期刊
CELL HOST & MICROBE
卷 18, 期 3, 页码 363-370出版社
CELL PRESS
DOI: 10.1016/j.chom.2015.08.001
关键词
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资金
- French Agence Nationale de la Recherche [ANR-12-BSV3-0003]
- Finovi foundation
- NIH [T32 AI007180, F31 AI112290, T32 GM007308, R01 AI099394, R01 AI105129]
- NHMRC [565526]
- Smart Futures Fund Research Partnerships Program
In order for Staphylococcus aureus to thrive inside the mammalian host, the bacterium has to overcome iron scarcity. S. aureus is thought to produce toxins that lyse erythrocytes, releasing hemoglobin, the most abundant iron source in mammals. Here we identify the Duffy antigen receptor for chemokines (DARC) as the receptor for the S. aureus hemolytic leukocidins LukED and HlgAB. By assessing human erythrocytes with DARC polymorphisms, we determined that HlgAB- and LukED-mediated lysis directly relates to DARC expression. DARC is required for S. aureus-mediated lysis of human erythrocytes, and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis. HlgA and LukE bind directly to DARC through different regions, and by targeting DARC, HlgAB and LukED support S. aureus growth in a hemoglobin- acquisition-dependent manner. These findings elucidate how S. aureus targets and lyses erythrocytes to release one of the scarcest nutrients within the mammalian host.
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