期刊
CELL HOST & MICROBE
卷 17, 期 5, 页码 704-715出版社
CELL PRESS
DOI: 10.1016/j.chom.2015.03.008
关键词
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资金
- NHMRC of Australia [1049539, 1061409, 1061435]
- Australian Heart Foundation
- Victorian Life Sciences Computation Initiative (VLSCI) [VR0082]
- Asthma UK [CH11SJ]
- Medical Research Council Centre [G1000758]
- NIH [U19 AI104317, P01 HL070831]
- National Health and Medical Research Council of Australia [1061435] Funding Source: NHMRC
- Asthma UK [CH11SJ] Funding Source: researchfish
- Medical Research Council [G1000758] Funding Source: researchfish
The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthma development. We examined the NP microbiome during the critical first year of life in a prospective cohort of 234 children, capturing both the viral and bacterial communities and documenting all incidents of ARIs. Most infants were initially colonized with Staphylococcus or Corynebacterium before stable colonization with Alloiococcus or Moraxella. Transient incursions of Streptococcus, Moraxella, or Haemophilus marked virus-associated ARIs. Our data identify the NP microbiome as a determinant for infection spread to the lower airways, severity of accompanying inflammatory symptoms, and risk for future asthma development. Early asymptomatic colonization with Streptococcus was a strong asthma predictor, and antibiotic usage disrupted asymptomatic colonization patterns. In the absence of effective anti-viral therapies, targeting pathogenic bacteria within the NP microbiome could represent a prophylactic approach to asthma.
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