4.7 Review

The Function and Therapeutic Implications of TNF Signaling in MDSCs

期刊

BIOMOLECULES
卷 12, 期 11, 页码 -

出版社

MDPI
DOI: 10.3390/biom12111627

关键词

tumor necrosis factor alpha (TNF-alpha); myeloid-derived suppressor cell (MDSCs); tumor; inflammation

资金

  1. National Natural Science Foundation of China
  2. Program for Huazhong University of Science and Technology Academic Frontier Youth Team [81800355, 81873506]
  3. [2019QYTD08]

向作者/读者索取更多资源

Myeloid-derived suppressor cells (MDSCs) are immature and heterogeneous myeloid cells with immunosuppressive functions, and they play important roles in cancer, chronic inflammatory diseases, and autoimmune disorders. Tumor necrosis factor alpha (TNF-alpha) regulates the accumulation and activation of MDSCs. In this review, the roles of TNF-alpha in the recruitment, immunosuppressive functions, and chemotaxis of MDSCs are summarized, and the potential therapeutic effects of TNF-alpha on these cells in tumor growth and inflammatory disorders are discussed.
Myeloid-derived suppressor cells (MDSCs) are a group of immature and heterogeneous myeloid cells with immunosuppressive functions. MDSCs play important roles in the pathogenesis of cancer, chronic inflammatory diseases, and many autoimmune disorders. The accumulation and activation of MDSCs can be regulated by tumor necrosis factor alpha (TNF-alpha). In this review, we summarize the roles played by TNF-alpha in the recruitment, immunosuppressive functions, and chemotaxis of MDSCs, and discuss the potential therapeutic effects of TNF-alpha upon these cells in tumor growth and some inflammatory disorders.

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