期刊
VACCINES
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/vaccines10121997
关键词
SARS-CoV-2; virus-like particle; VLP; vaccine; protective efficacy
VLP vaccines exhibit strong immune responses against SARS-CoV-2, showing neutralizing activity against multiple virus variants. In the Golden Syrian hamster model, VLP vaccines offer significant protection against infection with the Beta or Delta variants of SARS-CoV-2.
Virus-like particles (VLPs) offer great potential as a safe and effective vaccine platform against SARS-CoV-2, the causative agent of COVID-19. Here, we show that SARS-CoV-2 VLPs can be generated by expression of the four viral structural proteins in a mammalian expression system. Immunization of mice with a monovalent VLP vaccine elicited a potent humoral response, showing neutralizing activity against multiple variants of SARS-CoV-2. Subsequent immunogenicity and efficacy studies were performed in the Golden Syrian hamster model, which closely resembles the pathology and progression of COVID-19 in humans. Hamsters immunized with a bivalent VLP vaccine were significantly protected from infection with the Beta or Delta variant of SARS-CoV-2. Vaccinated hamsters showed reduced viral load, shedding, replication, and pathology in the respiratory tract. Immunized hamsters also showed variable levels of cross-neutralizing activity against the Omicron variant. Overall, the VLP vaccine elicited robust protective efficacy against SARS-CoV-2. These promising results warrant further study of multivalent VLP vaccines in Phase I clinical trials in humans.
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