Shedding Light on the Hidden Benefit of Porphyridium cruentum Culture

Microalgae can represent a reliable source of natural compounds with different activities. Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE), two molecules naturally produced by the red marine microalga Porphyridium cruentum (CCALA415). In vitro and cell-based assays were performed to assess the biological activities of these compounds. The s-EPSs, owing to the presence of sulfate groups, showed biocompatibility on immortalized eukaryotic cell lines and a high antioxidant activity on cell-based systems. PE showed powerful antioxidant activity both in vitro and on cell-based systems, but purification is mandatory for its safe use. Finally, both molecules showed anti-inflammatory activity comparable to that of ibuprofen and helped tissue regeneration. Thus, the isolated molecules from microalgae represent an excellent source of antioxidants to be used in different fields.

Automated summary

The antioxidant and anti-inflammatory activities of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE) from the red marine microalga Porphyridium cruentum (CCALA415) were evaluated. s-EPSs showed biocompatibility and high antioxidant activity, while PE demonstrated powerful antioxidant activity. Both molecules exhibited anti-inflammatory activity and facilitated tissue regeneration. Therefore, microalgae-derived compounds are excellent sources of antioxidants for various applications.