相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity
Ahmed Ghallab et al.
JOURNAL OF HEPATOLOGY (2022)
Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test
Anna Cherianidou et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2022)
Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury
M. M. Heldring et al.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS (2022)
Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice
Christian H. Holland et al.
HEPATOLOGY COMMUNICATIONS (2022)
Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion-Dominated Canalicular and Flow-Augmented Ductular Bile Flux
Nachiket Vartak et al.
HEPATOLOGY (2021)
Simulation of a detoxifying organ function: Focus on hemodynamics modeling and convection-reaction numerical simulation in microcirculatory networks
Noemie Boissier et al.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING (2021)
Population pharmacokinetic-pharmacodynamic modeling of acetaminophen in preterm neonates with hemodynamically significant patent ductus arteriosus
Kannan Sridharan et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)
Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD Progression
Ahmed Ghallab et al.
CELLS (2021)
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling
Kai Markus Schneider et al.
NATURE METABOLISM (2021)
Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury
Kai Markus Schneider et al.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2021)
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
Gisela Campos et al.
ARCHIVES OF TOXICOLOGY (2020)
Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice
Michael A. Malfatti et al.
SCIENTIFIC REPORTS (2020)
Virtual Lobule Models Are the Key for Multiscale Biomechanical and Pharmacological Modeling for the Liver
Harvey Ho et al.
FRONTIERS IN PHYSIOLOGY (2020)
Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood
Ahmed Ghallab et al.
HEPATOLOGY (2019)
Road Map for Development of Stem Cell-Based Alternative Test Methods
Agapios Sachinidis et al.
TRENDS IN MOLECULAR MEDICINE (2019)
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
Wiebke Albrecht et al.
ARCHIVES OF TOXICOLOGY (2019)
A computational model for hepatotoxicity by coupling drug transport and acetaminophen metabolism equations
Sylvain Franiatte et al.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING (2019)
A spatial-temporal model for zonal hepatotoxicity of acetaminophen
Shawn A. Means et al.
DRUG METABOLISM AND PHARMACOKINETICS (2019)
Influence of Liver Fibrosis on Lobular Zonation
Ahmed Ghallab et al.
CELLS (2019)
Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI
Selahaddin Sezgin et al.
ARCHIVES OF TOXICOLOGY (2018)
Modeling of xenobiotic transport and metabolism in virtual hepatic lobule models
Xiao Fu et al.
PLOS ONE (2018)
Case 2-2017: An 18-Year-Old Woman with Acute Liver Failure
Kristian R. Olson et al.
NEW ENGLAND JOURNAL OF MEDICINE (2017)
Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage
Arne Schenk et al.
SCIENTIFIC REPORTS (2017)
Adverse outcome pathways: opportunities, limitations and open questions
Marcel Leist et al.
ARCHIVES OF TOXICOLOGY (2017)
Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue
Patricio Godoy et al.
ARCHIVES OF TOXICOLOGY (2016)
Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments
Andrew K. Smith et al.
PLOS COMPUTATIONAL BIOLOGY (2016)
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
L. Kuepfer et al.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2016)
Optimality in the zonation of ammonia detoxification in rodent liver
Martin Bartl et al.
ARCHIVES OF TOXICOLOGY (2015)
Investigation of acetaminophen toxicity in HepG2/C3a microscale cultures using a system biology model of glutathione depletion
Eric Leclerc et al.
CELL BIOLOGY AND TOXICOLOGY (2015)
Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity
Dennis Reddyhoff et al.
JOURNAL OF THEORETICAL BIOLOGY (2015)
Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis
Seddik Hammad et al.
ARCHIVES OF TOXICOLOGY (2014)
Integrated Metabolic Spatial-Temporal Model for the Prediction of Ammonia Detoxification During Liver Damage and Regeneration
Freimut Schliess et al.
HEPATOLOGY (2014)
How predictive quantitative modelling of tissue organisation can inform liver disease pathogenesis
Dirk Drasdo et al.
JOURNAL OF HEPATOLOGY (2014)
Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development: Part 3-Introduction to Pharmacodynamic Modeling Methods
R. N. Upton et al.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2014)
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
Patricio Godoy et al.
ARCHIVES OF TOXICOLOGY (2013)
Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis
Mitchell R. McGill et al.
PHARMACEUTICAL RESEARCH (2013)
A multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk
Juan G. Diaz Ochoa et al.
FRONTIERS IN PHARMACOLOGY (2013)
The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model
Rotem Ben-Shachar et al.
THEORETICAL BIOLOGY AND MEDICAL MODELLING (2012)
Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity
Mitchell R. McGill et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2012)
The virtual liver: a multidisciplinary, multilevel challenge for systems biology
Hermann-Georg Holzhuetter et al.
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2012)
Using Expression Data for Quantification of Active Processes in Physiologically Based Pharmacokinetic Modeling
Michaela Meyer et al.
DRUG METABOLISM AND DISPOSITION (2012)
Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes
Diana M. Feidt et al.
DRUG METABOLISM AND DISPOSITION (2010)
Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration
Stefan Hoehme et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Alteration of Acetaminophen-induced Cytotoxicity in Mouse Hepatocytes during Primary Culture
Atika Jaruchotikamol et al.
JOURNAL OF HEALTH SCIENCE (2009)
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
Sabrina L. Spencer et al.
NATURE (2009)
Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes
Katalin Jemnitz et al.
TOXICOLOGY IN VITRO (2008)
Variability and memory of protein levels in human cells
Alex Sigal et al.
NATURE (2006)
Acetaminophen metabolism does not contribute to gender difference in its hepatotoxicity in mouse
Guoli Dai et al.
TOXICOLOGICAL SCIENCES (2006)
Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver
T Lang et al.
PHARMACOGENETICS (2001)
分享论文
