Necroptosis Related Genes Predict Prognosis and Therapeutic Potential in Gastric Cancer

Article Oncology

Tertiary lymphoid structures are associated with favorable survival outcomes in patients with endometrial cancer

Meng Qin et al.

Summary: The tumor microenvironment in endometrial cancer, including tertiary lymphoid structures (TLSs) and B cell infiltration, has been associated with favorable survival outcomes, representing an active immune reaction.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

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Review Oncology

Hallmarks of Cancer: New Dimensions

Douglas Hanahan

Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.

CANCER DISCOVERY (2022)

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Review Oncology

Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect

Yu-Ling Bin et al.

Summary: This review summarizes the impact of metabolic reprogramming on the tumor microenvironment and overcoming drug resistance in gastric cancer, and discusses clinical studies on combination treatments with conventional chemotherapy or molecular targeted therapy.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

PD-1 Blockade in Solid Tumors with Defects in Polymerase Epsilon

Benoit Rousseau et al.

Summary: Missense mutations in the POLE gene can lead to tumors with high mutational burden and a higher response rate to immunotherapy. This study found that only specific POLE mutation variants were associated with increased T-cell infiltrates and high response to anti-PD-1 therapy.

CANCER DISCOVERY (2022)

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Article Genetics & Heredity

A Necroptosis-Related lncRNA-Based Signature to Predict Prognosis and Probe Molecular Characteristics of Stomach Adenocarcinoma

Lianghua Luo et al.

Summary: A 12-NRLs signature was developed to improve the prognosis prediction of STAD patients, with significant implications for clinical applications.

FRONTIERS IN GENETICS (2022)

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Article Oncology

Immunotherapy in Gastric Cancer

Anica Hoegner et al.

Summary: Immune checkpoint inhibition is a new standard of targeted therapy in the treatment of advanced or metastatic gastric cancer. Clinical trials have shown that combination therapy with immune checkpoint inhibitors and chemotherapy or targeted therapy can improve overall survival in patients at different treatment stages.

CURRENT ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Cell death pathways: intricate connections and disease implications

Matthias Kist et al.

Summary: In recent years, research has identified various forms of cell death, each relying on different proteins for activation. Many pathways share components and signaling principles, working together rather than independently. Several cell death regulators are linked to human diseases and may be potential therapeutic targets.

EMBO JOURNAL (2021)

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Review Pharmacology & Pharmacy

Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy

Minlin Jiang et al.

Summary: Genomic instability is a crucial feature of cancer development, enabled by alterations in DNA damage response pathways that promote malignant transformation. These changes impact the immune system, generate new antigens, and interact with various signaling pathways, potentially serving as targets and biomarkers in cancer immunotherapy.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Oncology

Current treatment and recent progress in gastric cancer

Smita S. Joshi et al.

Summary: Gastric cancer is a common cause of cancer death worldwide, with treatment options including systemic chemotherapy, radiotherapy, surgery, immunotherapy, and targeted therapy. Classification and biomarkers for gastric cancer help in personalized therapy and identifying populations most likely to benefit from immunotherapy and targeted therapy.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma

Kevin Bi et al.

Summary: The study shows that immune checkpoint blockade (ICB) remodels the RCC microenvironment and modifies the interplay between cancer and immune cell populations, critical for understanding response and resistance to ICB.

CANCER CELL (2021)

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Article Cell Biology

Disruption of DNA polymerase ζ engages an innate immune response

Sara K. Martin et al.

Summary: The disruption of pol zeta in mammalian cells leads to altered expression of 1,117 transcripts, showing signs of inducing an innate immune response. The increased expression of interferon-stimulated genes in these cells is driven by the cGAS-STING signaling pathway. Additionally, key interferon-stimulated chemokines are elevated in cells with disrupted Rev3l.

CELL REPORTS (2021)

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Article Oncology

KEYNOTE-859: a Phase III study of pembrolizumab plus chemotherapy in gastric/gastroesophageal junction adenocarcinoma

Josep Tabernero et al.

Summary: Current guidelines recommend two-drug cytotoxic chemotherapy with a fluoropyrimidine and a platinum-based agent as first-line treatment for advanced gastric cancer. Pembrolizumab monotherapy has shown durable antitumor activity in patients with advanced programmed death ligand 1-positive gastric/gastroesophageal junction adenocarcinoma. Combining pembrolizumab with standard-of-care chemotherapy for advanced or metastatic cancer may enhance clinical outcomes.

FUTURE ONCOLOGY (2021)

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Article Oncology

Necroptosis-Related lncRNAs: Predicting Prognosis and the Distinction between the Cold and Hot Tumors in Gastric Cancer

Zirui Zhao et al.

Summary: This study constructed a model with necroptosis-related lncRNAs to predict prognosis and aid in precision medication for gastric cancer patients. Analysis of IC50 differences between risk groups and clustering helped effectively distinguish between cold and hot tumors, contributing to precise mediation.

JOURNAL OF ONCOLOGY (2021)

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Review Cell Biology

The TNF-α/TNFR2 Pathway: Targeting a Brake to Release the Anti-tumor Immune Response

Audrey Moatti et al.

Summary: Newly discovered anti-cancer immunotherapies focus on stimulating anti-tumor T cell responses, but a significant proportion of patients do not respond. A novel approach proposes targeting the suppressive action of Tregs on anti-tumoral responses. TNFR2 has emerged as a legitimate target for anti-cancer immune checkpoint therapy, showing potential in overcoming the immune suppression in cancer patients.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Medicine, Research & Experimental

Multi-omics characterization and validation of MSI-related molecular features across multiple malignancies

Yuansheng Zheng et al.

Summary: A microsatellite instability (MSI) predictive model was established in pan-cancer and the multi-omics characterization of MSI-related molecular features was compared. Samples with high MSI-scores were mainly distributed in six cancers: BRCA, COAD, LUAD, LIHC, STAD, and UCEC. Various genes and miRNAs showed dysregulation in high-MSI groups, and several drugs exhibited higher sensitivity towards high MSI-score groups.

LIFE SCIENCES (2021)

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Review Oncology

Biomarker-targeted therapies for advanced-stage gastric and gastro-oesophageal junction cancers: an emerging paradigm

Yoshiaki Nakamura et al.

Summary: Despite the lack of clinically relevant biomarkers in the treatment of patients with gastric and gastro-oesophageal junction cancers, advances in identifying molecular subtypes and developing novel therapies are moving towards personalized medicine for individual patients.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Oncology

LncRNA NEAT1 mediates intestinal inflammation by regulating TNFRSF1B

Shiyu Pan et al.

Summary: The study demonstrates that NEAT1 is involved in the development of inflammatory bowel disease by regulating the expression of TNFRSF1B and promoting the translocation of NF-kB p65, which mediates intestinal inflammation.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Medicine, General & Internal

First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial

Yelena Y. Janjigian et al.

Summary: Nivolumab plus chemotherapy showed superior overall survival and progression-free survival compared to chemotherapy alone in previously untreated patients with advanced gastric, gastro-oesophageal junction, or oesophageal adenocarcinoma, indicating it as a new standard first-line treatment option with acceptable safety profile.

LANCET (2021)

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Review Biochemistry & Molecular Biology

Necroptosis and its role in infectious diseases

Xiaojing Xia et al.

APOPTOSIS (2020)

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Article Multidisciplinary Sciences

Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5

Yohei Ando et al.

PLOS ONE (2020)

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Review Cell Biology

The future of cancer immunotherapy: microenvironment-targeting combinations

Yonina R. Murciano-Goroff et al.

CELL RESEARCH (2020)

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Review Oncology

Targeting apoptosis in cancer therapy

Benedito A. Carneiro et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Review Cell Biology

Selective Targeting of TNF Receptors as a Novel Therapeutic Approach

Roman Fischer et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Cell Biology

Necroptosis in Immuno-Oncology and Cancer Immunotherapy

Jenny Sprooten et al.

CELLS (2020)

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Review Oncology

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Rong Tang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Review Chemistry, Multidisciplinary

Emerging roles of class I PI3K inhibitors in modulating tumor microenvironment and immunity

Pu Sun et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Article Medicine, General & Internal

Gastric cancer

Elizabeth C Smyth et al.

LANCET (2020)

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Article Oncology

Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study

Aurelien Marabelle et al.

LANCET ONCOLOGY (2020)

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Correction Immunology

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3 (vol 50, pg 576, 2019)

Xinghui Li et al.

IMMUNITY (2019)

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Review Biochemistry & Molecular Biology

The role of necroptosis in cancer biology and therapy

Yitao Gong et al.

MOLECULAR CANCER (2019)

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Article Medicine, General & Internal

Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer

Wei Peng et al.

EBIOMEDICINE (2019)

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Review Oncology

Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy

Zhongping Yin et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Celastrol Induces Necroptosis and Ameliorates Inflammation via Targeting Biglycan in Human Gastric Carcinoma

Dandan Guo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Biotechnology & Applied Microbiology

Delivery technologies for cancer immunotherapy

Rachel S. Riley et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Review Medicine, Research & Experimental

Necroptosis: a crucial pathogenic mediator of human disease

Mary E. Choi et al.

JCI INSIGHT (2019)

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Article Immunology

Tumor immune evasion arises through loss of TNF sensitivity

Conor J. Kearney et al.

SCIENCE IMMUNOLOGY (2018)

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Review Oncology

Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics

Rosie Elizabeth Ann Gutteridge et al.

MOLECULAR CANCER THERAPEUTICS (2016)

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Article Cell Biology

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

Tania Love Aaes et al.

CELL REPORTS (2016)

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Article Cell Biology

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

Gi-Bang Koo et al.

CELL RESEARCH (2015)

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Article Oncology

Receptor-interacting protein kinase 3 is a predictor of survival and plays a tumor suppressive role in colorectal cancer

X. Feng et al.

NEOPLASMA (2015)

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Review Immunology

Innate and adaptive immune cells in the tumor microenvironment

Thomas F. Gajewski et al.

NATURE IMMUNOLOGY (2013)

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Article Multidisciplinary Sciences

Combination of glycolysis inhibition with chemotherapy results in an antitumor immune response

Marie Beneteau et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Immunology

Th-1 Lymphocytes Induce Dendritic Cell Tumor Killing Activity by an IFN-γ-Dependent Mechanism

Collin J. LaCasse et al.

JOURNAL OF IMMUNOLOGY (2011)

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Review Biochemistry & Molecular Biology

Regulation of death receptor signaling by the ubiquitin system

I. E. Wertz et al.

CELL DEATH AND DIFFERENTIATION (2010)

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Review Oncology

Shared and separate functions of polo-like kinases and aurora kinases in cancer

Susanne M. A. Lens et al.

NATURE REVIEWS CANCER (2010)

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Review Cell Biology

Tumor suppressors and cell metabolism: a recipe for cancer growth

Russell G. Jones et al.

GENES & DEVELOPMENT (2009)

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Review Oncology

Tumor cell metabolism: Cancer's Achilles' heel

Guido Kroemer et al.

CANCER CELL (2008)

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Article Medicine, General & Internal

Effector memory T cells, early metastasis, and survival in colorectal cancer

F Pagès et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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Necroptosis Related Genes Predict Prognosis and Therapeutic Potential in Gastric Cancer

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