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Sigurd Lenzen
BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?
Cecile Guichard et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet
Chie Ebato et al.
CELL METABOLISM (2008)
Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-β in memory-impaired older adults
Mark A. Reger et al.
JOURNAL OF ALZHEIMERS DISEASE (2008)
Calcium-independent Phospholipase A2 (iPLA2β)-mediated Ceramide Generation Plays a Key Role in the Cross-talk between the Endoplasmic Reticulum (ER) and Mitochondria during ER Stress-induced Insulin-secreting Cell Apoptosis
Xiaoyong Lei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Initiation and execution of lipotoxic ER stress in pancreatic β-cells
Daniel A. Cunha et al.
JOURNAL OF CELL SCIENCE (2008)
Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production
Huaqi Xiong et al.
NEUROBIOLOGY OF DISEASE (2008)
Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis
Futoshi Yukioka et al.
NEUROCHEMISTRY INTERNATIONAL (2008)
Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
Tracy O'Connor et al.
NEURON (2008)
Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death
R. Resende et al.
NEUROSCIENCE (2008)
Muscular diacylglycerol metabolism and insulin resistance
Silvie Timmers et al.
PHYSIOLOGY & BEHAVIOR (2008)
Obese men respond to cognitive but not to catabolic brain insulin signaling
M. Hallschmid et al.
INTERNATIONAL JOURNAL OF OBESITY (2008)
Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans
O. Tschritter et al.
DIABETOLOGIA (2007)
Free fatty acid-induced reduction in glucose-stimulated insulin secretion
Andrei I. Oprescu et al.
DIABETES (2007)
Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes
M. Straczkowski et al.
DIABETOLOGIA (2007)
Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons
Sachin Patil et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2007)
Adipokines oversecreted by omental adipose tissue in human obesity
E. Maury et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic β-cell apoptosis
Silvia Casas et al.
DIABETES (2007)
Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity
Maria Kolak et al.
DIABETES (2007)
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
D. R. Laybutt et al.
DIABETOLOGIA (2007)
Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line
D. Morgan et al.
DIABETOLOGIA (2007)
Mechanisms linking obesity to insulin resistance and type 2 diabetes
Steven E. Kahn et al.
NATURE (2006)
The cerebrocortical response to hyperinsulinemia is reduced in overweight humans:: A magnetoencephalographic study
Otto Tschritter et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The aggregation potential of human amylin determines its cytotoxicity towards islet β-cells
Barbara Konarkowska et al.
FEBS JOURNAL (2006)
Soluble oligomers of amyloid-β peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway
Catherine Malaplate-Armand et al.
NEUROBIOLOGY OF DISEASE (2006)
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis
Elizabeth Karaskov et al.
ENDOCRINOLOGY (2006)
Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease
DA Butterfield et al.
NEUROBIOLOGY OF DISEASE (2006)
Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression
MM Wright et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
P-amyloid and endoplasmic reticulum stress reponses in primary neurons - Effects of drugs that interact with the cytoskeleton
KI Seyb et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2006)
Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin
MOW Grimm et al.
NATURE CELL BIOLOGY (2005)
Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons
S Patil et al.
NEUROSCIENCE LETTERS (2005)
NAD(P)H oxidase activation:: A potential target mechanism for diabetic vascular complications, progressive β-cell dysfunction and metabolic syndrome
T Inoguchi et al.
CURRENT DRUG TARGETS (2005)
Apelin, a newly identified adipokine up-regulated by insulin and obesity
J Boucher et al.
ENDOCRINOLOGY (2005)
Involvement of mtDNA damage in free fatty acid-induced apoptosis
V Grishko et al.
FREE RADICAL BIOLOGY AND MEDICINE (2005)
High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex
XC Zhang et al.
EXPERIMENTAL NEUROLOGY (2005)
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function
Z Arvanitakis et al.
ARCHIVES OF NEUROLOGY (2004)
Prospective study of type 2 diabetes and cognitive decline in women aged 70-81 years
G Logroscino et al.
BMJ-BRITISH MEDICAL JOURNAL (2004)
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
L Ho et al.
FASEB JOURNAL (2004)
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
RG Cutler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
U Özcan et al.
SCIENCE (2004)
Leptin modulates β cell expression of IL-1 receptor antagonist and release of IL-lβ in human islets
K Maedler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death
J Hitomi et al.
JOURNAL OF CELL BIOLOGY (2004)
Fibrillogenic amylin evokes islet β-cell apoptosis through linked activation of a caspase cascade and JNK1
SP Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3β, and induction of the mitochondrial-dependent intrinsic caspase pathway
BA Stoica et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2003)
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function
K Maedler et al.
DIABETES (2003)
Increased dietary fat promotes islet amyloid formation and β-cell secretory dysfunction in a transgenic mouse model of islet amyloid
RL Hull et al.
DIABETES (2003)
Obesity is associated with macrophage accumulation in adipose tissue
SP Weisberg et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
Increased expression and activation of c-Jun contributes to human amylin-induced apoptosis in pancreatic islet β-cells
SP Zhang et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets:: Possible role of oxidative stress
S Piro et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2002)
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets -: Evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
R Lupi et al.
DIABETES (2002)
Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies - The Honolulu-Asia Aging Study
R Peila et al.
DIABETES (2002)
Identification of a common protein association region in the neuronal Cdk5 activator
XJ Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Cellular mechanisms of insulin resistance
GI Shulman
JOURNAL OF CLINICAL INVESTIGATION (2000)
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