☆ 4.7 Review

Extracellular Vesicles for Dental Pulp and Periodontal Regeneration

PHARMACEUTICS (2023)

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Review Urology & Nephrology

Microfluidics facilitating the use of small extracellular vesicles in innovative approaches to male infertility

Dale M. Goss et al.

Summary: In this study, Goss et al. explore the diagnostic potential of male reproductive small extracellular vesicles (S-EVs) and the practical approaches of implementing point-of-need and multianalyte diagnostics in infertility treatment. They find that S-EVs have the potential to influence sperm physiology therapeutically and diagnostically. However, the isolation of pure populations of S-EVs from bodily fluids with current conventional methods presents a substantial hurdle. Microfluidic technology has the potential to simplify and improve S-EV isolation and detection.

NATURE REVIEWS UROLOGY (2023)

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Review Engineering, Biomedical

From Conventional to Microfluidic: Progress in Extracellular Vesicle Separation and Individual Characterization

Mingrui Chen et al.

Summary: Extracellular vesicles (EVs) are membrane vesicles containing various cargo, and they show promise as biomarkers for disease diagnosis and therapy. However, their use in personalized healthcare is limited by their heterogeneity and isolation difficulties. To address this challenge, microfluidic platforms are being explored for single-particle level characterization of EVs. This review discusses the biogenesis and heterogeneity of EVs, and provides an overview on the advances in microfluidics-based research for EV separation and single EV characterization. It also highlights the potential of combining microfluidics with artificial intelligence (AI) for single EV analysis and precision medicine applications.

ADVANCED HEALTHCARE MATERIALS (2023)

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Article Engineering, Biomedical

Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair

Lan Ma et al.

Summary: Over 300 billion cells die every day, producing endogenous apoptotic extracellular vesicles (apoEVs). This study discovers that a portion of exogenous apoEVs is metabolized in the integumentary skin and hair follicles. The migration of apoEVs is influenced by treadmill exercise and tail suspension. Exogenous apoEVs promote wound healing and hair growth by activating the Wnt/beta-catenin pathway. This research reveals a new metabolic pathway of apoEVs and suggests their potential therapeutic applications in skin and hair disorders.

BIOACTIVE MATERIALS (2023)

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Article Engineering, Biomedical

Apoptotic vesicles ameliorate lupus and arthritis via phosphatidylserine-mediated modulation of T cell receptor signaling

Runci Wang et al.

Summary: Mesenchymal stem cells influence T cells through extracellular vesicles, and in this study, we demonstrate the immunomodulatory potential of apoptotic vesicles generated by MSCs. Replenishing apoVs in Fas mutant mice rescued the deficiency and improved inflammation and lupus activity. ApoVs directly interacted with CD4+ T cells, inhibiting CD25 expression and IL-2 production.

BIOACTIVE MATERIALS (2023)

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Article Engineering, Biomedical

Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes

Fengzhen Lei et al.

Summary: Exosomes secreted by healthy periodontal ligament stem cells (PDLSCs) promote osteogenic differentiation of PDLSCs derived from periodontitis tissue. Treatment with exosomes can accelerate bone formation in rat models of periodontitis. Mechanistically, exosomes suppress over-activation of the canonical Wnt signaling pathway to recover the osteogenic differentiation capacity of inflammatory PDLSCs. These findings suggest that MSC-derived exosomes are an effective and practical cell-free therapeutic for the treatment of periodontitis.

ACTA BIOMATERIALIA (2022)

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Article Nanoscience & Nanotechnology

The Application of Pulp Tissue Derived-Exosomes in Pulp Regeneration: A Novel Cell-Homing Approach

Yan Chen et al.

Summary: This study demonstrated that exosomes derived from dental pulp tissue can recruit stem cells to regenerate dental pulp, suggesting their potential in treating pulp deficiencies caused by various diseases.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Review Dentistry, Oral Surgery & Medicine

Dental stem cell-derived extracellular vesicles as promising therapeutic agents in the treatment of diseases

Ye Li et al.

Summary: Dental stem cells (DSCs) are an important source of mesenchymal stem cells (MSCs) and have been used for the treatment of various diseases. The therapeutic effects of DSCs are attributed to their extracellular vesicles (DSC-EVs), which carry bioactive contents and have therapeutic potential. This review provides insights into the therapeutic effects of DSC-EVs and highlights challenges and future directions for their clinical translation.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2022)

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Article Cell & Tissue Engineering

Matrix vesicles from dental follicle cells improve alveolar bone regeneration via activation of the PLC/PKC/MAPK pathway

Genzheng Yi et al.

Summary: This study found that matrix vesicles (MVs) can effectively improve the proliferation, migration, and osteogenic differentiation of dental follicle cells (DFCs), with collagenase-released MVs (CRMVs) showing better bone regeneration capabilities. In a rat alveolar bone defect model, CRMVs loaded on a collagen scaffold had more significant therapeutic outcomes compared to media MVs (MMVs) and DFCs-based treatment.

STEM CELL RESEARCH & THERAPY (2022)

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Article Engineering, Biomedical

Engineered Delivery of Dental Stem-Cell-Derived Extracellular Vesicles for Periodontal Tissue Regeneration

Jana Zarubova et al.

Summary: A delivery platform for small extracellular vesicles derived from gingival mesenchymal stem cells (GMSCs) has been developed to treat periodontitis, showing potential clinical applications in promoting regeneration of damaged periodontal tissues.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Dentistry, Oral Surgery & Medicine

Exosomes derived from stem cells from the apical papilla alleviate inflammation in rat pulpitis by upregulating regulatory T cells

Si Yu et al.

Summary: This study aims to evaluate the effects of exosomes derived from stem cells from the apical papilla (SCAP-Exos) on experimentally induced pulpitis in rats and the conversion of regulatory T cells (Tregs) in vitro. The results show that SCAP-Exos promoted Treg conversion and alleviated inflammation in dental pulp.

INTERNATIONAL ENDODONTIC JOURNAL (2022)

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Article Biotechnology & Applied Microbiology

Apoptotic vesicles activate autophagy in recipient cells to induce angiogenesis and dental pulp regeneration

Zihan Li et al.

Summary: In this study, the researchers found that apoptotic cell-derived extracellular vesicles (apoVs) were ingested by endothelial cells (ECs) and elevated the expression of angiogenesis-related genes, leading to pulp revascularization and tissue regeneration.

MOLECULAR THERAPY (2022)

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Review Biotechnology & Applied Microbiology

Therapeutically harnessing extracellular vesicles

Lesley Cheng et al.

Summary: The field of extracellular vesicle (EV) research has rapidly developed and is now recognized for its potential in the treatment and diagnosis of diseases. This article provides an overview of the characteristics and physiological functions of EVs, their association with diseases, and the strategies for their therapeutic exploitation.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Cell & Tissue Engineering

Small extracellular vesicles from dental follicle stem cells provide biochemical cues for periodontal tissue regeneration

Liya Ma et al.

Summary: This study investigates the potential of DFSCs-sEVs in regenerating damaged periodontal tissue. The results show that DFSCs-sEVs promoted the proliferation, migration, and osteogenic differentiation of PDLSCs, potentially through the activation of the p38 MAPK signaling pathway. DFSCs-sEVs provide a novel strategy for periodontal regeneration.

STEM CELL RESEARCH & THERAPY (2022)

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Review Biotechnology & Applied Microbiology

Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research

Yan Hu et al.

Summary: This article reviews the subtype of extracellular vesicles (EVs) called microparticles (MPs), which function as delivery vectors for bioactive antitumor compounds. MPs, with their unique antitumor functionalities, have gained interest for their potential use in therapeutic vaccines and direct antitumor agents. The mechanisms underlying MP biogenesis, factors that influence MP production, properties of MP membranes, size, composition, and isolation methods are discussed. Additionally, the applications, mechanisms of action, and main hurdles for MP use in cancer management are introduced.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Immunology

Extracellular Vesicles From TNFα Preconditioned MSCs: Effects on Immunomodulation and Bone Regeneration

Miya Kang et al.

Summary: Mesenchymal stem cells respond to external cues and change their behavior. The immunomodulatory properties of MSCs are well-documented, and their secreted extracellular vesicles (EVs) play a role in this process. The study found that TNF alpha can enhance the immunomodulatory properties of MSC EVs, leading to reduced inflammation and enhanced bone formation.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Exosomes Derived From Human Gingival Mesenchymal Stem Cells Attenuate the Inflammatory Response in Periodontal Ligament Stem Cells

Jiayao Sun et al.

Summary: This study aimed to explore the effects of exosomes derived from human gingival mesenchymal stem cells (GMSC-Exo) on the inflammatory response of periodontal ligament stem cells (PDLSCs) in an inflammatory microenvironment. The study found that GMSC-Exo attenuated the inflammatory response of PDLSCs by regulating the expression of NF-kappa B signaling and Wnt5a.

FRONTIERS IN CHEMISTRY (2022)

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Review Pharmacology & Pharmacy

Extracellular vesicles: Emerging tools as therapeutic agent carriers

Shan Liu et al.

Summary: Extracellular vesicles (EVs) are important carriers in cell-to-cell communication, transferring substances such as DNA and RNA to recipient cells. EVs, with excellent biocompatibility and stability, can be used as therapeutic carriers for signal transduction, immunoregulation, and other therapeutic effects. This review summarizes the classification, isolation, and characterization strategies of EVs, and highlights recent advances in the application of EV therapeutics in in vitro research, in vivo animal models, and clinical settings.

ACTA PHARMACEUTICA SINICA B (2022)

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Review Biochemistry & Molecular Biology

Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications

Shenmin Xie et al.

Summary: Extracellular vesicles, specifically exosomes, are nanoscale membrane vesicles released by cells and have the potential to uncover unknown cellular and molecular mechanisms in intercellular communication and disease. They are effective drug delivery systems and display complexity in their formation, release, and bioengineering.

MEMBRANES (2022)

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Review Biochemistry & Molecular Biology

Advances in the Therapeutic Effects of Apoptotic Bodies on Systemic Diseases

Xiaoyan Li et al.

Summary: Apoptotic bodies (ApoBDs) generated from apoptotic cells play crucial roles in maintaining homeostasis, intercellular communications, and the treatment of systemic diseases. Research on the generation, application, and reconstruction of ApoBDs provides evidence and therapeutic strategies for understanding related diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine

Yasunari Matsuzaka et al.

Summary: Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in intracellular communication. Mesenchymal stem cells (MSCs) induce tissue regeneration by direct recruitment into injured tissues or secreting factors. Recent studies have shown that MSC-derived EVs have regenerative effects against various diseases and can serve as drug delivery systems.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cell & Tissue Engineering

Extracellular Vesicles for Immunomodulation in Tissue Regeneration

Kaichao Zhang et al.

Summary: Extracellular vesicles (EVs) possess potent immunomodulatory abilities and show great therapeutic potential for tissue repair and regeneration through immune modulation. The development of engineering technology provides a feasible tool for optimizing the performance of natural EVs. This review outlines the features of EVs and the construction strategies of engineered EVs, as well as the immunomodulation effects of both natural and engineered EVs. The applications of EV-based therapies for tissue regeneration, with a particular emphasis on immune system modulation, are highlighted.

TISSUE ENGINEERING PART C-METHODS (2022)

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Review Cell Biology

Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

Meng Kou et al.

Summary: Mesenchymal stem cells (MSCs) have paracrine effects in therapy, and extracellular vesicles (EVs) play a crucial role in intercellular communication. MSC-EVs have potential therapeutic applications and play an important role in fibrosis treatment and tissue repair.

CELL DEATH & DISEASE (2022)

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Review Pharmacology & Pharmacy

Practical Considerations for Translating Mesenchymal Stromal Cell-Derived Extracellular Vesicles from Bench to Bed

Pauline Po Yee Lui et al.

Summary: This review discusses the general and tissue-specific considerations for manufacturing MSC-EVs for clinical translation in the treatment of tendon and ligament injuries, including GMP-compliant manufacturing and quality control, safety and efficacy issues, and compatibility with arthroscopy.

PHARMACEUTICS (2022)

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Article Cell Biology

Proteomic analysis of MSC-derived apoptotic vesicles identifies Fas inheritance to ameliorate haemophilia a via activating platelet functions

Xiao Zhang et al.

Summary: This study compared the characteristics and functions of apoptotic vesicles (apoVs) and exosomes derived from different sources of mesenchymal stem cells (MSCs). The results revealed unique protein compositions and specific enrichment of proteins in apoVs, which can serve as biomarkers. Additionally, apoVs exhibited therapeutic effects in treating haemophilia A through a specific Fas/FasL linkage mechanism.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Analysis of Thrombin-Activated Platelet-Derived Exosome (T-aPDE) Potential for Dental Pulp Regeneration: In-Vitro Study

Dini Asrianti Bagio et al.

European Journal of Dentistry (2022)

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Review Medicine, Research & Experimental

The potential applications of microparticles in the diagnosis, treatment, and prognosis of lung cancer

Yu Liu et al.

Summary: Microparticles (MPs) are submicron membranous vesicles derived from various cell types that contain bioactive chemicals and surface receptors, which play important roles in cell-to-cell communication. MPs in the tumor microenvironment can influence tumor progression through their interactions with receptors. MPs provide diverse biomolecular information and have potential applications as biomarkers for lung cancer risk assessment, diagnosis, prognosis, and surveillance. They can also be used as drug carriers and cancer vaccines.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

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Review Engineering, Biomedical

Extracellular Vesicles in Tissue Engineering: Biology and Engineered Strategy

Ziyin Pan et al.

Summary: Extracellular vesicles are important in tissue engineering for intercellular communication, promoting signal delivery in regeneration processes. Using bioactive carriers to extend EV retention time and achieve controlled release enhances their therapeutic effectiveness in tissue regeneration.

ADVANCED HEALTHCARE MATERIALS (2022)

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Review Cell & Tissue Engineering

Composition, Biogenesis, and Role of Exosomes in Tumor Development

Leila Moeinzadeh et al.

Summary: Exosomes and their mechanism of action at the tumor site have gained increasing attention. These microvesicles are produced by various cells, including mesenchymal stem cells (MSCs) and immune cells. Tumor cells release large amounts of exosomes, which can spread to distant organs through the blood and enhance the possibility of tumor metastasis. The effects of exosomes on tumors vary depending on the tumor type and cell source.

STEM CELLS INTERNATIONAL (2022)

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Review Immunology

CD47 as a promising therapeutic target in oncology

Hai Zhao et al.

Summary: CD47 is a protein that is ubiquitously expressed on the surface of cells and plays a critical role in self-recognition. It modulates cellular phagocytosis, determines the lifespan of erythrocytes, regulates immune cell activation, and manipulates synaptic pruning during neuronal development. Recently, CD47 has been identified as a novel target for cancer immunotherapy. This review discusses the diverse functions of CD47, its role in immune system homeostasis, and its potential therapeutic roles against cancer.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Cell & Tissue Engineering

Extracellular vesicles delivering nuclear factor I/C for hard tissue engineering: Treatment of apical periodontitis and dentin regeneration

Shengyan Yang et al.

Summary: This study reveals the impact of apical periodontitis on tooth root development and the underlying mechanism of impaired odontoblastic differentiation of stem cells from apical papilla. The study also develops a novel strategy for dentin regeneration using a nuclear factor I/C-encapsulated extracellular vesicle.

JOURNAL OF TISSUE ENGINEERING (2022)

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Article Cell Biology

Exosomes derived from lipopolysaccharide-preconditioned human dental pulp stem cells regulate Schwann cell migration and differentiation

Jiabei Li et al.

Summary: This study found that exosomes from human dental pulp stem cells can promote the proliferation, migration, and odontogenic differentiation of Schwann cells. Exosomes pre-treated with LPS showed better capability in regulating Schwann cells migration and odontogenic differentiation compared to untreated exosomes.

CONNECTIVE TISSUE RESEARCH (2021)

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Article Cell & Tissue Engineering

Bone Marrow Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Promote Periodontal Regeneration

Li Liu et al.

Summary: The study demonstrated that bone marrow mesenchymal stem cell-derived small extracellular vesicles (BMSC-sEVs) can promote periodontal tissue regeneration through modulation of various signaling pathways and cell functions.

TISSUE ENGINEERING PART A (2021)

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Article Engineering, Biomedical

Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss

Yuki Nakao et al.

Summary: Preconditioning gingival tissue-derived MSCs (GMSCs) with tumor necrosis factor-alpha (TNF-alpha) enhances the secretion of exosomes and the expression of CD73, promoting antiinflammatory M2 macrophage polarization. GMSC-derived exosomes exhibit significant ability to regulate inflammation and osteoclastogenesis, providing a potential therapeutic approach for periodontitis. The findings suggest a promising strategy for treating inflammatory osteoimmune disorders using TNF-alpha-preconditioned GMSC-derived exosomes.

ACTA BIOMATERIALIA (2021)

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Article Dentistry, Oral Surgery & Medicine

Bacterial Invasion of Pulp Blood Vessels in Teeth with Symptomatic Irreversible Pulpitis

Domenico Ricucci et al.

Summary: Teeth with symptomatic irreversible pulpitis showed severe acute inflammation, necrosis, and bacterial infection in the pulp chamber. Bacterial invasion and colonization were observed in all teeth with caries exposure, suggesting a significant role in bacterial spread through the pulp tissue.

JOURNAL OF ENDODONTICS (2021)

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Article Dentistry, Oral Surgery & Medicine

Reparative Dentin Formation by Dentin Matrix Proteins and Small Extracellular Vesicles

Bo Wen et al.

Summary: Dental pulp tissue is crucial for maintaining teeth stability and health, and damaged pulp tissue can affect normal dental functioning. Recent studies have shown that a combination of treated dentin matrix proteins and dental pulp cell-derived small extracellular vesicles has positive effects on pulp-dentin complex repair.

JOURNAL OF ENDODONTICS (2021)

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Article Nanoscience & Nanotechnology

Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels Accelerate Bone Repair by Enhancing Angiogenesis

Yuntong Zhang et al.

Summary: Repairing large bone defects remains a major challenge for orthopedic surgeons, but this study demonstrates a promising strategy using umbilical MSC-derived exosomes in combination with hyaluronic acid hydrogel and nanohydroxyapatite/poly-epsilon-caprolactone scaffolds to enhance bone regeneration in rats. The exosomes were found to promote angiogenesis and potentially regulate it through the miR-21/NOTCH1/DLL4 signaling axis.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Pharmacology & Pharmacy

Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities

Anika Nagelkerke et al.

Summary: Extracellular vesicles (EVs) are biological nanoparticles secreted by cells that act as delivery vehicles for molecular messages, showing potential as therapeutic mediators for various diseases. EVs have regenerative properties and can mediate signaling cascades in target cells to achieve functional outcomes in tissue repair and regeneration. Their interactions and biodistribution in vivo, especially when combined with biomaterials, influence their regenerative effects, with progress being made towards successful implementation of EV regenerative therapies in a clinical setting.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Dentistry, Oral Surgery & Medicine

The Role of Small Extracellular Vesicles Derived from Lipopolysaccharide-preconditioned Human Dental Pulp Stem Cells in Dental Pulp Regeneration

Wen-Jin Chen et al.

Summary: The study demonstrated that LPS-preconditioned sEVs can enhance the proliferation, migration, angiogenesis, and differentiation of mesenchymal stem cells, leading to structurally improved regenerated tissue similar to normal dental pulp in vivo. These findings suggest that LPS-preconditioned sEVs play a significant role in dental pulp regeneration.

JOURNAL OF ENDODONTICS (2021)

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Article Cell & Tissue Engineering

Exploring a Chemotactic Role for EVs from Progenitor Cell Populations of Human Exfoliated Deciduous Teeth for Promoting Migration of Naive BMSCs in Bone Repair Process

Lin Luo et al.

Summary: This study examined the potential of extracellular vesicles (EVs) derived from human exfoliated deciduous teeth mesenchymal progenitor cell populations in mobilizing naive bone marrow mesenchymal stromal cells (BMSCs). Results showed that EVs from different culturing times had an impact on the migratory efficiency of BMSCs, but the migration of BMSCs driven by different EV groups did not exhibit statistical significance.

STEM CELLS INTERNATIONAL (2021)

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Article Cell & Tissue Engineering

Exosomes from LPS-Stimulated hDPSCs Activated the Angiogenic Potential of HUVECs In Vitro

Xiangyu Huang et al.

Stem Cells International (2021)

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Review Cell Biology

Extracellular Vesicles: An Emerging Regenerative Treatment for Oral Disease

Fanzhen He et al.

Summary: Extracellular Vesicles (EVs) are important regulators of intercellular communication, playing a crucial role in the occurrence and prognosis of oral diseases. They have been shown to have a significant impact on oral tissue regeneration, including dental pulp, periodontal tissue, cartilage, and bone.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Pharmacology & Pharmacy

Separation, characterization, and standardization of extracellular vesicles for drug delivery applications

Dominik Buschmann et al.

Summary: EVs are membrane nanovesicles secreted from living cells which have potential therapeutic activity and are being explored as drug delivery vehicles in preclinical investigations and early clinical trials. However, progress in EV-based drug delivery is hindered by heterogeneity of sample types and methods, as well as a persistent lack of standardization, validation, and comprehensive reporting.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Engineering, Biomedical

Schwann cell-derived EVs facilitate dental pulp regeneration through endogenous stem cell recruitment via SDF-1/CXCR4 axis

Dianri Wang et al.

Acta Biomaterialia (2021)

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Article Cell Biology

SHED aggregate exosomes shuttled miR-26a promote angiogenesis in pulp regeneration via TGF-β/SMAD2/3 signalling

Meiling Wu et al.

Summary: The study demonstrated that SHED aggregate-derived exosomes significantly improved pulp tissue regeneration and angiogenesis by regulating miR-26a and the TGF-beta/SMAD2/3 signaling pathway to enhance vascular formation in SHED and HUVECs.

CELL PROLIFERATION (2021)

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Review Biochemistry & Molecular Biology

Functional Dental Pulp Regeneration: Basic Research and Clinical Translation

Zhuo Xie et al.

Summary: Treatment of pulpal and periapical diseases faces challenges, but significant progress has been made in achieving true pulp tissue regeneration through technologies such as stem cells, biomaterials, and growth factors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker

Fernanda G. Kugeratski et al.

Summary: The study used an unbiased and quantitative proteomic approach to identify core constituents of exosomes, with syntenin-1 identified as a potential universal biomarker. A comprehensive quantitative atlas of core proteins ubiquitous to exosomes was provided, highlighting the potential use of syntenin-1 as a putative universal biomarker for exosomes.

NATURE CELL BIOLOGY (2021)

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Article Multidisciplinary Sciences

Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9

Mathilde Mathieu et al.

Summary: This study tracks the intracellular trafficking of two proteins before their secretion in EVs, reporting the biogenesis and protein markers of EV subtypes: ectosomes budding from the plasma membrane as well as exosomes from late endosomes.

NATURE COMMUNICATIONS (2021)

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Review Cell & Tissue Engineering

Mesenchymal stromal cell-derived exosomes in cardiac regeneration and repair

Si-Jia Sun et al.

Summary: MSC-derived exosomes show promising potential in cardiac regeneration and repair due to their trophic and immunomodulatory effects. Compared to parent stem cells, they offer lower tumorigenic risk and superior stability.

STEM CELL REPORTS (2021)

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Article Cell Biology

Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes

Chenxi Zheng et al.

Summary: The study revealed that apoptotic vesicles (apoVs) derived from MSCs can modulate liver macrophage homeostasis and counteract type 2 diabetes (T2D) by inducing macrophage reprogramming. Through efferocytosis, apoVs inhibit macrophage accumulation and promote their transformation towards an anti-inflammatory phenotype in the liver to ameliorate T2D phenotypes.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Cell & Tissue Engineering

THERAPEUTIC POTENTIAL OF MESENCHYMAL STEM CELL- DERIVED ExTRACELLULAR VESICLES IN REGENERATIVE

A. Ivica et al.

Summary: Regenerative endodontic procedures involve two tissue engineering approaches, one using transplanted mesenchymal stem cells and the other relying on bioactive molecules. A potential third approach involves the application of MSC-derived exosomes for pulp regeneration. Future research should focus on investigating the therapeutic use of these exosomes in in-vivo and clinical studies.

EUROPEAN CELLS & MATERIALS (2021)

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Review Biochemistry & Molecular Biology

Apoptotic cell-derived exosomes: messages from dying cells

Ramesh Kakarla et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Review Medicine, Research & Experimental

Free and hydrogel encapsulated exosome-based therapies in regenerative medicine

Ali Akbari et al.

LIFE SCIENCES (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Medicine, General & Internal

Pulp-Derived Exosomes in a Fibrin-Based Regenerative Root Filling Material

Anja Ivica et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Cell & Tissue Engineering

The proangiogenic effects of extracellular vesicles secreted by dental pulp stem cells derived from periodontally compromised teeth

Huan Zhou et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Cell & Tissue Engineering

Exosomes Derived from Stem Cells from the Apical Papilla Promote Dentine-Pulp Complex Regeneration by Inducing Specific Dentinogenesis

Xueying Zhuang et al.

STEM CELLS INTERNATIONAL (2020)

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Review Parasitology

Membrane-bound extracellular vesicles secreted by parasitic protozoa: cellular structures involved in the communication between cells

Wanderley de Souza et al.

PARASITOLOGY RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Extracellular Vesicles-Loaded Fibrin Gel Supports Rapid Neovascularization for Dental Pulp Regeneration

Siyuan Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Exosomes derived from human exfoliated deciduous teeth ameliorate adult bone loss in mice through promoting osteogenesis

Jizhen Wei et al.

JOURNAL OF MOLECULAR HISTOLOGY (2020)

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Review Dentistry, Oral Surgery & Medicine

Potential Therapeutic Effects of Exosomes in Regenerative Endodontics

Sijing Yu et al.

ARCHIVES OF ORAL BIOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Technologies and Standardization in Research on Extracellular Vesicles

Srujan Gandham et al.

TRENDS IN BIOTECHNOLOGY (2020)

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Article Chemistry, Medicinal

Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization

Shurong Duan et al.

Drug Design Development and Therapy (2020)

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Article Materials Science, Biomaterials

Small Extracellular Vesicles from Lipopolysaccharide-Preconditioned Dental Follicle Cells Promote Periodontal Regeneration in an Inflammatory Microenvironment

Weiwei Shi et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Review Cell Biology

Extracellular Vesicles Derived From Apoptotic Cells: An Essential Link Between Death and Regeneration

Maojiao Li et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Cell & Tissue Engineering

MicroRNA-enriched small extracellular vesicles possess odonto-immunomodulatory properties for modulating the immune response of macrophages and promoting odontogenesis

Jianmao Zheng et al.

STEM CELL RESEARCH & THERAPY (2020)

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Review Pharmacology & Pharmacy

Extracellular Vesicle-Based Therapeutics: Preclinical and Clinical Investigations

Natalia L. Klyachko et al.

PHARMACEUTICS (2020)

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Article Engineering, Biomedical

Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism

Zongshan Shen et al.

BIOACTIVE MATERIALS (2020)

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Article Medicine, Research & Experimental

Exosome-like vesicles derived from Hertwig's epithelial root sheath cells promote the regeneration of dentin-pulp tissue

Sicheng Zhang et al.

THERANOSTICS (2020)

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Article Cell Biology

Quantitative proteomic analysis of trypsin-treated extracellular vesicles to identify the real-vesicular proteins

Dongsic Choi et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Review Biology

Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication

Michela Battistelli et al.

BIOLOGY-BASEL (2020)

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Article Medicine, General & Internal

PDLSCs Regulate Angiogenesis of Periodontal Ligaments via VEGF Transferred by Exosomes in Periodontitis

Zhang Zhang et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)

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Review Pediatrics

Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases

Anne-lie Stahl et al.

PEDIATRIC NEPHROLOGY (2019)

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Review Dentistry, Oral Surgery & Medicine

Cellular therapy in periodontal regeneration

Javier Nunez et al.

PERIODONTOLOGY 2000 (2019)

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Review Biochemistry & Molecular Biology

Exosomes: biogenesis, biologic function and clinical potential

Yuan Zhang et al.

CELL AND BIOSCIENCE (2019)

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Article Chemistry, Multidisciplinary

Elimination Pathways of Nanoparticles

Wilson Poon et al.

ACS NANO (2019)

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Article Biochemistry & Molecular Biology

Reassessment of Exosome Composition

Dennis K. Jeppesen et al.

CELL (2019)

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Article Cell & Tissue Engineering

Periodontal Ligament Stem Cells: Current Knowledge and Future Perspectives

Oriana Trubiani et al.

STEM CELLS AND DEVELOPMENT (2019)

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Article Cell & Tissue Engineering

Lineage-specific exosomes promote the odontogenic differentiation of human dental pulp stem cells (DPSCs) through TGF1/smads signaling pathway via transfer of microRNAs

Xiaoli Hu et al.

STEM CELL RESEARCH & THERAPY (2019)

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Review Cell Biology

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

Laura M. Doyle et al.

CELLS (2019)

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Article Cell Biology

Moving beyond size and phosphatidylserine exposure: evidence for a diversity of apoptotic cell-derived extracellular vesicles in vitro

Ivan K. H. Poon et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Review Cell Biology

Extracellular vesicles in urologic malignancies-Implementations for future cancer care

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CELL PROLIFERATION (2019)

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Review Cell & Tissue Engineering

Functional proteins of mesenchymal stem cell-derived extracellular vesicles

Guanguan Qiu et al.

STEM CELL RESEARCH & THERAPY (2019)

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Review Biochemistry & Molecular Biology

Apoptosis and apoptotic body: disease message and therapeutic target potentials

Xuebo Xu et al.

BIOSCIENCE REPORTS (2019)

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Review Engineering, Biomedical

Extracellular vesicle and mesenchymal stem cells in bone regeneration: recent progress and perspectives

Chenyu Chu et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2019)

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Review Dentistry, Oral Surgery & Medicine

Pulp Stem Cell-Mediated Functional Pulp Regeneration

B. Sui et al.

JOURNAL OF DENTAL RESEARCH (2019)

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Review Biotechnology & Applied Microbiology

Extracellular Microvesicles as New Industrial Therapeutic Frontiers

Vivek Agrahari et al.

TRENDS IN BIOTECHNOLOGY (2019)

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Article Engineering, Biomedical

Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration

Jacob Ren Jie Chew et al.

ACTA BIOMATERIALIA (2019)

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Review Oncology

Role of stem cell derived exosomes in tumor biology

Aman Sharma

INTERNATIONAL JOURNAL OF CANCER (2018)

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Article Oncology

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

Marat S. Pavlyukov et al.

CANCER CELL (2018)

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Article Oncology

Predicting the Presence of Oral Squamous Cell Carcinoma Using Commonly Dysregulated MicroRNA in Oral Swirls

Tami Yap et al.

CANCER PREVENTION RESEARCH (2018)

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Article Cell Biology

Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors

Dawei Liu et al.

CELL RESEARCH (2018)

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Article Dentistry, Oral Surgery & Medicine

Pulp Regeneration by 3-dimensional Dental Pulp Stem Cell Constructs

Y. Itoh et al.

JOURNAL OF DENTAL RESEARCH (2018)

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Article Dentistry, Oral Surgery & Medicine

Exosomes with Highly Angiogenic Potential for Possible Use in Pulp Regeneration

Xuehong Xian et al.

JOURNAL OF ENDODONTICS (2018)

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Review Biochemistry & Molecular Biology

Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles

Claudia Verderio et al.

JOURNAL OF LIPID RESEARCH (2018)

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Review Cell Biology

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Article Cell Biology

The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing

Xiaoxing Kou et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Review Immunology

Apoptotic Cell-Derived extracellular vesicles: More Than Just Debris

Sarah Caruso et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Cell Biology

Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth

Kun Xuan et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Review Neurosciences

Schwann Cell Responses and Plasticity in Different Dental Pulp Scenarios

Eduardo Couve et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Article Cell Biology

MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis

Yubao Liu et al.

CELL CYCLE (2018)

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Article Multidisciplinary Sciences

Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns

Soo Jeong Park et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Cell Biology

Large-scale, cross-flow based isolation of highly pure and endocytosis-competent extracellular vesicles

Ryan P. McNamara et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Biochemistry & Molecular Biology

Effect of Adipose-Derived Stem Cells and Their Exo as Adjunctive Therapy to Nonsurgical Periodontal Treatment: A Histologic and Histomorphometric Study in Rats

Ebtehal Mohammed et al.

BIOMOLECULES (2018)

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Review Cell Biology

Microfluidics-based on-a-chip systems for isolating and analysing extracellular vesicles

Shang-Chun Guo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Review Cell Biology

Plasma membrane changes during programmed cell deaths

Yingying Zhang et al.

CELL RESEARCH (2018)

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Review Dentistry, Oral Surgery & Medicine

Pulp Vascularization during Tooth Development, Regeneration, and Therapy

C. Rombouts et al.

JOURNAL OF DENTAL RESEARCH (2017)

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Article Dentistry, Oral Surgery & Medicine

The Effects of M1 and M2 Macrophages on Odontogenic Differentiation of Human Dental Pulp Cells

Hee Chul Park et al.

JOURNAL OF ENDODONTICS (2017)

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Article Dentistry, Oral Surgery & Medicine

Regenerative Endodontics for Adult Patients

Ling He et al.

JOURNAL OF ENDODONTICS (2017)

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Review Dentistry, Oral Surgery & Medicine

Efficacy of stem cells on periodontal regeneration: Systematic review of pre-clinical studies

S. A. Tassi et al.

JOURNAL OF PERIODONTAL RESEARCH (2017)

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Article Multidisciplinary Sciences

Determining the contents and cell origins of apoptotic bodies by flow cytometry

Lanzhou Jiang et al.

SCIENTIFIC REPORTS (2017)

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Review Immunology

Extracellular Vesicles Arising from Apoptotic Cells in Tumors: Roles in Cancer Pathogenesis and Potential Clinical Applications

Catherine Lynch et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Medicine, General & Internal

Periodontal diseases

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NATURE REVIEWS DISEASE PRIMERS (2017)

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Article Cell Biology

Exosomes purified from a single cell type have diverse morphology

Davide Zabeo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2017)

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Article Chemistry, Multidisciplinary

A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

Ramon Subiros-Funosas et al.

CHEMICAL COMMUNICATIONS (2017)

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Article Engineering, Biomedical

Exosomes as biomimetic tools for stem cell differentiation: Applications in dental pulp tissue regeneration

Chun-Chieh Huang et al.

BIOMATERIALS (2016)

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Article Cell & Tissue Engineering

Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling

Johnathon D. Anderson et al.

STEM CELLS (2016)

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Article Cell Biology

MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus

Shiyu Liu et al.

CELL METABOLISM (2015)

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Article Dentistry, Oral Surgery & Medicine

Periodontal Regeneration - Intrabony Defects: A Consensus Report From the AAP Regeneration Workshop

Mark A. Reynolds et al.

JOURNAL OF PERIODONTOLOGY (2015)

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Article Biochemistry & Molecular Biology

MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3

Hongwei Liang et al.

MOLECULAR CANCER (2015)

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Article Multidisciplinary Sciences

A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure

Georgia K. Atkin-Smith et al.

NATURE COMMUNICATIONS (2015)

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Review Immunology

Periodontitis: from microbial immune subversion to systemic inflammation

George Hajishengallis

NATURE REVIEWS IMMUNOLOGY (2015)

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Review Immunology

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

Peter J. Murray et al.

IMMUNITY (2014)

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Article Biotechnology & Applied Microbiology

Characterization of human plasma-derived exosomal RNAs by deep sequencing

Xiaoyi Huang et al.

BMC GENOMICS (2013)

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Review Cardiac & Cardiovascular Systems

On the origin of microparticles: From platelet dust to mediators of intercellular communication

Leslie A. Hargett et al.

PULMONARY CIRCULATION (2013)

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Article Cell Biology

Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes

Rossella Crescitelli et al.

JOURNAL OF EXTRACELLULAR VESICLES (2013)

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Article Immunology

Induction of Type I IFN Is a Physiological Immune Reaction to Apoptotic Cell-Derived Membrane Microparticles

Martin Schiller et al.

JOURNAL OF IMMUNOLOGY (2012)

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Article Cell Biology

Syndecan-syntenin-ALIX regulates the biogenesis of exosomes

Maria Francesca Baietti et al.

NATURE CELL BIOLOGY (2012)

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Review Cell Biology

Secreted microRNAs: a new form of intercellular communication

Xi Chen et al.

TRENDS IN CELL BIOLOGY (2012)

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Review Biochemistry & Molecular Biology

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

Bence Gyoergy et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

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Article Multidisciplinary Sciences

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

Maria Mittelbrunn et al.

NATURE COMMUNICATIONS (2011)

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Article Biochemistry & Molecular Biology

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

Caroline Subra et al.

JOURNAL OF LIPID RESEARCH (2010)

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Article Multidisciplinary Sciences

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

Thomas Wollert et al.

NATURE (2010)

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Article Oncology

Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis

HD Halicka et al.

EXPERIMENTAL CELL RESEARCH (2000)

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