☆ 4.7 Article

Wnt signaling directs human pluripotent stem cells into vascularized cardiac organoids with chamber-like structures

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Engineering, Biomedical

Chemically-defined generation of human hemogenic endothelium and definitive hematopoietic progenitor cells

Yun Chang et al.

Summary: This study demonstrates the successful generation of AGM-like hematopoietic system from human pluripotent stem cells through temporal manipulation of Wnt signaling. The generated hematopoietic progenitor cells resemble primary cord blood HSCs at the transcriptional level and exhibit lymphoid and myeloid potential in vitro. The cells also show the ability to home to a definitive hematopoietic site, rescue bloodless zebrafish, and engraft and repopulate in mouse recipients.

BIOMATERIALS (2022)

添加到收藏夹

Article Cell & Tissue Engineering

BMP10 Signaling Promotes the Development of Endocardial Cells from Human Pluripotent Stem Cell-Derived Cardiovascular Progenitors

Alexander A. Mikryukov et al.

Summary: The embryonic endocardium plays a vital role in early heart development by inducing the formation of trabecular myocardium, the source of valvular cells and part of the coronary vasculature. Human endocardial cells offer unique therapeutic opportunities, such as engineering biological valves and cell-based therapy for damaged hearts. By generating hPSC-derived endothelial cells, key signaling pathways for the development of endocardial cells were identified, with a novel role for BMP10 in lineage specification.

CELL STEM CELL (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Adiponectin, Leptin and Cardiovascular Disorders

Shangang Zhao et al.

Summary: The discovery of leptin and adiponectin established adipose tissue as an important endocrine organ in cardiovascular health. Normal levels of adiponectin and leptin are crucial for proper cardiovascular function, while both excess and insufficient levels may contribute to cardiovascular disorders. High levels of both adiponectin and leptin are a paradoxical factor in the pathogenesis of cardiovascular diseases.

CIRCULATION RESEARCH (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Human heart-forming organoids recapitulate early heart and foregut development

Lika Drakhlis et al.

Summary: This study successfully generated three-dimensional heart-forming organoids that closely resemble early native heart anlagen, containing myocardial layer, endocardial-like cells, septum-transversum-like anlagen, and distinct anterior versus posterior foregut endoderm tissues. These organoids were used to study genetic defects in vitro and demonstrated a phenotype similar to cardiac malformations seen in transgenic mice with the knockout of NKX2.5 gene.

NATURE BIOTECHNOLOGY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Non-cardiovascular disorders in a contemporary cardiovascular intensive care unit in Japan

Kosuke Kadooka et al.

Summary: The study found that approximately half of patients admitted to the CICU had non-cardiovascular disorders, including acute respiratory failure and sepsis, which were significantly associated with mortality in the CICU. Acute kidney injury was also significantly associated with the length of stay in the CICU.

JOURNAL OF CARDIOLOGY (2021)

添加到收藏夹

Editorial Material Biochemical Research Methods

Recapitulating early cardiogenesis in vitro

Madhura Mukhopadhyay

NATURE METHODS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cardioids reveal self-organizing principles of human cardiogenesis

Pablo Hofbauer et al.

Summary: Organoids derived from human pluripotent stem cells can spontaneously form chamber-like structures resembling the human heart, which can be controlled and manipulated for studying heart diseases and regeneration. The establishment of self-organizing cardioids provides a powerful platform for mechanistic studies on developmental defects and potential translational research in the future.

CELL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro

Jun Jie Tan et al.

Summary: The study demonstrates the generation of premature PECs using BVR stimulation, co-culturing PECs with cardiomyocytes leads to cardiomyocyte aggregation, proliferation and the formation of more mature structures with improved beating/contractility.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease

Yonatan R. Lewis-Israeli et al.

Summary: The study presents a method to generate human heart organoids using pluripotent stem cells, which are comparable to fetal cardiac tissues at transcriptomic, structural, and cellular levels. These organoids exhibit sophisticated internal chambers, well-organized cardiac cell types, heart field formation, atrioventricular specification, and a complex vasculature, with robust functional activity. Additionally, the organoid platform can reproduce metabolic disorders associated with congenital heart defects, such as pregestational diabetes-induced congenital heart defects.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Review Obstetrics & Gynecology

The Transitional Heart: From Early Embryonic and Fetal Development to Neonatal Life

Cheryl Mei Jun Tan et al.

FETAL DIAGNOSIS AND THERAPY (2020)

添加到收藏夹

Article Cell & Tissue Engineering

Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway

Richard J. Mills et al.

CELL STEM CELL (2019)

添加到收藏夹

Review Biochemical Research Methods

Three-dimensional microengineered models of human cardiac diseases

Jaimeson Veldhuizen et al.

JOURNAL OF BIOLOGICAL ENGINEERING (2019)

添加到收藏夹

Article Cell Biology

Cardiac endothelial cell transcriptome in neonatal, adult, and remodeling hearts

Zarha Vermeulen et al.

PHYSIOLOGICAL GENOMICS (2019)

添加到收藏夹

Article Engineering, Biomedical

Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions

Xiaoping Bao et al.

NATURE BIOMEDICAL ENGINEERING (2017)

添加到收藏夹

Article Biochemical Research Methods

Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions

Xiaoping Bao et al.

NATURE PROTOCOLS (2017)

添加到收藏夹

Review Engineering, Biomedical

Nanomaterials for treating cardiovascular diseases: A review

Wensen Jiang et al.

BIOACTIVE MATERIALS (2017)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Human pluripotent stem cell-derived epicardial progenitors can differentiate to endocardial-like endothelial cells

Xiaoping Bao et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2017)

添加到收藏夹

Article Developmental Biology

Development of a human cardiac organoid injury model reveals innate regenerative potential

Holly K. Voges et al.

DEVELOPMENT (2017)

添加到收藏夹

Article Developmental Biology

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells

Elisa Giacomelli et al.

DEVELOPMENT (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

In vitro cardiac tissue models: Current status and future prospects

Anurag Mathur et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

添加到收藏夹

Letter Biochemical Research Methods

Chemically defined, albumin-free human cardiomyocyte generation

Xiaojun Lian et al.

NATURE METHODS (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Prolonged presence of VEGF promotes vascularization in 3D bioprinted scaffolds with defined architecture

Michelle T. Poldervaart et al.

JOURNAL OF CONTROLLED RELEASE (2014)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Cardiovascular Pharmacogenomics: The Future of Cardiovascular Therapeutics?

Dan M. Roden

CANADIAN JOURNAL OF CARDIOLOGY (2013)

添加到收藏夹

Article Biochemical Research Methods

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/beta-catenin signaling under fully defined conditions

Xiaojun Lian et al.

NATURE PROTOCOLS (2013)

添加到收藏夹

Review Genetics & Heredity

Anti-Inflammatory Gene Therapy for Cardiovascular Disease

Tetsuya Matoba et al.

CURRENT GENE THERAPY (2011)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Arsenic Exposure and Cardiovascular Disorders: An Overview

Pitchai Balakumar et al.

CARDIOVASCULAR TOXICOLOGY (2009)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.