4.7 Article

Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Ferret Lung Transplantation Models Differential Lymphoid Aggregate Morphology Between Restrictive and Obstructive Forms of Chronic Lung Allograft Dysfunction

Thomas J. Lynch et al.

Summary: This study utilized a ferret transplantation model to investigate the characteristics and pathogenesis of obliterative bronchiolitis (OB) and restrictive alveolar fibroelastosis (AFE) in chronic lung allograft dysfunction (CLAD). The results showed that both OB and AFE allografts developed tertiary lymphoid organs (TLOs), but AFE had larger and more abundant TLOs. The expression of B-cell lymphoma 6 Transcription Repressor (BCL-6) and forkhead box P3 were associated with AFE, along with higher levels of immunoglobulins, plasma cells, and complement 4d. This study provides valuable insights into the factors contributing to OB and AFE, and may guide the development of immunomodulatory and antifibrotic therapies for lung transplant patients.

TRANSPLANTATION (2022)

Article Cell & Tissue Engineering

Sox9 and Lef1 Regulate the Fate and Behavior of Airway Glandular Progenitors in Response to Injury

Vitaly Ievlev et al.

Summary: Cartilaginous airways of larger mammals and the mouse trachea contain distinct stem cell compartments that play important roles in maintaining and repairing the airway epithelium. We found that glandular progenitors expressing Sox9 decline with age in mice and are unable to produce secretory cells. Lef1 and Sox9 signals regulate the proliferation and migration behavior of glandular progenitors, respectively.

STEM CELLS (2022)

Article Biochemistry & Molecular Biology

Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition

Gianni Carraro et al.

Summary: Single-cell RNA profiling of human cystic fibrosis proximal airway tissue shows an abundance of epithelial cells transitioning to specialized ciliated and secretory cells, coupled with a decrease in cycling basal cells. The study provides insights into disease-related changes and offers potential for the development of new targeted therapies for cystic fibrosis airway disease.

NATURE MEDICINE (2021)

Article Cell Biology

Stem cells and lung regeneration

Kalpaj R. Parekh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

Article Critical Care Medicine

A Single-Cell Atlas of the Human Healthy Airways

Marie Deprez et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Article Multidisciplinary Sciences

Genetic compensation triggered by mutant mRNA degradation

Mohamed A. El-Brolosy et al.

NATURE (2019)

Article Critical Care Medicine

Depletion of Airway Submucosal Glands and TP63(+)KRT5(+) Basal Cells in Obliterative Bronchiolitis

Anthony M. Swatek et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Article Cell & Tissue Engineering

Mouse Intestinal Krt15+ Crypt Cells Are Radio-Resistant and Tumor Initiating

Veronique Giroux et al.

STEM CELL REPORTS (2018)

Article Medicine, Research & Experimental

Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration

Veronique Giroux et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Biochemistry & Molecular Biology

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores

Alberto Elosegui-Artola et al.

Article Critical Care Medicine

Advances in Understanding Bronchiolitis Obliterans After Lung Transplantation

Stijn E. Verleden et al.

Article Biochemistry & Molecular Biology

Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration

Ya-Chieh Hsu et al.

Article Dermatology

Crosstalk among p53 family members in cutaneous carcinoma

Caterina Missero et al.

EXPERIMENTAL DERMATOLOGY (2014)

Article Dermatology

Interaction of Plectin with Keratins 5 and 14: Dependence on Several Plectin Domains and Keratin Quaternary Structure

Jamal-Eddine Bouameur et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

Article Biochemistry & Molecular Biology

Loss of Basal Cells Precedes Bronchiolitis Obliterans-Like Pathological Changes in a Murine Model of Chlorine Gas Inhalation

Emily G. O'Koren et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Keratin K15 as a Biomarker of Epidermal Stem Cells

Amrita Bose et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Dermatology

The Cell Cycle Regulator Protein 14-3-3σ Is Essential for Hair Follicle Integrity and Epidermal Homeostasis

Nigel L. Hammond et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)

Article Biochemistry & Molecular Biology

Structural basis for heteromeric assembly and perinuclear organization of keratin filaments

Chang-Hun Lee et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Respiratory System

Repair of tracheal epithelium by basal cells after chlorine-induced injury

Sadiatu Musah et al.

RESPIRATORY RESEARCH (2012)

Article Biochemistry & Molecular Biology

Context-Dependent Differentiation of Multipotential Keratin 14-Expressing Tracheal Basal Cells

Moumita Ghosh et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)

Article Oncology

14-3-3Σ and p63 play opposing roles in epidermal tumorigenesis

Qiutang Li et al.

CARCINOGENESIS (2011)

Editorial Material Cardiac & Cardiovascular Systems

The Registry of the International Society for Heart and Lung Transplantation: Twenty-eighth Adult Lung and Heart-Lung Transplant Report-2011

Jason D. Christie et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2011)

Article Pathology

Tracheal Basal Cells A Facultative Progenitor Cell Pool

Brook B. Cole et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

Article Multidisciplinary Sciences

Basal cells as stem cells of the mouse trachea and human airway epithelium

Jason R. Rock et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

14-3-3σ positively regulates p53 and suppresses tumor growth

HY Yang et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)