☆ 4.7 Review

Advances and perspectives for antimicrobial peptide and combinatory therapies

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Biotechnology & Applied Microbiology

In vitro synergistic activity of colistin and teicoplanin combination against multidrug-resistant Acinetobacter spp

Osama Mohamed Samy Mohamed Rady et al.

Summary: This study evaluated the synergistic activity of colistin and teicoplanin combination against multidrug resistant Acinetobacter spp. The results showed that the combination exhibited synergistic and bactericidal effects against most tested isolates, indicating its potential therapeutic value.

JOURNAL OF ANTIBIOTICS (2022)

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Article Medicine, General & Internal

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Christopher J. L. Murray et al.

Summary: Antimicrobial resistance (AMR) poses a significant threat to global human health, and this study provides the most comprehensive estimates of AMR burden to date. By estimating deaths and disability-adjusted life-years (DALYs) associated with bacterial AMR in 204 countries and territories in 2019, the study highlights the impact of resistance and the leading pathogen-drug combinations contributing to it.

LANCET (2022)

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Review Chemistry, Medicinal

Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug-resistant infections

Yiyun Zhu et al.

Summary: Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important immune defense molecules in multicellular organisms. AMPs have great potential as new generation antimicrobial agents and can be used in combination with conventional antibiotics to kill drug-resistant pathogens and improve therapeutic effects.

MEDICINAL RESEARCH REVIEWS (2022)

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Review Microbiology

Antibiotic resistance in the environment

D. G. Joakim Larsson et al.

Summary: Antibiotic resistance is a global health challenge, with factors driving evolution and transmission being important to quantify and identify. The environment plays a crucial role, and understanding and managing the resistance crisis can be achieved through implementing monitoring and assessment methods to reduce risks.

NATURE REVIEWS MICROBIOLOGY (2022)

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Review Multidisciplinary Sciences

Multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance

Huy Xuan Luong et al.

Summary: Conventional antibiotics have contributed significantly to global healthcare, but they have also led to the emergence of drug resistance. Host defence systems, particularly the expression of ribosomal antimicrobial peptides (AMPs), play a vital role in combating infectious diseases and addressing the antimicrobial resistance crisis.

ROYAL SOCIETY OPEN SCIENCE (2022)

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Article Infectious Diseases

Antibiotic Discovery and Resistance: The Chase and the Race

Katia Iskandar et al.

Summary: The history and challenges of antibiotic discovery, as well as the need for diversity and innovation in tackling antimicrobial resistance (AMR), are described in this review. It emphasizes the public health concerns of acquired resistance caused by anthropogenic use of antibiotics and the global spread of AMR at an alarming rate. The lack of new leads in the current pipeline and the need to address resistance to old and novel antibiotics are also highlighted.

ANTIBIOTICS-BASEL (2022)

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Article Chemistry, Medicinal

Identification of Antibacterial Peptide Candidates Encrypted in Stress-Related and Metabolic Saccharomyces cerevisiae Proteins

Maria Fernanda da Silva Santos et al.

Summary: A protein-rich extract containing antimicrobial peptides was obtained from Saccharomyces cerevisiae through autolysis and mild thermal treatment. The extract showed improved antibacterial activities against foodborne and clinically significant bacteria, while also being safe for human tissues in a mixture format. The peptides in the extract were derived from induced-proteolysis and proteasome activity in abundant proteins, including those upregulated under stress conditions during S. cerevisiae biomass manufacturing. In silico analysis predicted 58 potential antimicrobial peptide sequences in the extract.

PHARMACEUTICALS (2022)

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Article Chemistry, Medicinal

Human Cryptic Host Defence Peptide GVF27 Exhibits Anti-Infective Properties against Biofilm Forming Members of the Burkholderia cepacia Complex

Andrea Bosso et al.

Summary: In this study, the promising anti-biofilm and immunomodulatory activities of human HDP GVF27 against Burkholderia multivorans and Burkholderia cenocepacia were discovered. GVF27 exhibited inhibitory effects on the biofilms of both bacterial strains, and showed synergistic effects with ciprofloxacin. Furthermore, GVF27 demonstrated interaction with the lipopolysaccharides isolated from B. cenocepacia, and had the ability to mitigate the release of pro-inflammatory cytokines in human cells stimulated by the same endotoxin.

PHARMACEUTICALS (2022)

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Article Biochemistry & Molecular Biology

Starch/PBAT blown antimicrobial films based on the synergistic effects of two commercial antimicrobial peptides

Shan Gao et al.

Summary: A starch/PBAT antimicrobial film based on two commercial antimicrobial peptides was fabricated and showed improved mechanical properties and antimicrobial activity. New intermolecular hydrogen bonds were formed among starch, nisin, and e-PL. The antimicrobial peptides enhanced the physical properties and morphology of the film, making it promising for food packaging applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Review Microbiology

The physiology and genetics of bacterial responses to antibiotic combinations

Roderich Roemhild et al.

Summary: This review discusses the importance of using combination antibiotics to enhance treatment efficacy and combat resistance evolution. While several promising strategies have been proposed, a deeper understanding of the physiological responses and genetic mechanisms underlying antibiotic interactions and their clinical applicability is still lacking.

NATURE REVIEWS MICROBIOLOGY (2022)

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Review Pharmacology & Pharmacy

Antibiotic Combination Therapy: A Strategy to Overcome Bacterial Resistance to Aminoglycoside Antibiotics

Nuoyan Wang et al.

Summary: After the first application of aminoglycoside antibiotic streptomycin in the mid-1940s, aminoglycoside antibiotics (AGAs) have been widely used for treating bacterial infections. However, bacterial resistance to AGAs is increasing due to various mechanisms such as modification of AGAs' structures and decreased drug concentration within bacteria. Combining AGAs with other drugs can provide a synergistic antibacterial effect and reduce side effects. Therefore, the development of combined therapies using AGAs is of great importance for overcoming bacterial resistance.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Medicine, General & Internal

Potential risks of treating bacterial infections with a combination of β-lactam and aminoglycoside antibiotics: A systematic quantification of antibiotic interactions in E. coli blood stream infection isolates

Nikos Fatsis-Kavalopoulos et al.

Summary: This study elucidates the potential risks of common combination treatment for blood stream infections and demonstrates the specificity of different antibiotics in combination therapy. The results indicate that certain combinations exhibit antagonistic effects on bacterial strains, highlighting the need for careful consideration of combination choices when using antibacterial drugs.

EBIOMEDICINE (2022)

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Article Infectious Diseases

Antimicrobial Random Peptide Mixtures Eradicate Acinetobacter baumannii Biofilms and Inhibit Mouse Models of Infection

Hannah E. Caraway et al.

Summary: Antibiotic resistance is a major crisis in human medicine, with Acinetobacter baumannii being a significant threat. Random peptide mixtures (RPMs) have shown potential as powerful therapeutics against antibiotic-resistant A. baumannii, rapidly killing the bacteria, inhibiting biofilm formation, and reducing bacterial burden and mortality rates in mouse models of pneumonia, soft tissue infection, and sepsis.

ANTIBIOTICS-BASEL (2022)

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Article Microbiology

Synergistic Antimicrobial Effect of Antimicrobial Peptides CATH-1, CATH-3, and PMAP-36 With Erythromycin Against Bacterial Pathogens

Yi Lu et al.

Summary: With increasing antibiotic resistance among bacteria, finding alternative drugs or antibiotic adjuvants to enhance antibacterial efficacy is urgently needed. This study demonstrates that the combination of antimicrobial peptides (AMPs) and traditional antibiotics has synergistic bactericidal effects against Staphylococcus aureus, Salmonella enteritidis, and Escherichia coli. The AMPs tested, including CATH-1, -3, and PMAP-36, showed good antibacterial activity, and their combination with erythromycin exhibited continuous killing effect on bacteria within 3 hours. Importantly, the combination treatment showed lower hemolytic activity and cytotoxicity to mammalian cells compared to erythromycin alone. Mechanistic studies suggest that CATH-1 enhances the antibacterial activity of erythromycin by increasing the permeability of bacterial cell membrane. Additionally, the combination treatment delayed the emergence of E. coli resistance to erythromycin. These findings provide valuable information for the development of AMPs as potential substitutes or adjuvants for traditional antibiotics.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Microbiology

Antimicrobial Peptide Combination Can Hinder Resistance Evolution

Bar Maron et al.

Summary: The study shows that combination therapy with AMPs can delay the evolution of resistance in S. aureus, with some AMP pairs showing significantly lower resistance compared to individual AMPs. Treatment with a random AMP library resulted in no detectable resistance. The rate of resistance development to combination therapy correlated with the cost of resistance to individual AMPs and their cross-resistance. No broad-range AMP resistance evolved, as strains that developed resistance to some AMPs remained sensitive to others.

MICROBIOLOGY SPECTRUM (2022)

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Article Immunology

Synergistic effect of two antimicrobial peptides, Nisin and P10 with conventional antibiotics against extensively drug-resistant Acinetobacter baumannii and colistin-resistant Pseudomonas aeruginosa isolates

Abolfazl Jahangiri et al.

Summary: The study demonstrated the antimicrobial effects of Nisin and P10 peptides against drug-resistant bacterial strains, with the P10+Nisin combination showing synergistic effects against standard strains and additive effects against drug-resistant isolates. Additionally, synergistic combinations were found with P10+ceftazidim, P10+doripenem, and Nisin+colistin, highlighting potential therapeutic value against infections caused by colistin-resistant P. aeruginosa and XDR A. baumannii.

MICROBIAL PATHOGENESIS (2021)

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Article Biology

Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens

Qian Li et al.

Summary: Li, Cebrian et al. demonstrate that a combination of peptide D-11 and vancomycin shows potent antimicrobial activity against a panel of Gram-negative pathogens without apparent toxicity. They also find that this combination effectively clears Pseudomonas aeruginosa in mice, providing a potential antimicrobial therapy for humans.

COMMUNICATIONS BIOLOGY (2021)

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Editorial Material Pharmacology & Pharmacy

Future prospects for Antimicrobial peptide development: peptidomimetics and antimicrobial combinations

Josep M. Sierra et al.

EXPERT OPINION ON DRUG DISCOVERY (2021)

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Article Microbiology

Synergistic effect of antimicrobial peptide LL-37 and colistin combination against multidrug-resistant Escherichia coli isolates

Gianluca Morroni et al.

Summary: The antimicrobial peptide LL-37 showed good activity against multidrug-resistant Escherichia coli strains, especially when used in combination with colistin, demonstrating synergistic effects and the ability to reduce biofilm formation. This suggests a new possible clinical application for combating antibiotic resistance.

FUTURE MICROBIOLOGY (2021)

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Article Biochemical Research Methods

Recombinant production of Trx-Ib-AMP4 and Trx-E50-52 antimicrobial peptides and antimicrobial synergistic assessment on the treatment of methicillin-resistant Staphylococcus aureus under in vitro and in vivo situations

Parastu Satei et al.

Summary: The study aimed to recombinantly produce E50-52 and Ib-AMP4 antimicrobial peptides and investigate their synergistic effects on methicillin-resistant Staphylococcus aureus (MRSA). The results showed promising antibacterial effects and potential as an efficient way to combat multidrug-resistant bacteria.

PROTEIN EXPRESSION AND PURIFICATION (2021)

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Article Multidisciplinary Sciences

Adaptive evolution of hybrid bacteria by horizontal gene transfer

Jeffrey J. Power et al.

Summary: Horizontal gene transfer is an important factor in bacterial evolution, allowing for rapid evolution and increased adaptation in recipient organisms. Adaptive evolution mainly occurs in populations with increased fitness, with HGT selection having a broad genetic basis and showing different types of selection in functional gene networks.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Chemistry, Medicinal

Random Peptide Mixtures as Safe and Effective Antimicrobials against Pseudomonas aeruginosa and MRSA in Mouse Models of Bacteremia and Pneumonia

Richard C. Bennett et al.

Summary: Antibiotic resistance poses a significant challenge in modern medicine, with antimicrobial peptides and random peptide mixtures emerging as promising alternatives to combat resistant pathogens effectively.

ACS INFECTIOUS DISEASES (2021)

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Article Microbiology

Boosting Synergistic Effects of Short Antimicrobial Peptides With Conventional Antibiotics Against Resistant Bacteria

Chih-Lung Wu et al.

Summary: The study developed a strategy to enhance and synergize the activity of conventional antibiotics by combining antimicrobial peptides with a bulky non-natural amino acid. The results show that this approach can reduce the impact of antibiotics on Gram-negative bacteria, improve the antimicrobial activity of peptides, and increase the synergistic effects with antibiotics.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Pharmacology & Pharmacy

Analysis of Antibiotic Consumption by AWaRe Classification in Shandong Province, China, 2012-2019: A Panel Data Analysis

Jia Yin et al.

Summary: The study examines the changes in clinical antibiotic consumption in Shandong, China over 10 years, finding a decrease in overall consumption rate but a dominance of watch group antibiotics. Antibiotic stewardship policies have varying effects on regions with different economic levels, indicating an ongoing inappropriate pattern of antibiotic consumption in China.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Public, Environmental & Occupational Health

Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects

Tanvir Mahtab Uddin et al.

Summary: Antibiotics have been a crucial tool in treating bacterial infections for over 70 years, but the rise of multidrug-resistant bacteria has posed a significant challenge, necessitating the discovery of innovative medicinal approaches and antimicrobial therapies. Further research and development in combating antibiotic resistance are vital in addressing the emerging threat of antimicrobial resistance.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2021)

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Review Infectious Diseases

Bacterial Targets of Antibiotics in Methicillin-Resistant Staphylococcus aureus

Harshad Lade et al.

Summary: MRSA is a prevalent bacterial pathogen worldwide, and finding new antibiotic targets is crucial for successful treatment. Most antibiotics target essential biochemical processes of S. aureus, such as cell wall synthesis. Further research into novel antibiotics targeting bacterial cellular processes could lead to new therapeutic strategies against antibiotic-resistant pathogens.

ANTIBIOTICS-BASEL (2021)

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Review Chemistry, Medicinal

Physicochemical Features and Peculiarities of Interaction of AMP with the Membrane

Malak Pirtskhalava et al.

Summary: Antimicrobial peptides (AMPs) have the potential to be novel biotherapeutics with interactions on the cell envelope, requiring comprehensive understanding for rational design. In-depth studies on the physicochemical, aggregative, and structural features of AMPs are essential for accurate classification and effective prediction methods. The knowledge of AMPs' physicochemical properties is crucial for the development of peptide-based antibiotics design tools.

PHARMACEUTICALS (2021)

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Article Biochemistry & Molecular Biology

Antimicrobial and Antioxidative Activity of Newly Synthesized Peptides Absorbed into Bacterial Cellulose Carrier against Acne vulgaris

Iwona Golonka et al.

Summary: The study focuses on developing new amino acid derivatives with potential activity against dermal infections caused by acne. Peptides P1-P6 showed lack of cytotoxicity, antimicrobial activity, or antioxidative properties linked to certain structural properties.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biotechnology & Applied Microbiology

Fosfomycin and nitrofurantoin: classic antibiotics and perspectives

Cristiane dos Santos et al.

Summary: Antibiotics are crucial for treating and preventing infectious diseases, but their overuse can lead to antimicrobial resistance. Strategies such as reintroducing traditional antibiotics may be necessary due to the decrease in treatment options and the emergence of resistance. Systematic evaluation of old drugs, especially for community-acquired infections, is essential to avoid increasing multidrug resistance.

JOURNAL OF ANTIBIOTICS (2021)

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Article Immunology

Synergistic effect and antibiofilm activity of an antimicrobial peptide with traditional antibiotics against multi-drug resistant bacteria

Huimin Duan et al.

Summary: The study demonstrates the synergistic antibacterial effect between the AMP Pt5-1c derived from phosvitin and traditional antibiotics against multidrug-resistant bacteria. It also suggests the potential of using Pt5-1c to prolong the efficacy of certain antibiotics under threat of antibiotic resistance.

MICROBIAL PATHOGENESIS (2021)

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Article Biochemistry & Molecular Biology

Zopfiellasins A-D, Two Pairs of Epimeric Cytochalasins from Kiwi-Associated Fungus Zopfiella sp. and Their Antibacterial Assessment

Jie-Yu Zhang et al.

Summary: In the search for antibacterial agents against Pseudomonas syringae pv. actinidiae (Psa) from kiwi-associated fungi, two pairs of epimeric cytochalasins, zopfiellasins A-D, were identified from the fungus Zopfiella sp. Compounds 1 and 3 showed antibacterial activity against Psa, marking the first report of cytochalasin derivatives with anti-Psa activity.

MOLECULES (2021)

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Review Immunology

Antimicrobial Peptides: A New Hope in Biomedical and Pharmaceutical Fields

Antonio Moretta et al.

Summary: Antibiotic resistance is a serious challenge, driving the search for new alternative molecules like AMPs as potential next-generation antibiotics. AMPs, as bioactive small proteins naturally produced by all living organisms, have aroused great interest for their ability to serve as the first line of defense against fungi, viruses, and bacteria.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Review Microbiology

Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

Zhanyi Yang et al.

Summary: Antimicrobial peptides (AMPs) are considered a viable alternative to antibiotics due to their broad-spectrum antimicrobial activity and ease of synthesis, but they have disadvantages such as low bioavailability, poor protease resistance, and high cytotoxicity. Nanostructured antimicrobial peptides (Ns-AMPs) address these limitations through various nanosystem modifications, improving therapeutic efficacy and reducing side effects. This review highlights the advantages of Ns-AMPs in terms of biological stability and antimicrobial activity, as well as discussing their controlled release mechanisms and future research directions.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Chemistry, Medicinal

Antibiotic Potentiation in Multidrug-Resistant Gram-Negative Pathogenic Bacteria by a Synthetic Peptidomimetic

Elnaz Harifi Mood et al.

Summary: The peptidomimetic CEP-136 significantly potentiates the antibacterial activity of clinically important antibiotics against several human pathogens, showing strong synergy with some combinations resulting in over 50-fold reduction in antibiotic concentration. Mechanistic studies suggest the potentiation effect arises from permeabilization of the Gram-negative bacteria's outer membrane lipopolysaccharide layer. Additionally, CEP-136 exhibits low toxicity to mammalian cells and mice, making it a promising compound for developing adjuvants to combat infections by multidrug-resistant Gram-negative bacteria.

ACS INFECTIOUS DISEASES (2021)

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Review Medicine, General & Internal

Antimicrobial peptides: mechanism of action, activity and clinical potential

Qi-Yu Zhang et al.

Summary: Antimicrobial peptides (AMPs) are a promising candidate to combat antibiotic resistant bacteria, showing broad-spectrum antimicrobial activity with low toxicity and utilizing sophisticated mechanisms of action. This comprehensive review provides an overview of the origin, structural characteristics, mechanisms of action, biological activities, and clinical applications of AMPs. Strategies to optimize and develop AMP-based treatments for potential antimicrobial and anticancer therapeutics are also discussed.

MILITARY MEDICAL RESEARCH (2021)

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Review Engineering, Biomedical

Developing Antimicrobial Synergy With AMPs

Leora Duong et al.

Summary: Antimicrobial peptides (AMPs) are being studied for their natural abundance and ability to kill microbes. Combining AMPs with other antimicrobials may improve their efficacy against bacteria resistant to AMPs, by keeping bacterial pores open for longer periods of time or preventing pore repair. Additional research is needed to fully understand the mechanisms behind these synergies and potentially improve drug design.

FRONTIERS IN MEDICAL TECHNOLOGY (2021)

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Review Medicine, Research & Experimental

Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria

Yuan Liu et al.

Summary: Antimicrobial resistance poses a global health challenge, but a combination of antibiotics and non-antibiotic compounds offers an effective strategy. A pathogen-by-pathogen approach highlights the critical value of drug repurposing.

THERANOSTICS (2021)

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Article Pharmacology & Pharmacy

Effect of antimicrobial peptides HNP-1 and hBD-1 on Staphylococcus aureus strains in vitro and in vivo

Albert Bolatchiev et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2020)

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Article Chemistry, Medicinal

Potentiation of Antibiotics against Gram-Negative Bacteria by Polymyxin B Analogue SPR741 from Unique Perturbation of the Outer Membrane

Shawn French et al.

ACS INFECTIOUS DISEASES (2020)

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Article Medicine, General & Internal

Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018

Olivier J. Wouters et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Plant Sciences

The isoleucic acid triad: distinct impacts on plant defense, root growth, and formation of reactive oxygen species

Sibylle Bauer et al.

JOURNAL OF EXPERIMENTAL BOTANY (2020)

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Review Immunology

Strategies in Translating the Therapeutic Potentials of Host Defense Peptides

Darren Shu Jeng Ting et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells

Rebecca L. Lloyd et al.

ONCOGENE (2020)

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Review Immunology

Antimicrobial Susceptibility Testing of Antimicrobial Peptides to Better Predict Efficacy

Derry K. Mercer et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Article Chemistry, Multidisciplinary

Individual Roles of Peptides PGLa and Magainin 2 in Synergistic Membrane Poration

Wendong Ma et al.

LANGMUIR (2020)

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Article Biochemistry & Molecular Biology

In Vitro Evaluation of Antimicrobial Peptide Tridecaptin M in Combination with Other Antibiotics against Multidrug ResistantAcinetobacter baumannii

Manoj Jangra et al.

MOLECULES (2020)

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Article Biochemistry & Molecular Biology

Synergistic Effect of Propidium Iodide and Small Molecule Antibiotics with the Antimicrobial Peptide Dendrimer G3KL against Gram-Negative Bacteria

Bee-Ha Gan et al.

MOLECULES (2020)

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Article Chemistry, Physical

Aggregation State of Synergistic Antimicrobial Peptides

Jacob M. Remington et al.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2020)

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Review Engineering, Biomedical

Revealing the Mechanisms of Synergistic Action of Two Magainin Antimicrobial Peptides

Burkhard Bechinger et al.

FRONTIERS IN MEDICAL TECHNOLOGY (2020)

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Review Engineering, Biomedical

Mode-of-Action of Antimicrobial Peptides: Membrane Disruption vs. Intracellular Mechanisms

Aurelie H. Benfield et al.

FRONTIERS IN MEDICAL TECHNOLOGY (2020)

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Article Microbiology

Cationic antimicrobial peptides: alternatives and/or adjuvants to antibiotics active againstmethicillin-resistant Staphylococcus aureus and multidrug-resistantPseudomonas aeruginosa

Regina Geitani et al.

BMC MICROBIOLOGY (2019)

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Article Pharmacology & Pharmacy

Pharmacodynamic Drug-Drug Interactions

Jin Niu et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)

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Article Biochemistry & Molecular Biology

Evaluation of the Antimicrobial Activity of Cationic Peptides Loaded in Surface-Modified Nanoliposomes against Foodborne Bacteria

Stefania Cantor et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Oncology

Effects of the antimicrobial peptide L12 against multidrug-resistant Staphylococcus aureus

Fu Xiong et al.

MOLECULAR MEDICINE REPORTS (2019)

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Review Cell Biology

Bacterial Metabolism and Antibiotic Efficacy

Jonathan M. Stokes et al.

CELL METABOLISM (2019)

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Editorial Material Microbiology

Combinatory Therapy Antimicrobial Peptide-Antibiotic to Minimize the Ongoing Rise of Resistance

Luis R. Pizzolato-Cezar et al.

FRONTIERS IN MICROBIOLOGY (2019)

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Review Microbiology

Antibiotics: past, present and future

Matthew I. Hutchings et al.

CURRENT OPINION IN MICROBIOLOGY (2019)

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Article Microbiology

Synergistic Antibacterial Activity of Designed Trp-Containing Antibacterial Peptides in Combination With Antibiotics Against Multidrug-Resistant Staphylococcus epidermidis

Dejing Shang et al.

FRONTIERS IN MICROBIOLOGY (2019)

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Article Chemistry, Multidisciplinary

Antimicrobial synergy of monolaurin lipid nanocapsules with adsorbed antimicrobial peptides against Staphylococcus aureus biofilms in vitro is absent in vivo

Rene T. Rozenbaum et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Infectious Diseases

Highly Synergistic Effects of Melittin with Conventional Antibiotics Against Multidrug-Resistant Isolates of Acinetobacter baumannii and Pseudomonas aeruginosa

Reza Akbari et al.

MICROBIAL DRUG RESISTANCE (2019)

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Review Microbiology

Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions

Nigare Raheem et al.

FRONTIERS IN MICROBIOLOGY (2019)

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Article Infectious Diseases

A Pilot Study of the Synergy between Two Antimicrobial Peptides and Two Common Antibiotics

Franziska Kampshoff et al.

ANTIBIOTICS-BASEL (2019)

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Article Microbiology

Assessment of the In Vivo Activity of SPR741 in Combination with Azithromycin against Multidrug-Resistant Enterobacteriaceae Isolates in the Neutropenic Murine Thigh Infection Model

Sean M. Stainton et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

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Article Microbiology

Synergistic and antibiofilm properties of ocellatin peptides against multidrug-resistant Pseudomonas aeruginosa

Lucinda J. Bessa et al.

FUTURE MICROBIOLOGY (2018)

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Article Infectious Diseases

Antimicrobial Peptides: Features, Action, and Their Resistance Mechanisms in Bacteria

Hoda Moravej et al.

MICROBIAL DRUG RESISTANCE (2018)

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Review Biochemistry & Molecular Biology

The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs

Alicia Boto et al.

MOLECULES (2018)

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Article Multidisciplinary Sciences

CISNE: An accurate description of dose-effect and synergism in combination therapies

Amador Garcia-Fuente et al.

SCIENTIFIC REPORTS (2018)

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From Antimicrobial Peptides to Antimicrobial Poly(alpha-amino acid)s

Wei Shen et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Microbiology

Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens

Daniel Pletzer et al.

PLOS PATHOGENS (2018)

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Review Chemistry, Multidisciplinary

Antimicrobial Peptides: Interaction With Model and Biological Membranes and Synergism With Chemical Antibiotics

Axel Hollmann et al.

FRONTIERS IN CHEMISTRY (2018)

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Review Biochemistry & Molecular Biology

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

Jinzhong Lin et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

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Article Chemistry, Multidisciplinary

Synergy Between Proline-Rich Antimicrobial Peptides and Small Molecule Antibiotics Against Selected Gram-Negative Pathogens in vitro and in vivo

Laszlo Otvos et al.

FRONTIERS IN CHEMISTRY (2018)

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Article Multidisciplinary Sciences

Natural molecules induce and synergize to boost expression of the human antimicrobial peptide beta-defensin-3

Emmanuel Sechet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Infectious Diseases

Synergistic activity of synthetic N-terminal peptide of human lactoferrin in combination with various antibiotics against carbapenem-resistant Klebsiella pneumoniae strains

P. Morici et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2017)

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Article Chemistry, Medicinal

LL-37-derived short antimicrobial peptide KR-12-a5 and its D-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with conventional antibiotics, and anti-inflammatory activity

Eun Young Kim et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Article Pharmacology & Pharmacy

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