期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2023.1112954
关键词
seipin; lipid droplet; lipid droplet-ER contact sites; membrane contact site; endoplasmic reticulum; mitochondria-ER contact sites
Cells store excess energy in lipid droplets (LDs), and the lipodystrophy protein seipin plays a crucial role in LD biogenesis and ER-LD contact site maintenance. Recent studies have provided insights into the molecular function of seipin as a LD nucleator in early LD biogenesis and its potential involvement in ER-mitochondria contact sites and calcium metabolism. This minireview discusses these recent findings.
Cells store excess energy in the form of lipid droplets (LDs), a specialized sub-compartment of the endoplasmic reticulum (ER) network. The lipodystrophy protein seipin is a key player in LD biogenesis and ER-LD contact site maintenance. Recent structural and in silico studies have started to shed light on the molecular function of seipin as a LD nucleator in early LD biogenesis, whilst new cell biological work implies a role for seipin in ER-mitochondria contact sites and calcium metabolism. In this minireview, I discuss recent insights into the molecular function of seipin.
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