4.7 Review

Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Cardiac & Cardiovascular Systems

Current and Emerging Classes of Pharmacological Agents for the Management of Hypertension

Utkarsh Ojha et al.

Summary: Cardiovascular disease causes over 17 million deaths worldwide annually, with 9.4 million deaths attributed to complications of hypertension. Management of hypertension involves lifestyle changes and medication, with ongoing research focusing on developing new drug classes to reduce the global burden of high blood pressure.

AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS (2022)

Review Endocrinology & Metabolism

The many faces of diabetes. Is there a need for re-classification? A narrative review

Nasser Sakran et al.

Summary: The worldwide rise in obesity and type 2 diabetes has become epidemic. Bariatric and metabolic surgery have been proven to be effective treatment options for weight loss and improvement of diabetes and metabolic conditions.

BMC ENDOCRINE DISORDERS (2022)

Review Pharmacology & Pharmacy

Post-Translational Modification of Cav1.2 and its Role in Neurodegenerative Diseases

Yun Li et al.

Summary: Cav1.2 plays a crucial role in neurodegenerative diseases, but the regulation of its activity remains incompletely understood. The repurposing of DHP drugs may offer potential therapeutic strategies, but further research is needed.

FRONTIERS IN PHARMACOLOGY (2022)

Article Physiology

Effects of Pharmacological Inhibitors of NADPH Oxidase on Myogenic Contractility and Evoked Vasoactive Responses in Rat Resistance Arteries

Dylan J. Kendrick et al.

Summary: This study examined the potential contribution of reactive oxygen species (ROS) to intrinsic myogenic contractility in resistance arteries. The results suggest that ROS contribute to myogenic contractility in small resistance arteries, and different inhibitors have varying effects on resistance arteries.

FRONTIERS IN PHYSIOLOGY (2022)

Article Obstetrics & Gynecology

Small extracellular vesicles from plasma of women with preeclampsia increase myogenic tone and decrease endothelium-dependent relaxation of mouse mesenteric arteries

Juliana S. Powell et al.

Summary: Preeclampsia is a pregnancy syndrome that can threaten the survival of both mother and baby. Research suggests that sEVs from pregnant women with preeclampsia play a significant role in the regulation of arterial tone.

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH (2022)

Review Peripheral Vascular Disease

Mitochondrial Dysfunction in the Pathogenesis of Preeclampsia

Xiang-Qun Hu et al.

Summary: Preeclampsia is a common complication in pregnancy, associated with high rates of maternal and perinatal mortality and morbidity. Mitochondrial abnormality is a major contributor to placental dysfunction, which is believed to be the cause of preeclampsia. Circulating bioactive factors released from the placenta can cause mitochondrial damage, leading to endothelial dysfunction and elevated maternal blood pressure.

CURRENT HYPERTENSION REPORTS (2022)

Editorial Material Neurosciences

The emerging role of TRPV1 in myogenic tone

Khaled Skaik et al.

JOURNAL OF PHYSIOLOGY-LONDON (2022)

Review Physiology

CALCIUM-RELEASE CHANNELS: STRUCTURE AND FUNCTION OF IP3 RECEPTORS AND RYANODINE RECEPTORS

Kellie A. Woll et al.

Summary: Ca2+-release channels are membrane proteins that control the release of Ca2+ from the endoplasmic and sarcoplasmic reticulum. They are activated by cytosolic Ca2+ and have a common architecture, with additional modules in the cytosolic region for ryanodine receptors (RyRs). Their regulation involves the binding of proteins and small molecules, with major triggers including IP3 and membrane depolarization. Electron microscopic studies have provided valuable insights into their structure and mechanisms, including the binding of auxiliary proteins, regulation of channel opening, and disease-associated mutations.

PHYSIOLOGICAL REVIEWS (2022)

Article Hematology

Defining a role of NADPH oxidase in myogenic tone development

Galina Yu Mironova et al.

Summary: This study reveals the impact of NADPH oxidase (Nox) on myogenic tone in rat cerebral resistance arteries, providing insight into the role of G protein-coupled receptors (GPCR) and reactive oxygen species (ROS) in the myogenic response.

MICROCIRCULATION (2022)

Article Biochemistry & Molecular Biology

Vascular hyperacetylation is associated with vascular smooth muscle dysfunction in a rat model of non-obese type 2 diabetes

Maria Alicia Carrillo-Sepulveda et al.

Summary: The study demonstrated that vascular hyperacetylation is associated with vascular smooth muscle cell dysfunction in advanced type 2 diabetes mellitus. Inhibition of hyperacetylation by garcinol reduced high glucose-induced ROS production in VSMCs, highlighting a potential novel therapeutic approach for diabetic vascular complications.

MOLECULAR MEDICINE (2022)

Review Medicine, General & Internal

International Guidelines for Hypertension: Resemblance, Divergence and Inconsistencies

Junior Justin et al.

Summary: High blood pressure is the leading cause of death worldwide, with approximately 1.5 billion people suffering from hypertension in 2010. The guidelines for hypertension management by Canadian, American, International, and European organizations provide the basic principles, but they differ in the definition, measurement, and treatment of blood pressure.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Biochemistry & Molecular Biology

Aldosterone Suppresses Endothelial Mitochondria through Mineralocorticoid Receptor/Mitochondrial Reactive Oxygen Species Pathway

Shih-Yuan Peng et al.

Summary: Excessive aldosterone suppressed endothelial mitochondria through the MR/mitochondrial ROS pathway, leading to endothelial dysfunction, vascular inflammation, and vascular fibrosis.

BIOMEDICINES (2022)

Article Pharmacology & Pharmacy

MicroRNA-210-mediated mtROS confer hypoxia-induced suppression of STOCs in ovine uterine arteries

Xiang-Qun Hu et al.

Summary: This study demonstrates a novel mechanistic role for the miR-210-ISCU-mtROS axis in inhibiting Ca2+ sparks/STOCs in the maladaptation of uterine arteries and provides new insights into the understanding of mitochondrial perturbations in the pathogenesis of pregnancy complications resulted from hypoxia.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Article Peripheral Vascular Disease

Chronic Hypoxia in Ovine Pregnancy Recapitulates Physiological and Molecular Markers of Preeclampsia in the Mother, Placenta, and Offspring

Wen Tong et al.

Summary: This study investigated the inter-relationship between chronic hypoxia during pregnancy and maternal, placental, and fetal outcomes, common in preeclampsia. The results showed that chronic hypoxia in ovine pregnancy promoted fetal growth restriction and activated placental stress response pathways. It also led to changes in maternal blood pressure and angiogenic balance. These findings demonstrate that chronic hypoxia recapitulates physiological and molecular features of preeclampsia in the mother, placenta, and offspring.

HYPERTENSION (2022)

Article Public, Environmental & Occupational Health

Influence of circulating nesfatin-1, GSH and SOD on insulin secretion in the development of T2DM

Kangkang Huang et al.

Summary: This study evaluated the correlation between nesfatin-1, GSH, and SOD levels with beta-cell insulin secretion and found that these biomarkers were significantly decreased in patients with type 2 diabetes mellitus (T2DM) compared to prediabetes and healthy participants. Furthermore, the study showed that circulating levels of nesfatin-1, GSH, and SOD were strongly correlated with beta-cell insulin secretion and significantly influenced the secretion.

FRONTIERS IN PUBLIC HEALTH (2022)

Article Peripheral Vascular Disease

S-Nitrosylation-Mediated Reduction of CaV1.2 Surface Expression and Open Probability Underlies Attenuated Vasoconstriction Induced by Nitric Oxide

Zhenyu Hu et al.

Summary: This study provides evidence that S-nitrosylation significantly reduces Ca(V)1.2 channel activity through lysosomal degradation and reduced open probability, contributing to hypertension. These findings offer potential pathways for therapeutic interventions in hypertension.

HYPERTENSION (2022)

Article Biochemistry & Molecular Biology

Oxidative and Inflammatory Imbalance in Placenta and Kidney of sFlt1-Induced Early-Onset Preeclampsia Rat Model

Alvaro Santana-Garrido et al.

Summary: This study investigates the role of the NADPH oxidase system in a rodent model of preeclampsia. The results suggest that NADPH oxidase mediates oxidative stress and inflammation in the placenta and kidney, providing important insights into the pathogenesis and potential treatment of preeclampsia.

ANTIOXIDANTS (2022)

Article Biochemistry & Molecular Biology

The Potent Antioxidant MitoQ Protects Against Preeclampsia During Late Gestation but Increases the Risk of Preeclampsia When Administered in Early Pregnancy

Yike Yang et al.

Summary: This study found that while MitoQ administration in late gestation could protect mice from hypertension and kidney damage induced by RUPP, it exacerbated the PE phenotype when given in early gestation, indicating the necessity of mild oxidative stress for trophoblast proliferation, invasion, and migration.

ANTIOXIDANTS & REDOX SIGNALING (2021)

Article Biochemistry & Molecular Biology

Hypoglycemia Induces Mitochondrial Reactive Oxygen Species Production Through Increased Fatty Acid Oxidation and Promotes Retinal Vascular Permeability in Diabetic Mice

Ayaka Yoshinaga et al.

Summary: Hypoglycemia induces mitochondrial ROS production through fatty acid oxidation and leads to increased vascular permeability in retinal endothelial cells. Blocking fatty acid oxidation reduces mtROS production and prevents hypoglycemia-induced vascular permeability in the retina.

ANTIOXIDANTS & REDOX SIGNALING (2021)

Review Chemistry, Medicinal

Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status

Aurelia Magdalena Pisoschi et al.

Summary: This review paper examines the chemistry of oxidative stress mitigation by antioxidants, highlighting the crucial role of balancing pro-oxidant and antioxidant species. It discusses the association between oxidative stress and various diseases, elucidating the types, mechanisms, and defense strategies of antioxidants.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Multidisciplinary Sciences

Hypoxia-induced mitochondrial abnormalities in cells of the placenta

Philippe Vangrieken et al.

Summary: The study found that placental hypoxia resulted in mitochondrial-generated reactive oxygen species and significant alterations in the molecular pathways controlling mitochondrial content and function. Targeting mitochondrial oxidative stress may have therapeutic benefit in managing pathologies related to placental hypoxia.

PLOS ONE (2021)

Article Obstetrics & Gynecology

Galectin-1 expression in the serum and placenta of pregnant women with fetal growth restriction and its significance

Xiao-Xiao Jin et al.

Summary: This study investigated the expression of Gal-1 in the serum and placenta of pregnant women with FGR. The results showed that Gal-1 levels were lower in the serum and placenta of FGR women compared to the control group. Gal-1 may play a role in the pathogenesis of FGR and could serve as a potential diagnostic marker for the disease.

BMC PREGNANCY AND CHILDBIRTH (2021)

Article Obstetrics & Gynecology

Placental Mitochondrial Abnormalities in Preeclampsia

Philippe Vangrieken et al.

Summary: Preeclamptic placentae exhibit oxidative stress, mitochondrial abnormalities, and inflammation, leading to decreased mitochondrial content and dysregulation of molecular pathways, which may contribute to the pathophysiology of preeclampsia.

REPRODUCTIVE SCIENCES (2021)

Review Biochemistry & Molecular Biology

Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications

Xiang-Qun Hu et al.

Summary: Hypoxia during gestation has significant impacts on maternal complications and fetal development. Mitochondrial ROS play a key role in placental dysfunction and pregnancy complications. Therapeutic approaches targeting mitochondrial ROS in placental cells are discussed for potential treatment strategies.

ANTIOXIDANTS (2021)

Article Cardiac & Cardiovascular Systems

Oxidative Stress and Hypertension

Kathy K. Griendling et al.

Summary: The link between oxidative stress and hypertension has been established in animal models, but remains elusive in humans. Research has expanded our understanding of reactive oxygen species and their impact on signaling pathways, with potential for developing novel antihypertensive therapies.

CIRCULATION RESEARCH (2021)

Review Physiology

Calcium-Dependent Ion Channels and the Regulation of Arteriolar Myogenic Tone

William F. Jackson

Summary: Arterioles in the peripheral microcirculation play a crucial role in regulating blood flow and pressure in tissues and organs. Ca2+-dependent ion channels in vascular smooth muscle cells and endothelial cells are essential for controlling arteriolar tone through both negative and positive feedback mechanisms.

FRONTIERS IN PHYSIOLOGY (2021)

Article Medicine, General & Internal

Characterization of Mitochondrial Bioenergetics in Preeclampsia

Ramana Vaka et al.

Summary: Preeclampsia is associated with oxidative stress, placental ischemia, and autoantibodies to angiotensin II type I receptor. This study found that mitochondrial dysfunction plays a role in the pathophysiology of preeclampsia, particularly in affecting placental function. Antioxidants may not be an effective treatment for the oxidative stress in preeclampsia.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Chemistry, Multidisciplinary

Fustin Ameliorates Elevated Levels of Leptin, Adiponectin, Serum TNF-α, and Intracellular Oxidative Free Radicals in High-Fat Diet and Streptozotocin-Induced Diabetic Rats

Sadaf Jamal Gilani et al.

Summary: The study evaluated the antidiabetic potential of fustin in streptozotocin- and high-fat diet-induced diabetes in rats. Fustin treatment significantly restored all serum parameters related to diabetes, showing promising antidiabetic properties.

ACS OMEGA (2021)

Article Biochemistry & Molecular Biology

Aldosterone Negatively Regulates Nrf2 Activity: An Additional Mechanism Contributing to Oxidative Stress and Vascular Dysfunction by Aldosterone

Daniel Rodrigues et al.

Summary: High levels of aldosterone can cause oxidative stress and vascular dysfunction independently of blood pressure. The study found that aldosterone reduces vascular Nrf2 transcriptional activity by Keap1-dependent mechanisms, leading to mineralocorticoid-induced vascular dysfunction. Activation of Nrf2 with SFN can reverse the vascular dysfunction and ROS generation induced by aldosterone.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biotechnology & Applied Microbiology

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

Henry Jay Forman et al.

Summary: Oxidative stress plays a role in various diseases, and understanding the mechanisms behind antioxidants and how to enhance antioxidant defences may lead to greater pharmacological success.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Physiology

Myogenic Tone in Peripheral Resistance Arteries and Arterioles: The Pressure Is On!

William F. Jackson

Summary: Resistance arteries and arterioles in the peripheral microcirculation play crucial roles in controlling blood pressure, blood flow distribution, and vascular resistance, with myogenic tone being a hallmark feature. However, our understanding of the signaling pathways underlying this key microvascular property remains incomplete, with emphasis on the roles of G-protein-coupled receptors, ion channels, and various kinases in the activity of vascular smooth muscle cells.

FRONTIERS IN PHYSIOLOGY (2021)

Article Obstetrics & Gynecology

The role of tumor necrosis factor in triggering activation of natural killer cell, multi-organ mitochondrial dysfunction and hypertension during pregnancy

Aswathi Jayaram et al.

Summary: TNF-alpha may induce hypertension during pregnancy by activating NK cells and causing multi-organ mitochondrial dysfunction.

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH (2021)

Review Obstetrics & Gynecology

Blood pressure and hypertensive disorders of pregnancy at high altitude: a systematic review and meta-analysis

Imogen D. Grant et al.

Summary: Exposure to high altitude is associated with higher maternal blood pressure at term and increased prevalence of hypertensive disorders of pregnancy. Gestational hypertension is nearly twice as common at high altitude compared to low altitude, while the prevalence of preeclampsia is halved. The risk of stillbirth is also significantly increased at high altitude.

AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM (2021)

Review Medicine, Research & Experimental

Experimental animal models for diabetes and its related complications-a review

Chidhambara Priya Dharshini Kottaisamy et al.

Summary: Diabetes mellitus, characterized by hyperglycemia, is considered as one of the fastest growing public health problems globally. Animal models have played a critical role in exploring disease pathophysiology, identifying therapeutic targets, and assessing new drugs. This study reviews experimental models for diabetes and its complications, highlighting chemical inductions and models in various species.

LABORATORY ANIMAL RESEARCH (2021)

Article Obstetrics & Gynecology

Vascular endothelial mitochondrial oxidative stress in response to preeclampsia: a role for angiotension II type 1 autoantibodies

Evangeline Deer et al.

Summary: This study found that serum from preterm preeclampsia patients can cause endothelial mitochondrial dysfunction, which can be restored by blocking circulating angiotensin II type 1 autoantibodies, indicating a potential new therapeutic target for preeclampsia.

AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM (2021)

Article Physiology

Blockade of endogenous angiotensin II type I receptor agonistic autoantibody activity improves mitochondrial reactive oxygen species and hypertension in a rat model of preeclampsia

Venkata Ramana Vaka et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2020)

Article Biochemistry & Molecular Biology

Oxidative stress: Normal pregnancy versus preeclampsia

Delia Chiarello et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

Review Peripheral Vascular Disease

High Blood Pressure and Cardiovascular Disease

Flavio D. Fuchs et al.

HYPERTENSION (2020)

Article Multidisciplinary Sciences

Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

Guoxia Liu et al.

NATURE (2020)

Review Urology & Nephrology

The global epidemiology of hypertension

Katherine T. Mills et al.

NATURE REVIEWS NEPHROLOGY (2020)

Article Cardiac & Cardiovascular Systems

Pressure-induced constriction of the middle cerebral artery is abolished in TrpC6 knockout mice

Zoltan Nemeth et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

Article Oncology

Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice

Guoqing Chen et al.

MOLECULAR MEDICINE REPORTS (2020)

Review Pharmacology & Pharmacy

On the Clinical Pharmacology of Reactive Oxygen Species

Ana Casas et al.

PHARMACOLOGICAL REVIEWS (2020)

Article Pharmacology & Pharmacy

Fine tuning by protein kinases of CaV1.2 channel current in rat tail artery myocytes

F. Fusi et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Review Immunology

Reactive Oxygen Species: Drivers of Physiological and Pathological Processes

Javier Checa et al.

JOURNAL OF INFLAMMATION RESEARCH (2020)

Article Biochemistry & Molecular Biology

Altered Redox State Modulates Endothelial KCa2.3 and KCa3.1 Levels in Normal Pregnancy and Preeclampsia

Shinkyu Choi et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

Article Cardiac & Cardiovascular Systems

Preeclampsia Pathophysiology, Challenges, and Perspectives

Sarosh Rana et al.

CIRCULATION RESEARCH (2019)

Article Medicine, Research & Experimental

Calcium signals that determine vascular resistance

Matteo Ottolini et al.

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2019)

Article Neurosciences

Intermittent hypoxia impairs uterine artery function in pregnant mice

Mohammad Badran et al.

JOURNAL OF PHYSIOLOGY-LONDON (2019)

Review Public, Environmental & Occupational Health

Preeclampsia link to gestational hypoxia

W. Tong et al.

JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2019)

Review Endocrinology & Metabolism

The Pathophysiology and Treatment of Hypertension in Patients With Cushing's Syndrome

Mattia Barbot et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Article Medicine, Research & Experimental

Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia

Arsalan U. Syed et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Multidisciplinary Sciences

Characterisation of the Selective Reduced Uteroplacental Perfusion (sRUPP) Model of Preeclampsia

J. S. Morton et al.

SCIENTIFIC REPORTS (2019)

Article Multidisciplinary Sciences

Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia

Hong Wa Yung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Cardiac & Cardiovascular Systems

Effects of prolonged type 2 diabetes on mitochondrial function in cerebral blood vessels

Ivan Merdzo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

Article Multidisciplinary Sciences

Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation

Julia Schewe et al.

NATURE COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

S-Nitrosylation: An Emerging Paradigm of Redox Signaling

Veani Fernando et al.

ANTIOXIDANTS (2019)

Article Biochemistry & Molecular Biology

Hydrogen peroxide constricts rat arteries by activating Na+-permeable and Ca2+-permeable cation channels

Hyun Ji Park et al.

FREE RADICAL RESEARCH (2019)

Review Physiology

SOURCES OF VASCULAR NITRIC OXIDE AND REACTIVE OXYGEN SPECIES AND THEIR REGULATION

Jesus Tejero et al.

PHYSIOLOGICAL REVIEWS (2019)

Article Cardiac & Cardiovascular Systems

Voltage-gated Ca2+ channel activity modulates smooth muscle cell calcium waves in hamster cremaster arterioles

William F. Jackson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

Review Cardiac & Cardiovascular Systems

Vascular smooth muscle contraction in hypertension

Rhian M. Touyz et al.

CARDIOVASCULAR RESEARCH (2018)

Article Cardiac & Cardiovascular Systems

Regulation of Blood Pressure by Targeting Ca(V)1.2-Galectin-1 Protein Interaction

Zhenyu Hu et al.

CIRCULATION (2018)

Article Peripheral Vascular Disease

Hypertension and Diabetes Mellitus Coprediction and Time Trajectories

Vasilis Tsimihodimos et al.

HYPERTENSION (2018)

Review Physiology

GESTATIONAL HYPOXIA AND DEVELOPMENTAL PLASTICITY

Charles A. Ducsay et al.

PHYSIOLOGICAL REVIEWS (2018)

Article Physiology

Soluble Fms-Like Tyrosine Kinase-1 Alters Cellular Metabolism and Mitochondrial Bioenergetics in Preeclampsia

Lissette C. Sanchez-Aranguren et al.

FRONTIERS IN PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice

Flavia Rezende et al.

REDOX BIOLOGY (2018)

Article Multidisciplinary Sciences

Engineering selectivity into RGK GTPase inhibition of voltage-dependent calcium channels

Akil A. Puckerin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Obstetrics & Gynecology

Comprehensive analysis of oxidative stress markers and antioxidants status in preeclampsia

Ali Taravati et al.

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY (2018)

Review Physiology

Vascular Oxidative Stress: Impact and Therapeutic Approaches

Cristina M. Sena et al.

FRONTIERS IN PHYSIOLOGY (2018)

Review Biochemistry & Molecular Biology

Cyclophilin D, Somehow a Master Regulator of Mitochondrial Function

George A. Porter et al.

BIOMOLECULES (2018)

Article Pharmacology & Pharmacy

Estradiol decreases blood pressure in association with redox regulation in preeclampsia

Goran M. Babic et al.

CLINICAL AND EXPERIMENTAL HYPERTENSION (2018)

Review Cardiac & Cardiovascular Systems

Use of Antihypertensive Drugs During Preeclampsia

Obinnaya Odigboegwu et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)

Article Peripheral Vascular Disease

Epigenetic regulation of L-type voltage-gated Ca2+ channels in mesenteric arteries of aging hypertensive rats

Jingwen Liao et al.

HYPERTENSION RESEARCH (2017)

Review Biochemistry & Molecular Biology

The Future Challenge of Reactive Oxygen Species (ROS) in Hypertension: From Bench to Bed Side

Gabriele Togliatto et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Physiology

Impaired Mitochondrial Respiration in Large Cerebral Arteries of Rats with Type 2 Diabetes

Ivan Merdzo et al.

JOURNAL OF VASCULAR RESEARCH (2017)

Review Medicine, General & Internal

Type 2 diabetes

Sudesna Chatterjee et al.

LANCET (2017)

Article Multidisciplinary Sciences

Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart

Alexander Katchman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Endocrinology & Metabolism

A Practical Approach to Hypertension Management in Diabetes

Altamash Shaikh

DIABETES THERAPY (2017)

Review Endocrinology & Metabolism

A Practical Approach to Hypertension Management in Diabetes

Altamash Shaikh

DIABETES THERAPY (2017)

Article Cardiac & Cardiovascular Systems

Regional heterogeneity in the mechanisms of myogenic tone in hamster arterioles

William F. Jackson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)

Article Endocrinology & Metabolism

Diabetes and Hypertension: A Position Statement by the American Diabetes Association

Ian H. de Boer et al.

DIABETES CARE (2017)

Article Cardiac & Cardiovascular Systems

Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension

Anna E. Dikalova et al.

CIRCULATION RESEARCH (2017)

Article Cell Biology

Rab25 influences functional Cav1.2 channel surface expression in arterial smooth muscle cells

John P. Bannister et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Rotenone-stimulated superoxide release from mitochondrial complex I acutely augments L-type Ca2+ current in A7r5 aortic smooth muscle cells

Rikuo Ochi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)

Article Pharmacology & Pharmacy

Animal models for diabetes: Understanding the pathogenesis and finding new treatments

Aileen King et al.

BIOCHEMICAL PHARMACOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes

Manasi S. Shah et al.

CIRCULATION RESEARCH (2016)

Article Medicine, Research & Experimental

Mechanism of vascular dysfunction due to circulating factors in women with pre-eclampsia

Cindy K. Kao et al.

CLINICAL SCIENCE (2016)

Article Peripheral Vascular Disease

Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension

Hana A. Itani et al.

HYPERTENSION (2016)

Article Cell Biology

Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model

Amy C. Keller et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Article Pharmacology & Pharmacy

Apocynin reduces blood pressure and restores the proper function of vascular endothelium in SHR

Ligia A. Perassa et al.

VASCULAR PHARMACOLOGY (2016)

Article Multidisciplinary Sciences

Evidence for redox sensing by a human cardiac calcium channel

Padmapriya Muralidharan et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

Reduced Uterine Perfusion Pressure (RUPP) Model of Preeclampsia in Mice

Tomofumi Fushima et al.

PLOS ONE (2016)

Article Multidisciplinary Sciences

Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia

Cathal McCarthy et al.

SCIENTIFIC REPORTS (2016)

Article Peripheral Vascular Disease

Expression of Calcium Channel Subunit Variants in Small Mesenteric Arteries of WKY and SHR

Robert H. Cox et al.

AMERICAN JOURNAL OF HYPERTENSION (2015)

Article Obstetrics & Gynecology

Activin and NADPH-oxidase in preeclampsia: insights from in vitro and murine studies

Rebecca Lim et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor

Paulo W. Pires et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Unitary TRPV3 channel Ca2+ influx events elicit endothelium-dependent dilation of cerebral parenchymal arterioles

Paulo W. Pires et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)

Review Public, Environmental & Occupational Health

The Elusiveness of Population-Wide High Blood Pressure Control

Paul K. Whelton

ANNUAL REVIEW OF PUBLIC HEALTH, VOL 36 (2015)

Review Cardiac & Cardiovascular Systems

Oxidative Stress and Human Hypertension: Vascular Mechanisms, Biomarkers, and Novel Therapies

Augusto C. Montezano et al.

CANADIAN JOURNAL OF CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species

Yasin Shaifta et al.

CARDIOVASCULAR RESEARCH (2015)

Article Cardiac & Cardiovascular Systems

Arterial Smooth Muscle Mitochondria Amplify Hydrogen Peroxide Microdomains Functionally Coupled to L-Type Calcium Channels

Nathan L. Chaplin et al.

CIRCULATION RESEARCH (2015)

Article Medicine, Research & Experimental

Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways

Thiago Bruder-Nascimento et al.

CLINICAL SCIENCE (2015)

Article Peripheral Vascular Disease

Superoxide Enhances Ca2+ Entry Through L-Type Channels in the Renal Afferent Arteriole

Paul A. Vogel et al.

HYPERTENSION (2015)

Review Cell Biology

The Role of Auxiliary Subunits for the Functional Diversity of Voltage-Gated Calcium Channels

Marta Campiglio et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2015)

Review Peripheral Vascular Disease

The hypertension of Cushing's syndrome: controversies in the pathophysiology and focus on cardiovascular complications

Andrea M. Isidori et al.

JOURNAL OF HYPERTENSION (2015)

Article Pharmacology & Pharmacy

Regulation of the Cav1.2 cardiac channel by redox via modulation of CaM interaction with the channel

Yu Sun et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2015)

Article Geriatrics & Gerontology

Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries

Zsolt Springo et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2015)

Review Pharmacology & Pharmacy

Mechanisms for redox-regulation of protein kinase C

Susan F. Steinberg

FRONTIERS IN PHARMACOLOGY (2015)

Article Physiology

Role of smooth muscle cell mineralocorticoid receptor in vascular tone

Antoine Tarjus et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2015)

Article Ophthalmology

Ca(V)3.1 T-Type Ca2+ Channels Contribute to Myogenic Signaling in Rat Retinal Arterioles

Jose A. Fernandez et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2015)

Article Cardiac & Cardiovascular Systems

Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice

Modar Kassan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2014)

Article Cardiac & Cardiovascular Systems

Contractile protein expression is upregulated by reactive oxygen species in aorta of Goto-Kakizaki rat

Sukrutha Chettimada et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2014)

Article Biochemistry & Molecular Biology

Nox2-Induced Production of Mitochondrial Superoxide in Angiotensin II-Mediated Endothelial Oxidative Stress and Hypertension

Sergey I. Dikalov et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Review Biochemistry & Molecular Biology

Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research

Augusto C. Montezano et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Review Cardiac & Cardiovascular Systems

Secondary arterial hypertension: when, who, and how to screen?

Stefano F. Rimoldi et al.

EUROPEAN HEART JOURNAL (2014)

Review Physiology

L-TYPE CaV1.2 CALCIUM CHANNELS: FROM IN VITRO FINDINGS TO IN VIVO FUNCTION

Franz Hofmann et al.

PHYSIOLOGICAL REVIEWS (2014)

Review Physiology

MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE

Dmitry B. Zorov et al.

PHYSIOLOGICAL REVIEWS (2014)

Article Pharmacology & Pharmacy

Dexamethasone Upregulates Nox1 Expression in Vascular Smooth Muscle Cells

Daniel Siuda et al.

PHARMACOLOGY (2014)

Article Obstetrics & Gynecology

Effect of Prenatal Hypoxia in Transgenic Mouse Models of Preeclampsia and Fetal Growth Restriction

C. F. Rueda-Clausen et al.

REPRODUCTIVE SCIENCES (2014)

Review Physiology

Reactive oxygen species and redox compartmentalization

Nina Kaludercic et al.

FRONTIERS IN PHYSIOLOGY (2014)

Article Cell Biology

Regulation of L-type calcium channel sparklet activity by c-Src and PKC-α

Jyoti Gulia et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)

Article Cell Biology

Coronary endothelial dysfunction and mitochondrial reactive oxygen species in type 2 diabetic mice

Young-Eun Cho et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)

Article Cardiac & Cardiovascular Systems

Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice

Peter Toth et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2013)

Article Cardiac & Cardiovascular Systems

Identification of L- and T-type Ca2+ channels in rat cerebral arteries: role in myogenic tone development

Rasha R. Abd El-Rahman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2013)

Review Immunology

'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface

Ada G. Blidner et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2013)

Review Biochemistry & Molecular Biology

Regulation of voltage-dependent calcium channels by RGK proteins

Tingting Yang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2013)

Article Cardiac & Cardiovascular Systems

Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes

Gopal V. Velmurugan et al.

CARDIOVASCULAR RESEARCH (2013)

Article Biochemistry & Molecular Biology

Signaling pathways involved in the H2O2-induced vasoconstriction of rat coronary arteries

Elvira Santiago et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Article Biochemistry & Molecular Biology

NADPH oxidase 2-derived superoxide downregulates endothelial KCa3.1 in preeclampsia

Shinkyu Choi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Article Ophthalmology

The effect of reactive oxygen species on the myogenic tone of rat ophthalmic arteries with and without endothelium

Lars Wagenfeld et al.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2013)

Article Peripheral Vascular Disease

L-arginine-nitric oxide pathway and oxidative stress in plasma and platelets of patients with pre-eclampsia

Adriana M. L. Pimentel et al.

HYPERTENSION RESEARCH (2013)

Article Cell Biology

Antihypertensive effects of inducible nitric oxide synthase inhibition in experimental pre-eclampsia

Lorena M. Amaral et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2013)

Article Developmental Biology

Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy

Irene Tirado-Gonzalez et al.

MOLECULAR HUMAN REPRODUCTION (2013)

Article Clinical Neurology

Nitric oxide suppresses L-type calcium currents in basilar artery smooth muscle cells in rabbits

Naveen Sharma et al.

NEUROLOGICAL RESEARCH (2013)

Article Multidisciplinary Sciences

Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia

Nancy Freitag et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cell Biology

Hydrogen peroxide mediates oxidant-dependent stimulation of arterial smooth muscle L-type calcium channels

Nathan L. Chaplin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2012)

Article Cardiac & Cardiovascular Systems

Increased arterial smooth muscle Ca2+ signaling, vasoconstriction, and myogenic reactivity in Milan hypertensive rats

Cristina I. Linde et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2012)

Article Physiology

eNOS knockout mouse as a model of fetal growth restriction with an impaired uterine artery function and placental transport phenotype

Laura C. Kusinski et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2012)

Article Hematology

Adverse Alterations in Mitochondrial Function Contribute to Type 2 Diabetes Mellitus-Related Endothelial Dysfunction in Humans

Tinoy J. Kizhakekuttu et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes

V. Calabrese et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Article Reproductive Biology

Effect of the Anti-Oxidant Tempol on Fetal Growth in a Mouse Model of Fetal Growth Restriction

Joanna L. Stanley et al.

BIOLOGY OF REPRODUCTION (2012)

Article Cardiac & Cardiovascular Systems

PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism

Daniela Carnevale et al.

CARDIOVASCULAR RESEARCH (2012)

Article Pharmacology & Pharmacy

Scavenging of NADPH oxidase-derived superoxide anions improves depressed baroreflex sensitivity in spontaneously hypertensive rats

D. D. Guimaraes et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2012)

Review Biochemistry & Molecular Biology

Cell Signaling through Protein Kinase C Oxidation and Activation

Daniela Cosentino-Gomes et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

Article Neurosciences

Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats

H. G. Richter et al.

JOURNAL OF PHYSIOLOGY-LONDON (2012)

Article Biochemistry & Molecular Biology

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

Amy McCurley et al.

NATURE MEDICINE (2012)

Article Multidisciplinary Sciences

Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone

Pooneh Bagher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Obstetrics & Gynecology

Increased myogenic reactivity of uterine arteries from pregnant rats with reduced uterine perfusion pressure

John J. Reho et al.

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH (2012)

Article Peripheral Vascular Disease

Role of Reactive Oxygen Species During Hypertension in Response to Chronic Antiangiogenic Factor (sFlt-1) Excess in Pregnant Rats

Kiran B. Tam Tam et al.

AMERICAN JOURNAL OF HYPERTENSION (2011)

Article Peripheral Vascular Disease

Hypertension in Response to AT1-AA: Role of Reactive Oxygen Species in Pregnancy-Induced Hypertension

Marc R. Parrish et al.

AMERICAN JOURNAL OF HYPERTENSION (2011)

Article Cell Biology

Spatial association of the Cav1.2 calcium channel with α5β1-integrin

Jun-Tzu Chao et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)

Article Cardiac & Cardiovascular Systems

Altered Mitochondrial Dynamics Contributes to Endothelial Dysfunction in Diabetes Mellitus

Sherene M. Shenouda et al.

CIRCULATION (2011)

Article Cardiac & Cardiovascular Systems

Splice Variant Specific Modulation of CaV1.2 Calcium Channel by Galectin-1 Regulates Arterial Constriction

Juejin Wang et al.

CIRCULATION RESEARCH (2011)

Review Medicine, Research & Experimental

Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5

Augusto C. Montezano et al.

CLINICAL SCIENCE (2011)

Article Biochemistry & Molecular Biology

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

Yaohui Chen et al.

EMBO REPORTS (2011)

Article Pharmacology & Pharmacy

Ox-LDL-induced LOX-1 expression in vascular smooth muscle cells: role of reactive oxygen species

Yiyi Sun et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2011)

Article Toxicology

The effect of high-fat diet-induced obesity on cardiovascular toxicity in wistar albino rats

Uma Bhandari et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2011)

Article Peripheral Vascular Disease

Activation of NADPH Oxidase 1 Increases Intracellular Calcium and Migration of Smooth Muscle Cells

Matthew C. Zimmerman et al.

HYPERTENSION (2011)

Article Peripheral Vascular Disease

Superoxide Modulates Myogenic Contractions of Mouse Afferent Arterioles

En Yin Lai et al.

HYPERTENSION (2011)

Article Obstetrics & Gynecology

Hypertension Induced by Episodic Reductions in Uteroplacental Blood Flow in Gravid Rat

John J. Reho et al.

HYPERTENSION IN PREGNANCY (2011)

Review Peripheral Vascular Disease

Oxidative stress and endothelial dysfunction in hypertension

Eberhard Schulz et al.

HYPERTENSION RESEARCH (2011)

Article Cell Biology

Voltage-Gated Calcium Channels

William A. Catterall

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Article Cell Biology

Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells

Manuel F. Navedo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2010)

Article Cardiac & Cardiovascular Systems

Activation of L-type Ca2+ channels by protein kinase C is reduced in smooth muscle-specific Na+/Ca2+ exchanger knockout mice

Chongyu Ren et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

Article Cardiac & Cardiovascular Systems

Enhanced myogenic response in the afferent arteriole of spontaneously hypertensive rats

YiLin Ren et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

Article Cardiac & Cardiovascular Systems

Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling

Anna E. Dikalova et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

Article Cardiac & Cardiovascular Systems

Molecular Mechanisms, and Selective Pharmacological Rescue, of Rem-Inhibited CaV1.2 Channels in Heart

Xianghua Xu et al.

CIRCULATION RESEARCH (2010)

Article Cardiac & Cardiovascular Systems

Mitochondria Control Functional CaV1.2 Expression in Smooth Muscle Cells of Cerebral Arteries

Damodaran Narayanan et al.

CIRCULATION RESEARCH (2010)

Article Cardiac & Cardiovascular Systems

Local Regulation of Arterial L-Type Calcium Channels by Reactive Oxygen Species

Gregory C. Amberg et al.

CIRCULATION RESEARCH (2010)

Review Cardiac & Cardiovascular Systems

Oxidative Stress and Diabetic Complications

Ferdinando Giacco et al.

CIRCULATION RESEARCH (2010)

Review Biochemistry & Molecular Biology

Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signaling

Michael A. Hill et al.

FEBS LETTERS (2010)

Article Obstetrics & Gynecology

Role of nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia

Keiichi Matsubara et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2010)

Article Cardiac & Cardiovascular Systems

Alternative splicing of Cav1.2 channel exons in smooth muscle cells of resistance-size arteries generates currents with unique electrophysiological properties

Xiaoyang Cheng et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway

Katherine Chang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells

Zoltan Ungvari et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)

Article Physiology

SOD1 deficiency causes salt sensitivity and aggravates hypertension in hydronephrosis

Mattias Carlstrom et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2009)

Review Biochemistry & Molecular Biology

How mitochondria produce reactive oxygen species

Michael P. Murphy

BIOCHEMICAL JOURNAL (2009)

Article Cardiac & Cardiovascular Systems

Smooth Muscle Cell α2δ-1 Subunits Are Essential for Vasoregulation by CaV1.2 Channels

John P. Bannister et al.

CIRCULATION RESEARCH (2009)

Article Physiology

Cardiovascular and autonomic phenotype of db/db diabetic mice

Danielle Senador et al.

EXPERIMENTAL PHYSIOLOGY (2009)

Article Cardiac & Cardiovascular Systems

The L-type Ca2+ Channel as a Potential Mediator of Pathology During Alterations in Cellular Redox State

Livia C. Hool

HEART LUNG AND CIRCULATION (2009)

Article Pharmacology & Pharmacy

Apocynin improves endothelial function and prevents the development of hypertension in fructose fed rat

Banappa S. Unger et al.

INDIAN JOURNAL OF PHARMACOLOGY (2009)

Article Cell Biology

Akt regulates L-type Ca2+ channel activity by modulating Cavα1 protein stability

Daniele Catalucci et al.

JOURNAL OF CELL BIOLOGY (2009)

Article Pharmacology & Pharmacy

Hypertension Increases Contractile Responses to Hydrogen Peroxide in Resistance Arteries through Increased Thromboxane A2, Ca2+, and Superoxide Anion Levels

Ana Belen Garcia-Redondo et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

Article Peripheral Vascular Disease

Role of reactive oxygen species in hypertension produced by reduced uterine perfusion in pregnant rats

Mona Sedeek et al.

AMERICAN JOURNAL OF HYPERTENSION (2008)

Article Cardiac & Cardiovascular Systems

Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats

Emilie C. Viel et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)

Article Cardiac & Cardiovascular Systems

Neuronal nitric oxide synthase-derived hydrogen peroxide is a major endothelium-dependent relaxing factor

L. S. A. Capettini et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)

Article Cardiac & Cardiovascular Systems

NAD(P)H oxidase-derived peroxide mediates elevated basal and impaired flow-induced NO production in SHR mesenteric arteries in vivo

Xiaosun Zhou et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)

Article Physiology

Differential [Ca2+]i signaling of vasoconstriction in mesenteric microvessels of normal and reduced uterine perfusion pregnant rats

Wensheng Chen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2008)

Review Biochemistry & Molecular Biology

Mitochondria and cellular oxygen sensing in the HIF pathway

Cormac T. Taylor

BIOCHEMICAL JOURNAL (2008)

Article Cardiac & Cardiovascular Systems

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species

Tianzheng Yu et al.

CARDIOVASCULAR RESEARCH (2008)

Article Cardiac & Cardiovascular Systems

AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension

Manuel F. Navedo et al.

CIRCULATION RESEARCH (2008)

Article Biochemistry & Molecular Biology

Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction

Michael Mederos y Schnitzler et al.

EMBO JOURNAL (2008)

Article Pharmacology & Pharmacy

Myogenic tone and reactivity of cerebral arteries in Type II diabetic BBZDR/Wor rat

Yagna P. R. Jarajapu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

Article Pharmacology & Pharmacy

Angiotensin II causes endothelial-dependent increase in expression of CaV1.2 protein in cultured arteries

Wen-ze Wang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

Article Biochemistry & Molecular Biology

AT(1)-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats

Philip Wenzel et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Article Biochemistry & Molecular Biology

Carbon monoxide inhibits L-type Ca2+ channels via redox modulation of key cysteine residues by mitochondrial reactive oxygen species

Jason L. Scragg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Physiology

TRP channels and mechanosensory transduction: insights into the arterial myogenic response

Reza Sharif-Naeini et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2008)

Article Multidisciplinary Sciences

The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension

Madeline Nieves-Cintron et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

High blood pressure arising from a defect in vascular function

Simon K. Michael et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Ophthalmology

Mitochondrial DNA oxidative damage triggering mitochondrial dysfunction and apoptosis in high glucose-induced HRECs

Lin Xie et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)

Article Cardiac & Cardiovascular Systems

Protein kinase G phosphorylates Cav1.2 α1c and β2 subunits

Lin Yang et al.

CIRCULATION RESEARCH (2007)

Article Cardiac & Cardiovascular Systems

Role of L-type calcium channels and PKC in active tone development in rabbit coronary artery

Caroline A. Cobine et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

Review Biochemistry & Molecular Biology

High-altitude hypoxia and preeclampsia

Stacy Zamudio

FRONTIERS IN BIOSCIENCE-LANDMARK (2007)

Article Cardiac & Cardiovascular Systems

Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes

Alejandra San Martin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

Article Immunology

Tumor necrosis factor-alpha in gestation and puerperium of women with gestational hypertension and pre-eclampsia

Jose Carlos Peracoli et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2007)

Review Physiology

The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology

Karen Bedard et al.

PHYSIOLOGICAL REVIEWS (2007)

Article Physiology

Association of mitochondrial SOD deficiency with salt-sensitive hypertension and accelerated renal senescence

Bernardo Rodriguez-Iturbe et al.

JOURNAL OF APPLIED PHYSIOLOGY (2007)

Article Cardiac & Cardiovascular Systems

H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in Type 2 diabetic mice

Nora Erdei et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

Article Pharmacology & Pharmacy

Increased NADPH oxidase activity mediates spontaneous aortic tone in genetically hypertensive rats

Federica Lodi et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2006)

Article Cardiac & Cardiovascular Systems

Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway

DaLiao Xiao et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways

Peichun Gui et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Cardiac & Cardiovascular Systems

Redox-dependent transcriptional regulation

HJ Liu et al.

CIRCULATION RESEARCH (2005)

Article Cardiac & Cardiovascular Systems

Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension

YPR Jarajapu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)

Article Cardiac & Cardiovascular Systems

Nox1 is involved in angiotensin II-mediated hypertension - A study in Nox1-deficient mice

K Matsuno et al.

CIRCULATION (2005)

Article Cardiac & Cardiovascular Systems

Myogenic contraction in rat skeletal muscle arterioles:: smooth muscle membrane potential and Ca2+ signaling

N Kotecha et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)

Article Multidisciplinary Sciences

Constitutively active L-type Ca2+ channels

MF Navedo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4

MC Wendt et al.

FREE RADICAL BIOLOGY AND MEDICINE (2005)

Article Endocrinology & Metabolism

Molecular evidence of placental hypoxia in preeclampsia

N Soleymanlou et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)

Article Endocrinology & Metabolism

Effects of metabolic control and vascular complications on indices of oxidative stress in type 2 diabetic patients

K Komosinska-Vassev et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2005)

Article Biochemistry & Molecular Biology

Differential role of the α1C subunit tails in regulation of the Cav1.2 channels by membrane potential ß subunits, and Ca2+ ions

E Kobrinsky et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Peripheral Vascular Disease

Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src

GE Callera et al.

HYPERTENSION (2005)

Article Physiology

Oxidant stress and constrictor reactivity impair cerebral artery dilation in obese Zucker rats

SA Phillips et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2005)

Article Obstetrics & Gynecology

Circulating oxidized low-density lipoprotein and paraoxonase activity in preeclampsia

H Uzun et al.

GYNECOLOGIC AND OBSTETRIC INVESTIGATION (2005)

Article Cardiac & Cardiovascular Systems

Muscarinic M2 receptor stimulation of Cav1.2b requires phosphatidylinositol 3-kinase, protein kinase C, and c-Src

B Callaghan et al.

CIRCULATION RESEARCH (2004)

Article Obstetrics & Gynecology

Plasma malondialdehyde, superoxide dismutase, sE-selectin, fibronectin, endothelin-1 and nitric oxide levels in women with preeclampsia

S Aydin et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2004)

Article Peripheral Vascular Disease

Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice

A Virdis et al.

JOURNAL OF HYPERTENSION (2004)

Article Biochemistry & Molecular Biology

Enhanced oxidative stress and impaired thioredoxin expression in spontaneously hypertensive rats

M Tanito et al.

ANTIOXIDANTS & REDOX SIGNALING (2004)

Article Cardiac & Cardiovascular Systems

Regulation of vascular L-type Ca2+ channels by phosphatidylinositol 3,4,5-trisphosphate

C Le Blanc et al.

CIRCULATION RESEARCH (2004)

Article Cardiac & Cardiovascular Systems

Gender differences in myogenic tone in superoxide dismutase knockout mouse: animal model of oxidative stress

S Veerareddy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)

Article Cardiac & Cardiovascular Systems

Gender differences in superoxide generation in microvessels of hypertensive rats: role of NAD(P)H-oxidase

APV Dantas et al.

CARDIOVASCULAR RESEARCH (2004)

Article Endocrinology & Metabolism

High glucose mediates pro-oxidant and antioxidant enzyme activities in coronary endothelial cells

P Weidig et al.

DIABETES OBESITY & METABOLISM (2004)

Article Endocrinology & Metabolism

Antioxidant vitamins C and E ameliorate hyperglycaemia-induced oxidative stress in coronary endothelial cells

S Ülker et al.

DIABETES OBESITY & METABOLISM (2004)

Article Cardiac & Cardiovascular Systems

Ionic mechanisms mediating the myogenic response in newborn porcine cerebral arteries

A Ahmed et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)

Article Cardiac & Cardiovascular Systems

Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries

S Earley et al.

CIRCULATION RESEARCH (2004)

Article Peripheral Vascular Disease

Superoxide dismutase, catalase and glutathione peroxidase in SHR kidney: effect of antioxidant-rich diet

CD Zhan et al.

JOURNAL OF HYPERTENSION (2004)

Review Peripheral Vascular Disease

Oxidative stress and preeclampsia - Rationale for antioxidant clinical trials

MTM Raijmakers et al.

HYPERTENSION (2004)

Article Multidisciplinary Sciences

Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

BS Finlin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation

S Moosmang et al.

EMBO JOURNAL (2003)

Article Biochemistry & Molecular Biology

Modified cardiovascular L-type channels in mice lacking the voltage-dependent Ca2+ channel β3 subunit

M Murakami et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Neurosciences

Mitochondrial formation of reactive oxygen species

JF Turrens

JOURNAL OF PHYSIOLOGY-LONDON (2003)

Article Peripheral Vascular Disease

Antioxidant activities and oxidative stress byproducts in human hypertension

J Redón et al.

HYPERTENSION (2003)

Article Cardiac & Cardiovascular Systems

AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase

R Dechend et al.

CIRCULATION (2003)

Article Hematology

Lipid and protein oxidation contribute to a prothrombotic state in patients with type 2 diabetes mellitus

R De Cristofaro et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2003)

Article Cardiac & Cardiovascular Systems

Enhanced [Ca2+](i) in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressure

JG Murphy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)

Article Cardiac & Cardiovascular Systems

Vascular adaptations to pregnancy in mice: effects on myogenic tone

S Veerareddy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2002)

Article Cardiac & Cardiovascular Systems

Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats

JC Frisbee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2002)

Article Peripheral Vascular Disease

Role of p47phox in vascular oxidative stress and hypertension caused by angiotensin II

U Landmesser et al.

HYPERTENSION (2002)

Article Cardiac & Cardiovascular Systems

α4β1 integrin activation of L-type calcium channels in vascular smooth muscle causes arteriole vasoconstriction

KR Waitkus-Edwards et al.

CIRCULATION RESEARCH (2002)

Article Cardiac & Cardiovascular Systems

Transient receptor potential channels regulate myogenic tone of resistance arteries

DG Welsh et al.

CIRCULATION RESEARCH (2002)

Article Biochemistry & Molecular Biology

Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries

T Matoba et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Article Cardiac & Cardiovascular Systems

Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca2+ channels

N Macrez et al.

CIRCULATION RESEARCH (2001)

Article Cardiac & Cardiovascular Systems

Tyrosine phosphorylation following alterations in arteriolar intraluminal pressure and wall tension

TV Murphy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2001)

Article Peripheral Vascular Disease

Ca2+ influx is increased in 2-kidney, 1-clip hypertensive rat aorta

GE Callera et al.

HYPERTENSION (2001)

Article Biochemistry & Molecular Biology

Regulation of the L-type calcium channel by α5β1 integrin requires signaling between focal adhesion proteins

X Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Cardiac & Cardiovascular Systems

Redox signaling of the arteriolar myogenic response

PT Nowicki et al.

CIRCULATION RESEARCH (2001)

Article Biochemistry & Molecular Biology

S-nitrosation controls gating and conductance of the α1 subunit of class C L-type Ca2+ channels

M Poteser et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Developmental Biology

Placental superoxide is increased in pre-eclampsia

JM Sikkema et al.

PLACENTA (2001)

Review Cardiac & Cardiovascular Systems

Integrins and mechanotransduction of the vascular myogenic response

MJ Davis et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2001)

Article Peripheral Vascular Disease

Increased oxidative stress in experimental renovascular hypertension

LO Lerman et al.

HYPERTENSION (2001)

Article Physiology

[Ca2+](i) signaling in renal arterial smooth muscle cells of pregnant rat is enhanced during inhibition of NOS

JG Murphy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2001)

Article Medicine, Research & Experimental

Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice

T Matoba et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)

Article Pharmacology & Pharmacy

Effects of mibefradil and nifedipine on arteriolar myogenic responsiveness and intracellular Ca2+

SJ Potocnik et al.

BRITISH JOURNAL OF PHARMACOLOGY (2000)

Article Cardiac & Cardiovascular Systems

Upregulation of p67phox and gp91phox in aortas from angiotensin II-infused mice

ME Cifuentes et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2000)

Review Cell Biology

The versatility and universality of calcium signalling

MJ Berridge et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)

Article Obstetrics & Gynecology

Preeclampsia:: Evidence for impaired shear stress-mediated nitric oxide release in uterine circulation

KR Kublickiene et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2000)

Article Cardiac & Cardiovascular Systems

Tyrosine phosphorylation modulates arteriolar tone but is not fundamental to myogenic response

BE Spurrell et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2000)

Article Biochemistry & Molecular Biology

Plasma protein carbonyls in nonpregnant, healthy pregnant and preeclamptic women

PLM Zusterzeel et al.

FREE RADICAL RESEARCH (2000)

Article Pathology

Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsia

A Many et al.

AMERICAN JOURNAL OF PATHOLOGY (2000)

Article Peripheral Vascular Disease

High-fat diet elevates blood pressure and cerebrovascular muscle Ca2+ current

DW Wilde et al.

HYPERTENSION (2000)