期刊
CURRENT OPINION IN FOOD SCIENCE
卷 49, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cofs.2022.100959
关键词
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Diet-related diseases are characterized by imbalanced gut microbiomes, which can be targeted for therapeutic interventions. Microbiome-based therapies have shown inconsistent results due to individual variability. Personalized microbiome-targeted nutrition therapies are being developed to modulate gut microbiomes more effectively. This review explores the concept of targeted prebiotics, which are specific fibers that can manipulate the gut microbial community. The application of targeted prebiotics in personalized nutrition aims to achieve predictable shifts in the gut microbiome composition and function.
Diet-related diseases are characterized by 'dysbiotic' gut microbiomes that represent a promising therapeutic target. Microbiome-based therapies broadly modulate the composition and function of gut microbiomes, but exhibit inconsistency due to wide individual variability between patients. Alternatively, personalized microbiome-targeted nutrition therapies are rapidly developing under increasing interest. In light of the recently renewed interest in harnessing fibers and polyphenols for the targeted manipulation of gut microbial community structure and metabolic output, we propose the term 'targeted prebiotics' to denote microbiota-directed fiber with a discrete structure, and discuss recent advances in targeted manipulation of health-promoting microbes by current and candidate prebiotics. We further explore the application of targeted prebiotics in personalized nutrition, aiming for predictable shifts in bacterial composition, functional genes, and metabolites. In conclusion, our review will advance the precise modulation of the gut microbiome via the optimization of prebiotic-based strategies.
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