期刊
VACCINES
卷 10, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/vaccines10111859
关键词
seroprevalence; serosurveillance; measles virus; MMR vaccine; waning immunity
资金
- National Institute of Allergy, Infectious Diseases of the National Institutes of Health and National Institute of Allergy and Infectious Diseases [R01 AI127365, R01 AI121054, R01 AI33144]
The study found that even in a highly vaccinated population, a significant proportion of adults lack immunity to measles, with gender and age influencing the immune response.
As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20-44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our findings suggest that even within a highly vaccinated population, a subset of individuals may still have sub-optimal immunity against measles and potentially be susceptible during any future measles outbreaks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据