Parent Acceptance toward Inactivated COVID-19 Vaccination in Children with Acute Lymphoblastic Leukemia: The Power of Oncologist and Alliance

News Item Medicine, General & Internal

Why Parents Still Hesitate to Vaccinate Their Children Against COVID-19

Melissa Suran

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

Article Medicine, General & Internal

Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age

E. B. Walter et al.

Summary: A regimen of two 10-mu g doses of BNT162b2 administered 21 days apart was found to be safe, immunogenic, and efficacious in children aged 5 to 11 years.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Letter Oncology

COVID-19 vaccination for children with cancer

Rishi S. Kotecha

PEDIATRIC BLOOD & CANCER (2022)

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Article Oncology

Factors affecting COVID-19 vaccine hesitancy in parents of children with cancer

Micah A. Skeens et al.

Summary: This study investigated vaccine hesitancy among caregivers of children with cancer, finding moderate hesitancy levels and a focus on vaccine side effects. Vaccine hesitancy may be related to lower COVID exposure, higher COVID impact, concern for side effects, and lower income among parents of children with cancer.

PEDIATRIC BLOOD & CANCER (2022)

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Article Psychology, Clinical

Using AI chatbots to provide self-help depression interventions for university students: A randomized trial of effectiveness

Hao Liu et al.

Summary: This study found that the chatbot-delivered self-help depression intervention was superior to the minimal level of bibliotherapy in terms of reducing depression, anxiety, and establishing a therapeutic alliance with participants.

INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH (2022)

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Article Multidisciplinary Sciences

Third primary SARS-CoV-2 mRNA vaccines enhance antibody responses in most patients with haematological malignancies

Lucy B. Cook et al.

Summary: SARS-CoV-2 infection and COVID-19 have high mortality among patients with haematological malignancies. Although global vaccine rollouts have reduced hospitalizations and deaths, the efficacy of vaccines in these patients is reduced. A retrospective study on 381 patients with haematological malignancies shows that a third vaccine dose enhances SARS-CoV-2 antibody responses.

NATURE COMMUNICATIONS (2022)

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Review Geriatrics & Gerontology

Aging, inflammaging and immunosenescence as risk factors of severe COVID-19

Anteneh Mehari Tizazu et al.

Summary: COVID-19 severity is related to host factors, and aging plays a significant role in detrimental clinical outcomes. Aging affects the immune system and inflammatory processes, which may be involved in the pathogenesis of SARS-CoV-2 and poor recovery in elderly individuals.

IMMUNITY & AGEING (2022)

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Article Public, Environmental & Occupational Health

Vaccine Hesitancy and Concerns About Vaccine Safety and Effectiveness in Shanghai, China

Abram L. Wagner et al.

Summary: This study found disparities in vaccine hesitancy in Shanghai, with rural migrants showing more concerns about vaccine side effects, safety, and effectiveness compared to local residents. These differences could lead to geographical and sociodemographic disparities in vaccination coverage and outbreaks of vaccine-preventable diseases.

AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2021)

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Review Public, Environmental & Occupational Health

COVID-19 Vaccination in Pregnancy, Paediatrics, Immunocompromised Patients, and Persons with History of Allergy or Prior SARS-CoV-2 Infection: Overview of Current Recommendations and Pre- and Post-Marketing Evidence for Vaccine Efficacy and Safety

Nicoletta Luxi et al.

Summary: While the benefit-risk profile of the four authorized COVID-19 vaccines has been largely favorable in the general population, evidence remains limited for special cohorts such as pregnant women, children, immunocompromised individuals, and those with a history of allergies or previous SARS-CoV-2 infection. This narrative review critically examines the potential benefits and risks of COVID-19 vaccines in these special cohorts, and summarizes recommendations from scientific societies and regulatory agencies for primary prevention in these vaccinee categories.

DRUG SAFETY (2021)

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Review Oncology

COVID19 and acute lymphoblastic leukemias of children and adolescents: Updated recommendations (Version 2) of the Leukemia Committee of the French Society for the fight against Cancers and leukemias in children and adolescents (SFCE)

Jeremie Rouger-Gaudichon et al.

Summary: Recommendations specifically tailored for the treatment of acute lymphoblastic leukemias in children and adolescents have been updated by the Leukemia Committee of SFCE in response to the evolving knowledge on COVID19.

BULLETIN DU CANCER (2021)

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Article Oncology

Impacts of COVID-19 on caregivers of childhood cancer survivors

Courtney E. Wimberly et al.

Summary: Caregivers of childhood cancer survivors are experiencing changes to medical care, financial disruptions, and emotional distress due to COVID-19. Caregivers who express confidence in the government response to COVID-19 report less disruption to daily life, decreased feelings of depression and anxiety, better sleep, and greater hopefulness.

PEDIATRIC BLOOD & CANCER (2021)

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Article Public, Environmental & Occupational Health

Characteristics and Clinical Outcomes of Children and Adolescents Aged

Valentine Wanga et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Immunology

Parents' Decisions to Vaccinate Children against COVID-19: A Scoping Review

Fengming Pan et al.

Summary: The study found that the vaccination rate for children against COVID-19 was 59.3%, with factors influencing parents' decision being diverse, but the main reasons for vaccinating were to protect children, family, and others, while fear of side effects and safety concerns were the main reasons for not vaccinating.

VACCINES (2021)

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Article Medicine, General & Internal

Prevalence and Impact Factors of COVID-19 Vaccination Hesitancy Among Breast Cancer Survivors: A Multicenter Cross-Sectional Study in China

Xin Peng et al.

Summary: Cancer patients, particularly breast cancer survivors, face high risk of COVID-19 infection but have low vaccination rates. Factors contributing to vaccination hesitancy included current treatment, lack of information, and influence of healthcare providers. Effective communication, clear vaccination guidelines, and timely information dissemination could help combat vaccine hesitancy among this population.

FRONTIERS IN MEDICINE (2021)

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Article Public, Environmental & Occupational Health

Parental Attitudes and Hesitancy About COVID-19 vs. Routine Childhood Vaccinations: A National Survey

Mohamad-Hani Temsah et al.

Summary: The study found that many parents are hesitant towards the COVID-19 vaccine mainly due to lack of confidence in its effectiveness, safety, and necessity for their children. Parents who rely on official healthcare authority websites for information are more likely to accept childhood COVID-19 vaccination.

FRONTIERS IN PUBLIC HEALTH (2021)

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Article Infectious Diseases

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy children and adolescents: a double-blind, randomised, controlled, phase 1/2 clinical trial

Bihua Han et al.

Summary: The study evaluated the safety, tolerability, and immunogenicity of the candidate COVID-19 vaccine CoronaVac containing inactivated SARS-CoV-2 in children and adolescents aged 3-17 years. The research findings indicate that the 3.0 μg dose induced higher levels of neutralizing antibodies compared to the 1.5 μg dose, supporting the use of the 3.0 μg dose for further studies in this age group.

LANCET INFECTIOUS DISEASES (2021)

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Article Oncology

Safety of administration of BNT162b2 mRNA (Pfizer-BioNTech) COVID-19 vaccine in youths and young adults with a history of acute lymphoblastic leukemia and allergy to PEG-asparaginase

Catherine Mark et al.

Summary: Vaccination is crucial for preventing COVID-19 infection for both individuals and communities, however, some patients with acute lymphoblastic leukemia may develop allergic reactions to vaccines due to the medications they receive. Thus, it is essential to develop a safe vaccination plan for these patients.

PEDIATRIC BLOOD & CANCER (2021)

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Article Medicine, General & Internal

Risks of covid-19 hospital admission and death for people with learning disability: population based cohort study using the OpenSAFELY platform

Elizabeth J. Williamson et al.

Summary: The study found that individuals with learning disabilities in England have significantly increased risks of hospital admission and death from covid-19, highlighting the need for prompt access to covid-19 testing and healthcare for this vulnerable group. Prioritisation for covid-19 vaccination and other targeted preventive measures should be considered.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Biophysics