期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.1044198
关键词
placenta; trophoblast; single-cell sequencing; pathogenesis; placenta accreta spectrum
资金
- National Key R&D Program of China
- National Natural Science Foundation of China-Major program
- National Key Technologies R&D program of China
- Ferring Institute of Reproductive Medicine (FIRM) Project fund
- National Key Technologies R&D programme of China [FIRMA180305]
- National Natural Science Foundation of China
- [82001562]
This study used single-cell RNA-sequencing analysis to investigate the pathological landscape of invasive placenta accreta spectrum disorders (PAS) placenta and revealed the interaction between invasive trophoblasts and maternal stromal cells during the invasion process. The study also presented the immune microenvironmental landscape of invasive PAS. These findings provide a foundation for future research on PAS.
Placenta accreta spectrum disorders (PAS) are severe pregnancy complications that occur when extravillous trophoblast cells (EVTs) invade beyond the uterine inner myometrium and are characterized by hypervascularity on prenatal ultrasound and catastrophic postpartum hemorrhage. The potential mechanisms remain incompletely understood. With single-cell RNA-sequencing analysis on the representative invasive parts and the normal part obtained from the same PAS placenta, we profiled the pathological landscape of invasive PAS placenta and deciphered an intensified differentiation pathway from progenitor cytotrophoblasts (CTBs) to EVTs via LAMB4 (+) and KRT6A (+) CTBs. In the absence of the decidua, the invasive trophoblasts of various differentiation states interacted with ADIRF (+) and DES (+) maternal stromal cells. The PAS-associated hypervascularity might be due to the enhanced crosstalk of trophoblasts, stromal cells and vascular endothelial cells. Finally, we presented an immune microenvironmental landscape of invasive PAS. The pathogenesis of PAS could be further explored with current resources for future targeted translational studies.
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