hesperidin ameliorates heavy metal induced toxicity mediated by oxidative stress in brain of Wistar rats

Mohammad Haaris Ajmal Khan et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2015)

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Article Food Science & Technology

In vitro colonic catabolism of orange juice (poly)phenols

Gema Pereira-Caro et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Identification of the Chemical Constituents in Aqueous Extract of Zhi-Qiao and Evaluation of Its Antidepressant Effect

Ming Wu et al.

MOLECULES (2015)

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Article Cell Biology

The role of quercetin on the survival of neuron-like PC12 cells and the expression of α-synuclein

Tae-Beom Ahn et al.

NEURAL REGENERATION RESEARCH (2015)

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Article Geriatrics & Gerontology

Quercetin reduces eIF2α phosphorylation by GADD34 induction

Miki Hayakawa et al.

NEUROBIOLOGY OF AGING (2015)

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Article Biochemistry & Molecular Biology

Neuroprotective Effect of Hesperidin on Aluminium Chloride Induced Alzheimer's Disease in Wistar Rats

Arokiasamy Justin Thenmozhi et al.

NEUROCHEMICAL RESEARCH (2015)

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Article Neurosciences

The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice

Angelica Maria Sabogal-Guaqueta et al.

NEUROPHARMACOLOGY (2015)

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Article Neurosciences

Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats

Chia Ying Chang et al.

NEUROTOXICOLOGY (2015)

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Article Behavioral Sciences

Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways

Iandra Holzmann et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2015)

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Article Neurosciences

Phytochemical constituents as future antidepressants: a comprehensive review

Roodabeh Bahramsoltani et al.

REVIEWS IN THE NEUROSCIENCES (2015)

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Review Food Science & Technology

Effects of Dietary Components on Cancer of the Digestive System

Sara Zanini et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2015)

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Review Chemistry, Medicinal

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

Hamideh Parhiz et al.

PHYTOTHERAPY RESEARCH (2015)

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Article Public, Environmental & Occupational Health

Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats

Suat Kamisli et al.

TOXICOLOGY AND INDUSTRIAL HEALTH (2015)

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Article Public, Environmental & Occupational Health

Role of quercetin in cadmium-induced oxidative stress, neuronal damage, and apoptosis in rats

Cuneyt Unsal et al.

TOXICOLOGY AND INDUSTRIAL HEALTH (2015)

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Review Biochemistry & Molecular Biology

Flavonoids as Therapeutic Compounds Targeting Key Proteins Involved in Alzheimer's Disease

Filipa I. Baptista et al.

ACS CHEMICAL NEUROSCIENCE (2014)

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Article Cell Biology

Hesperidin Alleviates Cognitive Impairment, Mitochondrial Dysfunction and Oxidative Stress in a Mouse Model of Alzheimer's Disease

Dongmei Wang et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2014)

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Review Nutrition & Dietetics

Dietary patterns and the risk of depression in adults: a systematic review of observational studies

Corinna Rahe et al.

EUROPEAN JOURNAL OF NUTRITION (2014)

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Article Ophthalmology

Retinal neuroprotective effects of quercetin in streptozotocin-induced diabetic rats

Binit Kumar et al.

EXPERIMENTAL EYE RESEARCH (2014)

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Editorial Material Clinical Neurology

What is the risk of aluminium as a neurotoxin?

Christopher Exley

EXPERT REVIEW OF NEUROTHERAPEUTICS (2014)

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Article Clinical Neurology

Oxidant and Antioxidant Status in Children With Subacute Sclerosing Panencephalitis

Huseyin Caksen et al.

JOURNAL OF CHILD NEUROLOGY (2014)

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Article Food Science & Technology

Amyloid-beta (Aβ1-42)-induced paralysis in Caenorhabditis elegans is inhibited by the polyphenol quercetin through activation of protein degradation pathways

Charlotte Regitz et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2014)

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Review Medicine, Research & Experimental

Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin - A mini-review

Ali Roohbakhsh et al.

LIFE SCIENCES (2014)

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Article Biochemistry & Molecular Biology

Effects of Long-Term Treatment with Quercetin on Cognition and Mitochondrial Function in a Mouse Model of Alzheimer's Disease

Dong-Mei Wang et al.

NEUROCHEMICAL RESEARCH (2014)

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Article Biochemistry & Molecular Biology

Chronic Functional Bowel Syndrome Enhances Gut-Brain Axis Dysfunction, Neuroinflammation, Cognitive Impairment, and Vulnerability to Dementia

Mak Adam Daulatzai

NEUROCHEMICAL RESEARCH (2014)

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Article Nutrition & Dietetics

Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice

Michelle S. Antunes et al.

NUTRITION (2014)

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Article Psychology, Biological

Quercetin protects the impairment of memory and anxiogenic-like behavior in rats exposed to cadmium: Possible involvement of the acetylcholinesterase and Na+,K+-ATPase activities

Fatima H. Abdalla et al.

PHYSIOLOGY & BEHAVIOR (2014)

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Article Toxicology

Hesperidin restores experimentally induced neurotoxicity in Wistar rats

Mehar Naseem et al.

TOXICOLOGY MECHANISMS AND METHODS (2014)

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Article Biotechnology & Applied Microbiology

Neuromodulatory Effects of Hesperidin in Mitigating Oxidative Stress in Streptozotocin Induced Diabetes

Mohammad Ashafaq et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Review Biochemistry & Molecular Biology

The effects of flavonoids on the ABC transporters: consequences for the pharmacokinetics of substrate drugs

Yan Li et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2013)

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Review Pharmacology & Pharmacy

Natural polyphenols in the management of major depression

Lokesh Pathak et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2013)

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Article Neurosciences

Ascorbate Prevents Cell Death From Prolonged Exposure to Glutamate in an In Vitro Model of Human Dopaminergic Neurons

Santiago Ballaz et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2013)

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Article Neurosciences

Quercetin protects against the Aβ25-35-induced amnesic injury: Involvement of inactivation of RAGE-mediated pathway and conservation of the NVU

Rui Liu et al.

NEUROPHARMACOLOGY (2013)

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Article Neurosciences

QUERCETIN SUPPRESS MICROGLIAL NEUROINFLAMMATORY RESPONSE AND INDUCE ANTIDEPRESSENT-LIKE EFFECT IN OLFACTORY BULBECTOMIZED RATS

P. Rinwa et al.

NEUROSCIENCE (2013)

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Article Cell Biology

Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson's Disease

Kuppusamy Tamilselvam et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)

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Article Multidisciplinary Sciences

Neuroprotective Role of Nanoencapsulated Quercetin in Combating Ischemia-Reperfusion Induced Neuronal Damage in Young and Aged Rats

Aparajita Ghosh et al.

PLOS ONE (2013)

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Article Biochemistry & Molecular Biology

Astrocyte signaling and neurodegeneration New insights into CNS disorders

Liliana Brambilla et al.

PRION (2013)

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Article Clinical Neurology

Evidence for the involvement of the serotonergic 5-HT-1A receptors in the antidepressant-like effect caused by hesperidin in mice

Leandro C. Souza et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2013)

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Review Biochemistry & Molecular Biology

Mechanisms of Oxidative Damage in Multiple Sclerosis and Neurodegenerative Diseases: Therapeutic Modulation via Fumaric Acid Esters

De-Hyung Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

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Article Neurosciences

Effects of natural antioxidants in neurodegenerative disease

Sonia Luz Albarracin et al.

NUTRITIONAL NEUROSCIENCE (2012)

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Article Chemistry, Medicinal

Chronic Intraperitoneal and Oral Treatments with Hesperidin Induce Central Nervous System Effects in Mice

Cristina Wasowski et al.

PHYTOTHERAPY RESEARCH (2012)

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Article Cell Biology

Quercetin and Sesamin Protect Dopaminergic Cells from MPP+-Induced Neuroinflammation in a Microglial (N9)-Neuronal (PC12) Coculture System

Julie Bournival et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2012)

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Article Behavioral Sciences

Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish

S. K. Richetti et al.

BEHAVIOURAL BRAIN RESEARCH (2011)

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Article Pharmacology & Pharmacy

Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence

Fani L. Neto et al.

Current Neuropharmacology (2011)

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Article Neurosciences

Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders

Giovanni Scapagnini et al.

MOLECULAR NEUROBIOLOGY (2011)

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Article Biochemistry & Molecular Biology

Quercetin Protects Against Oxidative Stress Associated Damages in a Rat Model of Transient Focal Cerebral Ischemia and Reperfusion

Ajmal Ahmad et al.

NEUROCHEMICAL RESEARCH (2011)

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Article Neurosciences

Neuroprotective effect of bioflavonoid quercetin in 6-hydroxydopamine-induced oxidative stress biomarkers in the rat striatum

Nagaraja Haleagrahara et al.

NEUROSCIENCE LETTERS (2011)

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Article Biochemical Research Methods

Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity

Chia-Jui Weng et al.

NEW BIOTECHNOLOGY (2011)

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Article Nutrition & Dietetics

Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria

Saki Yoshino et al.

NUTRITION (2011)

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Article Plant Sciences

Antidepressant effect and pharmacological evaluation of standardized extract of flavonoids from Byrsonima crassifolia

M. Herrera-Ruiz et al.

PHYTOMEDICINE (2011)

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Article Biochemistry & Molecular Biology

A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors

Franco Chimenti et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2010)

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Review Oncology

Apoptosis by dietary agents for prevention and treatment of prostate cancer

Naghma Khan et al.

ENDOCRINE-RELATED CANCER (2010)

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Article Geriatrics & Gerontology

Anti-ageing and rejuvenating effects of quercetin

Niki Chondrogianni et al.

EXPERIMENTAL GERONTOLOGY (2010)

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Article Biochemistry & Molecular Biology

After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult

Florencia Arredondo et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

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Article Immunology

Stimulus-specific regulation of CD63 and CD203c membrane expression in human basophils by the flavonoid quercetin

S. Chirumbolo et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2010)

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Article Biochemistry & Molecular Biology

Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats

Kyuichi Kawabata et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2010)

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Article Medicine, Research & Experimental

Inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microglia

Tsung-Kuei Kao et al.

LIFE SCIENCES (2010)

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Review Biochemistry & Molecular Biology

Nutraceutical Antioxidants as Novel Neuroprotective Agents

Natalie A. Kelsey et al.

MOLECULES (2010)

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Article Neurosciences

Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice

Yan Hou et al.

NEUROPHARMACOLOGY (2010)

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Article Pharmacology & Pharmacy

Hesperidin pre-treatment attenuates NO-mediated cerebral ischemic reperfusion injury and memory dysfunction

Vaibhav Gaur et al.

PHARMACOLOGICAL REPORTS (2010)

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Article Pharmacology & Pharmacy

Effect of dietary quercetin on brain quercetin levels and the expression of antioxidant and Alzheimer's disease relevant genes in mice

Patricia Huebbe et al.

PHARMACOLOGICAL RESEARCH (2010)

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Review Clinical Neurology

Reversal by quercetin of corticotrophin releasing factor induced anxiety- and depression-like effect in mice

Pravinkumar Bhutada et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2010)

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Article Cell Biology

Protective Effects of Resveratrol and Quercetin Against MPP+ -Induced Oxidative Stress Act by Modulating Markers of Apoptotic Death in Dopaminergic Neurons

Julie Bournival et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2009)

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Article Neurosciences

Stimulation of Neurogenesis and Synaptogenesis by Bilobalide and Quercetin via Common Final Pathway in Hippocampal Neurons

Flaubert Tchantchou et al.

JOURNAL OF ALZHEIMERS DISEASE (2009)

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Review Biochemistry & Molecular Biology

Dietary phenolics: chemistry, bioavailability and effects on health

Alan Crozier et al.

NATURAL PRODUCT REPORTS (2009)

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Article Clinical Neurology

Oxidative stress in developmental brain disorders

Masaharu Hayashi

NEUROPATHOLOGY (2009)

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Article Plant Sciences

Pharmacological Exploration of the Sedative Mechanism of Hesperidin Identified as the Active Principle of Citrus sinensis Flowers

Silvia Laura Guzman-Gutierrez et al.

PLANTA MEDICA (2009)

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Review Cell Biology

Plant polyphenols as dietary antioxidants in human health and disease

Kanti Bhooshan Pandey et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2009)

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Article Behavioral Sciences

Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice

M. Cecilia Martinez et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2009)

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Article Biochemistry & Molecular Biology

Glial metabolism of quercetin reduces its neurotoxic potential

Katerina Vafeiadou et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2008)

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Article Biochemistry & Molecular Biology

Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: Implications for Parkinson's disease and protection by polyphenols

David Vauzour et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2008)

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Article Pharmacology & Pharmacy

Quercetin pharmacokinetics in humans

Young J. Moon et al.

BIOPHARMACEUTICS & DRUG DISPOSITION (2008)

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Article Biochemistry & Molecular Biology

Antidepressant-like effect of onion (Allium cepa L.) powder in a rat behavioral model of depression

Hiroyuki Sakakibara et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2008)

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Article Pharmacology & Pharmacy

Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines

Leonardo M. Loscalzo et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

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Review Pharmacology & Pharmacy

Central CRH system in depression and anxiety -: Evidence from clinical studies with CRH1 receptor antagonists

Florian Holsboer et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

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Review Pharmacology & Pharmacy

Health effects of quercetin: From antioxidant to nutraceutical

Agnes W. Boots et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

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Article Neurosciences

Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

Genevieve Bureau et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2008)

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Article Nutrition & Dietetics

Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans

Sarah Egert et al.

JOURNAL OF NUTRITION (2008)

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Article Neurosciences

Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insults

Bruno Silva et al.

NEUROTOXICITY RESEARCH (2008)

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Review Food Science & Technology

A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcino genic properties

M. Harwood et al.

FOOD AND CHEMICAL TOXICOLOGY (2007)

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Article Biochemistry & Molecular Biology

Acetylcholinesterase inhibition by flavonoids from agrimonia pilosa

Mankil Jung et al.

MOLECULES (2007)

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Review Biochemistry & Molecular Biology

Flavonoid composition of citrus juices

Giuseppe Gattuso et al.

MOLECULES (2007)

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Article Plant Sciences

Effects of St. John's Wort extract and single constituents on stress-induced hyperthermia in mice

Oliver Grundmann et al.

PLANTA MEDICA (2006)

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Article Behavioral Sciences

Quercetin reverses D-galactose induced neurotoxicity in mouse brain

Jun Lu et al.

BEHAVIOURAL BRAIN RESEARCH (2006)

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Article Chemistry, Medicinal

Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin

Jungsook Cho

ARCHIVES OF PHARMACAL RESEARCH (2006)

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Article Psychiatry

The HPA and immune axes in stress: the involvement of the serotonergic system

BE Leonard

EUROPEAN PSYCHIATRY (2005)

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Article Pharmacology & Pharmacy

Synergistic interaction between hesperidin, a natural flavonoid, and diazepam

SP Fernández et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2005)

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Review Biochemistry & Molecular Biology

Polyphenols and prevention of cardiovascular diseases

C Manach et al.

CURRENT OPINION IN LIPIDOLOGY (2005)

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Article Pharmacology & Pharmacy

Studies on the mechanisms of action of picrotoxin, quercetin and pregnanolone at the GABAρ1 receptor

JD Goutman et al.

BRITISH JOURNAL OF PHARMACOLOGY (2004)

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Article Behavioral Sciences

Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis

S Fernández et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2004)

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Article Immunology

Intestinal lymphocyte populations in children with regressive autism: Evidence for extensive mucosal immunopathology

P Ashwood et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2003)

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Article Behavioral Sciences

6-Methylapigenin and hesperidin:: new valeriana flavonoids with activity on the CNS

M Marder et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2003)

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Article Biochemistry & Molecular Biology

Interaction between flavonoids and the blood-brain barrier:: in vitro studies

KA Youdim et al.

JOURNAL OF NEUROCHEMISTRY (2003)

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Article Pharmacology & Pharmacy

Flavonoid modulation of ionic currents mediated by GABAA and GABAC receptors

JD Goutman et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2003)

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Article Nutrition & Dietetics

Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice

C Manach et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2003)

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Article Nutrition & Dietetics

Flavonoid intake and risk of chronic diseases

P Knekt et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2002)

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Review Gastroenterology & Hepatology

Review article: the concept of entero-colonic encephalopathy, autism and opioid receptor ligands

AJ Wakefield et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2002)

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Article Nutrition & Dietetics

Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice

I Erlund et al.

JOURNAL OF NUTRITION (2001)

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Article Oncology

Allium sativum potentiates suicide gene therapy for murine transitional cell carcinoma

PG Moon et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2000)

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