期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2023.1136005
关键词
spectroscopic imaging; photoacoustic endoscopy; deep lesion; indocyanine green; multimodal
This study presents a cross-scale endoscopic imaging system for rectal tumors using a combined photoacoustic/ultrasound tomography system and wide-field optical microscopy. The system offers advantages such as deep penetration, multi-spectral imaging, cross-scale imaging ability, low cost, and 360-degree view. Results showed that the system accurately depicts the location of cancer invasion depth spectroscopically and identifies tumor angiogenesis in the wide-field optical imaging mode. This work could enhance the characterization of colorectal cancer and promote the clinical application of photoacoustic-based colorectal endoscopy.
The inadequacy of existing colorectal imaging tools has significantly obstructed the efficient detection of colorectal cancer. To address this issue, this work presents the cross-scale endoscopic imaging of rectal tumors with a combined photoacoustic/ultrasound tomography system and wide-field optical microscopy. This multimodal system combines the merits of centimeter-scale deep penetration, multi-spectral imaging, cross-scale imaging ability, low system cost, and 360 & DEG; view in a single modality. Results indicated that the proposed system could reliably depict the location of the cancer invasion depth spectroscopically with indocyanine green The tumor angiogenesis can be well identified in the wide-field optical imaging mode, which helps to localize the tumors and guide the following photoacoustic/ultrasound scan. This work may facilitate the accurate characterization of colorectal cancer and promote the clinical translation of photoacoustic-based colorectal endoscopy.
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