Biological Distribution after Oral Administration of Radioiodine-Labeled Acetaminophen to Estimate Gastrointestinal Absorption Function via OATPs, OATs, and/or MRPs

Article Biochemistry & Molecular Biology

A Pharmacokinetic Study of Mix-160 by LC-MS/MS: Oral Bioavailability of a Dosage Form of Citroflavonoids Mixture

Jesus Alfredo Araujo-Leon et al.

Summary: This study evaluated and compared the pharmacokinetic parameters of two dosage forms of hesperidin and naringenin: mixture and tablet. The results showed that tablet form did not significantly alter the pharmacokinetic parameters and could be a suitable candidate for drug product development.

MOLECULES (2022)

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Article Pharmacology & Pharmacy

Biological Distribution of Orally Administered [123I]MIBG for Estimating Gastrointestinal Tract Absorption

Masato Kobayashi et al.

Summary: This study used whole-body imaging with [I-123]MIBG to investigate the absorption of cationic anticancer drugs and medicines in the gastrointestinal tract. The results showed different uptake mechanisms mediated by OCTN and OCT, which were affected by inhibitors L-carnitine and cimetidine. Furthermore, the accumulation of [I-123]MIBG was significantly altered in DSS-induced experimental colitis mice and mice with cimetidine loading. Therefore, [I-123]MIBG imaging can be used to estimate gastrointestinal absorption via OCTN and/or OCT in the small intestine.

PHARMACEUTICS (2022)

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Review Pharmacology & Pharmacy

Cell Surface Transporters and Novel Drug Developments

Natasha Carmichael et al.

Summary: Despite advances in science and technology, the attrition rates for anticancer drugs remain high. It is timely to question the generic drug development process and find a more efficient approach. Recent evidence suggests that carrier mediated transport may be the primary mechanism of drug uptake, rather than diffusion. Computational biology is increasingly used in drug design to achieve desirable properties. Perfecting drug entry into target cells is expected to reduce attrition rates. Utilizing transporters as drug targets and advocating bRo5 molecules may revolutionize drug development.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology