期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2022.1016001
关键词
infection; antibacterial coating; Staphylococcus aureus; layer-by-layer; microenvironment
Bone implant-associated infection is a challenging problem. Developing drug-loaded antibacterial coatings for metal implants is of interest but achieving stable local drug release is difficult. This study confirmed the successful assembly of multilamellar membrane structures and showed gradual degradation of the (MMT/HA)(10) multilamellar film structure with concentration-dependent degradation during incubation. The results demonstrated good antibacterial properties and biocompatibility of the (MMT/HA-rifampicin)(10) multilamellar film structure.
Bone implant-associated infection is one of the most challenging problems encountered by orthopedic surgeons. There is considerable interest in the development of drug-loaded antibacterial coatings for the surfaces of metal implants. However, it is difficult to achieve the stable local release of an effective drug dose for many antibacterial coatings. In the present study, analyses of the thickness and water contact angle of multiple layers confirmed the successful assembly of multilamellar membrane structures. Measurement of the zone of bacterial inhibition indicated gradual degradation of the (montmorillonite [MMT]/hyaluronic acid [HA])(10) multilamellar film structure with concentration-dependent degradation during incubation with hyaluronidase solution and Staphylococcus aureus. In vivo results resembled the in vitro results. Overall, the findings confirm that the (MMT/HA-rifampicin)(10) multilamellar film structure exhibits good antibacterial properties and excellent biocompatibility. Further studies of the clinical potential of the antibacterial coating prepared in this experiment are warranted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据