期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.1092776
关键词
osteoarthritis; cartilage homeostasis; microRNA; lncRNA; regeneration
资金
- Shanghai three year clinical plan on TCM development
- clinical major project of Integrative Medicine [SHDC2020CR1051B]
- National Natural Science Foundation of China [82004395]
Osteoarthritis (OA) is a common musculoskeletal disease that is characterized by progressive loss of articular cartilage and other pathological changes. Non-coding RNAs (ncRNAs), especially miRNAs and lncRNAs, play vital roles in regulating cartilage homeostasis and the progression of OA. Changes in ncRNA expression levels can promote or decelerate OA progression through distinct molecular mechanisms. The potential of ncRNAs as diagnostic biomarkers, prognostic indicators, and therapeutic targets for OA has been emphasized.
During the last decade, osteoarthritis (OA) has become one of the most prevalent musculoskeletal diseases worldwide. OA is characterized by progressive loss of articular cartilage, abnormal remodeling of subchondral bone, hyperplasia of synovial cells, and growth of osteophytes, which lead to chronic pain and disability. The pathological mechanisms underlying OA initiation and progression are still poorly understood. Non-coding RNAs (ncRNAs) constitute a large portion of the transcriptome that do not encode proteins but function in numerous biological processes. Cumulating evidence has revealed a strong association between the changes in expression levels of ncRNA and the disease progression of OA. Moreover, loss- and gain-of-function studies utilizing transgenic animal models have demonstrated that ncRNAs exert vital functions in regulating cartilage homeostasis, degeneration, and regeneration, and changes in ncRNA expression can promote or decelerate the progression of OA through distinct molecular mechanisms. Recent studies highlighted the potential of ncRNAs to serve as diagnostic biomarkers, prognostic indicators, and therapeutic targets for OA. MiRNAs and lncRNAs are two major classes of ncRNAs that have been the most widely studied in cartilage tissues. In this review, we focused on miRNAs and lncRNAs and provided a comprehensive understanding of their functional roles as well as molecular mechanisms in cartilage homeostasis and OA pathogenesis.
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