4.7 Article

Study of Excipients in Delayed Skin Reactions to mRNA Vaccines: Positive Delayed Intradermal Reactions to Polyethylene Glycol Provide New Insights for COVID-19 Arm

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Allergy

COVID-19 Vaccine Tolerability in a Patient With a Delayed Allergic Reaction to Polyethylene Glycol: A Case Report

D. Loli-Ausej et al.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2023)

Article Pharmacology & Pharmacy

Patch testing versus interferon-gamma release assay in evaluation of drug eruptions

Yehonatan Kaplan et al.

Summary: Delayed-onset T-cell-mediated cutaneous adverse drug reactions are rare but potentially serious. Our study found that IFN gamma-RA testing may be more effective in identifying medications associated with cutaneous drug eruptions, with positive or borderline results more likely in patients with fixed drug eruption compared to other types of eruptions. Further research into ancillary tests for drug eruptions is necessary.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2022)

Article Allergy

Optimizing investigation of suspected allergy to polyethylene glycols

Maria Anna Bruusgaard-Mouritsen et al.

Summary: This study evaluated the reactivity of different molecular weight PEGs in skin prick tests and investigated cross-sensitization patterns in PEG allergy. The results showed that skin test reactivity to PEG can decrease over time, but titrated SPT with increasing concentrations of PEG 20,000 can be diagnostic.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Dermatology

Cutaneous reactions after SARS-CoV-2 vaccination: a cross-sectional Spanish nationwide study of 405 cases

A. Catala et al.

Summary: This study investigated cutaneous reactions after SARS-CoV-2 vaccination, finding that most were mild to moderate, but severe cases were also reported. Understanding these reactions can help healthcare professionals and reassure patients.

BRITISH JOURNAL OF DERMATOLOGY (2022)

Article Allergy

Assessment of Immediate Allergic Reactions After Immunization With the Pfizer BNT162b2 Vaccine Using Intradermal Skin Testing With the COVID-19 Vaccines

Ronen Shavit et al.

Summary: This study evaluated immediate allergic reactions to COVID-19 vaccines and found that they are rare but can be severe and recur. Intradermal testing with the whole vaccine can identify sensitized subjects, detect cross-sensitization between vaccines, and assess patients at higher risk.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

Article Immunology

Evaluation of Patients with Vaccine Allergies Prior to mRNA-Based COVID-19 Vaccination

Xin Rong Lim et al.

Summary: During the initial rollout of COVID-19 vaccination in Singapore, patients with a history of vaccine allergy were recommended to be assessed for suitability. Testing and surveys showed that most patients tolerated the BNT162b2 vaccine without major allergic reactions.

VACCINES (2022)

Article Allergy

EAACI statement on the diagnosis, management and prevention of severe allergic reactions to COVID-19 vaccines

Milena Sokolowska et al.

Summary: The discussion focuses on the management and prevention of vaccine allergic reactions, providing a detailed algorithm for diagnosing and treating severe allergic reactions, along with recommendations for appropriate medications and equipment. A workup for identifying potential allergenic components in vaccines is proposed, along with a suggested international collaborative approach to reduce the risk of allergic reactions to COVID-19 vaccines.

ALLERGY (2021)

Review Allergy

Allergenic components of the mRNA-1273 vaccine for COVID-19: Possible involvement of polyethylene glycol and IgG-mediated complement activation

Ludger Klimek et al.

Summary: Following the emergency use authorization of the mRNA-1273 vaccine, two mRNA vaccines have been used to prevent COVID-19, but reports of allergic reactions have surfaced in the UK, Canada, and the US. The culprit may be the PEG-2000 contained in both vaccines as a potential trigger.

ALLERGY (2021)

Article Pharmacology & Pharmacy

PEG That Reaction: A Case Series of Allergy to Polyethylene Glycol

Fionnuala Cox et al.

Summary: This study presents 6 cases of acute hypersensitivity to PEG, all female with an average age of 36.4 years. Biphasic allergic reactions were prominent in these cases, and diagnosis relied on a high index of suspicion and focused clinical history.

JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Review Immunology

Allergic Reactions to Current Available COVID-19 Vaccinations: Pathophysiology, Causality, and Therapeutic Considerations

Nicholas G. Kounis et al.

Summary: Vaccines are highly effective in public health, but can trigger allergic reactions, particularly severe ones that activate mast cells and lead to anaphylactic shock. Allergic reactions to vaccines are typically caused by excipients rather than the active vaccine itself.

VACCINES (2021)

Article Immunology

Polyethylene glycol and polysorbate skin testing in the evaluation of coronavirus disease 2019 vaccine reactions

Mitchell M. Pitlick et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2021)

Letter Allergy

Polyethylene glycol (PEG) is a cause of anaphylaxis to the Pfizer/BioNTech mRNA COVID-19 vaccine

Priya Sellaturay et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2021)

Article Dermatology

Delayed Localized Hypersensitivity Reactions to the Moderna COVID-19 Vaccine A Case Series

Margaret S. Johnston et al.

Summary: In response to the COVID-19 pandemic, mRNA vaccines from Pfizer-BioNTech and Moderna received emergency use authorization in the US. This study focused on localized cutaneous reactions to the Moderna COVID-19 vaccine, finding them to be delayed hypersensitivity reactions that are self-limited and not associated with serious adverse effects. Most patients who had a reaction to the first vaccine dose also developed a similar reaction to the second dose, typically sooner. The reactions, dubbed COVID arm, are not a contraindication to subsequent vaccination.

JAMA DERMATOLOGY (2021)

Review Allergy

Allergy to COVID-19 vaccines: A current update

Beatriz Cabanillas et al.

Summary: This passage discusses adverse allergic reactions to COVID-19 vaccines, with a focus on anaphylactic reactions following the administration of mRNA-1273 and BNT162b2 vaccines. It emphasizes the importance of avoiding vaccination for individuals with allergies to drugs or vaccine components.

ALLERGOLOGY INTERNATIONAL (2021)

Letter Allergy

COVID Arm: Very delayed large injection site reactions to mRNA COVID-19 vaccines

Courtney L. Ramos et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

Article Immunology

Allergy to Polyethilenglicole of Anti-SARS CoV2 Vaccine Recipient: A Case Report of Young Adult Recipient and the Management of Future Exposure to SARS-CoV2

Vincenzo Restivo et al.

Summary: The main contraindication to the anti-SARS CoV2 vaccine is an anaphylactic reaction to a vaccine component. Patients who have confirmed reaction to a vaccine component should undergo further investigation to select the right vaccine for immunization. Basophil activation test can be a useful tool in identifying vaccine-reactive patients.

VACCINES (2021)

Editorial Material Allergy

Immediate-Type Hypersensitivity to Polyethylene Glycol (PEG) and a PEG-Containing COVID-19 Vaccine Revealed by Intradermal Testing

J. Pickert et al.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2021)

Letter Dermatology

'COVID arm' - histological features of a delayed-type hypersensitivity reaction to Moderna mRNA-1273 SARS-CoV2 vaccine

W. Kempf et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

Article Allergy

First-Dose mRNA COVID-19 Vaccine Allergic Reactions: Limited Role for Excipient Skin Testing

Anna R. Wolfson et al.

Summary: Most patients with reported allergic reactions to the first dose of mRNA COVID-19 vaccines can safely receive the second dose after excipient skin testing, even if the results are positive. Some patients may require antihistamine medication or even epinephrine treatment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

Letter Allergy

Skin testing with Pfizer SARS-CoV-2 vaccine and PEG 2000

Joao Vieira et al.

ASIA PACIFIC ALLERGY (2021)

Article Multidisciplinary Sciences

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

Ugur Sahin et al.

NATURE (2020)

Review Allergy

Immediate-type hypersensitivity to polyethylene glycols: a review

E. Wenande et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2016)

Review Infectious Diseases

The Xs and Y of immune responses to viral vaccines

Sabra L. Klein et al.

LANCET INFECTIOUS DISEASES (2010)

Review Pharmacology & Pharmacy

Skin Tests in the Diagnosis of Drug Hypersensitivity Reactions

Knut Brockow et al.

CURRENT PHARMACEUTICAL DESIGN (2008)