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Kinesin family member 3A induces related diseases via wingless-related integration site/β-catenin signaling pathway

SCIENCE PROGRESS (2023)

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Article Oncology

Effectiveness of PD-(L)1 inhibitors alone or in combination with platinum-doublet chemotherapy in first-line (1L) non-squamous non-small-cell lung cancer (Nsq-NSCLC) with PD-L1-high expression using real-world data

M. Perol et al.

Summary: In patients with non-squamous non-small-cell lung cancer (NSCLC) with high PD-L1 expression, the choice between anti-PD-(L)1 monotherapy and combination with platinum-based chemotherapy did not significantly affect overall survival and real-world progression-free survival. However, CIT-chemo showed significant improvement in survival outcomes in the never-smoker subgroup.

ANNALS OF ONCOLOGY (2022)

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Review Oncology

Low-risk triple-negative breast cancers: Clinico-pathological and molecular features

Nicola Fusco et al.

Summary: Triple-negative breast cancers (TNBC) are characterized by the lack of hormone receptors and HER2 expression. There is a subset of low-risk TNBC with minimal metastatic potential, but reducing treatment is challenging. Studying the clinical and molecular features of low-risk TNBC can lead to improved clinical treatment.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2022)

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Review Biochemistry & Molecular Biology

Understanding how kinesin motor proteins regulate postsynaptic function in neuron

Ruolin Fan et al.

Summary: Kinesin superfamily proteins (KIFs) are essential molecular motors that transport cargoes to both axons and dendrites of neurons, influencing synaptic development and plasticity. This review summarizes major kinesin motors and their associated cargoes, discussing their roles in regulating postsynaptic function in neurons.

FEBS JOURNAL (2022)

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Article Endocrinology & Metabolism

Primary Cilia Direct Murine Articular Cartilage Tidemark Patterning Through Hedgehog Signaling and Ambulatory Load

Danielle Rux et al.

Summary: This study reveals the involvement of primary cilia in postnatal articular cartilage morphogenesis, including tidemark topography, zonal matrix composition, and load response.

JOURNAL OF BONE AND MINERAL RESEARCH (2022)

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Article Cell Biology

Cell cycle arrest induced by trichoplein depletion is independent of cilia assembly

Min Huang et al.

Summary: The protein TCHP plays a crucial role in cell cycle progression by disassembling cilia, and its depletion leads to cell cycle arrest in G(0) phase, which cannot be reversed by blocking cilia assembly. Additionally, TCHP-induced cell cycle arrest is not mediated by centrosome surveillance mechanism, but requires inhibition of Rb or both Rb and p53 signaling pathways to reverse the phenotype.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Review Dentistry, Oral Surgery & Medicine

Role of Primary Cilia in Bone and Cartilage

Z. Chinipardaz et al.

Summary: The primary cilium, a nonmotile microtubule-based organelle, plays a critical role in tissue development and homeostasis by sensing and transducing various signaling pathways. Mutations in ciliary proteins lead to ciliopathies and abnormalities in tooth development, highlighting the significance of primary cilia in skeletal development. Cilia are necessary for signaling propagation during osteogenesis and chondrogenesis, and also play a key role in mechanosensing for increased bone formation in response to mechanical forces.

JOURNAL OF DENTAL RESEARCH (2022)

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Review Chemistry, Medicinal

Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases

Li Wang et al.

Summary: GSK3 is a highly evolutionarily conserved serine/threonine protein kinase that regulates glycogen synthase in response to insulin stimulation. Its two isoforms, GSK3 alpha and GSK3 beta, are involved in various biological processes and are widely distributed in multiple cell types and tissues. Through animal model studies and the use of GSK3-specific inhibitors, its roles in regulating energy metabolism and homeostasis can be better understood.

MEDICINAL RESEARCH REVIEWS (2022)

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Editorial Material Cell Biology

The many regulators of epithelial-mesenchymal transition CoMMENT

Cameron P. Bracken et al.

Summary: The passage discusses the complexity of epithelial-mesenchymal transition (EMT) and questions whether the process truly requires so many regulators or if there are many 'false positives' reported in the literature.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Review Neurosciences

Primary cilia and ciliary signaling pathways in aging and age-related brain disorders

Rong Ma et al.

Summary: This review discusses the role of primary cilia in brain disorders, highlighting aging as a major risk factor and examining various cellular and molecular events involved in the progression of these diseases.

NEUROBIOLOGY OF DISEASE (2022)

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Article Nutrition & Dietetics

Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer

Juan C. Pardo et al.

Summary: Prostate cancer is the most commonly diagnosed male malignancy in the Western world. Metabolic reprogramming and epigenetic remodeling play important roles in the progression and therapy resistance of prostate cancer, and there is crosstalk between metabolism and epigenetics. A high-fat diet has been associated with prostate cancer progression. Understanding these alterations and mechanisms can help identify prognostic and predictive biomarkers, as well as targetable vulnerabilities.

NUTRIENTS (2022)

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Article Pharmacology & Pharmacy

Metformin Ameliorates Inflammation and Airway Remodeling of Experimental Allergic Asthma in Mice by Restoring AMPKα Activity

Wenxian Ma et al.

Summary: This study demonstrates that metformin can alleviate airway inflammation and remodeling in an OVA-induced chronic asthmatic model. The protective effects of metformin may be associated with the restoration of AMPKα activity and decreased asthma-related angiogenesis.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Oncology

Clinical Significance of the Duality of Wnt/β-Catenin Signaling in Human Hepatocellular Carcinoma

Tomoko Aoki et al.

Summary: Wnt/beta-catenin mutations in hepatocellular carcinomas (HCCs) can result in two distinct tumor phenotypes. The "Jekyll" phenotype, characterized by high HNF4 alpha status, is associated with low AFP levels, good prognosis, and repression of EMT. The "Hyde" phenotype, characterized by high FOXM1 status, is associated with high AFP levels, poor prognosis, and promotion of EMT. Imaging techniques such as Gd-EOB-DTPA-enhanced MRI and FGD-PET/CT can be used to detect the expression of OATP1B3 and GLUT1, respectively, which are markers for these phenotypes. Future research should focus on non-invasive detection of Wnt/beta-catenin activation and its application in the treatment of advanced HCC.

CANCERS (2022)

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Review Cell Biology

Epithelial Mesenchymal Transition (EMT) and Associated Invasive Adhesions in Solid and Haematological Tumours

David Greaves et al.

Summary: In solid tumors, EMT plays a crucial role in promoting invasive migration and drug resistance, while its association with poor prognosis in hematological tumors is still under investigation. Understanding the connection between EMT and specific types of adhesions in hematological malignancies may lead to new therapeutic interventions to overcome disease progression and resistance to therapies.

CELLS (2022)

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Review Cell Biology

Role of Canonical Wnt/β-Catenin Pathway in Regulating Chondrocytic Hypertrophy in Mesenchymal Stem Cell-Based Cartilage Tissue Engineering

Xueqi Wang et al.

Summary: This review examines the potential of mesenchymal stromal cells (MSCs) in cartilage repair based on animal studies conducted in the past three decades. However, the cartilage tissue derived from MSCs does not possess the same characteristics as native hyaline cartilage, especially in terms of chondrocytic hypertrophy. This undesired phenotype needs to be controlled before MSCs can be effectively used for cartilage repair in clinical settings. Current research focuses on suppressing hypertrophy and modulating the Wnt/β-catenin pathway to inhibit hypertrophy, along with exploring the potential crosstalk between Wnt/β-catenin and other pathways.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Oncology

Immunotherapy for early triple negative breast cancer: research agenda for the next decade

Paolo Tarantino et al.

Summary: Advancements in the treatment of localized triple negative breast cancer (TNBC) are reshaping the landscape of this disease, with the addition of pembrolizumab showing significant improvement in survival. However, there are still questions regarding patient selection, integration with other treatments, and minimizing side effects.

NPJ BREAST CANCER (2022)

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Managing the allergy and asthma epidemic in 2020s-Lessons from the Finnish experience

Tari Haahtela et al.

Summary: Finland implemented a systematic public health programme for a decade to reduce the burden of allergic disorders by revisiting prevention strategies. The programme emphasized on allergy health and the connection with the natural environment, improving allergy management practices. The results after ten years were favorable, with changes in healthcare practices, reduced disability among patients, and significant cost savings achieved.

ALLERGY (2022)

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Article Oncology

Combination of BMI1 and MAPK/ERK inhibitors is effective in medulloblastoma

Sara Badodi et al.

Summary: This study identifies the therapeutic potential of a combination treatment with BMI1 and MAPK/ERK inhibitors in BMI1(High);CHD7(Low) MB cells, and elucidates the role of the CHD7-BMI1-MAPK regulatory axis in the pathogenesis of MB.

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Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo

Maki Uenaka et al.

Summary: This study identifies a specific subset of mature osteoblast-derived extracellular vesicles (SOVs) that inhibit bone formation and enhance osteoclastogenesis. Co-culture experiments demonstrate that SOVs regulate the dynamic transition from bone-forming to bone-resorbing phases by suppressing osteoblast differentiation and promoting osteoclast differentiation. These findings reveal a mechanism of cell-to-cell communication controlling bone metabolism.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

PD-L1 mediates lung fibroblast to myofibroblast transition through Smad3 and β-catenin signaling pathways

Xia Guo et al.

Summary: PD-L1 may promote pulmonary fibrosis through both Smad3 and beta-catenin signaling, and may represent a novel interventional target for IPF.

SCIENTIFIC REPORTS (2022)

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Article Oncology

A synthetic targeted RNA demethylation system based on CRISPR-Cas13b inhibits bladder cancer progression

Ganglin Su et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

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Review Pharmacology & Pharmacy

Targeting hedgehog signaling in pancreatic ductal adenocarcinoma

Delphine Quatannens et al.

Summary: PDAC is a leading cause of cancer related death, with urgent need for effective therapies. Aberrant activation of the Hh signaling pathway in PDAC prompts it as a possible target for treatment, despite ongoing debate on its clinical benefits.

PHARMACOLOGY & THERAPEUTICS (2022)

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Review Medicine, Research & Experimental

β-Catenin signaling in hepatocellular carcinoma

Chuanrui Xu et al.

Summary: Deregulated Wnt/β-catenin signaling is a major genetic alteration in hepatocellular carcinoma (HCC), and its activation plays an oncogenic role in hepatocarcinogenesis. The activated pathway is associated with specific gene expression patterns and pathological features, and it synergizes with other signaling cascades to promote HCC formation. Therefore, understanding and targeting this pathway has important implications for the diagnosis, classification, and personalized treatment of HCC.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Review Cell & Tissue Engineering

On the horizon: Hedgehog signaling to heal broken bones

Stephanie T. Kuwahara et al.

Summary: Uncovering the molecular pathways involved in skeletal repair is a challenging task that requires a combination of in vitro assays and animal models. Genetic tests are crucial for providing definitive proof of the role of specific pathways in skeletal repair. The Hh pathway has shown potential in promoting cartilage and bone differentiation, but genetic evidence of its involvement in bone repair has been lacking. The use of emerging genetic tools may help to determine the precise role of Hh signaling in skeletal repair.

BONE RESEARCH (2022)

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Article Cell Biology

WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing

Ana R. G. De-Castro et al.

Summary: The study identified WDR-60 as a key player in the recruitment and dynamics of dynein-2, with its loss leading to reduced and slower retrograde IFT trains. Disrupting the NPHP module at the transition zone almost fully restored ciliary exit of underpowered retrograde trains in wdr-60 mutants.

JOURNAL OF CELL BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo

Qingchun Zhou et al.

Summary: The study reveals that KIF3A is highly expressed in bladder cancer, correlated with clinical features and associated with poor prognosis. The findings demonstrate that inhibition of KIF3A can result in cell cycle arrest in bladder cancer cells in vitro and impede tumor growth.

FEBS OPEN BIO (2021)

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Article Pharmacology & Pharmacy

Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma

Xiaohua Liu et al.

Summary: Medulloblastoma is a childhood malignant brain tumor with heterogeneous characteristics and lacks effective molecular targeted therapy. Compounds 25 and 35 show high potency in inhibiting hedgehog signaling and interacting with the transcriptional factor GLI, with potential to combat resistant and wild type smoothened receptor.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Neurosciences

Kif3a deletion prevents primary cilia assembly on oligodendrocyte progenitor cells, reduces oligodendrogenesis and impairs fine motor function

Carlie L. Cullen et al.

Summary: Primary cilia play a crucial role in the myelination process of oligodendrocyte progenitor cells, with their assembly regulated by the gene Kif3a. Deletion of Kif3a leads to decreased OPC proliferation and oligodendrogenesis, affecting fine motor coordination in specific brain regions.

GLIA (2021)

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Review Medicine, Research & Experimental

Recent advances in understanding ion transport mechanisms in polycystic kidney disease

Anastasia Sudarikova et al.

Summary: This review provides insights into the recent advancements in understanding electrolyte transport mechanisms in severe inherited renal disorders, particularly focusing on calcium and sodium transport in cystic cells and their implications in polycystic kidney disease.

CLINICAL SCIENCE (2021)

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Review Cell Biology

Motile cilia and airway disease

Marie Legendre et al.

Summary: The article discusses the role of regulated airway epithelial development in the differentiation of motile ciliated cells in the human respiratory tract, as well as ciliary dysfunction caused by genetic mutations. Advances in understanding respiratory epithelial development and ciliary biology have the potential to improve disease diagnosis, management, and family counseling.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2021)

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Article Cell Biology

WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing

Ana R. G. De-Castro et al.

Summary: WDR-60 plays a crucial role in the assembly and functions of cilia by regulating dynein-2 motor complex. Loss of WDR-60 impairs retrograde intraflagellar transport and disrupting the NPHP module partially restores ciliary exit for underpowered retrograde trains in wdr-60 mutants.

JOURNAL OF CELL BIOLOGY (2021)

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Article Genetics & Heredity

Renal plasticity revealed through reversal of polycystic kidney disease in mice

Ke Dong et al.

Summary: By re-activating Pkd genes in cystic kidneys, the phenotypic features of ADPKD can be rapidly reversed, leading to reduced cyst cell proliferation, activated autophagy, normalization of cystic tubules, decreased inflammation and fibrosis levels, and a smaller kidney size.

NATURE GENETICS (2021)

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Article Cell Biology

Phase separation of Axin organizes the β-catenin destruction complex

Junxiu Nong et al.

Summary: The liquid-liquid phase separation of Axin drives the formation of the destruction complex, facilitating the recruitment of other members and promoting phosphorylation of beta-catenin, critical for regulating Wnt/beta-catenin signaling.

JOURNAL OF CELL BIOLOGY (2021)

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Article Multidisciplinary Sciences

Loss of primary cilia promotes mitochondria-dependent apoptosis in thyroid cancer

Junguee Lee et al.

Summary: The primary cilium is well-preserved in human differentiated thyroid cancers, but specific types of thyroid cancers associated with abnormalities in mitochondrial function show reduced biogenesis of primary cilia. Experimental results suggest that defective ciliogenesis caused by loss-of-function of primary cilia in thyroid cancer cells can lead to apoptogenic stimuli and mitochondrial-dependent apoptotic cell death.

SCIENTIFIC REPORTS (2021)

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Article Cell Biology

Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression

Yuwei Li et al.

Journal of Molecular Cell Biology (2021)

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Article Oncology

Triptolide inhibits epithelial-mesenchymal transition phenotype through the p70S6k/GSK3/β-catenin signaling pathway in taxol-resistant human lung adenocarcinoma

Yu Tian et al.

Summary: The study demonstrates that triptolide can reverse epithelial-mesenchymal transition in taxol-resistant lung adenocarcinoma cells and inhibit tumor growth by suppressing the p70S6K/GSK3/β-catenin pathway, suggesting its potential as a new therapeutic agent for taxol-resistant lung adenocarcinoma.

TRANSLATIONAL LUNG CANCER RESEARCH (2021)

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Review Physiology

Primary Cilia Are Critical Regulators of White Adipose Tissue Expansion

Keren Hilgendorf

Summary: Primary cilia are microtubule-based cellular protrusions found in most mammalian cell types, functioning as cellular antennas to sense and transduce signals. They have emerged as critical regulators of metabolism, particularly playing a key role in obesity and diabetes.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Cell Biology

METTL3-mediated m6A modification of KIF3C-mRNA promotes prostate cancer progression and is negatively regulated by miR-320d

Honggui Ma et al.

Aging-US (2021)

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Article Biochemistry & Molecular Biology

Liquid-liquid phase separation drives the β-catenin destruction complex formation

Qiaoni Shi et al.

Summary: The intracellular multiprotein complex beta-catenin destruction complex is essential for Wnt/beta-catenin signaling, with recent studies showing the importance of liquid-liquid phase separation (LLPS) of Axin and APC in regulating this pathway. Post-translational modifications also play a role in the regulation of Axin LLPS.

BIOESSAYS (2021)

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Article Genetics & Heredity

Molecular characterization, dynamic transcription, and potential function of KIF3A/KIF3B during spermiogenesis in Opsariichthys bidens

Chenwen Lin et al.

Summary: Spermiogenesis is the final phase of sperm formation, where spermatids transform into mature spermatozoa. Kinesin proteins KIF3A/KIF3B play a crucial role in this morphological transformation process. The study on Chinese hook snout carp revealed that KIF3A and KIF3B may participate in nuclear reshaping, flagellum formation, and mitochondrial aggregation during spermatogenesis.

GENE (2021)

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Review Biochemistry & Molecular Biology

Molecular Pathogenesis of Pulmonary Fibrosis, with Focus on Pathways Related to TGF-β and the Ubiquitin-Proteasome Pathway

Naoki Inui et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease characterized by dysregulated repair response induced by recurrent epithelial cell damage and excessive extracellular matrix accumulation. While there is currently no curative therapy for IPF, medications like pirfenidone and nintedanib have been introduced based on understanding the pathogenesis of the disease. Recent advances in understanding IPF pathogenesis have focused on epithelial-mesenchymal transition, the ubiquitin-proteasome system, and the role of endothelial cells in the disease process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Retraction Biochemistry & Molecular Biology

撤稿声明: Loss of PDEF, a prostate-derived Ets factor is associated with aggressive phenotype of prostate cancer: Regulation of MMP 9 by PDEF (Retraction of Vol 9, art no 148, 2010)

Thomas R. Johnson et al.

MOLECULAR CANCER (2021)

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Article Genetics & Heredity

Kinesin-2 transports Orco into the olfactory cilium of Drosophila melanogaster at specific developmental stages

Swadhin Chandra Jana et al.

Summary: Cilia, antenna-like organelles of eukaryotic cells, play important roles in cellular signaling. Research shows that the entry of Orco into the cilia on olfactory sensory neurons in fruit flies is restricted to a narrow developmental window. Heterotrimeric kinesin-2 is critical for functionalizing olfactory cilia and interacts with Orco to transport it into the cilium.

PLOS GENETICS (2021)

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CHEMICAL REVIEWS (2020)

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Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition

Weilin Wang et al.

CANCER SCIENCE (2020)

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CLINICAL ANATOMY (2020)

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KIF3A regulates the Wnt/β-catenin pathway via transporting β-catenin during spermatogenesis in Eriocheir sinensis

Ya-Jing Liang et al.

CELL AND TISSUE RESEARCH (2020)

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Article Biochemistry & Molecular Biology

NRF2 negatively regulates primary ciliogenesis and hedgehog signaling

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PLOS BIOLOGY (2020)

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SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

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Review Genetics & Heredity

'Kinesinopathies': emerging role of the kinesin family member genes in birth defects

Silvia Kalantari et al.

JOURNAL OF MEDICAL GENETICS (2020)

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Role of dynein-dynactin complex, kinesins, motor adaptors, and their phosphorylation in dendritogenesis

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JOURNAL OF NEUROCHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Transient Primary Cilia Mediate Robust Hedgehog Pathway-Dependent Cell Cycle Control

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CURRENT BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Eif2s3y regulates the proliferation of spermatogonial stem cells via Wnt6/⟨beta⟩ -catenin signaling pathway

Wenqing Liu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

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Article Oncology

Kinesin family member 3A inhibits the carcinogenesis of non-small cell lung cancer and prolongs survival

Yie Yang et al.

ONCOLOGY LETTERS (2020)

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Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk

Mariana L. Stevens et al.

NATURE COMMUNICATIONS (2020)

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Article Biochemistry & Molecular Biology

A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β (Ser9)-mediated Nrf2 activation

Sha Liao et al.

REDOX BIOLOGY (2020)

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Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer

Jia Bian et al.

CELLS (2020)

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Silicosis: An Update and Guide for Clinicians

Silpa Krefft et al.

CLINICS IN CHEST MEDICINE (2020)

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JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Medicine, Research & Experimental

miR-4721, Induced by EBV-miR-BART22, Targets GSK3β to Enhance the Tumorigenic Capacity of NPC through the WNT/β-catenin Pathway

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MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus

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Article Oncology

TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer

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JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin

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Silica Perturbs Primary Cilia and Causes Myofibroblast Differentiation during Silicosis by Reduction of the KIF3A-Repressor GLI3 Complex

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THERANOSTICS (2020)

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Article Biochemistry & Molecular Biology

Acute Inhibition of Heterotrimeric Kinesin-2 Function Reveals Mechanisms of Intraflagellar Transport in Mammalian Cilia

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Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT

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MOLECULAR CANCER (2019)

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MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer

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Oncotarget (2018)

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Primary Cilia and Mammalian Hedgehog Signaling

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WNT signalling in prostate cancer

Virginia Murillo-Garzon et al.

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Article Oncology

Phospholipase Cδ1 suppresses cell migration and invasion of breast cancer cells by modulating KIF3A-mediated ERK1/2/β-catenin/MMP7 signalling

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ONCOTARGET (2017)

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Review Allergy

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Jamee R. Castillo et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2017)

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Correction Multidisciplinary Sciences

KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer (vol 6, 32770, 2016)

Minsuh Kim et al.

SCIENTIFIC REPORTS (2017)

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Article Agriculture, Dairy & Animal Science

Dynamic transcription and expression patterns of KIF3A and KIF3B genes during spermiogenesis in the shrimp, Palaemon carincauda

Yong-Qiang Zhao et al.

ANIMAL REPRODUCTION SCIENCE (2017)

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Review Developmental Biology

The thyroid hormone nuclear receptors and the Wnt/β-catenin pathway: An intriguing liaison

Seham Skah et al.

DEVELOPMENTAL BIOLOGY (2017)

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Article Cell Biology

The dual role of FOXF2 in regulation of DNA replication and the epithelial-mesenchymal transition in breast cancer progression

Pang-Kuo Lo et al.

CELLULAR SIGNALLING (2016)

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Article Biochemistry & Molecular Biology

Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism

Julia C. Chen et al.

FASEB JOURNAL (2016)

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Article Immunology

Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens

Premkumar Vummidi Giridhar et al.

JOURNAL OF IMMUNOLOGY (2016)

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Review Cell Biology

Spermatogenesis in humans and its affecting factors

Filipe Tenorio Lira Neto et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2016)

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Article Multidisciplinary Sciences

KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer

Minsuh Kim et al.

SCIENTIFIC REPORTS (2016)

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Review Biochemistry & Molecular Biology

IFT-Cargo Interactions and Protein Transport in Cilia

Karl F. Lechtreck

TRENDS IN BIOCHEMICAL SCIENCES (2015)

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Article Oncology

KIF3a Promotes Proliferation and Invasion via Wnt Signaling in Advanced Prostate Cancer

Zun Liu et al.

MOLECULAR CANCER RESEARCH (2014)

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Article Oncology

Kif3a is necessary for initiation and maintenance of medulloblastoma

Monique T. Barakat et al.

CARCINOGENESIS (2013)

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Review Biochemistry & Molecular Biology

Cell cycle progression by the repression of primary cilia formation in proliferating cells

Hidemasa Goto et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

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Review Biochemistry & Molecular Biology

The many faces and functions of β-catenin

Tomas Valenta et al.

EMBO JOURNAL (2012)

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Article Cell Biology

Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia

Ni Qiu et al.

JOURNAL OF CELL SCIENCE (2012)

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Article Biochemistry & Molecular Biology

Molecular characterization of a KIF3B-like kinesin gene in the testis of Octopus tankahkeei (Cephalopoda, Octopus)

Ran Dang et al.

MOLECULAR BIOLOGY REPORTS (2012)

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Article Multidisciplinary Sciences

Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences

Melinda Butsch Kovacic et al.

PLOS ONE (2011)

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Article Biochemistry & Molecular Biology

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis

Sunny Y. Wong et al.

NATURE MEDICINE (2009)

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Review Cell Biology

Kinesin superfamily motor proteins and intracellular transport

Nobutaka Hirokawa et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

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Article Multidisciplinary Sciences

β-arrestin-mediated localization of smoothened to the primary cilium

Jeffrey J. Kovacs et al.

SCIENCE (2008)

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Article Cell Biology

Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms

Kevin C. Corbit et al.

NATURE CELL BIOLOGY (2008)

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Article Developmental Biology

Development of the post-natal growth plate requires intraflagellar transport proteins

Buer Song et al.

DEVELOPMENTAL BIOLOGY (2007)

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Article Multidisciplinary Sciences

Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

FM Lin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Review Biochemistry & Molecular Biology

The molecular motor toolbox for intracellular transport

RD Vale

CELL (2003)

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Article Genetics & Heredity

The Wnt/Ca2+ pathway -: a new vertebrate Wnt signaling pathway takes shape

M Kühl et al.

TRENDS IN GENETICS (2000)

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Review Cell Biology

Stirring up development with the heterotrimeric kinesin KIF3

N Hirokawa

TRAFFIC (2000)

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