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Epigenetics and Metabolism Reprogramming Interplay into Glioblastoma: Novel Insights on Immunosuppressive Mechanisms

ANTIOXIDANTS (2023)

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Article Oncology

Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma

Lucia Longhitano et al.

Summary: This study investigates the crosstalk between lactate metabolism and IGFBP6 in the tumor microenvironment and progression of glioblastoma. The results demonstrate that lactate and IGFBP6 can increase the expression of related genes in microglia, contributing to immune escape activation. Additionally, glioblastoma cells can also influence the expression of lactate and IGFBP6. Animal experiments and analysis of human datasets support the hypothesis that there is a lactate/IGFBP6 interaction in microglial cells, with IGFBP6 expression regulated by lactate production.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2023)

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Article Oncology

Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: An international randomized phase III trial

Antonio Omuro et al.

Summary: This study showed that TMZ + RT had better efficacy than NIVO + RT in newly diagnosed GBM patients with unmethylated MGMT promoter. However, no new safety signals were detected with NIVO in this study.

NEURO-ONCOLOGY (2023)

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Review Clinical Neurology

Glutamine Imaging: A New Avenue for Glioma Management

S. Ekici et al.

Summary: Glutamine metabolism is becoming increasingly important in gliomas, but the challenge lies in the limited tools available to assess its metabolic changes. Various imaging techniques are currently available to measure glutamine levels in the brain, offering hope for personalized management of gliomas.

AMERICAN JOURNAL OF NEURORADIOLOGY (2022)

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Review Oncology

Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches

Md Sahab Uddin et al.

Summary: Research has shown that glioma progression is closely linked to different types of epigenetic phenomena, such as chromatin modifications, DNA methylation, chromatin remodeling, and aberrant microRNA. Targeting the genes and proteins that control these alterations can be an effective way to treat GBM. Treatment approaches include histone deacetylase inhibitors and DNA methyltransferase inhibitors.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Oncology

Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma

Yahaya A. Yabo et al.

Summary: Phenotypic plasticity plays a major role in tumor heterogeneity and treatment resistance in cancer, particularly in glioblastoma (GBM). GBM cells exhibit significant intrinsic plasticity and can adapt to dynamic microenvironments. This review discusses the role of GBM plasticity in creating heterogeneous cell populations, including those with cancer stem cell properties. The article highlights the importance of genetic, epigenetic, and microenvironmental factors in regulating phenotypic heterogeneity in tumors and emphasizes the need for innovative strategies to target regulators of plasticity and mechanisms of state transitions in order to limit GBM's adaptive capacities.

NEURO-ONCOLOGY (2022)

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Review Oncology

Immuno-oncology trends: preclinical models, biomarkers, and clinical development

Maryland Rosenfeld Franklin et al.

Summary: The field of immuno-oncology has seen significant changes, with a wide range of potential therapies and combinations being evaluated in clinical trials. Successful development of these therapies requires the use of appropriate tools and technologies, such as preclinical models, biomarkers, and efficient clinical trial designs.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Biochemistry & Molecular Biology

The Crosstalk between GPR81/IGFBP6 Promotes Breast Cancer Progression by Modulating Lactate Metabolism and Oxidative Stress

Lucia Longhitano et al.

Summary: The study reveals a novel axis between GPR81 and IGFBP6 in breast cancer cells, which modulates lactate metabolism and oxidative stress. The overexpression of GPR81 and IGFBP6 promotes cell proliferation and wound healing. This complex signaling pathway may serve as a potential therapeutic target for breast cancer treatment.

ANTIOXIDANTS (2022)

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Review Cell Biology

Adult stem cell niches for tissue homeostasis

Giuliana Mannino et al.

Summary: Adult stem cells are essential for tissue homeostasis, growth, and regeneration, residing in specialized environments called niches. Interactions within the niche, including intrinsic factors, supporting cells, extracellular matrix, and signaling pathways, govern cell fate and regulate proliferation and differentiation. Tissues can be classified based on their turnover rate and repair abilities, with stem cell niches playing a crucial role in tissue maintenance and response to injury or disease.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Telomere Targeting Approaches in Cancer: Beyond Length Maintenance

Eleonora Vertecchi et al.

Summary: Telomeres, crucial for maintaining genome stability, gradually shorten over time and can determine the senescence of cells and organisms. Targeting telomere maintenance mechanisms has become an important approach for cancer treatment, as telomere length homeostasis plays a critical role in cancer development. Dysfunction in telomeres can affect intracellular signaling pathways, particularly DNA damage signaling and repair, leading to implications for cancer cell survival and proliferation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Oncology

Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification

Yidian Fu et al.

Summary: Metabolites, intermediate products of cellular metabolism, can modify proteins to regulate gene expression and intracellular signaling pathways. This review focuses on nine novel lysine acylations beyond acetylation, summarizing their characteristics, functions, and potential applications in tumor control and therapy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Review Pathology

Glioblastoma microenvironment: The stromal interactions

Ramazan Uyar

Summary: Glioblastomas (GBMs) are the most common primary brain tumors with poor prognosis. The intimate relationship between GBM cells and the microenvironment plays a major role in their therapy-resistance and aggressive growth. Understanding the interactions between GBM cells and stromal cells is crucial for a comprehensive understanding of GBM pathology.

PATHOLOGY RESEARCH AND PRACTICE (2022)

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Review Oncology

Crosstalk of Epigenetic and Metabolic Signaling Underpinning Glioblastoma Pathogenesis

Mariam Markouli et al.

Summary: Epigenetic mechanisms play a role in regulating key metabolic pathways in glioblastoma cells, increasing their heterogeneity and plasticity. These mechanisms have the potential to be targeted for therapy and improving treatment strategies.

CANCERS (2022)

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Article Oncology

Lactate Induces the Expressions of MCT1 and HCAR1 to Promote Tumor Growth and Progression in Glioblastoma

Lucia Longhitano et al.

Summary: Lactate plays a crucial role in the progression and metabolic reprogramming of glioblastoma, promoting cell proliferation, migration, and colony formation. It functions as a signaling molecule through its receptor HCAR1/GPR81 and regulates the expression of MCT1, which is associated with EMT markers and mitochondrial fitness. The findings suggest that lactate and its transporters and receptors could be potential targets for therapeutic strategies against GBM progression.

FRONTIERS IN ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

EGFR Amplification Is a Phenomenon of IDH Wildtype and TERT Mutated High-Grade Glioma: An Integrated Analysis Using Fluorescence In Situ Hybridization and DNA Methylome Profiling

Dorothee Hoelzl et al.

Summary: In this study, the researchers compared the detection of EGFR amplification in glioma samples using the EPIC Bead Chip and FISH methods. They found that the EPIC analysis was equally effective in detecting EGFR amplification compared to FISH. EGFR amplification was mainly found in high-grade IDH wildtype and TERT mutated gliomas.

BIOMEDICINES (2022)

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Review Biochemistry & Molecular Biology

The Hallmarks of Glioblastoma: Heterogeneity, Intercellular Crosstalk and Molecular Signature of Invasiveness and Progression

Filippo Torrisi et al.

Summary: This article discusses the latest version of the World Health Organization's classification of central nervous system tumors in 2021, focusing on the biological and molecular mechanisms and tumor hallmarks of glioblastoma. The research findings indicate that the identification of glioblastoma subtypes has not led to personalized therapies and there have been no improvements in overall survival, highlighting unresolved issues. However, the evidence presented offers a promising perspective for understanding tumor pathophysiology and driving the development of new therapeutic strategies and approaches.

BIOMEDICINES (2022)

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Review Clinical Neurology

The 2021 World Health Organization Classification of Tumors of the Central Nervous System: What Neuroradiologists Need to Know

A. G. Osborn et al.

Summary: Neuroradiologists play a crucial role in the diagnosis and treatment of brain tumors, and it is important for them to stay updated with the latest classification systems and diagnostic markers to provide optimal patient care.

AMERICAN JOURNAL OF NEURORADIOLOGY (2022)

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Review Pharmacology & Pharmacy

NO, CO and H2S: A trinacrium of bioactive gases in the brain

Rosalba Siracusa et al.

Summary: Oxygen, carbon dioxide, nitric oxide, hydrogen sulfide, and carbon monoxide are gases that play critical physiological roles in the brain. The functional interaction between these gases is complex and intriguing. Considering toxicology concepts becomes imperative when developing therapies involving these gases.

BIOCHEMICAL PHARMACOLOGY (2022)

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Review Cell Biology

Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment

Guofeng Ma et al.

Summary: Metabolic reprogramming of tumor and immune cells plays a crucial role in tumorigenesis and immune escape. Reprogramming of glutamine metabolism affects the anti-tumor immune response and immune cell function. Targeting tumor glutamine metabolism can modulate the interaction between immune cells and tumor cells, offering a potential new strategy for cancer treatment.

CELL COMMUNICATION AND SIGNALING (2022)

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Article Biochemistry & Molecular Biology

Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma

Consuelo Torrini et al.

Summary: Lactate accumulation in glioblastomas plays a key role in rescuing cells from nutrient deprivation and can be targeted as a novel druggable pathway for treating GBM.

MOLECULAR CELL (2022)

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Review Biochemistry & Molecular Biology

Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development

Qian Wei et al.

Summary: Through activation of immune cells, the immune system identifies and destroys infected or damaged cells. However, tumor cells have developed mechanisms to evade immune detection and killing, resulting in tumor growth and progression. Understanding the signaling and crosstalk between immune cells and tumor cells helps in developing therapeutic strategies for cancer immunotherapy.

BIOCHEMICAL JOURNAL (2022)

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Article Oncology

The immunosuppression pathway of tumor-associated macrophages is controlled by heme oxygenase-1 in glioblastoma patients

Sara Magri et al.

Summary: This study investigates the immune-suppressive activity of tumor-associated macrophages (TAMs) in the glioblastoma tumor microenvironment (TME). Researchers found that sustained iron metabolism and immune-suppressive activity in TAMs were correlated. They also discovered that blocking the central enzyme heme oxygenase-1 (HO-1) could reverse the tolerogenic activity of TAMs. Additionally, the activation status of T cells affected the expression of PD-L1 and the activity of IDO1, with both being upregulated in the presence of activated T cells. These findings highlight the crucial role of HO-1 in TAMs' immune-suppressive activity and suggest the feasibility of reprogramming TAMs for immune surveillance restoration.

INTERNATIONAL JOURNAL OF CANCER (2022)

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Article Oncology

NMDA receptor signaling induces the chemoresistance of temozolomide via upregulation of MGMT expression in glioblastoma cells

Shohei Tsuji et al.

Summary: NMDAR signaling induces chemoresistance to TMZ via upregulation of MGMT expression in GBM cells. MEM enhances the cytotoxic effect of TMZ and reduces MGMT expression by inhibiting NMDAR, increasing DNA alkylation by TMZ in MGMT-positive cells.

JOURNAL OF NEURO-ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas

Zhumei Shi et al.

Summary: This study reveals a previously unrecognized mechanistic insight into the epigenetic activation of mutant TERT promoters, where ASL, which interacts with GABPA, plays a crucial role. EGFR activation induces ASL phosphorylation, leading to enhanced TERT expression through the interaction between ASL and GABPA. The generated fumarate from ASL inhibits KDM5C, resulting in increased trimethylation of histone H3 Lys4, which facilitates the recruitment of c-Myc to TERT promoters.

MOLECULAR CELL (2022)

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Article Cell Biology

Integrated Analysis of Multiomics Data Identified Molecular Subtypes and Oxidative Stress-Related Prognostic Biomarkers in Glioblastoma Multiforme

Yawen Ma et al.

Summary: This study identified molecular subtypes of GBM by integrating multiomic data and explored the connection between gene copy number variation (CNV) and methylation gene (MET) change data. It confirmed distinctive prognosis and molecule peculiarities in three clusters and identified potential characteristic markers for these clusters. The study provides novel insights into the multilayered molecules of GBM and may facilitate more accurate treatment for GBM patients.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Multidisciplinary Sciences

Critical role of lncEPAT in coupling dysregulated EGFR pathway and histone H2A deubiquitination during glioblastoma tumorigenesis

Linlin Li et al.

Summary: In this study, a previously unidentified oncogenic lncRNA called lncEPAT was discovered to mediate the integration of the dysregulated EGFR pathway with H2A deubiquitination in tumorigenesis. LncEPAT interacts with deubiquitinase USP16 and inhibits its recruitment to chromatin, thereby blocking USP16-mediated H2A deubiquitination and repressing target gene expression. Depletion of lncEPAT promotes USP16-induced cell cycle arrest and cellular senescence, and represses tumor formation in GBM cells.

SCIENCE ADVANCES (2022)

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Review Oncology

Roles of Chromatin Remodelling and Molecular Heterogeneity in Therapy Resistance in Glioblastoma

Huey-Miin Chen et al.

Summary: This review explores the relationship between cancer stem cells (CSCs) and treatment resistance in glioblastoma (GBM), as well as the intrinsic and extrinsic factors that contribute to epigenomic heterogeneity and therapy resistance. Understanding these mechanisms can provide promising applications for epigenetic treatment approaches in treating GBM.

CANCERS (2022)

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Review Oncology

Exploring glioblastoma stem cell heterogeneity: Immune microenvironment modulation and therapeutic opportunities

Amanda L. Johnson et al.

Summary: Immunotherapy has not been effective in clinical trials for gliomas due to the cold tumor immune microenvironment and the role of glioma stem cells in promoting immunosuppression. Recent studies have identified intrinsic mechanisms in glioma stem cells that contribute to immune escape and modulation of the tumor immune microenvironment.

FRONTIERS IN ONCOLOGY (2022)

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Review Oncology

The role of lipid metabolism in tumor immune microenvironment and potential therapeutic strategies

Danting Wang et al.

Summary: Aberrant lipid metabolism is crucial for tumor cells to adapt to the tumor microenvironment and plays a significant role in immune cell quantity and function. This review mainly discusses the importance of lipid metabolism in the formation of immunosuppressive TME and explores the effectiveness and sensitivity of immunotherapy by regulating lipid metabolism.

FRONTIERS IN ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Epigenetic Suppression of the IL-7 Pathway in Progressive Glioblastoma

Marton Tompa et al.

Summary: This study reveals the immune evasion mechanism of glioblastoma through the suppression of the IL-7 receptor-mediated pathway, highlighting it as a potential new treatment target.

BIOMEDICINES (2022)

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Review Oncology

Exploring the role of Nrf2 signaling in glioblastoma multiforme

Wireko Andrew Awuah et al.

Summary: Glioblastoma multiforme (GBM) is an aggressive glial cell tumor with limited treatment options. Recent studies suggest that Nrf2 may play a crucial role in GBM pathogenesis and could be a therapeutic target.

DISCOVER ONCOLOGY (2022)

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Review Oncology

Immune suppression in gliomas

Matthew M. Grabowski et al.

Summary: Gliomas evade immune detection and destruction through mechanisms such as dysfunctional T cells and NK cells, expansion of regulatory T cells and myeloid-derived suppressor cells, M2 phenotypic transformation in macrophages/microglia, upregulation of immunosuppressive factors, tumor microenvironment hypoxia, and iatrogenic effects of immunosuppressive treatments. Future research should focus on addressing these immunosuppressive mechanisms to develop treatment options with improved survival outcomes.

JOURNAL OF NEURO-ONCOLOGY (2021)

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Review Neurosciences

Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology

S. J. Kierans et al.

Summary: Under hypoxic conditions, eukaryotic cells can shift metabolism towards glycolysis to maintain ATP levels, a process regulated by HIF-1 alpha. This metabolic switch is crucial for cellular survival during acute hypoxic stress and has implications for cancer cell survival and growth. Understanding the mechanisms central to this reprogramming is important for both physiological and pathophysiological processes.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

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Article Oncology

Treatment with pembrolizumab in programmed death ligand 1-positive recurrent glioblastoma: Results from the multicohort phase 1 KEYNOTE-028 trial

David A. Reardon et al.

Summary: Pembrolizumab monotherapy showed durable antitumor activity in a subset of patients with recurrent glioblastoma, with an overall response rate of 8%. Treatment-related adverse events were common, but manageable. Future studies on combination regimens may further improve outcomes.

CANCER (2021)

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Article Oncology

Randomized Phase II and Biomarker Study of Pembrolizumab plus Bevacizumab versus Pembrolizumab Alone for Patients with Recurrent Glioblastoma

Lakshmi Nayak et al.

Summary: The study showed that pembrolizumab alone or in combination with bevacizumab had limited efficacy in the treatment of recurrent glioblastoma, failing to improve patient survival rates. Tumor immune biomarkers were not reliable predictors of treatment outcomes, while baseline dexamethasone use and certain tumor biomarkers may impact treatment efficacy.

CLINICAL CANCER RESEARCH (2021)

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Review Clinical Neurology

The Evolving Classification of Diffuse Gliomas: World Health Organization Updates for 2021

Alejandro Perez et al.

Summary: The upcoming 2021 WHO classification of CNS tumors will bring numerous changes in classification, diagnostic criteria, and grading. Research has shown how molecular changes impact the classification and grading of tumors.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2021)

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Review Cell Biology

Myeloid Cells in Glioblastoma Microenvironment

Alessandra De Leo et al.

Summary: Glioblastoma (GBM) is a highly aggressive and malignant brain tumor with a unique immune microenvironment that is resistant to immunotherapy. Myeloid cells play a crucial role in regulating immune and therapeutic responses in GBM. Studying the characteristics and functions of different populations of myeloid cells in GBM offers new insights for targeting specific cells for therapeutic purposes.

CELLS (2021)

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Review Biochemistry & Molecular Biology

Drug Resistance in Glioblastoma: The Two Faces of Oxidative Stress

Christophe Olivier et al.

Summary: GBM is a common primary brain tumor with poor prognosis, driven by GSCs in specialized microenvironments and characterized by resistance to therapy. ROS play a dual role in controlling cellular stability, affecting cell cycle, progression, and drug resistance in GBM, while also inducing cell death programs like apoptosis and autophagy. The metabolic adaptation and stromal components in the microenvironment contribute to oxidative stress and drug resistance in GBM progression.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Biochemistry & Molecular Biology

The cancer metabolic reprogramming and immune response

Longzheng Xia et al.

Summary: The overlapping metabolic reprogramming between cancer and immune cells is an important factor affecting the antitumor immune response, involving metabolic competition, nutrient limitation, and impaired immune cell function. Studies have shown that metabolic reprogramming is essential for maintaining immune cell homeostasis and executing effector functions during immune responses.

MOLECULAR CANCER (2021)

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Review Oncology

The Role of Hypoxia in Glioblastoma Radiotherapy Resistance

Agathe L. Chedeville et al.

Summary: Glioblastoma (GB) is the deadliest type of primary brain tumor with a median survival time of 16 months post-diagnosis, and radiotherapy remains the most effective treatment despite the common resistance observed in GB patients. Understanding the role of low tumor oxygenation (hypoxia) in radioresistance is crucial for developing novel strategies to improve tumor cell sensitivity to radiotherapy.

CANCERS (2021)

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Article Biochemistry & Molecular Biology

Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion

Ester Gangoso et al.

Summary: In this study, it was found that GBM stem cells acquire the ability to evade immune clearance through epigenetic immunoediting, leading to the formation of an immunosuppressive tumor microenvironment. This process is not driven by genetic selection but by altering the transcriptional and epigenetic profile of GSCs after immune attack.

CELL (2021)

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Article Biochemistry & Molecular Biology

Effects of High Glucose Concentration on Pericyte-Like Differentiated Human Adipose-Derived Mesenchymal Stem Cells

Giuliana Mannino et al.

Summary: In this experiment, human adipose-derived mesenchymal stem cells were induced to differentiate into pericyte-like cells under specific conditions, showing promising results in terms of proliferation, viability, migration, anti-inflammatory effects, reduction in ROS production, regulation of cytokines and angiogenic factors. These pericyte-like cells could potentially be used for treating retinal damages in diabetic patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Immunosuppression in Glioblastoma: Current Understanding and Therapeutic Implications

Benjamin T. Himes et al.

Summary: Glioblastoma (GBM) is the most common primary brain tumor in adults with a terrible prognosis. Immune suppression in many GBM patients has limited the effectiveness of immunotherapeutic agents, which have shown benefits in other cancers. Understanding tumor-mediated immune suppression is crucial for developing effective novel therapies for GBM, and overcoming this may be key for successful immunotherapy.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell & Tissue Engineering

ARPE-19 conditioned medium promotes neural differentiation of adipose-derived mesenchymal stem cells

Giuliana Mannino et al.

Summary: In this study, ASCs were cultured in different conditions to evaluate their proliferation, viability, and neural differentiation potential using conditioned medium from an RPE cell line. The results showed that the presence of growth factors from ARPE-19 cells induced ASCs to express neural differentiation markers typical of retinal neuronal and glial cells.

WORLD JOURNAL OF STEM CELLS (2021)

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Review Cell Biology

Interplay Among Metabolism, Epigenetic Modifications, and Gene Expression in Cancer

Miaomiao Huo et al.

Summary: Epigenetic modifications and metabolism play crucial roles in tumorigenesis and cancer development, with complex interactions between the two processes. Understanding the crosstalk among metabolism, epigenetic modifications, and gene expression can provide insights into the mechanisms of carcinogenesis and progression to metastasis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Immunology

The Diverse Roles of Heme Oxygenase-1 in Tumor Progression

Kim Ngan Luu Hoang et al.

Summary: HO-1 is an inducible intracellular enzyme expressed in various cancers to promote tumor progression through intracellular and extracellular mechanisms. Its catabolites provide antioxidant, anti-apoptotic, and cytoprotective effects within cells, while also influencing the wider tumor microenvironment to promote processes like angiogenesis, metastasis, anti-inflammation, and immune suppression. Pharmacological inhibition of HO-1 shows promise in inhibiting metastasis and promoting anti-tumor immune responses.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

Toshiro Hara et al.

Summary: The mesenchymal subtype of glioblastoma is believed to be influenced by both cancer cell-intrinsic alterations and external cellular interactions, with macrophages inducing a transition of glioblastoma cells into mesenchymal-like states. This transition is mediated by macrophage-derived oncostatin M (OSM) interacting with its receptors on glioblastoma cells, leading to the activation of STAT3. This study also reveals that mesenchymal-like glioblastoma states are associated with increased expression of a mesenchymal program in macrophages and enhanced cytotoxicity of T cells, suggesting potential therapeutic implications.

CANCER CELL (2021)

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Review Biochemistry & Molecular Biology

Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target

Vittoria Infantino et al.

Summary: In cancer cells, metabolic reprogramming under low-oxygen conditions is crucial for tumor survival, with HIF-1 playing a pivotal role. Mitochondria are key players in regulating cellular energy and closely interact with HIF-1 to drive metabolic and functional changes in cancer cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

The Impact of Epigenetic Modifications on Adaptive Resistance Evolution in Glioblastoma

Qiong Wu et al.

Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

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Review Clinical Neurology

Cross-Talk of the CNS With Immune Cells and Functions in Health and Disease

Agata Matejuk et al.

Summary: The immune system plays a crucial role in maintaining tissue homeostasis and integrity, beyond self-recognition, from early development to ensure proper organ function later in life. Recent research shows that immune cells in the blood can support the CNS through neuroimmune communication, challenging the traditional view of peripheral immunity being detrimental to the nervous system. Understanding the cross-talk between the CNS and the immune system is essential to uncover neurodestructive and neuroprotective immune mechanisms for more effective therapeutic strategies in health and disease.

FRONTIERS IN NEUROLOGY (2021)

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Article Oncology

Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas

Mirco Friedrich et al.

Summary: The study identifies different states of myeloid cells in gliomas and demonstrates that IDH-mutant tumors re-educate infiltrating macrophages through tryptophan metabolism, resulting in the formation of an immunosuppressive microenvironment. This suggests that targeting tryptophan metabolism could be a potential immunotherapy strategy for IDH-mutant tumors.

NATURE CANCER (2021)

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Article Cell Biology

Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells

Juan de los Santos-jimenez et al.

Summary: This study found that GLS and GAB affect miRNAs and oxidative status in glioblastoma cells. Silencing GLS and overexpressing GAB altered certain miRNAs, as well as oxidative status and antioxidant enzyme activity. Some miRNAs and total glutathione were identified as strong biomarkers of glioblastoma proliferation.

JOURNAL OF BIOMEDICAL SCIENCE (2021)

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Article Oncology

Impact of Radiochemotherapy on Immune Cell Subtypes in High-Grade Glioma Patients

Valerie Dutoit et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Oncology

IDH mutation in glioma: molecular mechanisms and potential therapeutic targets

Sue Han et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Oncology

Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma The CheckMate 143 Phase 3 Randomized Clinical Trial

David A. Reardon et al.

JAMA ONCOLOGY (2020)

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Article Multidisciplinary Sciences

B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response

Huoqun Gan et al.

SCIENCE ADVANCES (2020)

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Review Medicine, General & Internal

Heme Oxygenase-1 in Central Nervous System Malignancies

Giuseppe Sferrazzo et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Immune-Driven Pathogenesis of Neurotoxicity after Exposure of Cancer Patients to Immune Checkpoint Inhibitors

Noelia Vilarino et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

NRF2, a Transcription Factor for Stress Response and Beyond

Feng He et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance

Silvia Valtorta et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Oncology

Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model

Kristell Oizel et al.

CANCER & METABOLISM (2020)

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Review Immunology

Immune Escape in Glioblastoma Multiforme and the Adaptation of Immunotherapies for Treatment

Joshua R. D. Pearson et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Cell & Tissue Engineering

Pericyte-like differentiation of human adipose-derived mesenchymal stem cells: An in vitro study

Giuliana Mannino et al.

WORLD JOURNAL OF STEM CELLS (2020)

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Article Cell Biology

Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton

Sebastian Martewicz et al.

CELLS (2020)

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Review Oncology

Mitochondrial Bioenergetics at the Onset of Drug Resistance in Hematological Malignancies: An Overview

Alessandro Barbato et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Biotechnology & Applied Microbiology

The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation

Adam Kosti et al.

GENOME BIOLOGY (2020)

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Article Neurosciences

Heme Oxygenase Inhibition Sensitizes Neuroblastoma Cells to Carfilzomib

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MOLECULAR NEUROBIOLOGY (2019)

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Review Biochemistry & Molecular Biology

The role of α-ketoglutarate- dependent proteins in pluripotency acquisition and maintenance

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JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Review Biochemistry & Molecular Biology

Consequences of IDH1/2 Mutations in Gliomas and an Assessment of Inhibitors Targeting Mutated IDH Proteins

Bozena Kaminska et al.

MOLECULES (2019)

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Article Biochemistry & Molecular Biology

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

Timothy F. Cloughesy et al.

NATURE MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Succinylation Links Metabolism to Protein Functions

Yun Yang et al.

NEUROCHEMICAL RESEARCH (2019)

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Article Cell Biology

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

Felipe J. Nunez et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Review Oncology

Treatment of Glioblastoma (GBM) with the Addition of Tumor-Treating Fields (TTF): A Review

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CANCERS (2019)

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Article Immunology

The novel immunosuppressant prenylated quinolinecarboxylic acid-18 (PQA-18) suppresses macrophage differentiation and cytotoxicity in xenotransplantation

Pei-Chi Lo et al.

IMMUNOBIOLOGY (2019)

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Article Neurosciences

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

Maisa C. Takenaka et al.

NATURE NEUROSCIENCE (2019)

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Review Biochemistry & Molecular Biology

PKM2, function and expression and regulation

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CELL AND BIOSCIENCE (2019)

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Review Immunology

Recent Findings in the Regulation of Programmed Death Ligand 1 Expression

Xiangfeng Shen et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Endocrinology & Metabolism

Regulation of Adaptive Immune Cells by Sirtuins

Jonathan L. Warren et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

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Review Biochemistry & Molecular Biology

Heat Shock Proteins in Glioblastoma Biology: Where Do We Stand?

Rebeca Piatniczka Iglesia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biology

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

Tushar D. Bhagat et al.

ELIFE (2019)

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Review Oncology

Glutamine Metabolism in Brain Tumors

Siva Kumar Natarajan et al.

CANCERS (2019)

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Review Oncology

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

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FRONTIERS IN ONCOLOGY (2019)

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Review Biochemistry & Molecular Biology

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

Vaishali Aggarwal et al.

BIOMOLECULES (2019)

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Review Immunology

Immune cells and CNS physiology: Microglia and beyond

Geoffrey T. Norris et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Lipid accumulation and oxidation in glioblastoma multiforme

Bouchra Taib et al.

SCIENTIFIC REPORTS (2019)

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The hypoxic peri-arteriolar glioma stem cell niche, an integrated concept of five types of niches in human glioblastoma

Diana A. Aderetti et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2018)

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Review Hematology

The MYC oncogene is a global regulator of the immune response

Stephanie C. Casey et al.

BLOOD (2018)

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Review Biochemistry & Molecular Biology

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

Pierre-Benoit Ancey et al.

FEBS JOURNAL (2018)

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Article Cell Biology

Neural differentiation of human adipose-derived mesenchymal stem cells induced by glial cell conditioned media

Debora Lo Furno et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Review Biochemistry & Molecular Biology

Understanding the tumor immune microenvironment (TIME) for effective therapy

Mikhail Binnewies et al.

NATURE MEDICINE (2018)

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Article Chemistry, Medicinal

Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines

Valeria Sorrenti et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

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Article Oncology

Clinical activity and safety of atezolizumab in patients with recurrent glioblastoma

Rimas V. Lukas et al.

JOURNAL OF NEURO-ONCOLOGY (2018)

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Article Physiology

Conditioned Media From Glial Cells Promote a Neural-Like Connexin Expression in Human Adipose-Derived Mesenchymal Stem Cells

Debora Lo Furno et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Review Immunology

Microglia and macrophages in brain homeostasis and disease

Qingyun Li et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Review Oncology

Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates

Dan Ye et al.

TRENDS IN CANCER (2018)

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Review Biochemistry & Molecular Biology

Glutamate and α-ketoglutarate: key players in glioma metabolism

Andreas Maus et al.

AMINO ACIDS (2017)

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Glucose feeds the TCA cycle via circulating lactate

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NATURE (2017)

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Review Pharmacology & Pharmacy

Epigenetics: The third pillar of nitric oxide signaling

Samantha Socco et al.

PHARMACOLOGICAL RESEARCH (2017)

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Review Biotechnology & Applied Microbiology

MicroRNA Regulation of Glycolytic Metabolism in Glioblastoma

Huda Alfardus et al.

BIOMED RESEARCH INTERNATIONAL (2017)

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Review Cell Biology

The Role of Hypoxia in Glioblastoma Invasion

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CELLS (2017)

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Article Oncology

Redox-Related Epigenetic Mechanisms in Glioblastoma: Nuclear Factor (Erythroid-Derived 2)-Like 2, Cobalamin, and Dopamine Receptor Subtype 4

Matthew Scott Schrier et al.

FRONTIERS IN ONCOLOGY (2017)

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Review Oncology

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

Luisa Iommarini et al.

FRONTIERS IN ONCOLOGY (2017)

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Review Biochemistry & Molecular Biology

The Heme Oxygenase System in Hematological Malignancies

Giovanni Li Volti et al.

ANTIOXIDANTS & REDOX SIGNALING (2017)

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Review Biochemistry & Molecular Biology

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Lindsay B. Nicholson

UNDERSTANDING BIOCHEMISTRY 2 (2016)

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Article Immunology

Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia

Peter J. Siska et al.

JOURNAL OF IMMUNOLOGY (2016)

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Review Biochemistry & Molecular Biology

Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes

Jean-Pierre Etchegaray et al.

MOLECULAR CELL (2016)

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Review Biochemistry & Molecular Biology

Nitric oxide, the new architect of epigenetic landscapes

Divya Vasudevan et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2016)

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Review Cell Biology

MicroRNA and pediatric tumors: Future perspectives

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ACTA HISTOCHEMICA (2015)

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Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications

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CANCER RESEARCH (2015)

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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

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CELL METABOLISM (2015)

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Review Biochemical Research Methods

Metabolism and epigenetics: a link cancer cells exploit

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CURRENT OPINION IN BIOTECHNOLOGY (2015)

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Immunotherapy response assessment in neuro-oncology: a report of the RANO working group

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LANCET ONCOLOGY (2015)

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Survival and low-grade glioma: the emergence of genetic information

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NEUROSURGICAL FOCUS (2015)

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Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond

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EPIGENETICS & CHROMATIN (2015)

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Review Geriatrics & Gerontology

Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases

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IMMUNITY & AGEING (2015)

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Review Neurosciences

A Comprehensive View of the Epigenetic Landscape. Part II: Histone Post-translational Modification, Nucleosome Level, and Chromatin Regulation by ncRNAs

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NEUROTOXICITY RESEARCH (2015)

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Review Biochemistry & Molecular Biology

Glioblastoma stem cells (GSCs) epigenetic plasticity and interconversion between differentiated non-GSCs and GSCs

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GENES & DISEASES (2015)

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Article Oncology

Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages

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Review Clinical Neurology

IDH1 and IDH2 Mutations in Gliomas

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CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2013)

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Reverse Engineering of Modified Genes by Bayesian Network Analysis Defines Molecular Determinants Critical to the Development of Glioblastoma

Brian W. Kunkle et al.

PLOS ONE (2013)

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Review Geriatrics & Gerontology

Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondria as a chi

Carolin Cornelius et al.

IMMUNITY & AGEING (2013)

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Article Biochemistry & Molecular Biology

Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells

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REDOX BIOLOGY (2013)

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Review Clinical Neurology

Brain dendritic cells: biology and pathology

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ACTA NEUROPATHOLOGICA (2012)

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Review Geriatrics & Gerontology

Hormesis: why it is important to biogerontologists

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BIOGERONTOLOGY (2012)

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Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

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CANCER CELL (2012)

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Epigenetic modifications in cancer

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CLINICAL GENETICS (2012)

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Review Cell Biology

Emerging insights into the molecular and cellular basis of glioblastoma

Gavin P. Dunn et al.

GENES & DEVELOPMENT (2012)

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Review Genetics & Heredity

The Role of Bromodomain Proteins in Regulating Gene Expression

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GENES (2012)

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Hypoxia Potentiates Glioma-Mediated Immunosuppression

Jun Wei et al.

PLOS ONE (2011)

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Review Biochemistry & Molecular Biology

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

Vittorio Calabrese et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

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Article Oncology

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

Houtan Noushmehr et al.

CANCER CELL (2010)

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Article Oncology

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

Meghan J. Seltzer et al.

CANCER RESEARCH (2010)

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Article Biochemistry & Molecular Biology

Cellular Stress Responses, Mitostress and Carnitine Insufficiencies as Critical Determinants in Aging and Neurodegenerative Disorders: Role of Hormesis and Vitagenes

Vittorio Calabrese et al.

NEUROCHEMICAL RESEARCH (2010)

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Review Cell Biology

Redox regulation in cancer A double-edged sword with therapeutic potential

Asha Acharya et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2010)

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Review Biochemistry & Molecular Biology

Nitric Oxide in Cell Survival: A Janus Molecule

Vittorio Calabrese et al.

ANTIOXIDANTS & REDOX SIGNALING (2009)

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Article Cell Biology

An operational definition of epigenetics

Shelley L. Berger et al.

GENES & DEVELOPMENT (2009)

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Review Cell Biology

Epigenetic Control

Genevieve P. Delcuve et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2009)

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Article Biochemistry & Molecular Biology

Glutathione depletion reveals impairment of antigen processing and inhibition of cathepsin activity by nitric oxide in antigen-presenting cells

Genevieve Lemaire et al.

MOLECULAR IMMUNOLOGY (2009)

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Article Obstetrics & Gynecology

Epigenetics: Definition, Mechanisms and Clinical Perspective

Catherine Dupont et al.

SEMINARS IN REPRODUCTIVE MEDICINE (2009)

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Article Multidisciplinary Sciences

Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

Ralph J. DeBerardinis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Review Neurosciences

Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity

Vittorio Calabrese et al.

NATURE REVIEWS NEUROSCIENCE (2007)

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Article Dermatology

Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1

Joachim C. U. Lehmann et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

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Article Biochemistry & Molecular Biology

Malignant glioma progression and nitric oxide

Dora Lam-Himlin et al.

NEUROCHEMISTRY INTERNATIONAL (2006)

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Article Neurosciences

Elevation of mitochondrial glutathione by γ-glutamylcysteine ethyl ester protects mitochondria against peroxynitrite-induced oxidative stress

J Drake et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2003)

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Article Oncology

Thymic function and output of recent thymic emigrant T cells during intracranial glioma progression

RM Prins et al.

JOURNAL OF NEURO-ONCOLOGY (2003)

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Review Immunology

Cancer immunoediting: from immunosurveillance to tumor escape

GP Dunn et al.

NATURE IMMUNOLOGY (2002)

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Review Biochemistry & Molecular Biology

CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future

M Esteller

ONCOGENE (2002)

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Article Medicine, General & Internal

An overview of the immune system

J Parkin et al.

LANCET (2001)

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Article Biochemistry & Molecular Biology

Accelerated publication -: Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc

RC Osthus et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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