期刊
ADVANCED MATERIALS
卷 28, 期 7, 页码 1455-1460出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201504797
关键词
gastrointestinal stability; poly(ethylene glycol); site-specific polymer conjugation; therapeutic enzymes
类别
资金
- Swiss National Science Foundation [310030_135732]
- Swiss National Science Foundation (SNF) [310030_135732] Funding Source: Swiss National Science Foundation (SNF)
The site-specific conjugation of polymers to multiple engineered cysteine residues of a prolyl endopeptidase leads to its stabilization in the gastrointestinal tract of rats, without compromising the activity relative to the native enzyme. The importance of polymer attachment sites is investigated, as well as the significance of polymer structure.
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