期刊
BIOMOLECULES
卷 12, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/biom12111655
关键词
DNA damage response; post-translational modification; lipid metabolites; acetylation; S-succinylation; palmitoylation; N-myristoylation; crotonylation; cancer
资金
- National Natural Science Foundation of China [32090031, 31761133012, 31800683, 31530016]
- National Basic Research Program of China [2017YFA0503900]
- Shenzhen Science and Technology Innovation Commission [JCYJ20180507182213033, JCYJ20170412113009742]
This review summarizes the role of lipid metabolite-associated post-translational modifications in regulating the DNA damage response and tumorigenesis, and discusses potential novel targets for anti-cancer drug development.
Genomic DNA damage occurs as an inevitable consequence of exposure to harmful exogenous and endogenous agents. Therefore, the effective sensing and repair of DNA damage are essential for maintaining genomic stability and cellular homeostasis. Inappropriate responses to DNA damage can lead to genomic instability and, ultimately, cancer. Protein post-translational modifications (PTMs) are a key regulator of the DNA damage response (DDR), and recent progress in mass spectrometry analysis methods has revealed that a wide range of metabolites can serve as donors for PTMs. In this review, we will summarize how the DDR is regulated by lipid metabolite-associated PTMs, including acetylation, S-succinylation, N-myristoylation, palmitoylation, and crotonylation, and the implications for tumorigenesis. We will also discuss potential novel targets for anti-cancer drug development.
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