4.7 Review

Moving through a changing world: Single cell migration in 2D vs. 3D

期刊

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.1080995

关键词

cell migration; cytoskeletal forces; extracellular matrix; self-organization; membrane curvature

资金

  1. Medical Faculty of the University of Munster (IZKF)
  2. DFG [Ga3/016/21]
  3. [GA2268/3-1]
  4. [GA2268/4-1]
  5. [CRC1348/A06]

向作者/读者索取更多资源

This review discusses the differences in cell migration between 3D and 2D environments, and how these differences affect subcellular structures and motion patterns.
Migration of single adherent cells is frequently observed in the developing and adult organism and has been the subject of many studies. Yet, while elegant work has elucidated molecular and mechanical cues affecting motion dynamics on a flat surface, it remains less clear how cells migrate in a 3D setting. In this review, we explore the changing parameters encountered by cells navigating through a 3D microenvironment compared to cells crawling on top of a 2D surface, and how these differences alter subcellular structures required for propulsion. We further discuss how such changes at the micro-scale impact motion pattern at the macro-scale.

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