期刊
VACCINES
卷 10, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/vaccines10111906
关键词
chitosan; chitosan-based nanoparticles; vaccine adjuvant; delivery system
资金
- Pioneer and Leading Goose R&D Programs of Zhejiang [2022C02031]
- Natural Science Foundation of Heilongjiang Province [LH2020H129]
- Natural Science Foundation of Zhejiang Province [LTY22E030002]
- Taizhou Science and Technology Plan Project [22nya04]
This article introduces the application of chitosan in vaccine adjuvants and drug delivery systems. Chitosan has good biocompatibility and low toxicity, and can effectively enhance immune responses. Chitosan-based nanoparticles serve as excellent delivery systems and play important roles in protein vaccines and nucleic acid vaccines.
With the support of modern biotechnology, vaccine technology continues to iterate. The safety and efficacy of vaccines are some of the most important areas of development in the field. As a natural substance, chitosan is widely used in numerous fields-such as immune stimulation, drug delivery, wound healing, and antibacterial procedures-due to its good biocompatibility, low toxicity, biodegradability, and adhesion. Chitosan-based nanoparticles (NPs) have attracted extensive attention with respect to vaccine adjuvants and delivery systems due to their excellent properties, which can effectively enhance immune responses. Here, we list the classifications and mechanisms of action of vaccine adjuvants. At the same time, the preparation methods of chitosan, its NPs, and their mechanism of action in the delivery system are introduced. The extensive applications of chitosan and its NPs in protein vaccines and nucleic acid vaccines are also introduced. This paper reviewed the latest research progress of chitosan-based NPs in vaccine adjuvant and drug delivery systems.
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