☆ 4.6 Review

New Frontier in Terahertz Technologies for Virus Sensing

ELECTRONICS (2023)

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Spectroscopic evidence of the radioresistance of Chroococcidiopsis biosignatures: A combined Raman, FT-IR and THz-TDs spectroscopy study

Elisa Fardelli et al.

Summary: In recent decades, Mars has been extensively studied as a potential host for life through on-site missions and observations. Space Agencies have conducted experiments on living organisms to understand their behavior in extraterrestrial conditions and to develop techniques for identifying biosignatures remotely. This study focused on the radioresistant cyanobacterium Chroococcidiopsis, investigating its response to radiation stress using Raman spectroscopy, Fourier Transform InfraRed (FT-IR) and Terahertz Time Domain spectroscopy (THz-TDs), which demonstrated the suitability of these techniques for future space missions.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2023)

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Article Optics

Significant sensing performance of an all-silicon terahertz metasurface chip for Bacillus thuringiensis Cry1Ac protein

Zijian Cui et al.

Summary: This study proposes and experimentally verifies a novel scheme based on an all-silicon terahertz plasmon metasurface, which exhibits high sensitivity for detecting Bacillus thuringiensis Cry1Ac toxin. The resonance amplitude variation and frequency shift of the metasurface are investigated by analyzing the changes in sample thickness and permittivity, reflecting the protein residue in the actual process. The reliability and stability of the metasurface chip are verified through time period, temperature, and humidity control.

PHOTONICS RESEARCH (2022)

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Article Chemistry, Physical

Highly Sensitive THz Refractive Index Sensor Based on Folded Split-Ring Metamaterial Graphene Resonators

Mohammad-Reza Nickpay et al.

Summary: This translation introduces a highly sensitive absorption-based sensor based on metamaterial graphene resonators, which shows excellent performance and sensitivity in biomedical applications within the THz spectrum. The sensor's specifications can be adjusted by applying an external DC-bias voltage to the graphene layer.

PLASMONICS (2022)

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Article Optics

Terahertz continuous wave spectroscopy: a portable advanced method for atmospheric gas sensing

Annalisa D'Arco et al.

Summary: The study demonstrated the feasibility of a new experimental approach based on Terahertz continuous wave high resolution spectroscopy for detecting contaminants in the air, paving the way for environmental tracking.

OPTICS EXPRESS (2022)

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Article Physics, Multidisciplinary

High Sensitivity and Label-Free Detection of the SARS-CoV-2 S1 Protein Using a Terahertz Meta-Biosensor

Qiang Niu et al.

Summary: High sensitivity and label-free detection of the SARS-CoV-2 S1 protein can be achieved using terahertz time-domain spectroscopy and metamaterial-based biosensors, providing an important tool for the diagnosis and treatment of coronaviruses. Numerical simulations confirm the sensing characteristics observed in experiments and reveal key factors in the sensing mechanism.

FRONTIERS IN PHYSICS (2022)

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Article Engineering, Biomedical

Plasmonic nanosensors for point-of-care biomarker detection

Congran Jin et al.

Summary: Advancement in material science, particularly in the development of nanomaterials, has led to the creation of plasmonic biosensors that enable real-time diagnosis of various diseases through biomarker screening. These versatile and portable devices can be used in point-of-care settings, allowing for convenient and efficient testing of biomarkers in homes or elsewhere. This article reviews the recent progress in the design of these biosensors, including the development of nanomaterials and the applications in point-of-care diagnosis. Additionally, challenges and opportunities, such as incorporating machine learning algorithms and the testing of Covid-19, are discussed.

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Terahertz Metamaterial Sensor With Ultra-High Sensitivity and Tunability Based on Photosensitive Semiconductor GaAs

Jingwen Wu et al.

Summary: This article presents an ultra-high sensitive refractive index metamaterial sensor within the terahertz region. The sensor structure consists of GaAs on the top, aluminum in the middle, and a polyimide as the bottom substrate. The sensor shows high sensitivity to changes in the refractive index and has adjustable absorption peak properties. The proposed sensor has potential applications in biomedical sensing, disease diagnosis, and trace detection of hazardous substances.

IEEE SENSORS JOURNAL (2022)

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Article Chemistry, Analytical

Terahertz immunosensing assisted by functionalized Au NPs based on all-dielectric metasurface

Weinan Shi et al.

Summary: In this study, we developed a THz sensor that combines an all-dielectric metasurface with functionalized gold nanoparticles for immunosensing of target biomolecules. The sensor showed quantitative detection of HA antigen concentration and improved sensitivity with the functionalized Au NPs. Furthermore, the sensing method demonstrated specificity by selectively detecting only the HA antigen.

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Article Chemistry, Multidisciplinary

Strontium Substituted Tricalcium Phosphate Bone Cement: Short and Long-Term Time-Resolved Studies and In Vitro Properties

Julietta Rau et al.

Summary: By using short- and long-term time-resolved techniques, the potential of strontium substituted beta-tricalcium phosphate (Sr-TCP) cement for bone regeneration is explored. The disappearance of Sr-TCP phase and the appearance of brushite phase are observed after 45 minutes of cement setting. The compressive strength of Sr-TCP cement increases over time and reaches its maximum after 21 days. The presence of apatite final product with an admixture of brushite and TCP phases is detected after 21 days of cement soaking in Ringer solution.

ADVANCED MATERIALS INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Tunable Optimal Dual Band Metamaterial Absorber for High Sensitivity THz Refractive Index Sensing

Madurakavi Karthikeyan et al.

Summary: We present a simple dual band absorber design and investigate its functionality in the terahertz region. By adjusting the graphene chemical potential, the proposed absorber has the capability to achieve perfect absorption at various frequencies. The absorber shows near-unity absorption for incident angles up to 8 degrees and exhibits high sensitivity in glucose detection. It also has the potential for identifying malaria virus and cancer cells in blood.

NANOMATERIALS (2022)

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Article Biotechnology & Applied Microbiology

Flexible Terahertz Metamaterial Biosensor for Ultra-Sensitive Detection of Hepatitis B Viral DNA Based on the Metal-Enhanced Sandwich Assay

Yumin Li et al.

Summary: This study developed a flexible THz MM biosensor for ultrasensitive detection of HBV in clinical serum samples. The biosensor achieved highly specific and sensitive detection of HBV DNA, with a limit of detection down to 1.27E + 02 IU/ml, using a gold magnetic nanoparticle-mediated rolling circle amplification sandwich assay.

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Article Multidisciplinary Sciences

Sars-Cov2 world pandemic recurrent waves controlled by variants evolution and vaccination campaign

Gaetano Campi et al.

Summary: This study uses statistical physics to study the epidemic waves of the Covid-19 pandemic. The results show that there are different frequency components in the epidemic waves in the United States, United Kingdom, and Japan over a two-year period. The study finds that the vaccination campaign slows down the spread of the epidemic, and there is an intrinsic difference between infection waves and fatality waves, possibly due to genetic variations.

SCIENTIFIC REPORTS (2022)

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Article Chemistry, Multidisciplinary

Terahertz Resonators Based on YBa2Cu3O7 High-Tc Superconductor

Salvatore Macis et al.

Summary: In this study, superconducting split-ring resonator arrays were designed and experimentally realized to tune the metamaterial resonances by temperature, overcoming the limitations of metallic metamaterials in the terahertz range.

APPLIED SCIENCES-BASEL (2022)

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Article Materials Science, Multidisciplinary

Graphene-based metamaterial absorber for refractive index sensing applications in terahertz band

Mohammad-Reza Nickpay et al.

Summary: In this paper, a tunable triple-band absorption-based refractive index (RI) sensor with a combined graphene pattern in the terahertz (THz) band is proposed. The sensor shows three narrow absorption peaks at specific frequencies due to the surface plasmon resonance (SPR) phenomenon of graphene. The performance and resonance frequencies can be adjusted by applying an external DC-bias voltage to the graphene.

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Virus recognition with terahertz radiation: drawbacks and potentialities

Marta Di Fabrizio et al.

Summary: Virus sensing technology is gaining attention for detecting various dangerous diseases, with new approaches being proposed to overcome existing limitations. Terahertz radiation technology is emerging as a potential solution for high-sensitivity virus remote-sensing devices.

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Recent progress in nanomaterial-based sensing of airborne viral and bacterial pathogens

Sanjeev K. Bhardwaj et al.

Summary: Airborne pathogens, such as the common cold, flu, and tuberculosis, pose a threat to public health, requiring accurate monitoring and identification methods. Traditional detection techniques have limitations, leading to the development of nanomaterial-based biosensors as alternative options for portable, rapid, and direct on-site identification of target microbes. Advancements in nano-biosensors are expected for improved accuracy and portability.

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Performance Evaluation of a THz Pulsed Imaging System: Point Spread Function, Broadband THz Beam Visualization and Image Reconstruction

Marta Di Fabrizio et al.

Summary: THz technology shows promise in basic science and technology applications, particularly in THz imaging. This study investigates the performance of a broadband pulsed THz imaging system and presents the 3D beam profile of THz radiation emitted from a PCA. Evaluation of THz image formation on a test-sample is also carried out.

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Selection rules for the orbital angular momentum of optically produced THz radiation

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OPTICS LETTERS (2021)

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Disordered photonics behavior from terahertz to ultraviolet of a three-dimensional graphene network

Luca Tomarchio et al.

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Functionalized terahertz plasmonic metasensors: Femtomolar-level detection of SARS-CoV-2 spike proteins

Arash Ahmadivand et al.

Summary: This research focuses on the development of a miniaturized plasmonic immunosensor based on toroidal electrodynamics concept, which can detect the presence of SARS-CoV-2 virus protein with high sensitivity. This technology offers a valuable tool for rapid and precise screening of virus carriers.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Chemistry, Physical

A THz graphene metasurface for polarization selective virus sensing

M. Amin et al.

Summary: A novel method utilizing the chirality of highly sensitive graphene plasmonic metasurfaces is proposed to characterize the complex refractive indexes of viruses by detecting the polarization state of the reflected electric fields in the THz spectrum. The method exploits chiral surface currents to couple linearly polarized incident fields to circularly polarized reflected fields, resulting in unique polarization states in the far-field with ellipticity values that change rapidly with the analyte's refractive index. The method demonstrates potential for virus characterization with simpler instrumentation compared to traditional spectroscopic methods.

CARBON (2021)

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Article Chemistry, Multidisciplinary

Molecule-Specific Terahertz Biosensors Based on an Aptamer Hydrogel-Functionalized Metamaterial for Sensitive Assays in Aqueous Environments

Jie Zhou et al.

Summary: The novel THz biosensor, fabricated from aptamer hydrogel-functionalized THz metamaterial, can sensitively detect changes in the hydration state caused by trace thrombin, with low detection limit and excellent sensitivity in human serum matrices.

ACS SENSORS (2021)

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Article Biophysics

Label-free terahertz microfluidic biosensor for sensitive DNA detection using graphene-metasurface hybrid structures

Ruiyun Zhou et al.

Summary: This study investigates the integration of graphene with THz metasurface into a microfluidic cell for sensitive biosensing in liquid environment, demonstrating high sensitivity in detecting DNA sequences of Escherichia coli O157:H7. The results suggest the potential of the proposed graphene-metasurface microfluidic biosensor for label-free biosensing applications.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Physics, Multidisciplinary

Simultaneous elliptically and radially polarized THz from one-color laser-induced plasma filament

Sen Mou et al.

Summary: This study investigates the polarization of THz radiation emitted from a one-color laser-induced plasma filament, showing for the first time that both elliptical and radial polarizations are present simultaneously. The results suggest a new route for producing more complex polarization states and THz vortex beams through the electric quadrupole mechanism.

NEW JOURNAL OF PHYSICS (2021)

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Review Chemistry, Analytical

Detection of volatile organic compounds: From chemical gas sensors to terahertz spectroscopy

Vardan Galstyan et al.

Summary: Volatile organic compounds from various sources contribute to air pollution and impact human health. Advancements in sensing technologies have led to more efficient and accurate detection of these compounds. Research shows the potential and challenges of monitoring systems based on gas sensors and terahertz spectroscopy in this field.

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Carlo Grazianetti et al.

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ACS APPLIED NANO MATERIALS (2021)

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Review Materials Science, Multidisciplinary

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Arash Ahmadivand et al.

MATERIALS TODAY (2020)

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Yang Pan et al.

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Linear and Circular Dichroism in Graphene-Based Reflectors for Polarization Control

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Trieu Nguyen et al.

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James P. Broughton et al.

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Nathan M. Burford et al.

OPTICAL ENGINEERING (2017)

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Tuomas Jartti et al.

PAEDIATRIC RESPIRATORY REVIEWS (2013)

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Article Multidisciplinary Sciences

Atomic layer lithography of wafer-scale nanogap arrays for extreme confinement of electromagnetic waves

Xiaoshu Chen et al.

NATURE COMMUNICATIONS (2013)

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Article Chemistry, Multidisciplinary

Metamaterials on Paper as a Sensing Platform

Hu Tao et al.

ADVANCED MATERIALS (2011)

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Article Biophysics

Investigating Antibody Interactions with a Polar Liquid Using Terahertz Pulsed Spectroscopy

Yiwen Sun et al.

BIOPHYSICAL JOURNAL (2011)

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Article Optics

Scaling the spectral response of metamaterial dipolar filters in the terahertz

O. Limaj et al.

OPTICS COMMUNICATIONS (2011)

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Article Engineering, Electrical & Electronic

THz Chemical Imaging for Biological Applications

Katsuhiro Ajito et al.

IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY (2011)

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Article Physics, Applied

Performance enhancement of terahertz metamaterials on ultrathin substrates for sensing applications

Hu Tao et al.

APPLIED PHYSICS LETTERS (2010)

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Article Biotechnology & Applied Microbiology

Cooperative biological effects between ionizing radiation and other physical and chemical agents

Lorenzo Manti et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2010)

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Article Chemistry, Physical

Terahertz spectroscopy of L-proline in reverse aqueous micelles

Catherine C. Cooksey et al.

CHEMICAL PHYSICS LETTERS (2009)

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Article Chemistry, Multidisciplinary

Comparison of electrical properties of viruses studied by AC capacitance scanning probe microscopy

Robert I. MacCuspie et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

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Article Optics

Thin-film sensing with planar terahertz metamaterials: sensitivity and limitations

John F. O'Hara et al.

OPTICS EXPRESS (2008)

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Article Chemistry, Analytical

Label-free detection of bacteria by electrochemical impedance spectroscopy: Comparison to surface plasmon resonance

Rita Maalouf et al.

ANALYTICAL CHEMISTRY (2007)

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Article Engineering, Electrical & Electronic

THz imaging and sensing for security applications - explosives, weapons and drugs

JF Federici et al.

SEMICONDUCTOR SCIENCE AND TECHNOLOGY (2005)

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Article Engineering, Electrical & Electronic

Terahertz technology in biology and medicine

PH Siegel

IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES (2004)

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Article Chemistry, Physical

Terahertz pulsed imaging and spectroscopy for biomedical and pharmaceutical applications

VP Wallace et al.

FARADAY DISCUSSIONS (2004)

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Article Engineering, Biomedical

Terahertz wave imaging: horizons and hurdles

XC Zhang

PHYSICS IN MEDICINE AND BIOLOGY (2002)

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Article Biochemistry & Molecular Biology

Collective vibrational modes in biological molecules investigated by terahertz time-domain spectroscopy

M Walther et al.

BIOPOLYMERS (2002)

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