Evaluation of the Effectiveness of the Policy of Holding the Second Dose of Vaccination: Lessons from the Outbreak in Ho Chi Minh City

Article Immunology

Delayed-interval BNT162b2 mRNA COVID-19 vaccination enhances humoral immunity and induces robust T cell responses

Victoria G. Hall et al.

Summary: Delayed dosing intervals can enhance immune response to COVID-19 vaccination, including virus neutralization against wild-type and variant viruses. This finding has significant implications for the global implementation of vaccines.

NATURE IMMUNOLOGY (2022)

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Editorial Material Immunology

A potential silver lining of delaying the second dose

David R. Martinez et al.

NATURE IMMUNOLOGY (2022)

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Article Medicine, General & Internal

Determinants of COVID-19 vaccine hesitancy among parents in Ho Chi Minh City, Vietnam

Giao Huynh et al.

Summary: COVID-19 vaccine hesitancy among parents in Ho Chi Minh City, Vietnam is influenced by concerns about side effects and vaccine safety. However, factors such as sufficient knowledge, older children, and children with chronic conditions, as well as perceptions of susceptibility and severity to illness, benefits and barriers of vaccination, and cues to action in the Health Belief Model, can reduce hesitancy.

POSTGRADUATE MEDICINE (2022)

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Review Immunology

SARS-CoV-2 Variants, Vaccines, and Host Immunity

Priyal Mistry et al.

Summary: The emergence of SARS-CoV-2 and the subsequent COVID-19 pandemic has led to the development of vaccines and investigation into the immune response to the virus. Variants of the virus have presented challenges to vaccine effectiveness. It is important to understand the immune memory response and continue to develop new antibody treatments and future vaccine approaches.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Cost-effectiveness of Coronavirus Disease 2019 Vaccination in Low- and Middle-Income Countries

Mark J. Siedner et al.

Summary: In the presence of circulating Omicron-like variants, increasing vaccination rates for COVID-19 to 30% or 45% in low- and middle-income countries would be cost-effective in terms of saving lives. Increasing vaccination coverage to 60% would further prevent more infections and deaths, but at a higher cost.

JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Biochemistry & Molecular Biology

Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

Rebecca P. Payne et al.

Summary: The study demonstrates that the first dose of the BNT162b2 mRNA vaccine can induce protection against the B.1.1.7 variant within weeks, and extending the interval between doses can result in higher levels of neutralizing antibody response. Prior infection with the virus can accelerate the immune response.

CELL (2021)

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News Item Multidisciplinary Sciences

The lightning-fast quest for COVID vaccines - and what it means for other diseases

Philip Ball

Summary: The rapid approach used to address SARS-CoV-2 has the potential to revolutionize the future of vaccine science.

NATURE (2021)

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Review Biochemistry & Molecular Biology

SARS-CoV-2 (Covid-19) vaccines structure, mechanisms and effectiveness: A review

Hadis Fathizadeh et al.

Summary: The development of COVID-19 vaccines is aimed at preventing the spread of the disease globally, with some vaccines showing high levels of safety and protection. However, comparing different vaccines is not easy without a unified standard for measuring neutralization.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Immunology

COVID-19 in Low- and Middle-Income Countries (LMICs): A Narrative Review from Prevention to Vaccination Strategy

Sansone Pasquale et al.

Summary: Managing the COVID-19 pandemic is challenging for LMICs, with economic and health resource issues. Recommendations include targeted testing, personal protective measures, patient triage, and efficient resource utilization.

VACCINES (2021)

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Article Anthropology

Ho Chi Minh City during the fourth wave of COVID-19 in Vietnam

Rachel Tough

CITY & SOCIETY (2021)

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Article Medicine, General & Internal

Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)

Amy Flaxman et al.

Summary: The study shows that an extended interval before the second dose of the AstraZeneca vaccine leads to increased antibody titres, while a third dose significantly boosts antibody levels and enhances T-cell responses.

LANCET (2021)

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Article Biochemistry & Molecular Biology

COVID-19 vaccine acceptance and hesitancy in low- and middle-income countries

Julio S. Solis Arce et al.

Summary: The acceptance of COVID-19 vaccines in LMICs is higher compared to the United States and Russia, with a focus on personal protection and concerns about side effects. Healthcare workers are the most trusted sources of guidance in LMICs for COVID-19 vaccines, suggesting that prioritizing vaccine distribution to these countries could help advance global immunization coverage.

NATURE MEDICINE (2021)

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Article Multidisciplinary Sciences

Optimized delay of the second COVID-19 vaccine dose reduces ICU admissions

Paulo J. S. Silva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Microbiology

Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom

Jia Wei et al.

Summary: A longitudinal study on 45,965 adults in the UK revealed that older individuals, especially those aged >60 years, had lower antibody levels after a single dose of ChAdOx1 or BNT162b2 COVID-19 vaccines. Prioritizing vaccine allocation for those not previously infected and older individuals for the second dose is recommended based on the findings. Further data is needed to fully understand the relationship between quantitative antibody responses and vaccine-mediated protection.

NATURE MICROBIOLOGY (2021)

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Article Medicine, General & Internal