期刊
ANTIOXIDANTS
卷 11, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/antiox11112189
关键词
aging; age-related macular degeneration; cellular senescence; inflammation; oxidative stress
资金
- Bayer Japan Retina Award Foundation
Aging leads to a decline in organ function, including the eyes, resulting in age-related ocular diseases. Cellular senescence, characterized by cell cycle arrest, plays a significant role in aging and age-related diseases by altering cellular function and secretory phenotypes. Oxidative stress triggers cellular senescence and age-related diseases by inducing senescence markers through reactive oxygen species and mitochondrial dysfunction.
Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases. Because their pathogenesis is unclear, it is challenging to combat age-related diseases. Cellular senescence is a cellular response characterized by cell cycle arrest. Cellular senescence is an important contributor to aging and age-related diseases through the alteration of cellular function and the secretion of senescence-associated secretory phenotypes. As a driver of stress-induced premature senescence, oxidative stress triggers cellular senescence and age-related diseases by inducing senescence markers via reactive oxygen species and mitochondrial dysfunction. In this review, we focused on the mechanism of oxidative stress-induced senescence in retinal cells and its role in the pathogenesis of AMD.
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