期刊
CELL HOST & MICROBE
卷 18, 期 5, 页码 582-592出版社
CELL PRESS
DOI: 10.1016/j.chom.2015.10.007
关键词
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资金
- Swedish Research Council
- Swedish Cancer Foundation
- Knut and Alice Wallenberg Foundation
- IngaBritt and Arne Lundberg Foundation
- Sahlgren's University Hospital (LUA-ALF)
- Wilhelm and Martina Lundgren's Foundation
- Clas Groschinsky Foundation
- T. Soderberg Foundation
- Sahlgrenska Academy
- National Institute of Allergy and Infectious Diseases [U01AI095473]
- Swedish Foundation for Strategic Research-The Mucus-Bacteria-Colitis Center (MBC) of the Innate Immunity Program
The intestinal mucus layer provides a barrier limiting bacterial contact with the underlying epithelium. Mucus structure is shaped by intestinal location and the microbiota. To understand how commensals modulate gut mucus, we examined mucus properties under germ-free (GF) conditions and during microbial colonization. Although the colon mucus organization of GF mice was similar to that of conventionally raised (Convr) mice, the GF inner mucus layer was penetrable to bacteria-sized beads. During colonization, in which GF mice were gavaged with Convr microbiota, the small intestine mucus required 5 weeks to be normally detached and colonic inner mucus 6 weeks to become impenetrable. The composition of the small intestinal microbiota during colonization was similar to Convr donors until 3 weeks, when Bacteroides increased, Firmicutes decreased, and segmented filamentous bacteria became undetectable. These findings highlight the dynamics of mucus layer development and indicate that studies of mature microbe-mucus interactions should be conducted weeks after colonization.
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