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Review
Biochemistry & Molecular Biology
Cellular and molecular actors of myeloid cell fusion: podosomes and tunneling nanotubes call the tune
Ophelie Dufrancais et al.
Summary: Different types of multinucleated giant cells (MGCs) derived from the monocyte/macrophage lineage have been observed in pathological conditions, but their precise roles and formation mechanisms remain poorly understood due to their heterogeneity. This review highlights the known molecular actors in the early stages of fusion, particularly focusing on cell-surface receptors involved in cell-to-cell adhesion steps leading to multinucleation. Additionally, the evolution of F-actin-based structures, such as podosomes, zipper-like structures, and tunneling nanotubes (TNT), that are involved in macrophage fusion, is discussed.
CELLULAR AND MOLECULAR LIFE SCIENCES (2021)
Review
Biotechnology & Applied Microbiology
New therapeutic agents for the treatment of bone diseases
A Lipton
EXPERT OPINION ON BIOLOGICAL THERAPY (2005)