☆ 4.7 Article

Evaluation of the Chemical Composition, Antioxidant and Antidiabetic Activity of Rhaponticoides iconiensis Flowers: Effects on Key Enzymes Linked to Type 2 Diabetes In Vitro, In Silico and on Alloxan-Induced Diabetic Rats In Vivo

ANTIOXIDANTS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

Mihaly Varadi et al.

Summary: AlphaFold DB is an openly accessible database with high-accuracy protein-structure predictions, powered by DeepMind's AlphaFold v2.0. It provides programmatic access to a vast number of predicted structures and is expanding to cover more sequences.

NUCLEIC ACIDS RESEARCH (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis and molecular modelling of thiadizole based hydrazone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitory activities

A. Isik et al.

Summary: In this study, a series of novel substituted thiazolylhydrazine derivatives were designed and synthesized. Their inhibitory effects on BuChE enzyme and antioxidant activities were investigated. The results showed that some compounds exhibited significant inhibition potency against BuChE enzyme and displayed good antioxidant properties.

SAR AND QSAR IN ENVIRONMENTAL RESEARCH (2022)

添加到收藏夹

Article Chemistry, Physical

Synthesis and investigations of reactive properties, photophysical properties and biological activities of a pyrazole-triazole hybrid molecule

Khalid Karrouchi et al.

Summary: This work presents the synthesis, spectroscopic characterization, reactivity study, photophysical properties, and evaluation of the alpha-glucosidase inhibitory activity of a pyrazole-triazole hybrid molecule. The compound's reactivity was investigated using density functional theory calculations, and its photophysical properties were studied with time-independent density functional theory calculations. In vitro experiments revealed that the compound possesses alpha-glucosidase inhibitory activity. Molecular docking and molecular dynamics simulations were conducted to investigate the binding mechanism of the compound in the active site of the enzyme.

JOURNAL OF MOLECULAR STRUCTURE (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Novel Benzimidazole-Based Compounds as Antimicrobials: Synthesis, Molecular Docking, Molecular Dynamics and in silico ADME Profile Studies

Elif Yesilcayir et al.

Summary: Some novel benzimidazole derivatives were synthesized and compounds 3a and 3b showed excellent antibacterial activity, especially against Staphylococcus aureus. Molecular docking and molecular dynamics analyses confirmed the stability of protein-ligand interactions between these compounds and target proteins.

ACTA CHIMICA SLOVENICA (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Comparative Evaluation of Cytotoxicity and Phytochemical Composition of Centaurea iconiensis (Rhaponticoides iconiensis)

Osman Tugay et al.

Summary: The study evaluated the cytotoxic activity of methanol extracts and sub-extracts of Rhaponticoides iconiensis on various cancer cell lines. The results showed that sub-extracts were most effective against the MCF-7 cancer cell line, suggesting potential effectiveness in hormone-sensitive cancer cells. The cytotoxic effects of sub-extracts may be attributed to compound variances and synergistic effects of different secondary metabolites.

IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE (2021)

添加到收藏夹

Article Plant Sciences

Antidiabetic bioactive compounds from Tetrastigma angustifolia (Roxb.) Deb and Oxalis debilis Kunth.: Validation of ethnomedicinal claim by in vitro and in silico studies

Julfikar Ali Junejo et al.

Summary: This study isolated bioactive compounds, apigenin derivative (AGD) and stigmasterol (STM), from the leaf extracts of T. angustifolia and O. debilis, and validated their antidiabetic potential, with AGD showing better efficacy against human alpha-amylase enzyme.

SOUTH AFRICAN JOURNAL OF BOTANY (2021)

添加到收藏夹

Article Chemistry, Physical

OPLS4: Improving Force Field Accuracy on Challenging Regimes of Chemical Space

Chao Lu et al.

Summary: The development and validation of the OPLS4 force field, which builds upon previous work with OPLS3e, improved model accuracy on challenging regimes of drug-like chemical space. A novel parametrization strategy for charged species was introduced, leading to improved accuracy on benchmarks assessing small-molecule solvation and protein-ligand binding.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Phytochemical Profile, Antioxidant Capacity, alpha-Amylase and alpha-Glucosidase Inhibitory Potential of Wild Moroccan Inula viscosa (L.) Aiton Leaves

Fadoua Asraoui et al.

Summary: Inula viscosa (L.) Aiton, a traditional medicinal plant, shows significant antioxidant and anti-hyperglycemic potential with its rich content of polyphenolic compounds and volatile components. It exhibits strong inhibitory effects on digestive enzymes and demonstrates high antioxidant activity.

MOLECULES (2021)

添加到收藏夹

Article Food Science & Technology

Potential enzyme inhibitory properties of extracts and fractions from fruit latex ofFicus carica-based on inhibition ofα-amylase andα-glucosidase

Leyla Pasayeva et al.

JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION (2020)

添加到收藏夹

Article Chemistry, Analytical

Identification of bioactive compounds from Rhaponticoides iconiensis extracts and their bioactivities: An endemic plant to Turkey flora

Dimitrina Zheleva-Dimitrova et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines

Jesus J. Alvarado-Sansininea et al.

MOLECULES (2018)

添加到收藏夹

Article Biochemical Research Methods

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

Jing Huang et al.

NATURE METHODS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of human lysosomal acid α-glucosidase-a guide for the treatment of Pompe disease

Veronique Roig-Zamboni et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Medicine, Research & Experimental

Navel orange peel hydroethanolic extract, naringin and naringenin have anti-diabetic potentials in type 2 diabetic rats

Osama M. Ahmed et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Qualitative HPLC-DAD/ESI-TOF-MS Analysis, Cytotoxic, and Apoptotic Effects of Croatian Endemic Centaurea ragusina L. Aqueous Extracts

Mila Radan et al.

CHEMISTRY & BIODIVERSITY (2017)

添加到收藏夹

Article Biology

Citrus flavonoids collectively dominate the α-amylase and α-glucosidase inhibitions

Mouna Sahnoun et al.

BIOLOGIA (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Chemical Composition and Biological Activity of Centaurea baseri: New Species from Turkey

Yavuz Bulent Kose et al.

CHEMISTRY & BIODIVERSITY (2016)

添加到收藏夹

Article Immunology

Anti-TNF-α and anti-arthritic effect of patuletin: A rare flavonoid from Tagetes patula

Almas Jabeen et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

添加到收藏夹

Article Endocrinology & Metabolism

In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action

Ayman M. Mahmoud et al.

INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES (2015)

添加到收藏夹

Article Plant Sciences

Rhaponticoides gokceoglui (Asteraceae), a striking new species from Turkey

İLKER ÇİNBİLGEL et al.

Phytotaxa (2014)

添加到收藏夹

Article Integrative & Complementary Medicine

Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L

Naima Saeed et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012)

添加到收藏夹

Article Pharmacology & Pharmacy

Antihyperglycemic activity and antidiabetic effect of methyl caffeate isolated from Solanum torvum Swartz. fruit in streptozotocin induced diabetic rats

Gopalsamy Rajiv Gandhi et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

添加到收藏夹

Article Chemistry, Applied

α-Glucosidase inhibitory effect by the flower buds of Tussilago farfara L.

Hong Gao et al.

FOOD CHEMISTRY (2008)

添加到收藏夹

Article Chemistry, Multidisciplinary

Software news and updates - CHARNIM-GUI: A web-based grraphical user interface for CHARMM

Sunhwan Jo et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)

添加到收藏夹

Article Chemistry, Applied

Comparison of ABTS, DPPH, FRAP, and ORAC assays for estimating antioxidant activity from guava fruit extracts

Kriengsak Thaipong et al.

JOURNAL OF FOOD COMPOSITION AND ANALYSIS (2006)

添加到收藏夹

Article Chemistry, Medicinal

Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

RA Friesner et al.

JOURNAL OF MEDICINAL CHEMISTRY (2004)

添加到收藏夹

Article Nutrition & Dietetics

Antioxidant activities of peel, pulp and seed fractions of common fruits as determined by FRAP assay

CJ Guo et al.

NUTRITION RESEARCH (2003)

添加到收藏夹

Review Plant Sciences

Recommended testina in diabetes research

EJ Verspohl

PLANTA MEDICA (2002)

添加到收藏夹

Article Pharmacology & Pharmacy

Antioxidant properties of Thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea

MA Gyamfi et al.

BIOCHEMICAL PHARMACOLOGY (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.