期刊
CELL METABOLISM
卷 22, 期 5, 页码 886-894出版社
CELL PRESS
DOI: 10.1016/j.cmet.2015.08.020
关键词
-
资金
- Deutsche Forschungsgemeinschaft [CRC1181, SPP1468, BO3811/1-1, SPP1556]
- Bundesministerium fur Bildung und Forschung (BMBF)
- European Union (EU-FP7)
- IMI
- Marie Curie program (project Osteoimmune)
The effect of metabolic stress on the bone marrow microenvironment is poorly defined. We show that high-fat diet (HFD) decreased long-term Lin(-)Sca-1(+)c-Kit(+) (LSK) stem cells and shifted lymphoid to myeloid cell differentiation. Bone marrow niche function was impaired after HFD as shown by poor reconstitution of hematopoietic stem cells. HFD led to robust activation of PPAR gamma 2, which impaired osteoblastogenesis while enhancing bone marrow adipogenesis. At the same time, expression of genes such as Jag-1, SDF-1, and IL-7 forming the bone marrow niche was highly suppressed after HFD. Moreover, structural changes of microbiota were associated to HFD-induced bone marrow changes. Antibiotic treatment partially rescued HFD-mediated effects on the bone marrow niche, while transplantation of stools from HFD mice could transfer the effect to normal mice. These findings show that metabolic stress affects the bone marrow niche by alterations of gut microbiota and osteoblast-adipocyte homeostasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据