Lnc-uc.147 Is Associated with Disease Stage of Liver, Gastric, and Renal Cancer

Lnc-uc.147, a long non-coding RNA derived from a transcribed ultraconserved region (T-UCR), was previously evidenced in breast cancer. However, the role of this region in other tumor types was not previously investigated. The present study aimed to investigate lnc-uc.147 in different types of cancer, as well as to suggest lnc-uc.147 functional and regulation aspects. From solid tumor datasets analysis of The Cancer Genome Atlas (TCGA), deregulated lnc-uc.147 expression was associated with the histologic grade of hepatocellular carcinoma, and with the tumor stage of clear cell renal and gastric adenocarcinoma. Considering the epidemiologic relevance of liver cancer, silencing lnc-uc.147 reduced the viability and clonogenic capacity of HepG2 cell lines. Additionally, we suggest a relation between the transcription factor TEAD4 and lnc-uc.147 in liver and breast cancer cells.

Automated summary

This study aimed to investigate the role of long non-coding RNA lnc-uc.147 in different types of cancer and suggest its functional and regulation aspects. The results showed that deregulated expression of lnc-uc.147 was associated with histologic grade in hepatocellular carcinoma and tumor stage in clear cell renal and gastric adenocarcinoma. Silencing lnc-uc.147 reduced the viability and clonogenic capacity of HepG2 cell lines. Additionally, a relationship between the transcription factor TEAD4 and lnc-uc.147 was suggested in liver and breast cancer cells.