期刊
FOOD SCIENCE & NUTRITION
卷 11, 期 4, 页码 2036-2048出版社
WILEY
DOI: 10.1002/fsn3.3239
关键词
Corynoline; reactive oxygen species (ROS); osteoblast; Nrf2; HO-1 pathway
In this study, Corynoline was found to have antioxidative and anti-inflammatory properties and it reduced oxidative damage to osteoblasts by activating the Nrf2/HO-1 signaling pathway. These findings provide new insights into the treatment of osteoporosis induced by oxidative injury.
Oxidative stress is preferentially treated as a risk factor for the development and progression of osteoporosis. Corynoline as a component of Corydalis bungeana Turcz presents antioxidative and anti-inflammatory properties. In the present study, the effects of Corynoline on osteoblasts following hydrogen peroxide (H2O2)-induced injury were evaluated accompanied by the investigation of the molecular mechanisms involved. It was found that Corynoline downregulated the intracellular reactive oxygen species (ROS) generation and restored the osteogenic potential of the disrupted osteoblasts by H2O2 exposure. Furthermore, Corynoline was revealed to activate the Nrf2/HO-1 signaling pathway, while ML385 (an Nrf2 inhibitor) would prevent the Corynoline-mediated positive effects on the disrupted osteoblasts. In terms of the animal experiments, Corynoline treatment contributed to a significantly alleviated bone loss. These findings indicate that Corynoline may significantly attenuate the H2O2-induced oxidative damage of osteoblasts via the Nrf2/HO-1 signaling pathway, providing novel insights to the development of treatments for osteoporosis induced by oxidative injury.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据